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The map label for this gene is nagB

Identifier: 150010145

GI number: 150010145

Start: 4361046

End: 4361858

Strand: Direct

Name: nagB

Synonym: BDI_3568

Alternate gene names: 150010145

Gene position: 4361046-4361858 (Clockwise)

Preceding gene: 150010144

Following gene: 150010155

Centisome position: 90.64

GC content: 44.77

Gene sequence:

>813_bases
ATGAGATTAATTATCGAACCTAATTACGAGCAACTCTCAAAATGGGCTGCCAATTATGTAGCAGCGAAGATCAAAGCCGC
GAATCCAACCGCTGAAAAACCATTCGTACTGGGCTTGCCTACCGGATCTTCTCCGCTGGGTATGTACAAGAACCTGATTG
AATTGAACAAGCAGGGTGTCGTATCGTTCCAGAACGTGATCACTTTCAATATGGATGAGTATGTCGGCCTTCCGAAAGAT
CATCCGGAAAGCTATCATTCTTTCATGTGGAATAATTTCTTCAGTCATATCGATATCAAACCGGAGAACGTAAATATCTT
GAATGGTAACGCCGAGGATTTGGAGGCTGAGTGTGCGTCTTATGAGGCTCGCATGAAAGCGGTCGGTGGCGTAGACCTGT
TCTTGGGTGGTATCGGTCCTGATGGCCATATTGCGTTCAATGAGCCGGGTTCATCTTTGAGTTCTCGTACTCGTATCAAG
ACGTTAACTACAGATACGATTATCGCTAACTCCCGTTTCTTTGATAATGACGTGAATAAAGTTCCGAAGACTTCTGTAAC
GGTTGGTGTAGGTACGGTTCTTGACGCTAAGGAGGTATTGATCATGGTAAATGGTCATAACAAGGCTCGTGCGTTGCAAC
AAGCCGTTGAGGGTGCCGTGAACCAAATGTGGACAATTACCGCCTTGCAGTTGCATCCGAAGGGAATCATTGTTTGCGAT
GAGGCGGCTTGTGCGGATCTTAAGGTAGGTACTTATAACTATTTCAAGGATATCGAGAAGGATCATCTTTGTCCTTGTTC
ATTGCTAAAATAA

Upstream 100 bases:

>100_bases
ATCTAATTTATAAACAAAAGAAAGGCGAGATGCGTAGATTGGGAATCCTTTAATTTTCAATTTCCAATTTTCAATTTTCA
ATTAAAAAAAGCGTAACGTT

Downstream 100 bases:

>100_bases
ACGAATCTCAGATAGGGCTTTCTTTGAATGCCCATCATAAGGAGTTAAGAATGCCCATTGTAAGGAGTTTACGATGGGCA
TTCTTATAACCTTACGATGG

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MRLIIEPNYEQLSKWAANYVAAKIKAANPTAEKPFVLGLPTGSSPLGMYKNLIELNKQGVVSFQNVITFNMDEYVGLPKD
HPESYHSFMWNNFFSHIDIKPENVNILNGNAEDLEAECASYEARMKAVGGVDLFLGGIGPDGHIAFNEPGSSLSSRTRIK
TLTTDTIIANSRFFDNDVNKVPKTSVTVGVGTVLDAKEVLIMVNGHNKARALQQAVEGAVNQMWTITALQLHPKGIIVCD
EAACADLKVGTYNYFKDIEKDHLCPCSLLK

Sequences:

>Translated_270_residues
MRLIIEPNYEQLSKWAANYVAAKIKAANPTAEKPFVLGLPTGSSPLGMYKNLIELNKQGVVSFQNVITFNMDEYVGLPKD
HPESYHSFMWNNFFSHIDIKPENVNILNGNAEDLEAECASYEARMKAVGGVDLFLGGIGPDGHIAFNEPGSSLSSRTRIK
TLTTDTIIANSRFFDNDVNKVPKTSVTVGVGTVLDAKEVLIMVNGHNKARALQQAVEGAVNQMWTITALQLHPKGIIVCD
EAACADLKVGTYNYFKDIEKDHLCPCSLLK
>Mature_270_residues
MRLIIEPNYEQLSKWAANYVAAKIKAANPTAEKPFVLGLPTGSSPLGMYKNLIELNKQGVVSFQNVITFNMDEYVGLPKD
HPESYHSFMWNNFFSHIDIKPENVNILNGNAEDLEAECASYEARMKAVGGVDLFLGGIGPDGHIAFNEPGSSLSSRTRIK
TLTTDTIIANSRFFDNDVNKVPKTSVTVGVGTVLDAKEVLIMVNGHNKARALQQAVEGAVNQMWTITALQLHPKGIIVCD
EAACADLKVGTYNYFKDIEKDHLCPCSLLK

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=258, Percent_Identity=63.5658914728682, Blast_Score=359, Evalue=1e-99,
Organism=Homo sapiens, GI19923881, Length=262, Percent_Identity=60.3053435114504, Blast_Score=348, Evalue=2e-96,
Organism=Escherichia coli, GI1786893, Length=263, Percent_Identity=62.7376425855513, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1789530, Length=226, Percent_Identity=28.7610619469027, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994958, Length=241, Percent_Identity=28.2157676348548, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17554876, Length=262, Percent_Identity=58.3969465648855, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24581960, Length=261, Percent_Identity=62.4521072796935, Blast_Score=356, Evalue=8e-99,
Organism=Drosophila melanogaster, GI19920764, Length=261, Percent_Identity=62.4521072796935, Blast_Score=356, Evalue=8e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_PARD8 (A6LHV2)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001304888.1
- ProteinModelPortal:   A6LHV2
- SMR:   A6LHV2
- STRING:   A6LHV2
- GeneID:   5308717
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_3568
- eggNOG:   COG0363
- HOGENOM:   HBG725991
- OMA:   HLSITMG
- ProtClustDB:   PRK00443
- BioCyc:   PDIS435591:BDI_3568-MONOMER
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 29662; Mature: 29662

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 72-72 ACT_SITE 141-141 ACT_SITE 143-143 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIIEPNYEQLSKWAANYVAAKIKAANPTAEKPFVLGLPTGSSPLGMYKNLIELNKQGV
CEEEECCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCC
VSFQNVITFNMDEYVGLPKDHPESYHSFMWNNFFSHIDIKPENVNILNGNAEDLEAECAS
EEEEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHEEECCCCCEEEECCCHHHHHHHHHH
YEARMKAVGGVDLFLGGIGPDGHIAFNEPGSSLSSRTRIKTLTTDTIIANSRFFDNDVNK
HHHHHHHCCCEEEEEECCCCCCCEEECCCCCCCCCCCEEEEEECCEEEECCCCCCCCHHH
VPKTSVTVGVGTVLDAKEVLIMVNGHNKARALQQAVEGAVNQMWTITALQLHPKGIIVCD
CCCCEEEEEECCEECCCEEEEEEECCCHHHHHHHHHHHHHHCEEEEEEEEECCCEEEEEC
EAACADLKVGTYNYFKDIEKDHLCPCSLLK
CCCCCCEECCCHHHHHHCCCCCCCCHHCCC
>Mature Secondary Structure
MRLIIEPNYEQLSKWAANYVAAKIKAANPTAEKPFVLGLPTGSSPLGMYKNLIELNKQGV
CEEEECCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCC
VSFQNVITFNMDEYVGLPKDHPESYHSFMWNNFFSHIDIKPENVNILNGNAEDLEAECAS
EEEEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHEEECCCCCEEEECCCHHHHHHHHHH
YEARMKAVGGVDLFLGGIGPDGHIAFNEPGSSLSSRTRIKTLTTDTIIANSRFFDNDVNK
HHHHHHHCCCEEEEEECCCCCCCEEECCCCCCCCCCCEEEEEECCEEEECCCCCCCCHHH
VPKTSVTVGVGTVLDAKEVLIMVNGHNKARALQQAVEGAVNQMWTITALQLHPKGIIVCD
CCCCEEEEEECCEECCCEEEEEEECCCHHHHHHHHHHHHHHCEEEEEEEEECCCEEEEEC
EAACADLKVGTYNYFKDIEKDHLCPCSLLK
CCCCCCEECCCHHHHHHCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA