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The map label for this gene is macA [H]

Identifier: 150009936

GI number: 150009936

Start: 4063870

End: 4065096

Strand: Direct

Name: macA [H]

Synonym: BDI_3353

Alternate gene names: 150009936

Gene position: 4063870-4065096 (Clockwise)

Preceding gene: 150009935

Following gene: 150009937

Centisome position: 84.46

GC content: 54.03

Gene sequence:

>1227_bases
ATGGACAAGAAGAAACTAATCATGGGCGGTGTTGCCGTTATCCTCATCGCGGGGGGCGTGTTCCTTTTCACGGGCAAATC
CTCGAAAGGCGGGATCAAGCTGGAGACCGCTAAGGTAGGGCGCAGCACGATCACGAATACGGTTACGGCCACCGGTACGG
TAGAGCCCGTTACCGAGGTTGAGGTAGGTACGCAGGTATCCGGTATCATCGATAAGTTGTACGCTGATTATAACGACGTG
GTGAAGGCCGGCCAACTGATCGCCGAGATGGATAAGATCAACCTCCAAGCCGAACTTCGTTCCGCCGAGGCGCAATTGGC
GAGCAGCAAGACGGAGTTCGAGTATCAACAGAAGAACTACGCACGTAGCAAGGTGCTTCACGAGAAACAATTGATTAGCG
ATACGGATTATGAGACGGCTACCTATAATTATGAGAAGGCGAAGGCCGCTTACGACCAGAGTCAGGCCTCCATGGTGAAA
GTAAACCGTAATCTGGAATATGCCACGATCACGAGCCCTATAGACGGAGTGGTTATCAACCGGGCCGTTGAGGAAGGGCA
GACCGTTGCCGCCGGCTTCGAGACCCCGACTCTGTTTACCATTGCCGCCGACTTGACGAAGATGCAGGTGATAGCAGACG
TGGATGAGGCGGATATAGGGAACGTGGAGGAAGGCCAACGGGTTAGCTTTACGGTGGATGCCTACCCGAACGATCAATTC
GAGGGCGTGGTTCGCCAGATTCGCCTTGGGGATAGCGAAAGCACCTCCAGCGCTTCTTCCAGTACTTCTTCTTCTACGGT
CGTTACCTACGAGGTAGTGATTACGGCAGATAATCCGGACTTGAAACTGAAACCTCGCTTGACGGCGAATATCACGATTT
ATACGTTGGAACGTGCGAATGTCCTGACCTTGCCGAACAAGGCACTTCGTTTTATCCCCGAGCCCGCCATCATGGAATCG
TTGGGTATGACCGTGACAGATCCGAATGCGGAGGTACAACCCGGAAAACGCTTGGTTTGGTCCCGCCAAGGAAATACCTT
GAGCCCGAGGCAGATTACGGTCGGAACCAGCAACAACAGCGTGACCGAAGTAACCGAGGGCTTGAGCGAGGGCGATGAGG
TAGCCGTAGATTTAGCGAGCGCCGCTAACATGCCGGAAGTAGGTGCAGGAGCGGAGCGTAGCCCTTTCATGCCGGGCCCT
CCGGGAAGCAACAAAAATAAGAGATAG

Upstream 100 bases:

>100_bases
TTTACTCCACTCTCTTTTTTCAAGGTTACCCTGCGACGGAAGTCGCGGGGGCCTTTTGAACAAGAACAGAACGTAAAACA
GAAATAAAACGAATCAGAAT

Downstream 100 bases:

>100_bases
TTTGCGTCATGAAAGAAATTATCAGATTAGACAATATAAAACGAGACTTCCACGTGGGCGACGAGATCGTCCATGCCCTG
CGAGGCGTGTCGTTCACGAT

Product: efflux system periplasmic protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MDKKKLIMGGVAVILIAGGVFLFTGKSSKGGIKLETAKVGRSTITNTVTATGTVEPVTEVEVGTQVSGIIDKLYADYNDV
VKAGQLIAEMDKINLQAELRSAEAQLASSKTEFEYQQKNYARSKVLHEKQLISDTDYETATYNYEKAKAAYDQSQASMVK
VNRNLEYATITSPIDGVVINRAVEEGQTVAAGFETPTLFTIAADLTKMQVIADVDEADIGNVEEGQRVSFTVDAYPNDQF
EGVVRQIRLGDSESTSSASSSTSSSTVVTYEVVITADNPDLKLKPRLTANITIYTLERANVLTLPNKALRFIPEPAIMES
LGMTVTDPNAEVQPGKRLVWSRQGNTLSPRQITVGTSNNSVTEVTEGLSEGDEVAVDLASAANMPEVGAGAERSPFMPGP
PGSNKNKR

Sequences:

>Translated_408_residues
MDKKKLIMGGVAVILIAGGVFLFTGKSSKGGIKLETAKVGRSTITNTVTATGTVEPVTEVEVGTQVSGIIDKLYADYNDV
VKAGQLIAEMDKINLQAELRSAEAQLASSKTEFEYQQKNYARSKVLHEKQLISDTDYETATYNYEKAKAAYDQSQASMVK
VNRNLEYATITSPIDGVVINRAVEEGQTVAAGFETPTLFTIAADLTKMQVIADVDEADIGNVEEGQRVSFTVDAYPNDQF
EGVVRQIRLGDSESTSSASSSTSSSTVVTYEVVITADNPDLKLKPRLTANITIYTLERANVLTLPNKALRFIPEPAIMES
LGMTVTDPNAEVQPGKRLVWSRQGNTLSPRQITVGTSNNSVTEVTEGLSEGDEVAVDLASAANMPEVGAGAERSPFMPGP
PGSNKNKR
>Mature_408_residues
MDKKKLIMGGVAVILIAGGVFLFTGKSSKGGIKLETAKVGRSTITNTVTATGTVEPVTEVEVGTQVSGIIDKLYADYNDV
VKAGQLIAEMDKINLQAELRSAEAQLASSKTEFEYQQKNYARSKVLHEKQLISDTDYETATYNYEKAKAAYDQSQASMVK
VNRNLEYATITSPIDGVVINRAVEEGQTVAAGFETPTLFTIAADLTKMQVIADVDEADIGNVEEGQRVSFTVDAYPNDQF
EGVVRQIRLGDSESTSSASSSTSSSTVVTYEVVITADNPDLKLKPRLTANITIYTLERANVLTLPNKALRFIPEPAIMES
LGMTVTDPNAEVQPGKRLVWSRQGNTLSPRQITVGTSNNSVTEVTEGLSEGDEVAVDLASAANMPEVGAGAERSPFMPGP
PGSNKNKR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=388, Percent_Identity=28.0927835051546, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082036, Length=332, Percent_Identity=23.1927710843373, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787013, Length=252, Percent_Identity=25.7936507936508, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789929, Length=140, Percent_Identity=32.8571428571429, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43833; Mature: 43833

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKKLIMGGVAVILIAGGVFLFTGKSSKGGIKLETAKVGRSTITNTVTATGTVEPVTEV
CCCCEEECCCCEEEEEECCEEEEECCCCCCCEEEEEECCCCHHHCCEEEECCCCCCCCEE
EVGTQVSGIIDKLYADYNDVVKAGQLIAEMDKINLQAELRSAEAQLASSKTEFEYQQKNY
ECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHH
ARSKVLHEKQLISDTDYETATYNYEKAKAAYDQSQASMVKVNRNLEYATITSPIDGVVIN
HHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCEEH
RAVEEGQTVAAGFETPTLFTIAADLTKMQVIADVDEADIGNVEEGQRVSFTVDAYPNDQF
HHHHCCCEEEECCCCCEEEEEEHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHH
EGVVRQIRLGDSESTSSASSSTSSSTVVTYEVVITADNPDLKLKPRLTANITIYTLERAN
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEECCCEEEEEEEEEECCCC
VLTLPNKALRFIPEPAIMESLGMTVTDPNAEVQPGKRLVWSRQGNTLSPRQITVGTSNNS
EEECCCHHHHHCCCHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCC
VTEVTEGLSEGDEVAVDLASAANMPEVGAGAERSPFMPGPPGSNKNKR
HHHHHHHHCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDKKKLIMGGVAVILIAGGVFLFTGKSSKGGIKLETAKVGRSTITNTVTATGTVEPVTEV
CCCCEEECCCCEEEEEECCEEEEECCCCCCCEEEEEECCCCHHHCCEEEECCCCCCCCEE
EVGTQVSGIIDKLYADYNDVVKAGQLIAEMDKINLQAELRSAEAQLASSKTEFEYQQKNY
ECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHH
ARSKVLHEKQLISDTDYETATYNYEKAKAAYDQSQASMVKVNRNLEYATITSPIDGVVIN
HHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCEEH
RAVEEGQTVAAGFETPTLFTIAADLTKMQVIADVDEADIGNVEEGQRVSFTVDAYPNDQF
HHHHCCCEEEECCCCCEEEEEEHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHH
EGVVRQIRLGDSESTSSASSSTSSSTVVTYEVVITADNPDLKLKPRLTANITIYTLERAN
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEECCCEEEEEEEEEECCCC
VLTLPNKALRFIPEPAIMESLGMTVTDPNAEVQPGKRLVWSRQGNTLSPRQITVGTSNNS
EEECCCHHHHHCCCHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCC
VTEVTEGLSEGDEVAVDLASAANMPEVGAGAERSPFMPGPPGSNKNKR
HHHHHHHHCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]