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The map label for this gene is mdmC [H]

Identifier: 150009887

GI number: 150009887

Start: 3997070

End: 3997705

Strand: Direct

Name: mdmC [H]

Synonym: BDI_3303

Alternate gene names: 150009887

Gene position: 3997070-3997705 (Clockwise)

Preceding gene: 150009886

Following gene: 150009888

Centisome position: 83.08

GC content: 46.07

Gene sequence:

>636_bases
ATGTTTACGGGCGAGATTGATGCGTATATTCTTTCTCATATAGATGAAGAAGGGGATTTGCTGTCGGCGTTGAATCGCGA
CGCCAATGTGAACCTTCTCCGTCCGCGTATGCTATCCGGGCATTTGCAGGGTAGGATATTGAAGATGTTTTGCCGGATGA
TTCGTCCGAGAAGAGTCTTGGAGATCGGGACTTATACGTCTTATGCCACTTTGTGTATGGCGGAAGGCATGGAAGAGGGG
GCATTGATCCATACGATCGAGATCAATGACGAGATGGAGGATTTTATCATGAAATATCTTTCCCGCTCGCTACATAAGGA
CAAGATAAAAGTCCATTTTGGGGATGCGATGGAGATTATCCCCCGTTTGGATGAGACGTTCGATATGGTTTTTATCGATG
CCGACAAACGCCTGTATTCCGAGTATTATGATTTGGTATTCCCGATGGTCCGTCCGGGCGGCTTGATTCTCGCGGATAAT
ACGCTTTGGGACGGTAAAGTGGTAGAAGAAGTGCATCCTTCCGATAAACAAACGAAGGGAATACTGGTTTTTAATGAAAA
GGTTAAGCAAGACGATCGGGTAGAGAAGGTGATCCTCCCTTTACGTGACGGCTTGACGATGATCTGGAAAAAGTAA

Upstream 100 bases:

>100_bases
GCGAAGGTGGCGGTACCAGCTTTTTGGAGATTAACAACGTAGGAAAGGTGCTGGATGCCGGCACGCAATATCAGTTGCCT
ACTTTTAAAGAGTAAGAGGA

Downstream 100 bases:

>100_bases
ATAATAAAGCGTATGGAAAGTACTAGATTACAAAAGATCGAACGCCTTCTTCAGAAGGAGTTGAGTGATATATTTCAGAA
GCAGACGCAAGGAATGCATG

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MFTGEIDAYILSHIDEEGDLLSALNRDANVNLLRPRMLSGHLQGRILKMFCRMIRPRRVLEIGTYTSYATLCMAEGMEEG
ALIHTIEINDEMEDFIMKYLSRSLHKDKIKVHFGDAMEIIPRLDETFDMVFIDADKRLYSEYYDLVFPMVRPGGLILADN
TLWDGKVVEEVHPSDKQTKGILVFNEKVKQDDRVEKVILPLRDGLTMIWKK

Sequences:

>Translated_211_residues
MFTGEIDAYILSHIDEEGDLLSALNRDANVNLLRPRMLSGHLQGRILKMFCRMIRPRRVLEIGTYTSYATLCMAEGMEEG
ALIHTIEINDEMEDFIMKYLSRSLHKDKIKVHFGDAMEIIPRLDETFDMVFIDADKRLYSEYYDLVFPMVRPGGLILADN
TLWDGKVVEEVHPSDKQTKGILVFNEKVKQDDRVEKVILPLRDGLTMIWKK
>Mature_211_residues
MFTGEIDAYILSHIDEEGDLLSALNRDANVNLLRPRMLSGHLQGRILKMFCRMIRPRRVLEIGTYTSYATLCMAEGMEEG
ALIHTIEINDEMEDFIMKYLSRSLHKDKIKVHFGDAMEIIPRLDETFDMVFIDADKRLYSEYYDLVFPMVRPGGLILADN
TLWDGKVVEEVHPSDKQTKGILVFNEKVKQDDRVEKVILPLRDGLTMIWKK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=176, Percent_Identity=30.1136363636364, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565612, Length=211, Percent_Identity=32.2274881516588, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI72001028, Length=215, Percent_Identity=33.4883720930233, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72001127, Length=211, Percent_Identity=30.3317535545024, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25148771, Length=211, Percent_Identity=30.3317535545024, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24455; Mature: 24455

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGEIDAYILSHIDEEGDLLSALNRDANVNLLRPRMLSGHLQGRILKMFCRMIRPRRVL
CCCCHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCEE
EIGTYTSYATLCMAEGMEEGALIHTIEINDEMEDFIMKYLSRSLHKDKIKVHFGDAMEII
EECCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
PRLDETFDMVFIDADKRLYSEYYDLVFPMVRPGGLILADNTLWDGKVVEEVHPSDKQTKG
HCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCCCCC
ILVFNEKVKQDDRVEKVILPLRDGLTMIWKK
EEEECCCCCCCHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MFTGEIDAYILSHIDEEGDLLSALNRDANVNLLRPRMLSGHLQGRILKMFCRMIRPRRVL
CCCCHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCEE
EIGTYTSYATLCMAEGMEEGALIHTIEINDEMEDFIMKYLSRSLHKDKIKVHFGDAMEII
EECCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
PRLDETFDMVFIDADKRLYSEYYDLVFPMVRPGGLILADNTLWDGKVVEEVHPSDKQTKG
HCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCCCCC
ILVFNEKVKQDDRVEKVILPLRDGLTMIWKK
EEEECCCCCCCHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]