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The map label for this gene is uvrC [H]

Identifier: 150009554

GI number: 150009554

Start: 3551338

End: 3553173

Strand: Direct

Name: uvrC [H]

Synonym: BDI_2967

Alternate gene names: 150009554

Gene position: 3551338-3553173 (Clockwise)

Preceding gene: 150009553

Following gene: 150009555

Centisome position: 73.81

GC content: 45.37

Gene sequence:

>1836_bases
ATGATAGCCGATAAAGACGAACATATCAAGACGATCCTATCGGTCATTCCGGAAAAGCCGGGATGCTACCAGTATTTCGA
TGAAAACGGAACGATTATATACGTCGGCAAGGCGAAGAACCTAAAACGACGGGTATCCTCTTATTTCAACAAGGTACATG
ACAGCAATAAGACCCGTGTGTTAGTCAAGCAAATCCGGGATATCAAATATATAGTCGTCGATACGGAAGAAGACGCGTTA
CTACTGGAAAACAACCTCATCAAACAGTATCGTCCCCGCTATAACGTATTATTGAAGGACGACAAAACCTACCCTTCCAT
CGTGGTAAAGAATGAGTACTTTCCCCGGGTTTTCCAAACCCGGAACATCGTTCGGGACGGATCACAATATTACGGTCCTT
ATCCCTCTTTGTTCACGGCGAAAGTGATGCTACAGATGCTAAAGGAACTTTACCCTTTACGCACTTGTAAATATCCCCTC
ACTCCCGAATCCATCGCACAAGGACGCTATAAGGTTTGTCTGGAATACCATATCAAGCGTTGTAAAGGGCCTTGTGAAGG
CTTGCAATCATTGGAAGAATACCAGCAAAATATTTCCGAGATCAAAGAGATTCTGCGAGGCAACATCTCGCAAATCAGCA
AACACCTCTATGAGGAGATGCAATCGCTCGCTGCCGAGCTCAAGTTTGAGGAAGCGCAAAAGATCAAGGAAAAATACGAA
GTCATCGAGAACTACCGTTCTAAATCTACGGTCGTAACCCCGATGCTACATAATATAGATGTATTCACGATCATAGAGAA
TGACCATTCCGCTTATGTGAACTTTATGCATATCGGAAACGGGGCGATCGTACAAGCCTATACATTCGAGTATAAAAAAC
GATTGGACGAGAGTAAGGAGGAATTGTTAAGCCTCGGTATTATCGAGATGCGGAATCGTTTTAAAAGCACCGCCCGGGAG
ATTATCGTGCCTTTCAAGCTGGATATGCAACTAGAGAATGTCACCTTCACCATTCCCCAAAGAGGGGATAAAAAGAAACT
GCTCGATTTATCCGAGATGAACGTCAAGCAGTTTAAGGTTGACCGCTTGAAGCAAGCGGAAAAGTTGAATCCGGAACAAC
GGAATACCCGTATCTTGAAAGAGATCCAAGAGGCCTTGCATCTGGAGAAATTGCCTGCTCATATCGAATGTTTCGATAAT
TCAAACATACAGGGAAGCGATGCGGTAGCGGCTTGCGTGGTATTCAAGATGGGAAAACCGTCCAAGCAGGAGTATCGTAA
ATACAATATAAAGACCGTAGTCGGTCCGGATGATTACGCCTCTATGAAAGAAGTTGTCCGTAGGCGTTACGGGCGGGCAA
TCGAGGAGCGATCTCCCCTACCCGACTTAATTATAACAGACGGTGGAAAGGGGCAAATGGAAGTGGTTCGCTCGGTGGTA
GAAGATGAATTAGGCTTGTCCATTCCAATCGCCGGACTAGCGAAAGATGGTAAGCACCGGACCTCGGAGTTATTATTCGG
GTTCCCACCCGTAACCGTTGGCATGCGTTTGGACAGTCCGCTATTCCATCTGCTTACCCGGATACAAGACGAGGTACACC
GTTTCGCCATCACTTTCCACAAGGATAAACGAAGTAAGACCCAGACAAAATCCGAATTAGACACCATTAAGGGTATCGGT
GAAAAGACAAAAGTATTACTTTTACGTCACTTTAAAAGCGTAAAACGAATCAAGGAAGCAAGCTTCGAGGAACTGAAGTC
CGTGATTGGCGAGGCGAAAGCCAAGGCACTACAAGAGGGACTGGATGGAAAGCGAACAGAAAGCGAACAAAAATAG

Upstream 100 bases:

>100_bases
TGACGCTTTCTTTTATGGGATTGTTGGCGATCCCATCCTTAAAACTTAGCAACAAAGGTTTGTTCAATAGCGAGACATTC
CAATTTACTTCCCTATTCGT

Downstream 100 bases:

>100_bases
AACAAAAGCGAACAAGATGAGAACAGTTACACAACGTGTGCAGCACGCTTCCGTCACGATAGACGGACAGCTTAAGTCCA
AAATTGGAAAGGGGCTATTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MIADKDEHIKTILSVIPEKPGCYQYFDENGTIIYVGKAKNLKRRVSSYFNKVHDSNKTRVLVKQIRDIKYIVVDTEEDAL
LLENNLIKQYRPRYNVLLKDDKTYPSIVVKNEYFPRVFQTRNIVRDGSQYYGPYPSLFTAKVMLQMLKELYPLRTCKYPL
TPESIAQGRYKVCLEYHIKRCKGPCEGLQSLEEYQQNISEIKEILRGNISQISKHLYEEMQSLAAELKFEEAQKIKEKYE
VIENYRSKSTVVTPMLHNIDVFTIIENDHSAYVNFMHIGNGAIVQAYTFEYKKRLDESKEELLSLGIIEMRNRFKSTARE
IIVPFKLDMQLENVTFTIPQRGDKKKLLDLSEMNVKQFKVDRLKQAEKLNPEQRNTRILKEIQEALHLEKLPAHIECFDN
SNIQGSDAVAACVVFKMGKPSKQEYRKYNIKTVVGPDDYASMKEVVRRRYGRAIEERSPLPDLIITDGGKGQMEVVRSVV
EDELGLSIPIAGLAKDGKHRTSELLFGFPPVTVGMRLDSPLFHLLTRIQDEVHRFAITFHKDKRSKTQTKSELDTIKGIG
EKTKVLLLRHFKSVKRIKEASFEELKSVIGEAKAKALQEGLDGKRTESEQK

Sequences:

>Translated_611_residues
MIADKDEHIKTILSVIPEKPGCYQYFDENGTIIYVGKAKNLKRRVSSYFNKVHDSNKTRVLVKQIRDIKYIVVDTEEDAL
LLENNLIKQYRPRYNVLLKDDKTYPSIVVKNEYFPRVFQTRNIVRDGSQYYGPYPSLFTAKVMLQMLKELYPLRTCKYPL
TPESIAQGRYKVCLEYHIKRCKGPCEGLQSLEEYQQNISEIKEILRGNISQISKHLYEEMQSLAAELKFEEAQKIKEKYE
VIENYRSKSTVVTPMLHNIDVFTIIENDHSAYVNFMHIGNGAIVQAYTFEYKKRLDESKEELLSLGIIEMRNRFKSTARE
IIVPFKLDMQLENVTFTIPQRGDKKKLLDLSEMNVKQFKVDRLKQAEKLNPEQRNTRILKEIQEALHLEKLPAHIECFDN
SNIQGSDAVAACVVFKMGKPSKQEYRKYNIKTVVGPDDYASMKEVVRRRYGRAIEERSPLPDLIITDGGKGQMEVVRSVV
EDELGLSIPIAGLAKDGKHRTSELLFGFPPVTVGMRLDSPLFHLLTRIQDEVHRFAITFHKDKRSKTQTKSELDTIKGIG
EKTKVLLLRHFKSVKRIKEASFEELKSVIGEAKAKALQEGLDGKRTESEQK
>Mature_611_residues
MIADKDEHIKTILSVIPEKPGCYQYFDENGTIIYVGKAKNLKRRVSSYFNKVHDSNKTRVLVKQIRDIKYIVVDTEEDAL
LLENNLIKQYRPRYNVLLKDDKTYPSIVVKNEYFPRVFQTRNIVRDGSQYYGPYPSLFTAKVMLQMLKELYPLRTCKYPL
TPESIAQGRYKVCLEYHIKRCKGPCEGLQSLEEYQQNISEIKEILRGNISQISKHLYEEMQSLAAELKFEEAQKIKEKYE
VIENYRSKSTVVTPMLHNIDVFTIIENDHSAYVNFMHIGNGAIVQAYTFEYKKRLDESKEELLSLGIIEMRNRFKSTARE
IIVPFKLDMQLENVTFTIPQRGDKKKLLDLSEMNVKQFKVDRLKQAEKLNPEQRNTRILKEIQEALHLEKLPAHIECFDN
SNIQGSDAVAACVVFKMGKPSKQEYRKYNIKTVVGPDDYASMKEVVRRRYGRAIEERSPLPDLIITDGGKGQMEVVRSVV
EDELGLSIPIAGLAKDGKHRTSELLFGFPPVTVGMRLDSPLFHLLTRIQDEVHRFAITFHKDKRSKTQTKSELDTIKGIG
EKTKVLLLRHFKSVKRIKEASFEELKSVIGEAKAKALQEGLDGKRTESEQK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=613, Percent_Identity=34.747145187602, Blast_Score=351, Evalue=7e-98,
Organism=Escherichia coli, GI1788037, Length=206, Percent_Identity=27.6699029126214, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 70661; Mature: 70661

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIADKDEHIKTILSVIPEKPGCYQYFDENGTIIYVGKAKNLKRRVSSYFNKVHDSNKTRV
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHH
LVKQIRDIKYIVVDTEEDALLLENNLIKQYRPRYNVLLKDDKTYPSIVVKNEYFPRVFQT
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCCCHHHHHH
RNIVRDGSQYYGPYPSLFTAKVMLQMLKELYPLRTCKYPLTPESIAQGRYKVCLEYHIKR
HHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHCCHHHHHHHHHHHH
CKGPCEGLQSLEEYQQNISEIKEILRGNISQISKHLYEEMQSLAAELKFEEAQKIKEKYE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIENYRSKSTVVTPMLHNIDVFTIIENDHSAYVNFMHIGNGAIVQAYTFEYKKRLDESKE
HHHHHCCCCCEECHHHHCCEEEEEEECCCCEEEEEEEECCCCEEEHHHHHHHHHHCHHHH
ELLSLGIIEMRNRFKSTAREIIVPFKLDMQLENVTFTIPQRGDKKKLLDLSEMNVKQFKV
HHHHHHHHHHHHHHHHHHHHEEEEEEECEEECCEEEECCCCCCHHHHCCHHHCCHHHHHH
DRLKQAEKLNPEQRNTRILKEIQEALHLEKLPAHIECFDNSNIQGSDAVAACVVFKMGKP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
SKQEYRKYNIKTVVGPDDYASMKEVVRRRYGRAIEERSPLPDLIITDGGKGQMEVVRSVV
CHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCHHHHHHHHH
EDELGLSIPIAGLAKDGKHRTSELLFGFPPVTVGMRLDSPLFHLLTRIQDEVHRFAITFH
HHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEE
KDKRSKTQTKSELDTIKGIGEKTKVLLLRHFKSVKRIKEASFEELKSVIGEAKAKALQEG
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDGKRTESEQK
CCCCCCCCCCC
>Mature Secondary Structure
MIADKDEHIKTILSVIPEKPGCYQYFDENGTIIYVGKAKNLKRRVSSYFNKVHDSNKTRV
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHH
LVKQIRDIKYIVVDTEEDALLLENNLIKQYRPRYNVLLKDDKTYPSIVVKNEYFPRVFQT
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCCCHHHHHH
RNIVRDGSQYYGPYPSLFTAKVMLQMLKELYPLRTCKYPLTPESIAQGRYKVCLEYHIKR
HHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHCCHHHHHHHHHHHH
CKGPCEGLQSLEEYQQNISEIKEILRGNISQISKHLYEEMQSLAAELKFEEAQKIKEKYE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIENYRSKSTVVTPMLHNIDVFTIIENDHSAYVNFMHIGNGAIVQAYTFEYKKRLDESKE
HHHHHCCCCCEECHHHHCCEEEEEEECCCCEEEEEEEECCCCEEEHHHHHHHHHHCHHHH
ELLSLGIIEMRNRFKSTAREIIVPFKLDMQLENVTFTIPQRGDKKKLLDLSEMNVKQFKV
HHHHHHHHHHHHHHHHHHHHEEEEEEECEEECCEEEECCCCCCHHHHCCHHHCCHHHHHH
DRLKQAEKLNPEQRNTRILKEIQEALHLEKLPAHIECFDNSNIQGSDAVAACVVFKMGKP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
SKQEYRKYNIKTVVGPDDYASMKEVVRRRYGRAIEERSPLPDLIITDGGKGQMEVVRSVV
CHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCHHHHHHHHH
EDELGLSIPIAGLAKDGKHRTSELLFGFPPVTVGMRLDSPLFHLLTRIQDEVHRFAITFH
HHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEE
KDKRSKTQTKSELDTIKGIGEKTKVLLLRHFKSVKRIKEASFEELKSVIGEAKAKALQEG
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDGKRTESEQK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]