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The map label for this gene is pdxB [H]

Identifier: 150009417

GI number: 150009417

Start: 3368605

End: 3369714

Strand: Direct

Name: pdxB [H]

Synonym: BDI_2825

Alternate gene names: 150009417

Gene position: 3368605-3369714 (Clockwise)

Preceding gene: 150009416

Following gene: 150009419

Centisome position: 70.01

GC content: 51.44

Gene sequence:

>1110_bases
ATGAAAATAATAGCAGATAACACGGTTCCTTACCTAAAAGGGATCTTGGAGCCGATAGCAGACGTATCCTACCTTGACTC
CAAAGAGTTTACACCCACGAACATAAAAGACGCAGATGCCTTGATCGTACGTAGCATAGATAAATGTACACGCGAGCTAT
TGGAAGGTAGCCGGGTTCGCCTCATCACGACAGCCACGATCGGATACGACCATATCGATATCCATTATTGCGAGAAGGCA
GGGATCACGTGGAAGAACGCCCCGGGTTGCAACGCCGCTTCCGTGGGGCAATATGTATTATCCTCTTTGGTAGCCGTCGC
CCTCCGCAAAGGAGAGAGACTAGCAGGGAAGACTATCGGTATCGTTGGCGTAGGCCATGTAGGGAGTATCGTGGAGAGGC
TATGCGAGGCCATGGGGATGCGTGTGCTTCGCAATGACCCGCCCCGTGCCGAGCAGGAAGGCGACGGTGGATTCGTATCC
TTGGACACGATCGCGAAAGAGGCGGATATCATAACCTTGCATGTGCCGTTGACCAAAGAGGGACGTTTCGCCACCCGCCA
TCTCGCCGATCCTGCTTTTTTCGACAAATTGGAACGAAAACCATGGTTTATCAACAGTTGCCGGGGCGCCGTACATGATA
CGCAGGCCTTATTGCAGGCCAAACGAACCGGCAAGGTCAGCGAACTGATCATCGATTGCTGGGAGAACGAACCGGATATC
GACCGGAAATTACTGTCGGAAGCCACGATCGCCACTCCTCATATAGCCGGTTTCTCCGCCGACGGGAAGGCGAACGGGAC
ACGAATGTGCCTAGAGAATATAGGATGCTTTTTCGGTATCCGTATCGAAAAGATCAAGGAAGTCATTCCGCCTGCCCCAA
CCAACCTATTCATCGACTTGGGACAATTCAAGGAGCACCGTGTGGAAGAAGCCATCTTGAGAAGTTTCAACCCAGAAGTA
ATCGACCAAGCACTAAGAGCGAATCCTCATCATTTCGAGCGATTTAGGGCAGCGTATGATCATCCCCGTGAGTTCCATGC
TTACCAAGCGATCAAAGCTGACCCGGAAGAATTCGCCGTACTCCAAAAACTAGGTTTTCAAGTAGGCTAA

Upstream 100 bases:

>100_bases
TGAGAACAAAAGCGCATATAGAAATCGACAAGAAGCCATCATCACTTGTATATCCCCTGTTTTTTACTTAATATCGCGTA
ACGATAATCAAGCTGATAAG

Downstream 100 bases:

>100_bases
TGACAAAAAAGCCTTACAGTAAACTTTCGATCACATGAGGATAATGCGCATACTCCAAGGCATGCACTTTCGCGGCTACC
TCATCTGGCGTATCCGAAGG

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKIIADNTVPYLKGILEPIADVSYLDSKEFTPTNIKDADALIVRSIDKCTRELLEGSRVRLITTATIGYDHIDIHYCEKA
GITWKNAPGCNAASVGQYVLSSLVAVALRKGERLAGKTIGIVGVGHVGSIVERLCEAMGMRVLRNDPPRAEQEGDGGFVS
LDTIAKEADIITLHVPLTKEGRFATRHLADPAFFDKLERKPWFINSCRGAVHDTQALLQAKRTGKVSELIIDCWENEPDI
DRKLLSEATIATPHIAGFSADGKANGTRMCLENIGCFFGIRIEKIKEVIPPAPTNLFIDLGQFKEHRVEEAILRSFNPEV
IDQALRANPHHFERFRAAYDHPREFHAYQAIKADPEEFAVLQKLGFQVG

Sequences:

>Translated_369_residues
MKIIADNTVPYLKGILEPIADVSYLDSKEFTPTNIKDADALIVRSIDKCTRELLEGSRVRLITTATIGYDHIDIHYCEKA
GITWKNAPGCNAASVGQYVLSSLVAVALRKGERLAGKTIGIVGVGHVGSIVERLCEAMGMRVLRNDPPRAEQEGDGGFVS
LDTIAKEADIITLHVPLTKEGRFATRHLADPAFFDKLERKPWFINSCRGAVHDTQALLQAKRTGKVSELIIDCWENEPDI
DRKLLSEATIATPHIAGFSADGKANGTRMCLENIGCFFGIRIEKIKEVIPPAPTNLFIDLGQFKEHRVEEAILRSFNPEV
IDQALRANPHHFERFRAAYDHPREFHAYQAIKADPEEFAVLQKLGFQVG
>Mature_369_residues
MKIIADNTVPYLKGILEPIADVSYLDSKEFTPTNIKDADALIVRSIDKCTRELLEGSRVRLITTATIGYDHIDIHYCEKA
GITWKNAPGCNAASVGQYVLSSLVAVALRKGERLAGKTIGIVGVGHVGSIVERLCEAMGMRVLRNDPPRAEQEGDGGFVS
LDTIAKEADIITLHVPLTKEGRFATRHLADPAFFDKLERKPWFINSCRGAVHDTQALLQAKRTGKVSELIIDCWENEPDI
DRKLLSEATIATPHIAGFSADGKANGTRMCLENIGCFFGIRIEKIKEVIPPAPTNLFIDLGQFKEHRVEEAILRSFNPEV
IDQALRANPHHFERFRAAYDHPREFHAYQAIKADPEEFAVLQKLGFQVG

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=303, Percent_Identity=25.7425742574257, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4557497, Length=284, Percent_Identity=27.8169014084507, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI61743967, Length=284, Percent_Identity=28.169014084507, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI6912396, Length=310, Percent_Identity=25.4838709677419, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI145580578, Length=281, Percent_Identity=24.9110320284698, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4557499, Length=281, Percent_Identity=24.9110320284698, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI145580575, Length=281, Percent_Identity=24.9110320284698, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788660, Length=371, Percent_Identity=37.1967654986523, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787645, Length=270, Percent_Identity=25.9259259259259, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082289, Length=254, Percent_Identity=27.1653543307087, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789279, Length=267, Percent_Identity=26.5917602996255, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=271, Percent_Identity=28.4132841328413, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=265, Percent_Identity=29.811320754717, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=265, Percent_Identity=29.4339622641509, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=28.6290322580645, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921140, Length=256, Percent_Identity=28.125, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=25.2669039145907, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=25.2669039145907, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=25.2669039145907, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=25.2669039145907, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI62472511, Length=281, Percent_Identity=25.2669039145907, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=26.0377358490566, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574286, Length=270, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 40938; Mature: 40938

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIADNTVPYLKGILEPIADVSYLDSKEFTPTNIKDADALIVRSIDKCTRELLEGSRVR
CEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
LITTATIGYDHIDIHYCEKAGITWKNAPGCNAASVGQYVLSSLVAVALRKGERLAGKTIG
EEEEEEECCCCEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCEEE
IVGVGHVGSIVERLCEAMGMRVLRNDPPRAEQEGDGGFVSLDTIAKEADIITLHVPLTKE
EEECCHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCEEEHHHHHCCCCEEEEEECCCCC
GRFATRHLADPAFFDKLERKPWFINSCRGAVHDTQALLQAKRTGKVSELIIDCWENEPDI
CCHHHHHHCCHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
DRKLLSEATIATPHIAGFSADGKANGTRMCLENIGCFFGIRIEKIKEVIPPAPTNLFIDL
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHCCHHHHHHHHHCCCCCCCEEEEC
GQFKEHRVEEAILRSFNPEVIDQALRANPHHFERFRAAYDHPREFHAYQAIKADPEEFAV
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHH
LQKLGFQVG
HHHHCCCCC
>Mature Secondary Structure
MKIIADNTVPYLKGILEPIADVSYLDSKEFTPTNIKDADALIVRSIDKCTRELLEGSRVR
CEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
LITTATIGYDHIDIHYCEKAGITWKNAPGCNAASVGQYVLSSLVAVALRKGERLAGKTIG
EEEEEEECCCCEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCEEE
IVGVGHVGSIVERLCEAMGMRVLRNDPPRAEQEGDGGFVSLDTIAKEADIITLHVPLTKE
EEECCHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCEEEHHHHHCCCCEEEEEECCCCC
GRFATRHLADPAFFDKLERKPWFINSCRGAVHDTQALLQAKRTGKVSELIIDCWENEPDI
CCHHHHHHCCHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
DRKLLSEATIATPHIAGFSADGKANGTRMCLENIGCFFGIRIEKIKEVIPPAPTNLFIDL
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHCCHHHHHHHHHCCCCCCCEEEEC
GQFKEHRVEEAILRSFNPEVIDQALRANPHHFERFRAAYDHPREFHAYQAIKADPEEFAV
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHH
LQKLGFQVG
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12949112 [H]