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The map label for this gene is adh [H]

Identifier: 150008780

GI number: 150008780

Start: 2556824

End: 2557897

Strand: Reverse

Name: adh [H]

Synonym: BDI_2170

Alternate gene names: 150008780

Gene position: 2557897-2556824 (Counterclockwise)

Preceding gene: 150008783

Following gene: 150008777

Centisome position: 53.16

GC content: 50.28

Gene sequence:

>1074_bases
ATGCTTGCGTACACTTATATTGAACAAGGGAAATTTGAATTGCGGGAGAAACCGATACCGGAAATAAAGGATTCACGGGA
CGCTATCGTACGAGTGACTTTGGGTAGCATTTGTTCTAGCGATCTTCATATTAAACACGGTAGCGTACCACGTGCGGTAC
CCGGAATAACCGTTGGGCATGAGATGGTTGGTGTGGTGGAAAAGGTGGGTGCCGATGTTACTGCAGTCAAGCCGGGTGAC
AGGGTGACCGTGAATGTCGAGACCTTTTGCGGAGAGTGTTTCTTCTGCCGGCGTGGATATGTCAATAATTGTACCGATCC
CAATGGCGGTTGGGCGTTGGGCTGTCGTATCGATGGGGGGCAGGCGGAGTATGTCCGGGTTCCTTATGCGGATCGAGGCT
TGAATCGTATCCCAGATACGGTCAGTGATGAGCAGGCTTTGCTGGTCGGTGATGTGTTAGCGACAGGTTTTTGGGCTGCC
CGCATCTCGGAGGTCTCAGAGGAGGATACGGTTCTCATTATTGGCGCTGGTCCTACGGGGATCTGTACTTTGTTGTGCGT
GTTGTTGAAGAAGCCACGACGTATTATTGTTTGCGAGAAGTCTCCGGAAAGGGCCCGGTTCGTTCGTCAGCGTTATCCAG
AAGTCTTGGTGACAGATCCCAAAAACTGTAAGGAATTTGTTCTTCGTAACAGCGATCATGGCGGTGCGGATGTCGTATTG
GAGGTCGCGGGGAGTGAGGATACCTTCCGCTTGGCATGGGATTGTGCCCGTCCGAACGCCATTGTCACCATCGTAGCCCT
CTATGATAAACCTCAGCTTCTTCCTTTGCCAGACATGTATGGCAAGAACTTGACGTTCAAGACTGGTGGGGTGGATGGCT
GCGATTGCGCCGAGATTCTTAACCTAATAGAAGAAGGTAAGATAGACACGACGCCTCTTATTACCCATAAGTTTCCATTG
AACGAGATTGAGGAGGCTTACCGTATCTTCGAAAACAGGTTGGATGGGGTTATAAAGGTGGCGATTGAGGGGAATCTCAT
CAAACCTGTCTTTGTTTTGCCGCATACACTTTGA

Upstream 100 bases:

>100_bases
AAAAATGAAACAGTTTGTACCCAAATTACTGATATATCTGATATTTTTGGCGATACGATCCTTATCTTTGTAAGGCGATT
AACAAAAAGAAGGAAGTATC

Downstream 100 bases:

>100_bases
TTCTCTCCTCGCAACATTGTCGTGTGATATCCCGGAGCAGTTCTACTTTGGGGATAAGCGCCTCGATATCTTCTTTAGTG
ACGCGGAAGTGTAAATTATA

Product: putative zinc-type alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLAYTYIEQGKFELREKPIPEIKDSRDAIVRVTLGSICSSDLHIKHGSVPRAVPGITVGHEMVGVVEKVGADVTAVKPGD
RVTVNVETFCGECFFCRRGYVNNCTDPNGGWALGCRIDGGQAEYVRVPYADRGLNRIPDTVSDEQALLVGDVLATGFWAA
RISEVSEEDTVLIIGAGPTGICTLLCVLLKKPRRIIVCEKSPERARFVRQRYPEVLVTDPKNCKEFVLRNSDHGGADVVL
EVAGSEDTFRLAWDCARPNAIVTIVALYDKPQLLPLPDMYGKNLTFKTGGVDGCDCAEILNLIEEGKIDTTPLITHKFPL
NEIEEAYRIFENRLDGVIKVAIEGNLIKPVFVLPHTL

Sequences:

>Translated_357_residues
MLAYTYIEQGKFELREKPIPEIKDSRDAIVRVTLGSICSSDLHIKHGSVPRAVPGITVGHEMVGVVEKVGADVTAVKPGD
RVTVNVETFCGECFFCRRGYVNNCTDPNGGWALGCRIDGGQAEYVRVPYADRGLNRIPDTVSDEQALLVGDVLATGFWAA
RISEVSEEDTVLIIGAGPTGICTLLCVLLKKPRRIIVCEKSPERARFVRQRYPEVLVTDPKNCKEFVLRNSDHGGADVVL
EVAGSEDTFRLAWDCARPNAIVTIVALYDKPQLLPLPDMYGKNLTFKTGGVDGCDCAEILNLIEEGKIDTTPLITHKFPL
NEIEEAYRIFENRLDGVIKVAIEGNLIKPVFVLPHTL
>Mature_357_residues
MLAYTYIEQGKFELREKPIPEIKDSRDAIVRVTLGSICSSDLHIKHGSVPRAVPGITVGHEMVGVVEKVGADVTAVKPGD
RVTVNVETFCGECFFCRRGYVNNCTDPNGGWALGCRIDGGQAEYVRVPYADRGLNRIPDTVSDEQALLVGDVLATGFWAA
RISEVSEEDTVLIIGAGPTGICTLLCVLLKKPRRIIVCEKSPERARFVRQRYPEVLVTDPKNCKEFVLRNSDHGGADVVL
EVAGSEDTFRLAWDCARPNAIVTIVALYDKPQLLPLPDMYGKNLTFKTGGVDGCDCAEILNLIEEGKIDTTPLITHKFPL
NEIEEAYRIFENRLDGVIKVAIEGNLIKPVFVLPHTL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=25.7396449704142, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI4501929, Length=350, Percent_Identity=25.1428571428571, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI34577061, Length=344, Percent_Identity=25.2906976744186, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501933, Length=332, Percent_Identity=24.3975903614458, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=23.8356164383562, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=23.8356164383562, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI71565154, Length=334, Percent_Identity=23.6526946107784, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786825, Length=377, Percent_Identity=29.4429708222812, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1787863, Length=324, Percent_Identity=27.7777777777778, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=26.865671641791, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=27.4285714285714, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790045, Length=325, Percent_Identity=27.0769230769231, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790718, Length=318, Percent_Identity=24.5283018867925, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=344, Percent_Identity=25.5813953488372, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=25.9587020648968, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=335, Percent_Identity=27.1641791044776, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788075, Length=337, Percent_Identity=24.6290801186944, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081918, Length=141, Percent_Identity=32.6241134751773, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=340, Percent_Identity=24.4117647058824, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=340, Percent_Identity=25.2941176470588, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=339, Percent_Identity=23.3038348082596, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=23.2558139534884, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=338, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=310, Percent_Identity=29.3548387096774, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=26.3313609467456, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=26.3313609467456, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=352, Percent_Identity=24.4318181818182, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=340, Percent_Identity=25.2941176470588, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=347, Percent_Identity=26.8011527377522, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=24.4047619047619, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=266, Percent_Identity=25.5639097744361, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=30.5882352941176, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17737897, Length=340, Percent_Identity=29.1176470588235, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737895, Length=338, Percent_Identity=23.9644970414201, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221457811, Length=325, Percent_Identity=24, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45551930, Length=325, Percent_Identity=24, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550770, Length=325, Percent_Identity=24, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39267; Mature: 39267

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAYTYIEQGKFELREKPIPEIKDSRDAIVRVTLGSICSSDLHIKHGSVPRAVPGITVGH
CEEEEEECCCCHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCEEECCCCCCCCCCCEECH
EMVGVVEKVGADVTAVKPGDRVTVNVETFCGECFFCRRGYVNNCTDPNGGWALGCRIDGG
HHHHHHHHHCCCEEEECCCCEEEEEEHHHCCCEEEECCCCCCCCCCCCCCEEEEEEECCC
QAEYVRVPYADRGLNRIPDTVSDEQALLVGDVLATGFWAARISEVSEEDTVLIIGAGPTG
CEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCHH
ICTLLCVLLKKPRRIIVCEKSPERARFVRQRYPEVLVTDPKNCKEFVLRNSDHGGADVVL
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCCCEEEE
EVAGSEDTFRLAWDCARPNAIVTIVALYDKPQLLPLPDMYGKNLTFKTGGVDGCDCAEIL
EEECCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCCHHHCCCEEEECCCCCCCCHHHHH
NLIEEGKIDTTPLITHKFPLNEIEEAYRIFENRLDGVIKVAIEGNLIKPVFVLPHTL
HHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEECEEEECCCCC
>Mature Secondary Structure
MLAYTYIEQGKFELREKPIPEIKDSRDAIVRVTLGSICSSDLHIKHGSVPRAVPGITVGH
CEEEEEECCCCHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCEEECCCCCCCCCCCEECH
EMVGVVEKVGADVTAVKPGDRVTVNVETFCGECFFCRRGYVNNCTDPNGGWALGCRIDGG
HHHHHHHHHCCCEEEECCCCEEEEEEHHHCCCEEEECCCCCCCCCCCCCCEEEEEEECCC
QAEYVRVPYADRGLNRIPDTVSDEQALLVGDVLATGFWAARISEVSEEDTVLIIGAGPTG
CEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCHH
ICTLLCVLLKKPRRIIVCEKSPERARFVRQRYPEVLVTDPKNCKEFVLRNSDHGGADVVL
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCCCEEEE
EVAGSEDTFRLAWDCARPNAIVTIVALYDKPQLLPLPDMYGKNLTFKTGGVDGCDCAEIL
EEECCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCCHHHCCCEEEECCCCCCCCHHHHH
NLIEEGKIDTTPLITHKFPLNEIEEAYRIFENRLDGVIKVAIEGNLIKPVFVLPHTL
HHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEECEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]