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The map label for this gene is yfhQ [H]

Identifier: 150008608

GI number: 150008608

Start: 2356958

End: 2358037

Strand: Reverse

Name: yfhQ [H]

Synonym: BDI_1994

Alternate gene names: 150008608

Gene position: 2358037-2356958 (Counterclockwise)

Preceding gene: 150008614

Following gene: 150008607

Centisome position: 49.01

GC content: 46.02

Gene sequence:

>1080_bases
ATGTTACAGTATGAAAGTGAGTTAGAAATCAGCCGGATATTGGTTGAGTGGTATGAAACCTATAAAAGAGAGCTTCCTTG
GAGGGAAACGAGAGACCCTTATATCATCTGGATATCGGAGATTATATTGCAACAAACCCGGGTTGTACAGGGATTGGAGT
ATTTTTTGCGTTTTACCGAACGTTTCCCGGATGTGGCATCTCTAGCGGTGGCGGAAGAGGATGAGGTGCTGAAATATTGG
CAGGGCTTGGGGTATTATAGCCGGGCTCGTAACTTACATGCGGCGGCTAAATCTATCATGGAGCGGTTTAACGGGGTTTT
CCCGGAGAATTATAAAGAGGTATTATCCTTGAAAGGTATCGGGGAGTATACGGCGGCGGCGATCGTCTCCTTTGCTTGGA
ACCAACCGTGTCCGGTCGTGGATGGAAATGTGTACCGGGTACTTTCCCGTTTGTTTGCCGTAGATACGCCGATCGACACC
ACGAAGGGTAAAAAGCAATTTGCGGAACTGGCCGGAATGATCTTGGACCCTAAGAACGCAGGGACGCATAATCAGGCGAT
CATGGAATTGGGTGCTTTGCAATGTGTTCCTCAAAACCCGGACTGCGGGGTGTGCCCGCTAAAAGATAAATGCGTGGCGT
TCGCTTCCGGCAATGTGCAAGCTTATCCGGTGAAACAAAATAAGACGAAGACAAGGGATCGTTATTTCCACTATCTATAC
ATTATATATAAAGAACAAACTTGGATGAACAGACGGACGGGGAAGGATATCTGGACCGGTTTGTATGAATTTCCATTGAT
CGAGACGGATCATGCGATGGATTTTTCCGGTTTGTGTGAGACGCAAGCCTTCCGTAACCTATTGGGAGATGCTGGAAAAT
TGAGTATCACCCAAGGGTTATCGAATGTAAAGCATACGCTCTCCCATCAAATTTTATACGCTTCTTTCTATCAAATAGAG
ATAGAGCAGGTTCCGGAATCCTTGGGGAATTACCTCTCTCTGCCTTGTCGGGATATTGAGAAGTATGCCGTTCCCCGGCT
GATACATATTTATTTAGAGAAATTAAACGGAAACTTGTGA

Upstream 100 bases:

>100_bases
TCAATTTTTAAATAAAAAGATTCTTCTCGATTCGTAATATATATGTATGTTTGCGGTAATCAAATAGTTATGATGTTGAA
AAGTGAGAAAGGGAGCAGTT

Downstream 100 bases:

>100_bases
GAATGATTGAATTTGTGTTTCTTTGTATGGTTATTAAGAATTTGAATTATGTCATTGAATAAGGTTATATTGATCGGCAA
CGTAGGCAAAGATCCTGACG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MLQYESELEISRILVEWYETYKRELPWRETRDPYIIWISEIILQQTRVVQGLEYFLRFTERFPDVASLAVAEEDEVLKYW
QGLGYYSRARNLHAAAKSIMERFNGVFPENYKEVLSLKGIGEYTAAAIVSFAWNQPCPVVDGNVYRVLSRLFAVDTPIDT
TKGKKQFAELAGMILDPKNAGTHNQAIMELGALQCVPQNPDCGVCPLKDKCVAFASGNVQAYPVKQNKTKTRDRYFHYLY
IIYKEQTWMNRRTGKDIWTGLYEFPLIETDHAMDFSGLCETQAFRNLLGDAGKLSITQGLSNVKHTLSHQILYASFYQIE
IEQVPESLGNYLSLPCRDIEKYAVPRLIHIYLEKLNGNL

Sequences:

>Translated_359_residues
MLQYESELEISRILVEWYETYKRELPWRETRDPYIIWISEIILQQTRVVQGLEYFLRFTERFPDVASLAVAEEDEVLKYW
QGLGYYSRARNLHAAAKSIMERFNGVFPENYKEVLSLKGIGEYTAAAIVSFAWNQPCPVVDGNVYRVLSRLFAVDTPIDT
TKGKKQFAELAGMILDPKNAGTHNQAIMELGALQCVPQNPDCGVCPLKDKCVAFASGNVQAYPVKQNKTKTRDRYFHYLY
IIYKEQTWMNRRTGKDIWTGLYEFPLIETDHAMDFSGLCETQAFRNLLGDAGKLSITQGLSNVKHTLSHQILYASFYQIE
IEQVPESLGNYLSLPCRDIEKYAVPRLIHIYLEKLNGNL
>Mature_359_residues
MLQYESELEISRILVEWYETYKRELPWRETRDPYIIWISEIILQQTRVVQGLEYFLRFTERFPDVASLAVAEEDEVLKYW
QGLGYYSRARNLHAAAKSIMERFNGVFPENYKEVLSLKGIGEYTAAAIVSFAWNQPCPVVDGNVYRVLSRLFAVDTPIDT
TKGKKQFAELAGMILDPKNAGTHNQAIMELGALQCVPQNPDCGVCPLKDKCVAFASGNVQAYPVKQNKTKTRDRYFHYLY
IIYKEQTWMNRRTGKDIWTGLYEFPLIETDHAMDFSGLCETQAFRNLLGDAGKLSITQGLSNVKHTLSHQILYASFYQIE
IEQVPESLGNYLSLPCRDIEKYAVPRLIHIYLEKLNGNL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=228, Percent_Identity=39.4736842105263, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI115298654, Length=228, Percent_Identity=39.4736842105263, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI115298652, Length=228, Percent_Identity=39.4736842105263, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI6912520, Length=228, Percent_Identity=39.4736842105263, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI115298650, Length=228, Percent_Identity=39.4736842105263, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI190358497, Length=371, Percent_Identity=31.5363881401617, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789331, Length=302, Percent_Identity=37.7483443708609, Blast_Score=214, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41359; Mature: 41359

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQYESELEISRILVEWYETYKRELPWRETRDPYIIWISEIILQQTRVVQGLEYFLRFTE
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
RFPDVASLAVAEEDEVLKYWQGLGYYSRARNLHAAAKSIMERFNGVFPENYKEVLSLKGI
HCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
GEYTAAAIVSFAWNQPCPVVDGNVYRVLSRLFAVDTPIDTTKGKKQFAELAGMILDPKNA
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCEEECCCCC
GTHNQAIMELGALQCVPQNPDCGVCPLKDKCVAFASGNVQAYPVKQNKTKTRDRYFHYLY
CCHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCHHHHHEEEEEE
IIYKEQTWMNRRTGKDIWTGLYEFPLIETDHAMDFSGLCETQAFRNLLGDAGKLSITQGL
EEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
SNVKHTLSHQILYASFYQIEIEQVPESLGNYLSLPCRDIEKYAVPRLIHIYLEKLNGNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLQYESELEISRILVEWYETYKRELPWRETRDPYIIWISEIILQQTRVVQGLEYFLRFTE
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
RFPDVASLAVAEEDEVLKYWQGLGYYSRARNLHAAAKSIMERFNGVFPENYKEVLSLKGI
HCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
GEYTAAAIVSFAWNQPCPVVDGNVYRVLSRLFAVDTPIDTTKGKKQFAELAGMILDPKNA
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCEEECCCCC
GTHNQAIMELGALQCVPQNPDCGVCPLKDKCVAFASGNVQAYPVKQNKTKTRDRYFHYLY
CCHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCHHHHHEEEEEE
IIYKEQTWMNRRTGKDIWTGLYEFPLIETDHAMDFSGLCETQAFRNLLGDAGKLSITQGL
EEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
SNVKHTLSHQILYASFYQIEIEQVPESLGNYLSLPCRDIEKYAVPRLIHIYLEKLNGNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]