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The map label for this gene is napA [H]

Identifier: 150008353

GI number: 150008353

Start: 2042081

End: 2044369

Strand: Direct

Name: napA [H]

Synonym: BDI_1727

Alternate gene names: 150008353

Gene position: 2042081-2044369 (Clockwise)

Preceding gene: 150008350

Following gene: 150008354

Centisome position: 42.44

GC content: 47.4

Gene sequence:

>2289_bases
ATGAGCAAAGGAACAAAAAGTATAGCCTTTTACCTAATGATGATCCTCATTTTCGGTTCGCTGATGTACTTTATCGCCAA
AGAAGGGGAAAGTCAGCAACTGGAAAATTCGATTGCGTCCATTCAAAACGCACCTAGTAATTTAGAAGAGGGATTTACCA
TATTTACTCAATTATTAGTACATAATATCGAGTCTTCCATAGGAATTCTGCTTTTACAAATCATCACGATATTGCTTACG
TGCCGTTTGTTCGGTTGGTTATTCCAGAAGATCGGGCAACCCACCGTCATCGGCGAGATCGTTGCCGGAATCGTGCTAGG
GCCGTCCGTATTAGGCAATTTATTCCCGGAGGCTTCCGCCTTCCTTTTTCCTGTGGAATCGTTGGTGAATATAAATATGC
TGAGTCAATTCGGACTTATACTCTTTATGTTCGCTATCGGGATGGAACTTAATATCTCCGAGGTAAGGAAAAAGCTGAAA
GAGACGATCTTAATCAGTCATACCAGTACGATCGTCCCCTTCTTTTTCGGTATGCTGACCGCCTATTTCGTGTACGACAA
ATATGCGGATAAGAGTACGCCTTTCCTCTCTTTCGCCTTGTTTATAGGTATCGCCATGAGTATTACCGCCTTTCCCGTAT
TGGCACGTATTATCCAAGAGAAAGGACTTACCAAGACACATTTGGGTACCATCTCGTTGGCAAGCGCGGCGAATGGGGAT
ATCACCGCATGGTGCTTGCTAGCGGTTGTCATAGCGATCGCACAAGCGGGTTCGATGCTAAGTGCCGTTTACAACATCTT
ATTCTCAGTCCTTTACATAGTGTTTATGTTTTTGGCGGTGCGGCCATTCCTGCGGATGATCGGACATATTTACCACAACA
AGGAGGTAATCGACAAGGGGCTGGTCGCTTTCATCTTCTTGCTATTGATCACCTCGGCTTATCTGACTGAGATATTGGGA
TTGCATGCCTTGTTCGGCGCTTTTATCGCAGGGGTGGTGATGCCGGGAAATGTCAAATTCCGCAAGATCATGACCGAGAA
AGTAGAGGATGTATCCCTTGCGCTATTTCTTCCCTTATTCTTCGTATCCACCGGATTACGTACGGAAATAGGTCTTCTAA
ACAAGCCTGAGTTATGGTGGCTATGCCTTATCTTCATAATCGTGGCCATCGCGGGAAAGTTTGGGGGAGCGATGTTCTCC
GCCCGATTCGTGGGTGAGAGCTGGAAGGATAGCCTATACATAGGGGCACTCATGAACACCCGCGGGTTGATGGAGCTGGT
CGTATTGACGATCGGGTACGAGATGGGGATATTGACACCTTCCGTATTCGTGATCTTAGTGCTAATGACGCTGGTCACCA
CCTTTATGACAACACCGTTGGTCTCATTCATCAAATTCTGTTACCGGACGCATGACAAGCTGATGGAGCAAAAAGAGAGA
ATGCCATTGGAGGGAATATTCAAGGTACTGTTGTCCTTCGGACGAGCCGGAAATGGACAGATCATGCTGGACGTAGCCTA
CCAGATGTTCGCCCAAGGCAAAAACAAGCTGGAGCTGACGGCGCTGCACTTAACGGTTGGCTCGGACGTAAACCCGTTAC
ACACGGATAATTTCGAGGAAGTCAGCTTCGGCCCGATCCTTTACGGGGCCAAGAAGCTGGGCATTCAGATACAGACCCGC
TACGAGGTATCGAACAACGCCGGAGTGGATATTTGTAGCATCGTAAACAATGAGGGGTATGATTTCCTTCTGGTCGGTTC
CGGGATATCGATGAGCAACACACCGGATGATATAGCGGCAAGCCATTACCGGGCCTCTTTCTACAACCGTTATTTCAAAC
GCTTCAAGGCTCCGGAATCTTGGTTTTATCCGGGTGCCTTATTGAAAGACAAGACGAAGATGTTTATCGAGCAAAGCAAT
TGCCCGGTAGGTGTATTCGTGAACCGGAATTTCGTCAAGGCGTCGAACGTGATCGTGGTCATCGATTCCGAGGAGGATTT
ATTCCTGTTGGGATATGCCCAGACCTTATTGAAGTCTACACACGGCTCGGCCAGCGTACTTGATAAATCCAGCAGCACGA
CCCCGGGGAACGAGGTGATCAAGGAAGGAATCCTGCGATTCACGGAAGACGTGAAGCAGACCACGCTTCTACGAGAAAAA
GACCTTACGCCCCAGTCTTTCAACGGCTTCAACTTCATGCTGATCAGTTATAAGACATGGAACGATGTCTCCGAGCACCG
GAAAGAAGCCTTGCAGAAGATGCCTTCTACGTTGATATTAAGTAAATAA

Upstream 100 bases:

>100_bases
ATGATTTATTATAATTTGGTTCTCGGCAAAGATAAAAGAAAAAAACATACCCATTGATAATATTAGGATATTTCTTATAT
TCGCGGTAAACCGTATAAAG

Downstream 100 bases:

>100_bases
TCCGTTATAAACCATATAAATCCGTCTTTATGAGAATCTGTCTTTTCTTCTTGATCACCGTTTTCCTCATGGCCTGCTCC
TCTACGGGGAACCAGCGGCA

Product: cation/H+ antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MSKGTKSIAFYLMMILIFGSLMYFIAKEGESQQLENSIASIQNAPSNLEEGFTIFTQLLVHNIESSIGILLLQIITILLT
CRLFGWLFQKIGQPTVIGEIVAGIVLGPSVLGNLFPEASAFLFPVESLVNINMLSQFGLILFMFAIGMELNISEVRKKLK
ETILISHTSTIVPFFFGMLTAYFVYDKYADKSTPFLSFALFIGIAMSITAFPVLARIIQEKGLTKTHLGTISLASAANGD
ITAWCLLAVVIAIAQAGSMLSAVYNILFSVLYIVFMFLAVRPFLRMIGHIYHNKEVIDKGLVAFIFLLLITSAYLTEILG
LHALFGAFIAGVVMPGNVKFRKIMTEKVEDVSLALFLPLFFVSTGLRTEIGLLNKPELWWLCLIFIIVAIAGKFGGAMFS
ARFVGESWKDSLYIGALMNTRGLMELVVLTIGYEMGILTPSVFVILVLMTLVTTFMTTPLVSFIKFCYRTHDKLMEQKER
MPLEGIFKVLLSFGRAGNGQIMLDVAYQMFAQGKNKLELTALHLTVGSDVNPLHTDNFEEVSFGPILYGAKKLGIQIQTR
YEVSNNAGVDICSIVNNEGYDFLLVGSGISMSNTPDDIAASHYRASFYNRYFKRFKAPESWFYPGALLKDKTKMFIEQSN
CPVGVFVNRNFVKASNVIVVIDSEEDLFLLGYAQTLLKSTHGSASVLDKSSSTTPGNEVIKEGILRFTEDVKQTTLLREK
DLTPQSFNGFNFMLISYKTWNDVSEHRKEALQKMPSTLILSK

Sequences:

>Translated_762_residues
MSKGTKSIAFYLMMILIFGSLMYFIAKEGESQQLENSIASIQNAPSNLEEGFTIFTQLLVHNIESSIGILLLQIITILLT
CRLFGWLFQKIGQPTVIGEIVAGIVLGPSVLGNLFPEASAFLFPVESLVNINMLSQFGLILFMFAIGMELNISEVRKKLK
ETILISHTSTIVPFFFGMLTAYFVYDKYADKSTPFLSFALFIGIAMSITAFPVLARIIQEKGLTKTHLGTISLASAANGD
ITAWCLLAVVIAIAQAGSMLSAVYNILFSVLYIVFMFLAVRPFLRMIGHIYHNKEVIDKGLVAFIFLLLITSAYLTEILG
LHALFGAFIAGVVMPGNVKFRKIMTEKVEDVSLALFLPLFFVSTGLRTEIGLLNKPELWWLCLIFIIVAIAGKFGGAMFS
ARFVGESWKDSLYIGALMNTRGLMELVVLTIGYEMGILTPSVFVILVLMTLVTTFMTTPLVSFIKFCYRTHDKLMEQKER
MPLEGIFKVLLSFGRAGNGQIMLDVAYQMFAQGKNKLELTALHLTVGSDVNPLHTDNFEEVSFGPILYGAKKLGIQIQTR
YEVSNNAGVDICSIVNNEGYDFLLVGSGISMSNTPDDIAASHYRASFYNRYFKRFKAPESWFYPGALLKDKTKMFIEQSN
CPVGVFVNRNFVKASNVIVVIDSEEDLFLLGYAQTLLKSTHGSASVLDKSSSTTPGNEVIKEGILRFTEDVKQTTLLREK
DLTPQSFNGFNFMLISYKTWNDVSEHRKEALQKMPSTLILSK
>Mature_761_residues
SKGTKSIAFYLMMILIFGSLMYFIAKEGESQQLENSIASIQNAPSNLEEGFTIFTQLLVHNIESSIGILLLQIITILLTC
RLFGWLFQKIGQPTVIGEIVAGIVLGPSVLGNLFPEASAFLFPVESLVNINMLSQFGLILFMFAIGMELNISEVRKKLKE
TILISHTSTIVPFFFGMLTAYFVYDKYADKSTPFLSFALFIGIAMSITAFPVLARIIQEKGLTKTHLGTISLASAANGDI
TAWCLLAVVIAIAQAGSMLSAVYNILFSVLYIVFMFLAVRPFLRMIGHIYHNKEVIDKGLVAFIFLLLITSAYLTEILGL
HALFGAFIAGVVMPGNVKFRKIMTEKVEDVSLALFLPLFFVSTGLRTEIGLLNKPELWWLCLIFIIVAIAGKFGGAMFSA
RFVGESWKDSLYIGALMNTRGLMELVVLTIGYEMGILTPSVFVILVLMTLVTTFMTTPLVSFIKFCYRTHDKLMEQKERM
PLEGIFKVLLSFGRAGNGQIMLDVAYQMFAQGKNKLELTALHLTVGSDVNPLHTDNFEEVSFGPILYGAKKLGIQIQTRY
EVSNNAGVDICSIVNNEGYDFLLVGSGISMSNTPDDIAASHYRASFYNRYFKRFKAPESWFYPGALLKDKTKMFIEQSNC
PVGVFVNRNFVKASNVIVVIDSEEDLFLLGYAQTLLKSTHGSASVLDKSSSTTPGNEVIKEGILRFTEDVKQTTLLREKD
LTPQSFNGFNFMLISYKTWNDVSEHRKEALQKMPSTLILSK

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=322, Percent_Identity=27.3291925465839, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1789749, Length=287, Percent_Identity=26.1324041811847, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=412, Percent_Identity=35.6796116504854, Blast_Score=262, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 84739; Mature: 84608

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGTKSIAFYLMMILIFGSLMYFIAKEGESQQLENSIASIQNAPSNLEEGFTIFTQLLV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HNIESSIGILLLQIITILLTCRLFGWLFQKIGQPTVIGEIVAGIVLGPSVLGNLFPEASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHCCCHHH
FLFPVESLVNINMLSQFGLILFMFAIGMELNISEVRKKLKETILISHTSTIVPFFFGMLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHH
AYFVYDKYADKSTPFLSFALFIGIAMSITAFPVLARIIQEKGLTKTHLGTISLASAANGD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEECCCCCCC
ITAWCLLAVVIAIAQAGSMLSAVYNILFSVLYIVFMFLAVRPFLRMIGHIYHNKEVIDKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LVAFIFLLLITSAYLTEILGLHALFGAFIAGVVMPGNVKFRKIMTEKVEDVSLALFLPLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FVSTGLRTEIGLLNKPELWWLCLIFIIVAIAGKFGGAMFSARFVGESWKDSLYIGALMNT
HHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEHHHCC
RGLMELVVLTIGYEMGILTPSVFVILVLMTLVTTFMTTPLVSFIKFCYRTHDKLMEQKER
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPLEGIFKVLLSFGRAGNGQIMLDVAYQMFAQGKNKLELTALHLTVGSDVNPLHTDNFEE
CCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCC
VSFGPILYGAKKLGIQIQTRYEVSNNAGVDICSIVNNEGYDFLLVGSGISMSNTPDDIAA
CCCCHHHHCHHHHCEEEEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHH
SHYRASFYNRYFKRFKAPESWFYPGALLKDKTKMFIEQSNCPVGVFVNRNFVKASNVIVV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEEECCEEEECCEEEE
IDSEEDLFLLGYAQTLLKSTHGSASVLDKSSSTTPGNEVIKEGILRFTEDVKQTTLLREK
EECCCCEEEEHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DLTPQSFNGFNFMLISYKTWNDVSEHRKEALQKMPSTLILSK
CCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
SKGTKSIAFYLMMILIFGSLMYFIAKEGESQQLENSIASIQNAPSNLEEGFTIFTQLLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HNIESSIGILLLQIITILLTCRLFGWLFQKIGQPTVIGEIVAGIVLGPSVLGNLFPEASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHCCCHHH
FLFPVESLVNINMLSQFGLILFMFAIGMELNISEVRKKLKETILISHTSTIVPFFFGMLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHH
AYFVYDKYADKSTPFLSFALFIGIAMSITAFPVLARIIQEKGLTKTHLGTISLASAANGD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEECCCCCCC
ITAWCLLAVVIAIAQAGSMLSAVYNILFSVLYIVFMFLAVRPFLRMIGHIYHNKEVIDKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LVAFIFLLLITSAYLTEILGLHALFGAFIAGVVMPGNVKFRKIMTEKVEDVSLALFLPLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FVSTGLRTEIGLLNKPELWWLCLIFIIVAIAGKFGGAMFSARFVGESWKDSLYIGALMNT
HHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEHHHCC
RGLMELVVLTIGYEMGILTPSVFVILVLMTLVTTFMTTPLVSFIKFCYRTHDKLMEQKER
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPLEGIFKVLLSFGRAGNGQIMLDVAYQMFAQGKNKLELTALHLTVGSDVNPLHTDNFEE
CCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCC
VSFGPILYGAKKLGIQIQTRYEVSNNAGVDICSIVNNEGYDFLLVGSGISMSNTPDDIAA
CCCCHHHHCHHHHCEEEEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHH
SHYRASFYNRYFKRFKAPESWFYPGALLKDKTKMFIEQSNCPVGVFVNRNFVKASNVIVV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEEECCEEEECCEEEE
IDSEEDLFLLGYAQTLLKSTHGSASVLDKSSSTTPGNEVIKEGILRFTEDVKQTTLLREK
EECCCCEEEEHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DLTPQSFNGFNFMLISYKTWNDVSEHRKEALQKMPSTLILSK
CCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]