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The map label for this gene is comEC [H]

Identifier: 150008325

GI number: 150008325

Start: 2010294

End: 2011580

Strand: Reverse

Name: comEC [H]

Synonym: BDI_1694

Alternate gene names: 150008325

Gene position: 2011580-2010294 (Counterclockwise)

Preceding gene: 150008326

Following gene: 150008324

Centisome position: 41.81

GC content: 42.11

Gene sequence:

>1287_bases
ATGATTGAGGAAATACAAAAGCGGCCTTTTGTACGGCCGCTTTTTTTATGGATAACCGGAATTTTATGCTATGCGTTTTT
ACCTGCCTCTTCGCTCCTATATGTTTTAGGGGTTTTATCTGCTTTGGTTTTTCTTTTTTTGGGGTTCTCGTGGGGGCAAG
GGCATGCTGAGTTGCAATACGATTCCCGTTGGATATGGGGAGCTATAGTCTCCGTTTTGATTGTATGTTTGGCGGTTGAG
GTCTGTTGGTATAGTGACCGGCGTATAGCGCTTGTAAATGAGCCTGCTTCTTCTTTAGATTTATTGGCTACCAAGGCTCA
ATATTCTTTGGTAAATACATTTGATCGTTTGCGTTTATCTGATGAGGAGAAATCTATTTTGGCTACATTGACATTGGGAT
ATAAGAAAGCGATGAGTCGGGAAACGAAAAGGCGCTTCTCTTTGGCGGGCGTGTCTCATATATTAGCGGTGAGCGGTTTT
CATGTTGCCGTGATTTGTGGATTCTTATCTTTCTTTTGCTCGTTTATGCCAAGATGGGGGATAGGACGTTGGGTTCGTTA
TATCATTCTGGTGGGAAGTCTTTGGGGGTTTGTCTTTATCACAGGATTAGCGCCCTCGGCGGTACGGGCAGCCTTGATGC
TATCTTTATATTTAACAGGAAGGGCGCTTAGGCGTGTTACGGATGGATATAATACATTGGCCGCCGCCGCTTTCTGTATG
CTGGCCTATAATCCGTATTATCTGTTTGATGTCGGTTTTCAGTTAAGCTATTTGGCTGTGTTTTTTATTTTATTCCTAGT
GCCTCGTTTCAAGGAATGGATAGTGGTGAGAAATCCTTTGTTGGCCATGCCTTGGGAATGGATTACGGTGTCTATTGCTG
CACAGATAGGTACTGCTTTGCTCTGTTTTTATTATTTTGGACAATTTTCGACAGTTTTCTTGTTTACGAATCTACCGGTC
ACTCTCTTGGCTATGTTTTTGATTCCTTTTGCCTTTTTGTGGTTAGGCTATCCGGTGGATTTCTATGGATATGACTGGAT
ACAGAAGATCGTAGAAGGGCTGGTTCATGGCATGGTAAGGGTAGTGGACGTGTTTAGCGTTATGCCTTATGCGACGATTA
CGGGTCGTTTTAGCTTCTTTGAGATGCTAGGAGGTTATGGGTTTCTTGTTTTATGCTTGATATATATGAAGATACGGGAA
CCAAAAGTTTTGTTAGCCGCCTTAACCCTTTTGTTAATAATATCAGTAAAGATCCTTATTGAACTTTTTTTGATAGCCGG
AAACTAA

Upstream 100 bases:

>100_bases
TCGCCGGTAACTTCGTATTCAAATCTCCAGATCCGATACAAACAATTAAAGACTTGAAAGCTTTGTAGAACACATTAATA
TATCACAAAACCTAACTATC

Downstream 100 bases:

>100_bases
AAAAGTCGTACCTTTGGGGGTGAAAACAAAAAGATTATATGATCACTAAAATCATTCAAGAAGAGAAGATTCAGAAAGCC
AAAAAATACGTAGAGAAAGG

Product: competence protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIEEIQKRPFVRPLFLWITGILCYAFLPASSLLYVLGVLSALVFLFLGFSWGQGHAELQYDSRWIWGAIVSVLIVCLAVE
VCWYSDRRIALVNEPASSLDLLATKAQYSLVNTFDRLRLSDEEKSILATLTLGYKKAMSRETKRRFSLAGVSHILAVSGF
HVAVICGFLSFFCSFMPRWGIGRWVRYIILVGSLWGFVFITGLAPSAVRAALMLSLYLTGRALRRVTDGYNTLAAAAFCM
LAYNPYYLFDVGFQLSYLAVFFILFLVPRFKEWIVVRNPLLAMPWEWITVSIAAQIGTALLCFYYFGQFSTVFLFTNLPV
TLLAMFLIPFAFLWLGYPVDFYGYDWIQKIVEGLVHGMVRVVDVFSVMPYATITGRFSFFEMLGGYGFLVLCLIYMKIRE
PKVLLAALTLLLIISVKILIELFLIAGN

Sequences:

>Translated_428_residues
MIEEIQKRPFVRPLFLWITGILCYAFLPASSLLYVLGVLSALVFLFLGFSWGQGHAELQYDSRWIWGAIVSVLIVCLAVE
VCWYSDRRIALVNEPASSLDLLATKAQYSLVNTFDRLRLSDEEKSILATLTLGYKKAMSRETKRRFSLAGVSHILAVSGF
HVAVICGFLSFFCSFMPRWGIGRWVRYIILVGSLWGFVFITGLAPSAVRAALMLSLYLTGRALRRVTDGYNTLAAAAFCM
LAYNPYYLFDVGFQLSYLAVFFILFLVPRFKEWIVVRNPLLAMPWEWITVSIAAQIGTALLCFYYFGQFSTVFLFTNLPV
TLLAMFLIPFAFLWLGYPVDFYGYDWIQKIVEGLVHGMVRVVDVFSVMPYATITGRFSFFEMLGGYGFLVLCLIYMKIRE
PKVLLAALTLLLIISVKILIELFLIAGN
>Mature_428_residues
MIEEIQKRPFVRPLFLWITGILCYAFLPASSLLYVLGVLSALVFLFLGFSWGQGHAELQYDSRWIWGAIVSVLIVCLAVE
VCWYSDRRIALVNEPASSLDLLATKAQYSLVNTFDRLRLSDEEKSILATLTLGYKKAMSRETKRRFSLAGVSHILAVSGF
HVAVICGFLSFFCSFMPRWGIGRWVRYIILVGSLWGFVFITGLAPSAVRAALMLSLYLTGRALRRVTDGYNTLAAAAFCM
LAYNPYYLFDVGFQLSYLAVFFILFLVPRFKEWIVVRNPLLAMPWEWITVSIAAQIGTALLCFYYFGQFSTVFLFTNLPV
TLLAMFLIPFAFLWLGYPVDFYGYDWIQKIVEGLVHGMVRVVDVFSVMPYATITGRFSFFEMLGGYGFLVLCLIYMKIRE
PKVLLAALTLLLIISVKILIELFLIAGN

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 48554; Mature: 48554

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEEIQKRPFVRPLFLWITGILCYAFLPASSLLYVLGVLSALVFLFLGFSWGQGHAELQY
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
DSRWIWGAIVSVLIVCLAVEVCWYSDRRIALVNEPASSLDLLATKAQYSLVNTFDRLRLS
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
DEEKSILATLTLGYKKAMSRETKRRFSLAGVSHILAVSGFHVAVICGFLSFFCSFMPRWG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
IGRWVRYIILVGSLWGFVFITGLAPSAVRAALMLSLYLTGRALRRVTDGYNTLAAAAFCM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LAYNPYYLFDVGFQLSYLAVFFILFLVPRFKEWIVVRNPLLAMPWEWITVSIAAQIGTAL
HHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHCCHHHHHHHHHHHHHHHH
LCFYYFGQFSTVFLFTNLPVTLLAMFLIPFAFLWLGYPVDFYGYDWIQKIVEGLVHGMVR
HHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VVDVFSVMPYATITGRFSFFEMLGGYGFLVLCLIYMKIREPKVLLAALTLLLIISVKILI
HHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ELFLIAGN
HHHHHCCC
>Mature Secondary Structure
MIEEIQKRPFVRPLFLWITGILCYAFLPASSLLYVLGVLSALVFLFLGFSWGQGHAELQY
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
DSRWIWGAIVSVLIVCLAVEVCWYSDRRIALVNEPASSLDLLATKAQYSLVNTFDRLRLS
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
DEEKSILATLTLGYKKAMSRETKRRFSLAGVSHILAVSGFHVAVICGFLSFFCSFMPRWG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
IGRWVRYIILVGSLWGFVFITGLAPSAVRAALMLSLYLTGRALRRVTDGYNTLAAAAFCM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LAYNPYYLFDVGFQLSYLAVFFILFLVPRFKEWIVVRNPLLAMPWEWITVSIAAQIGTAL
HHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHCCHHHHHHHHHHHHHHHH
LCFYYFGQFSTVFLFTNLPVTLLAMFLIPFAFLWLGYPVDFYGYDWIQKIVEGLVHGMVR
HHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VVDVFSVMPYATITGRFSFFEMLGGYGFLVLCLIYMKIREPKVLLAALTLLLIISVKILI
HHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ELFLIAGN
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]