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The map label for this gene is icd [H]

Identifier: 150007720

GI number: 150007720

Start: 1251526

End: 1252803

Strand: Direct

Name: icd [H]

Synonym: BDI_1075

Alternate gene names: 150007720

Gene position: 1251526-1252803 (Clockwise)

Preceding gene: 150007719

Following gene: 150007721

Centisome position: 26.01

GC content: 46.09

Gene sequence:

>1278_bases
ATGAGTAAGATAACAAAGAAAGGTAATCATATTTTCGTTCCGGATCACGTGACGATCCCTTATATTGAAGGAGATGGCGT
GGGGCATGAGATCACTCCCGTTAGCCAAAAGATAGTAAACGCTGCCATCAAGCAAGCTTACAACGGAACCCGTTCCATTG
AATGGAAAGAGGTCTTAGCCGGTGAAAAGGCGTTTAAGCAAACCGGAAGTTGGCTTCCCGATGAGACTATGGAAGCATTC
CGTGAATACATCGTCGGTATTAAGGGACCGTTGACAACTCCGATTGGTGGAGGTATCCGTTCATTAAATGTGGCCCTCCG
TCAGACGTTGGATTTATATGTTTGTCTCCGTCCGGTACGTTGGTTTAAAGGAGTCGTATCTCCGGTAAAGGAGCCGCAAA
AAGTGAATATGTATATCTTCCGTGAGAATACGGAAGATATCTATGCCGGAATCGAATGGCAACAAGGGACTCCGGAGGCA
CAAAAGTTATTGAAGTTCCTCACCGAGGAAATGGGAGTGAAGAAAATACGTTTCCCGGAAACTTCCTCTTTCGGCATCAA
GCCGGTTTCTGTGGAAGGTACGGAGCGTCTGGTGCGTGCCGCTATCGAATACGCGATATTGCATCAGTTACCGAGCGTGA
CTTTGGTACACAAAGGTAACATCATGAAATTCACGGAAGGTGGTTTCAAACTATGGGGATACGCTTTAGCGGAACGGGAG
TTTGCGGATTTCACTTTCACATGGCCTCAATATGAGAAGATCAAGAAAGAGCAAGGCGAGGAAGCGGCCAATACCGCCTT
AGTGGAAGCTTCAAAGGCCGGTAAAATCATTATCAAGGATGTCATAGCCGATGCTTTCTTGCAAAACACTCTATTAATTC
CGGAAGAATATTCCGTGATCGCTACCTTGAACCTGAACGGCGATTATATCTCCGATCAATTAGCGGCGATGGTAGGTGGC
ATTGGCATTGCTCCCGGCGCTAATATCAACTATAACAGTGGTCATGCGATCTTCGAGGCAACACATGGAACCGCTCCGAA
TATCGCGGGAAAGAATCTCGTAAACCCCTCTTCCTTATTATTATCATCCGTGATGATGCTGGAATATATGGGATGGAGTG
ATGCGGCTAACCTGATTACATCTGCTATGGAGCAAGCTTTCTCCGCTGGAGAGGCCACTCATGACTTGGCTCGTTTTATG
CCGAACGGCAAATCTCTCGGCACCAAAGAATTTGGTGATCGTATCATCTCTATTATCGAAACAATTAAATTAGTATAG

Upstream 100 bases:

>100_bases
CCCGGTTAACCATACGTATAATGATTTACAAATTAAATGGTTCAAGGCGGGTTCCGCTTTAAATACAGCTCACTAAGACA
AACAAAAAAATCTTGATATC

Downstream 100 bases:

>100_bases
TCATGTTGAAGAAAGAATATTTAATTTACAAATTGTCCGAGGCTGCCAGAGAGGCTTGCAAGATTGACAACGAACTTTTC
CCGATGTATAATGTGAAACG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSKITKKGNHIFVPDHVTIPYIEGDGVGHEITPVSQKIVNAAIKQAYNGTRSIEWKEVLAGEKAFKQTGSWLPDETMEAF
REYIVGIKGPLTTPIGGGIRSLNVALRQTLDLYVCLRPVRWFKGVVSPVKEPQKVNMYIFRENTEDIYAGIEWQQGTPEA
QKLLKFLTEEMGVKKIRFPETSSFGIKPVSVEGTERLVRAAIEYAILHQLPSVTLVHKGNIMKFTEGGFKLWGYALAERE
FADFTFTWPQYEKIKKEQGEEAANTALVEASKAGKIIIKDVIADAFLQNTLLIPEEYSVIATLNLNGDYISDQLAAMVGG
IGIAPGANINYNSGHAIFEATHGTAPNIAGKNLVNPSSLLLSSVMMLEYMGWSDAANLITSAMEQAFSAGEATHDLARFM
PNGKSLGTKEFGDRIISIIETIKLV

Sequences:

>Translated_425_residues
MSKITKKGNHIFVPDHVTIPYIEGDGVGHEITPVSQKIVNAAIKQAYNGTRSIEWKEVLAGEKAFKQTGSWLPDETMEAF
REYIVGIKGPLTTPIGGGIRSLNVALRQTLDLYVCLRPVRWFKGVVSPVKEPQKVNMYIFRENTEDIYAGIEWQQGTPEA
QKLLKFLTEEMGVKKIRFPETSSFGIKPVSVEGTERLVRAAIEYAILHQLPSVTLVHKGNIMKFTEGGFKLWGYALAERE
FADFTFTWPQYEKIKKEQGEEAANTALVEASKAGKIIIKDVIADAFLQNTLLIPEEYSVIATLNLNGDYISDQLAAMVGG
IGIAPGANINYNSGHAIFEATHGTAPNIAGKNLVNPSSLLLSSVMMLEYMGWSDAANLITSAMEQAFSAGEATHDLARFM
PNGKSLGTKEFGDRIISIIETIKLV
>Mature_424_residues
SKITKKGNHIFVPDHVTIPYIEGDGVGHEITPVSQKIVNAAIKQAYNGTRSIEWKEVLAGEKAFKQTGSWLPDETMEAFR
EYIVGIKGPLTTPIGGGIRSLNVALRQTLDLYVCLRPVRWFKGVVSPVKEPQKVNMYIFRENTEDIYAGIEWQQGTPEAQ
KLLKFLTEEMGVKKIRFPETSSFGIKPVSVEGTERLVRAAIEYAILHQLPSVTLVHKGNIMKFTEGGFKLWGYALAEREF
ADFTFTWPQYEKIKKEQGEEAANTALVEASKAGKIIIKDVIADAFLQNTLLIPEEYSVIATLNLNGDYISDQLAAMVGGI
GIAPGANINYNSGHAIFEATHGTAPNIAGKNLVNPSSLLLSSVMMLEYMGWSDAANLITSAMEQAFSAGEATHDLARFMP
NGKSLGTKEFGDRIISIIETIKLV

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=383, Percent_Identity=33.6814621409922, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4758582, Length=371, Percent_Identity=27.2237196765499, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI28178838, Length=371, Percent_Identity=26.9541778975741, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI28178821, Length=368, Percent_Identity=25.5434782608696, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI28178816, Length=368, Percent_Identity=25.5434782608696, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787381, Length=416, Percent_Identity=58.8942307692308, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1788101, Length=415, Percent_Identity=26.7469879518072, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081683, Length=412, Percent_Identity=26.4563106796117, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71986051, Length=379, Percent_Identity=33.509234828496, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17550882, Length=405, Percent_Identity=24.6913580246914, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=385, Percent_Identity=32.4675324675325, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322097, Length=411, Percent_Identity=28.7104622871046, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324291, Length=408, Percent_Identity=27.2058823529412, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6319830, Length=421, Percent_Identity=24.9406175771971, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643270, Length=379, Percent_Identity=32.7176781002639, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24643268, Length=379, Percent_Identity=32.1899736147757, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24661184, Length=398, Percent_Identity=30.4020100502513, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161078635, Length=288, Percent_Identity=28.4722222222222, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161078637, Length=288, Percent_Identity=28.4722222222222, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161078633, Length=288, Percent_Identity=28.4722222222222, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24650122, Length=288, Percent_Identity=28.4722222222222, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161078639, Length=288, Percent_Identity=28.4722222222222, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281362242, Length=410, Percent_Identity=25.8536585365854, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648872, Length=410, Percent_Identity=25.8536585365854, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI20130355, Length=369, Percent_Identity=22.7642276422764, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46802; Mature: 46671

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKITKKGNHIFVPDHVTIPYIEGDGVGHEITPVSQKIVNAAIKQAYNGTRSIEWKEVLA
CCCCCCCCCEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GEKAFKQTGSWLPDETMEAFREYIVGIKGPLTTPIGGGIRSLNVALRQTLDLYVCLRPVR
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WFKGVVSPVKEPQKVNMYIFRENTEDIYAGIEWQQGTPEAQKLLKFLTEEMGVKKIRFPE
HHHHHHHHHCCCCEEEEEEEECCCCHHEECCCCCCCCHHHHHHHHHHHHHCCCCEEECCC
TSSFGIKPVSVEGTERLVRAAIEYAILHQLPSVTLVHKGNIMKFTEGGFKLWGYALAERE
CCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHH
FADFTFTWPQYEKIKKEQGEEAANTALVEASKAGKIIIKDVIADAFLQNTLLIPEEYSVI
CCCEEECCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEECCCCCEEE
ATLNLNGDYISDQLAAMVGGIGIAPGANINYNSGHAIFEATHGTAPNIAGKNLVNPSSLL
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHH
LSSVMMLEYMGWSDAANLITSAMEQAFSAGEATHDLARFMPNGKSLGTKEFGDRIISIIE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
TIKLV
HHHCC
>Mature Secondary Structure 
SKITKKGNHIFVPDHVTIPYIEGDGVGHEITPVSQKIVNAAIKQAYNGTRSIEWKEVLA
CCCCCCCCEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GEKAFKQTGSWLPDETMEAFREYIVGIKGPLTTPIGGGIRSLNVALRQTLDLYVCLRPVR
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WFKGVVSPVKEPQKVNMYIFRENTEDIYAGIEWQQGTPEAQKLLKFLTEEMGVKKIRFPE
HHHHHHHHHCCCCEEEEEEEECCCCHHEECCCCCCCCHHHHHHHHHHHHHCCCCEEECCC
TSSFGIKPVSVEGTERLVRAAIEYAILHQLPSVTLVHKGNIMKFTEGGFKLWGYALAERE
CCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHH
FADFTFTWPQYEKIKKEQGEEAANTALVEASKAGKIIIKDVIADAFLQNTLLIPEEYSVI
CCCEEECCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEECCCCCEEE
ATLNLNGDYISDQLAAMVGGIGIAPGANINYNSGHAIFEATHGTAPNIAGKNLVNPSSLL
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHH
LSSVMMLEYMGWSDAANLITSAMEQAFSAGEATHDLARFMPNGKSLGTKEFGDRIISIIE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
TIKLV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA