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The map label for this gene is trpC [H]

Identifier: 150007243

GI number: 150007243

Start: 688176

End: 688970

Strand: Reverse

Name: trpC [H]

Synonym: BDI_0588

Alternate gene names: 150007243

Gene position: 688970-688176 (Counterclockwise)

Preceding gene: 150007244

Following gene: 150007242

Centisome position: 14.32

GC content: 54.72

Gene sequence:

>795_bases
ATGAAAAAGGACATCTTACAAGATATTATCGCCAATAAGCGCATCGAGGTAGCCCGGCAAAAACAGGCCGTAAGCTTACA
GACCTTATTGGCTCTAGGTAGCGACCGTATGGAGCGTGACACACGTTCCATGCGTGCGGCGCTGGAATCATCCCCCTCCG
GTATTATCTCCGAGTTCAAGCGTAAAAGCCCCTCCAAGGGCTGGCTGCATCCGGGTGCGAATATCGCCGACGTGGTGCCC
GCTTACGAGGCCGGAGGAGCCTCCGCCTGCTCGATCCTTACGGATGGGGATTTCTTCGGAGGTTCCTTGGGCGACTTGCA
AAAGGCCCGCAAGCTGGTGGATCTCCCGTTACTTCGCAAGGACTTCATCATCGATACCTACCAACTCTTCCAAGCTCGGG
TGATGGGCGCCGACGCTGTCTTGTTGATCGCCGCCGCCCTTACGGAAGAAGAATGCCGGATACTCGCCGAGACCGCCCAT
AGCCTGCAATTGGAAGTCTTGCTGGAAGTCCATAGCGAGGACGAGCTCAAATACCTGAACGCAGATATCGATATGCTCGG
CGTGAACAACCGTAATCTCGGCACCTTCCATACGGACGTAAACAACTCATTCAAGTTGGTCGATAAGATGCGAGGCTTCT
CCCCTCTTTTAGTGTCCGAGAGCGGAATATCCGAGACCGATACCGTACGCCAATTGCGTGAGGCCGGTTTCCGTGGATTC
CTGATCGGAGAGACCTTCATGAAAACCGAGAGGCCGGGCGATACCCTAGCCGATTTTATAGGAGGACTGGCATGA

Upstream 100 bases:

>100_bases
ACATGTATCGCCGAGGCACGTGAATCATTGGAAAGCGGAAAAGCATTGGCCACATTCCGTAAATTTATATCTTTGAACCA
AAGATAAAGAAACATATCCT

Downstream 100 bases:

>100_bases
TCATCAAAGTTTGCGGAATGCGGGAGCCTCAGAATATCCGGGAAGTAGCCGCCCTAGCCATCAACTGGATCGGCTTTATC
TTCTACGAACGTTCCAAGCG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKKDILQDIIANKRIEVARQKQAVSLQTLLALGSDRMERDTRSMRAALESSPSGIISEFKRKSPSKGWLHPGANIADVVP
AYEAGGASACSILTDGDFFGGSLGDLQKARKLVDLPLLRKDFIIDTYQLFQARVMGADAVLLIAAALTEEECRILAETAH
SLQLEVLLEVHSEDELKYLNADIDMLGVNNRNLGTFHTDVNNSFKLVDKMRGFSPLLVSESGISETDTVRQLREAGFRGF
LIGETFMKTERPGDTLADFIGGLA

Sequences:

>Translated_264_residues
MKKDILQDIIANKRIEVARQKQAVSLQTLLALGSDRMERDTRSMRAALESSPSGIISEFKRKSPSKGWLHPGANIADVVP
AYEAGGASACSILTDGDFFGGSLGDLQKARKLVDLPLLRKDFIIDTYQLFQARVMGADAVLLIAAALTEEECRILAETAH
SLQLEVLLEVHSEDELKYLNADIDMLGVNNRNLGTFHTDVNNSFKLVDKMRGFSPLLVSESGISETDTVRQLREAGFRGF
LIGETFMKTERPGDTLADFIGGLA
>Mature_264_residues
MKKDILQDIIANKRIEVARQKQAVSLQTLLALGSDRMERDTRSMRAALESSPSGIISEFKRKSPSKGWLHPGANIADVVP
AYEAGGASACSILTDGDFFGGSLGDLQKARKLVDLPLLRKDFIIDTYQLFQARVMGADAVLLIAAALTEEECRILAETAH
SLQLEVLLEVHSEDELKYLNADIDMLGVNNRNLGTFHTDVNNSFKLVDKMRGFSPLLVSESGISETDTVRQLREAGFRGF
LIGETFMKTERPGDTLADFIGGLA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=246, Percent_Identity=36.9918699186992, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=258, Percent_Identity=35.6589147286822, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28944; Mature: 28944

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDILQDIIANKRIEVARQKQAVSLQTLLALGSDRMERDTRSMRAALESSPSGIISEFK
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHH
RKSPSKGWLHPGANIADVVPAYEAGGASACSILTDGDFFGGSLGDLQKARKLVDLPLLRK
HCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHH
DFIIDTYQLFQARVMGADAVLLIAAALTEEECRILAETAHSLQLEVLLEVHSEDELKYLN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEC
ADIDMLGVNNRNLGTFHTDVNNSFKLVDKMRGFSPLLVSESGISETDTVRQLREAGFRGF
CCEEEEECCCCCCCEEECCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEE
LIGETFMKTERPGDTLADFIGGLA
EECHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MKKDILQDIIANKRIEVARQKQAVSLQTLLALGSDRMERDTRSMRAALESSPSGIISEFK
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHH
RKSPSKGWLHPGANIADVVPAYEAGGASACSILTDGDFFGGSLGDLQKARKLVDLPLLRK
HCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHH
DFIIDTYQLFQARVMGADAVLLIAAALTEEECRILAETAHSLQLEVLLEVHSEDELKYLN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEC
ADIDMLGVNNRNLGTFHTDVNNSFKLVDKMRGFSPLLVSESGISETDTVRQLREAGFRGF
CCEEEEECCCCCCCEEECCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEE
LIGETFMKTERPGDTLADFIGGLA
EECHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]