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The map label for this gene is trpF

Identifier: 150007242

GI number: 150007242

Start: 687514

End: 688179

Strand: Reverse

Name: trpF

Synonym: BDI_0587

Alternate gene names: 150007242

Gene position: 688179-687514 (Counterclockwise)

Preceding gene: 150007243

Following gene: 150007241

Centisome position: 14.3

GC content: 51.05

Gene sequence:

>666_bases
ATGATCATCAAAGTTTGCGGAATGCGGGAGCCTCAGAATATCCGGGAAGTAGCCGCCCTAGCCATCAACTGGATCGGCTT
TATCTTCTACGAACGTTCCAAGCGCTTTGTCGAGCGATGCCCGACGGAGCAGCAGGCAACGGACAGTGAACAATTGTCCC
CTAAGAAAGTGGGCGTTTTCGTCAACGCTACCATCGAGTCCATGATGGAGAAAGCCTCCACCTACAAGCTAGACTATCTC
CAACTTCATGGTAACGAATCGCCGGAAGATTGCCACACCTTGCAAAAAAGGGGCTATTCATTGATCAAGGCTTTCCCCAT
CGCTACGAAAGAGGACTTCGAAAAAACAAGGGAATATGAGGGCCGAGTGGATTATTTCCTTTTCGATACGAGATGCGAGG
GCTATGGAGGCTCAGGCAAACGTTTCGATTGGTCTATCCTAACCGGATATAAAGGAGAGACTCCCTTCTTGCTCAGCGGA
GGCATCCGTCCGGAAAACGCAGAGGCGATCCGGAACTTCCGGCATCCCCGTTTCGCAGGTATCGACCTCAACAGTGGCTT
CGAGATCGAGCCGGGATTGAAAGACATCGACAAACTAAAGAATTTCATCCAACAAATTTTACATCCAGCTGTAGAGACGG
GGCGTGCCCCGTCTCCCACCGTCTGA

Upstream 100 bases:

>100_bases
AATTGCGTGAGGCCGGTTTCCGTGGATTCCTGATCGGAGAGACCTTCATGAAAACCGAGAGGCCGGGCGATACCCTAGCC
GATTTTATAGGAGGACTGGC

Downstream 100 bases:

>100_bases
TAGTATTTTTAAAATAGAATTCAAAATGAATCGCATCACAAACTTATTCCAGACCCAGAAAGACGGAATACTCTCCGTCT
ATTTCACCGCCGGTTATCCG

Product: N-(5'-phosphoribosyl) anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MIIKVCGMREPQNIREVAALAINWIGFIFYERSKRFVERCPTEQQATDSEQLSPKKVGVFVNATIESMMEKASTYKLDYL
QLHGNESPEDCHTLQKRGYSLIKAFPIATKEDFEKTREYEGRVDYFLFDTRCEGYGGSGKRFDWSILTGYKGETPFLLSG
GIRPENAEAIRNFRHPRFAGIDLNSGFEIEPGLKDIDKLKNFIQQILHPAVETGRAPSPTV

Sequences:

>Translated_221_residues
MIIKVCGMREPQNIREVAALAINWIGFIFYERSKRFVERCPTEQQATDSEQLSPKKVGVFVNATIESMMEKASTYKLDYL
QLHGNESPEDCHTLQKRGYSLIKAFPIATKEDFEKTREYEGRVDYFLFDTRCEGYGGSGKRFDWSILTGYKGETPFLLSG
GIRPENAEAIRNFRHPRFAGIDLNSGFEIEPGLKDIDKLKNFIQQILHPAVETGRAPSPTV
>Mature_221_residues
MIIKVCGMREPQNIREVAALAINWIGFIFYERSKRFVERCPTEQQATDSEQLSPKKVGVFVNATIESMMEKASTYKLDYL
QLHGNESPEDCHTLQKRGYSLIKAFPIATKEDFEKTREYEGRVDYFLFDTRCEGYGGSGKRFDWSILTGYKGETPFLLSG
GIRPENAEAIRNFRHPRFAGIDLNSGFEIEPGLKDIDKLKNFIQQILHPAVETGRAPSPTV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=32.6829268292683, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320210, Length=222, Percent_Identity=27.4774774774775, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_PARD8 (A6L9J9)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001301985.1
- ProteinModelPortal:   A6L9J9
- SMR:   A6L9J9
- STRING:   A6L9J9
- GeneID:   5305742
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_0587
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   IQLHGRE
- ProtClustDB:   CLSK822228
- BioCyc:   PDIS435591:BDI_0587-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 25196; Mature: 25196

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKVCGMREPQNIREVAALAINWIGFIFYERSKRFVERCPTEQQATDSEQLSPKKVGVF
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHCCHHHEEEE
VNATIESMMEKASTYKLDYLQLHGNESPEDCHTLQKRGYSLIKAFPIATKEDFEKTREYE
EHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHC
GRVDYFLFDTRCEGYGGSGKRFDWSILTGYKGETPFLLSGGIRPENAEAIRNFRHPRFAG
CCEEEEEEECEECCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHCCCCCEEE
IDLNSGFEIEPGLKDIDKLKNFIQQILHPAVETGRAPSPTV
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIIKVCGMREPQNIREVAALAINWIGFIFYERSKRFVERCPTEQQATDSEQLSPKKVGVF
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHCCHHHEEEE
VNATIESMMEKASTYKLDYLQLHGNESPEDCHTLQKRGYSLIKAFPIATKEDFEKTREYE
EHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHC
GRVDYFLFDTRCEGYGGSGKRFDWSILTGYKGETPFLLSGGIRPENAEAIRNFRHPRFAG
CCEEEEEEECEECCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHCCCCCEEE
IDLNSGFEIEPGLKDIDKLKNFIQQILHPAVETGRAPSPTV
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA