| Definition | Parabacteroides distasonis ATCC 8503 chromosome, complete genome. |
|---|---|
| Accession | NC_009615 |
| Length | 4,811,379 |
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The map label for this gene is uxuB [H]
Identifier: 150007034
GI number: 150007034
Start: 431115
End: 431927
Strand: Reverse
Name: uxuB [H]
Synonym: BDI_0377
Alternate gene names: 150007034
Gene position: 431927-431115 (Counterclockwise)
Preceding gene: 150007035
Following gene: 150007033
Centisome position: 8.98
GC content: 50.55
Gene sequence:
>813_bases ATGAACTCCTTATTTAGCGTAAAAGAGAAAGTGATTTTGTTGACCGGAGGCTATGGTATATTAGGAGCCTGCATGGCCAA GCACTTGGCGAGAGAAGGCGCGTACGTCGTAATCCTCGGACGAAACGAGCAAAAAGGATCTGCCTTGGTCAATGAAATTA AAGCGGAAGGGGGCGAGGCCTTATTCTTGGTTTCAAACGTATTGGATAAAGCCTTGCTGGAGCAAAACAAACAAGAGATA TTGAAAGCATATGGGAAGATTGATGTTTTAGTCAATTTGGCGGGTGGCAACCAAGCCGGAGCGACGATTCCTCCCGACAA GACGATCTTTGATCTGGATATCGATGCTTTCCGGACAGTCGTAGACCTGAACTTATTCGGGACCGTACTGCCGACAATGG TTTTCGCCGAGGTCATGGTGGGACAAGGGAAAGGAAGCATTATTAACATCTCGTCCGAATCATCCCTACGCCCATTGACT CGTGTGGTTGGCTATGGATGCGCAAAAGCCGCTATCAACAATTTCACGCAATACATGGCCGGGGAGCTGGCGATTAAATT CGGAGAGGGCCTGCGAGTGAACGCCATGGCACCGGGATTCTTCCTTACCGAGCAGAACCGGGCATTGATGAGCAATCCGG ATGGATCACCTAGTGATCGTTGCAACACGATCGTCGCACACACGCCGTTCCGCCGCTTAGGAAAACCGGAGGAGTTACTC GGTACTTTACAATGGCTGGCGAGCGACGCCTCCGCATTCGTAACCGGTACCGTGATCCCCATAGACGGAGGTTTCGACGC TTTCTCCATCTAA
Upstream 100 bases:
>100_bases TCAGGCATCTGATCCTTAAGGAGAAAATTGAGCCTGTCAATTATATGCCGATCGATATCTTGGTAAAGGAAAATATACAA TACTACAATAATTATATCTG
Downstream 100 bases:
>100_bases ATAATGTGCCAACCAGCCATGCATCAAACCGCATTGGCATATTGGCACATTGATAAATTTAAAAATTATTCATTATGTAT CTATGTGAGCAAACTTGGCG
Product: D-mannonate oxidoreductase
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 270; Mature: 270
Protein sequence:
>270_residues MNSLFSVKEKVILLTGGYGILGACMAKHLAREGAYVVILGRNEQKGSALVNEIKAEGGEALFLVSNVLDKALLEQNKQEI LKAYGKIDVLVNLAGGNQAGATIPPDKTIFDLDIDAFRTVVDLNLFGTVLPTMVFAEVMVGQGKGSIINISSESSLRPLT RVVGYGCAKAAINNFTQYMAGELAIKFGEGLRVNAMAPGFFLTEQNRALMSNPDGSPSDRCNTIVAHTPFRRLGKPEELL GTLQWLASDASAFVTGTVIPIDGGFDAFSI
Sequences:
>Translated_270_residues MNSLFSVKEKVILLTGGYGILGACMAKHLAREGAYVVILGRNEQKGSALVNEIKAEGGEALFLVSNVLDKALLEQNKQEI LKAYGKIDVLVNLAGGNQAGATIPPDKTIFDLDIDAFRTVVDLNLFGTVLPTMVFAEVMVGQGKGSIINISSESSLRPLT RVVGYGCAKAAINNFTQYMAGELAIKFGEGLRVNAMAPGFFLTEQNRALMSNPDGSPSDRCNTIVAHTPFRRLGKPEELL GTLQWLASDASAFVTGTVIPIDGGFDAFSI >Mature_270_residues MNSLFSVKEKVILLTGGYGILGACMAKHLAREGAYVVILGRNEQKGSALVNEIKAEGGEALFLVSNVLDKALLEQNKQEI LKAYGKIDVLVNLAGGNQAGATIPPDKTIFDLDIDAFRTVVDLNLFGTVLPTMVFAEVMVGQGKGSIINISSESSLRPLT RVVGYGCAKAAINNFTQYMAGELAIKFGEGLRVNAMAPGFFLTEQNRALMSNPDGSPSDRCNTIVAHTPFRRLGKPEELL GTLQWLASDASAFVTGTVIPIDGGFDAFSI
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=31.8181818181818, Blast_Score=101, Evalue=6e-22, Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=28.6274509803922, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI7705925, Length=265, Percent_Identity=28.3018867924528, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=28.7937743190661, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI66933014, Length=257, Percent_Identity=29.9610894941634, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI40254992, Length=257, Percent_Identity=26.4591439688716, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=29.535864978903, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=26.0700389105058, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=26.9662921348315, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=28.0442804428044, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI4758504, Length=265, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI4503301, Length=242, Percent_Identity=27.6859504132231, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI20149619, Length=203, Percent_Identity=27.0935960591133, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1790717, Length=265, Percent_Identity=31.3207547169811, Blast_Score=108, Evalue=4e-25, Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=29.6875, Blast_Score=100, Evalue=2e-22, Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=28.6259541984733, Blast_Score=97, Evalue=2e-21, Organism=Escherichia coli, GI1789208, Length=268, Percent_Identity=30.5970149253731, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1788459, Length=263, Percent_Identity=30.4182509505703, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=30.2325581395349, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=32.183908045977, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI2367175, Length=266, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1787820, Length=221, Percent_Identity=27.6018099547511, Blast_Score=71, Evalue=8e-14, Organism=Escherichia coli, GI2367365, Length=261, Percent_Identity=27.9693486590038, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1786812, Length=208, Percent_Identity=27.8846153846154, Blast_Score=66, Evalue=3e-12, Organism=Escherichia coli, GI1789057, Length=268, Percent_Identity=26.4925373134328, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI115534694, Length=266, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17555706, Length=271, Percent_Identity=29.8892988929889, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=32.8301886792453, Blast_Score=90, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=32.3308270676692, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=28.957528957529, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=28.5171102661597, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=29.9625468164794, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17551412, Length=278, Percent_Identity=29.8561151079137, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=30.4511278195489, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=31.0861423220974, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17563726, Length=273, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=25.0965250965251, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=27.3764258555133, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17536025, Length=267, Percent_Identity=29.2134831460674, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=28.2527881040892, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=29.8507462686567, Blast_Score=78, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=28.4132841328413, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17536651, Length=267, Percent_Identity=28.0898876404494, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=26.9961977186312, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=28.1954887218045, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538182, Length=278, Percent_Identity=28.0575539568345, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17561272, Length=244, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=25.9541984732824, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI72000259, Length=269, Percent_Identity=27.1375464684015, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=30.5970149253731, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=26.8939393939394, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17531453, Length=270, Percent_Identity=27.4074074074074, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538486, Length=268, Percent_Identity=27.6119402985075, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=26.1538461538462, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6324126, Length=263, Percent_Identity=27.3764258555133, Blast_Score=74, Evalue=3e-14, Organism=Saccharomyces cerevisiae, GI6322227, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=2e-12, Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=34.6153846153846, Blast_Score=130, Evalue=1e-30, Organism=Drosophila melanogaster, GI28571526, Length=271, Percent_Identity=34.3173431734317, Blast_Score=123, Evalue=1e-28, Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=32.4528301886792, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI24644339, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI24644337, Length=260, Percent_Identity=29.6153846153846, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=30.1158301158301, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=27.4131274131274, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI17737361, Length=268, Percent_Identity=27.9850746268657, Blast_Score=78, Evalue=8e-15, Organism=Drosophila melanogaster, GI24643142, Length=260, Percent_Identity=27.3076923076923, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24640492, Length=184, Percent_Identity=31.5217391304348, Blast_Score=72, Evalue=5e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 28774; Mature: 28774
Theoretical pI: Translated: 5.38; Mature: 5.38
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNSLFSVKEKVILLTGGYGILGACMAKHLAREGAYVVILGRNEQKGSALVNEIKAEGGEA CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCE LFLVSNVLDKALLEQNKQEILKAYGKIDVLVNLAGGNQAGATIPPDKTIFDLDIDAFRTV EEHHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHH VDLNLFGTVLPTMVFAEVMVGQGKGSIINISSESSLRPLTRVVGYGCAKAAINNFTQYMA HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHH GELAIKFGEGLRVNAMAPGFFLTEQNRALMSNPDGSPSDRCNTIVAHTPFRRLGKPEELL HHHEEEECCCEEEEEECCCEEEECCCCEEECCCCCCCCHHHCEEEEECCHHHCCCHHHHH GTLQWLASDASAFVTGTVIPIDGGFDAFSI HHHHHHHCCCCEEEEEEEEEECCCCCCCCC >Mature Secondary Structure MNSLFSVKEKVILLTGGYGILGACMAKHLAREGAYVVILGRNEQKGSALVNEIKAEGGEA CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCE LFLVSNVLDKALLEQNKQEILKAYGKIDVLVNLAGGNQAGATIPPDKTIFDLDIDAFRTV EEHHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHH VDLNLFGTVLPTMVFAEVMVGQGKGSIINISSESSLRPLTRVVGYGCAKAAINNFTQYMA HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHH GELAIKFGEGLRVNAMAPGFFLTEQNRALMSNPDGSPSDRCNTIVAHTPFRRLGKPEELL HHHEEEECCCEEEEEECCCEEEECCCCEEECCCCCCCCHHHCEEEEECCHHHCCCHHHHH GTLQWLASDASAFVTGTVIPIDGGFDAFSI HHHHHHHCCCCEEEEEEEEEECCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} 0.02 {NADP+}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9579062; 9384377 [H]