| Definition | Parabacteroides distasonis ATCC 8503 chromosome, complete genome. |
|---|---|
| Accession | NC_009615 |
| Length | 4,811,379 |
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The map label for this gene is thrA [H]
Identifier: 150006925
GI number: 150006925
Start: 287336
End: 289777
Strand: Reverse
Name: thrA [H]
Synonym: BDI_0261
Alternate gene names: 150006925
Gene position: 289777-287336 (Counterclockwise)
Preceding gene: 150006926
Following gene: 150006924
Centisome position: 6.02
GC content: 49.96
Gene sequence:
>2442_bases ATGAAAGTATTAAAATTCGGCGGAACATCCGTAGGTTCCGTGAATAGTATCTTAAGTGTAAAGAAAATAGTAGAGGCTAT CGAAGAGCCCGTAATCGTGGTTGTCTCCGCTTTAGGGGGCATCACCGATAAATTGCTGGCCACTTCTACCATGGCTTCTA AAGGCGACCTTGCCTACGAGAAAGAATTATCGGAGATCATCGCCCGCCATCTGGACGTGATCGAGGGAGTGATAGAGGAC AAGGAGGTACGCATGGATGTCCAGAAGAAAGTGATGGCTTTACTGGATGAATTGAGCAATATTTTCAAAGGTGTTTATTT GATTAACGATTTATCCGCCAAGACATCCGATACGATCGTAAGTTATGGCGAGCGCCTATCTTCCTTGATCGTCTCGAACG TGATCAAGGACGCTAAGTTATTCGACTCACGCAAATATATCAAGACAGTCAAGCAATTCAACAAGCATATCGTGGATTTC GACTTGACCAACAAGCTCATAAAAGAGACCTTCTCGCCGCTGCCCAAGGTTTCCTTGGTGCCCGGATTCATCTCTTCCAG CACGGAAACCGGAGAGGTTACGAACCTCGGACGAGGGGGATCGGATTATACCGCCTCCATCTTGGCGACCGCCTTAGACG CTAACACCTTGGAGATATGGACGGACGTGGATGGTTTCATGACCGCTGATCCCCGTGTGATCAGCTCCGCCTACGTAATC GACCGGCTTACTTTTACGGAGGCGATGGAGTTGTGTAACTTCGGGGCGAAAGTAATCTATCCGCCGACGATCTATCCGGT TTATCATAAGAATATCCCGATCCGTATCTTGAATACCTTCAACCCGACCGCTCCCGGAACCTATATCTCGAAAGAGCGGG TGAAAGAGGAAGGCAAGGCCATCATCAAGGGTATCTCCTCCATCAACGATACCTGTTTGATCACGGTACAAGGTTTAGGT ATGGTGGGCGTGATCGGCGTGAACTACCGGATCTTTAAGACGCTCGCCAAGAATGGCATCAGCGTATTTATGGTATCGCA GGCCAGCTCCGAGAATAATACGACTTTCGCCGTACGTAACGCCGACGCTGATTTGGCCGTACAAGTATTGAACGACGAGT TCGCCTTGGAGCGTGCGCAGGGTGATATGAACGATACCGTAGCGGAGAAGGATCTGGCTACCGTCGCTATCGTAGGCGAG AACATGAAACGTACCCCGGGTATCGCCGGTAAGCTGTTCGGTACGCTGGGACGTGCGGGCATCAGCGTGATCGCTTGCGC CCAAGGCGCTTCCGAGACGAATATCTCTTTCGTTATCAAGCATAAATACCTTCGCAAGGCGTTGAACTCCATTCATGACT CTTTTTTCCTATCCGAATATAAGGTATTGAACCTTTTCATCGCCGGTGTAGGAACCGTAGGCGGCAATTTATTGGAACAG ATACGCATCCAGCAACCGAAACTGATGCGGCAAAACGGTTTGAAGCTGAATGTCGTAGGTATCTCAAACTCCAAGAAAGC CCTTTTATGCCGGGAAGGGATCAACCTCGACAATTATCTGGAGGAGCTGAAGGAGAACGGGGAAGAGAGTAACCCGGAAC ATCTATGCGAGGAGATCGTAAAGATGAATATCTTCAACTCCGTATTCGTGGACTGTACGGCAAGCCCGGACGTGGCGGCT CTTTACGAGACGTTGATGAACAATAACGTATCCGTCGTGGCGGCTAATAAAGAAGCGGCTTCCTCCTCCTACGATAATTA TACCAAGCTCAAGGAGACCGCCCGCCACCGAGACATCAAGTTCTTGTTCGAGACGAACGTAGGCGCCGGCCTCCCGATCA TCAATACGATGAACGACTTGATCAATAGCGGTGACCATATATTGAAACTGGAGGCCGTACTTTCCGGTACGCTGAATTAT ATCTTTAATACGATCAGCGCCGATATTCCTTTCAGCGAGGCGATCCATATGGCAAAGGAAGCCGGATACGCCGAGCCGGA CCCACGTATCGACCTTAGCGGCAAAGACGTAATCCGTAAGCTGGTTATCTTGGCCCGTGAGGCCGGTTATCCGGTGGAGC AAGCCGACGTAAAACGGAACCTGTTCATCCCGGAAAAGTACTTCGAGGGTTCCCTTGAGGACTTCTGGAAGAATATCAAG GATACAGATGCCGGTTTCGAGGAGAAACGCCAGCTACTGGAAGCGGAAGGCAAACGCTTCCGTTTCGTGGCGAAGATGGA GAACGGCGCTTGCGAGGTAGGCCTACAAGCCGTAGACAGCCACCATCCGTTCTATGAACTGGAGGGCAGCAACAATATTA TCATGATCTCCACCGAGAGATATCATGAATATCCAATGATCATCAAGGGATATGGTGCCGGAGCCGACGTGACAGCCGCA GGCGTATTCGCCGACATCATATCCATTGCTAATATTCGATAG
Upstream 100 bases:
>100_bases ACATAAATAAGTTTAATCAATCGGTCATTGTCGGTTGCTAATCATGAAAAAGCCTTTTCTTGATTGCCAATCCTCGATGA ACCATTAAAAATACATATCG
Downstream 100 bases:
>100_bases GTATGAAGCACATTATCATTTTAGGCGATGGAATGGCCGACGAGCCGATAGAGGCTCTGGGAGGCAAGACCCCGATGCAA TACGCCAAGACTCCTTATAT
Product: bifunctional aspartokinase I/homoserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 813; Mature: 813
Protein sequence:
>813_residues MKVLKFGGTSVGSVNSILSVKKIVEAIEEPVIVVVSALGGITDKLLATSTMASKGDLAYEKELSEIIARHLDVIEGVIED KEVRMDVQKKVMALLDELSNIFKGVYLINDLSAKTSDTIVSYGERLSSLIVSNVIKDAKLFDSRKYIKTVKQFNKHIVDF DLTNKLIKETFSPLPKVSLVPGFISSSTETGEVTNLGRGGSDYTASILATALDANTLEIWTDVDGFMTADPRVISSAYVI DRLTFTEAMELCNFGAKVIYPPTIYPVYHKNIPIRILNTFNPTAPGTYISKERVKEEGKAIIKGISSINDTCLITVQGLG MVGVIGVNYRIFKTLAKNGISVFMVSQASSENNTTFAVRNADADLAVQVLNDEFALERAQGDMNDTVAEKDLATVAIVGE NMKRTPGIAGKLFGTLGRAGISVIACAQGASETNISFVIKHKYLRKALNSIHDSFFLSEYKVLNLFIAGVGTVGGNLLEQ IRIQQPKLMRQNGLKLNVVGISNSKKALLCREGINLDNYLEELKENGEESNPEHLCEEIVKMNIFNSVFVDCTASPDVAA LYETLMNNNVSVVAANKEAASSSYDNYTKLKETARHRDIKFLFETNVGAGLPIINTMNDLINSGDHILKLEAVLSGTLNY IFNTISADIPFSEAIHMAKEAGYAEPDPRIDLSGKDVIRKLVILAREAGYPVEQADVKRNLFIPEKYFEGSLEDFWKNIK DTDAGFEEKRQLLEAEGKRFRFVAKMENGACEVGLQAVDSHHPFYELEGSNNIIMISTERYHEYPMIIKGYGAGADVTAA GVFADIISIANIR
Sequences:
>Translated_813_residues MKVLKFGGTSVGSVNSILSVKKIVEAIEEPVIVVVSALGGITDKLLATSTMASKGDLAYEKELSEIIARHLDVIEGVIED KEVRMDVQKKVMALLDELSNIFKGVYLINDLSAKTSDTIVSYGERLSSLIVSNVIKDAKLFDSRKYIKTVKQFNKHIVDF DLTNKLIKETFSPLPKVSLVPGFISSSTETGEVTNLGRGGSDYTASILATALDANTLEIWTDVDGFMTADPRVISSAYVI DRLTFTEAMELCNFGAKVIYPPTIYPVYHKNIPIRILNTFNPTAPGTYISKERVKEEGKAIIKGISSINDTCLITVQGLG MVGVIGVNYRIFKTLAKNGISVFMVSQASSENNTTFAVRNADADLAVQVLNDEFALERAQGDMNDTVAEKDLATVAIVGE NMKRTPGIAGKLFGTLGRAGISVIACAQGASETNISFVIKHKYLRKALNSIHDSFFLSEYKVLNLFIAGVGTVGGNLLEQ IRIQQPKLMRQNGLKLNVVGISNSKKALLCREGINLDNYLEELKENGEESNPEHLCEEIVKMNIFNSVFVDCTASPDVAA LYETLMNNNVSVVAANKEAASSSYDNYTKLKETARHRDIKFLFETNVGAGLPIINTMNDLINSGDHILKLEAVLSGTLNY IFNTISADIPFSEAIHMAKEAGYAEPDPRIDLSGKDVIRKLVILAREAGYPVEQADVKRNLFIPEKYFEGSLEDFWKNIK DTDAGFEEKRQLLEAEGKRFRFVAKMENGACEVGLQAVDSHHPFYELEGSNNIIMISTERYHEYPMIIKGYGAGADVTAA GVFADIISIANIR >Mature_813_residues MKVLKFGGTSVGSVNSILSVKKIVEAIEEPVIVVVSALGGITDKLLATSTMASKGDLAYEKELSEIIARHLDVIEGVIED KEVRMDVQKKVMALLDELSNIFKGVYLINDLSAKTSDTIVSYGERLSSLIVSNVIKDAKLFDSRKYIKTVKQFNKHIVDF DLTNKLIKETFSPLPKVSLVPGFISSSTETGEVTNLGRGGSDYTASILATALDANTLEIWTDVDGFMTADPRVISSAYVI DRLTFTEAMELCNFGAKVIYPPTIYPVYHKNIPIRILNTFNPTAPGTYISKERVKEEGKAIIKGISSINDTCLITVQGLG MVGVIGVNYRIFKTLAKNGISVFMVSQASSENNTTFAVRNADADLAVQVLNDEFALERAQGDMNDTVAEKDLATVAIVGE NMKRTPGIAGKLFGTLGRAGISVIACAQGASETNISFVIKHKYLRKALNSIHDSFFLSEYKVLNLFIAGVGTVGGNLLEQ IRIQQPKLMRQNGLKLNVVGISNSKKALLCREGINLDNYLEELKENGEESNPEHLCEEIVKMNIFNSVFVDCTASPDVAA LYETLMNNNVSVVAANKEAASSSYDNYTKLKETARHRDIKFLFETNVGAGLPIINTMNDLINSGDHILKLEAVLSGTLNY IFNTISADIPFSEAIHMAKEAGYAEPDPRIDLSGKDVIRKLVILAREAGYPVEQADVKRNLFIPEKYFEGSLEDFWKNIK DTDAGFEEKRQLLEAEGKRFRFVAKMENGACEVGLQAVDSHHPFYELEGSNNIIMISTERYHEYPMIIKGYGAGADVTAA GVFADIISIANIR
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=819, Percent_Identity=36.7521367521368, Blast_Score=503, Evalue=1e-143, Organism=Escherichia coli, GI1790376, Length=828, Percent_Identity=29.7101449275362, Blast_Score=333, Evalue=2e-92, Organism=Escherichia coli, GI1790455, Length=464, Percent_Identity=30.3879310344828, Blast_Score=176, Evalue=6e-45, Organism=Saccharomyces cerevisiae, GI6320893, Length=505, Percent_Identity=30.4950495049505, Blast_Score=172, Evalue=1e-43, Organism=Saccharomyces cerevisiae, GI6322599, Length=363, Percent_Identity=33.8842975206612, Blast_Score=167, Evalue=4e-42,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 89190; Mature: 89190
Theoretical pI: Translated: 5.27; Mature: 5.27
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVLKFGGTSVGSVNSILSVKKIVEAIEEPVIVVVSALGGITDKLLATSTMASKGDLAYE CCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHH KELSEIIARHLDVIEGVIEDKEVRMDVQKKVMALLDELSNIFKGVYLINDLSAKTSDTIV HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHH SYGERLSSLIVSNVIKDAKLFDSRKYIKTVKQFNKHIVDFDLTNKLIKETFSPLPKVSLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCEEC PGFISSSTETGEVTNLGRGGSDYTASILATALDANTLEIWTDVDGFMTADPRVISSAYVI CCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHH DRLTFTEAMELCNFGAKVIYPPTIYPVYHKNIPIRILNTFNPTAPGTYISKERVKEEGKA HHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHH IIKGISSINDTCLITVQGLGMVGVIGVNYRIFKTLAKNGISVFMVSQASSENNTTFAVRN HHHHHHCCCCEEEEEEECCCEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEC ADADLAVQVLNDEFALERAQGDMNDTVAEKDLATVAIVGENMKRTPGIAGKLFGTLGRAG CCCCEEEEECCCHHHHHHHCCCCCHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHCC ISVIACAQGASETNISFVIKHKYLRKALNSIHDSFFLSEYKVLNLFIAGVGTVGGNLLEQ CEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IRIQQPKLMRQNGLKLNVVGISNSKKALLCREGINLDNYLEELKENGEESNPEHLCEEIV HHCCCCHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH KMNIFNSVFVDCTASPDVAALYETLMNNNVSVVAANKEAASSSYDNYTKLKETARHRDIK HHHHHHHEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHCCEE FLFETNVGAGLPIINTMNDLINSGDHILKLEAVLSGTLNYIFNTISADIPFSEAIHMAKE EEEECCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH AGYAEPDPRIDLSGKDVIRKLVILAREAGYPVEQADVKRNLFIPEKYFEGSLEDFWKNIK CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHCCCHHHHHHHCC DTDAGFEEKRQLLEAEGKRFRFVAKMENGACEVGLQAVDSHHPFYELEGSNNIIMISTER CCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCEEEEECCC YHEYPMIIKGYGAGADVTAAGVFADIISIANIR CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC >Mature Secondary Structure MKVLKFGGTSVGSVNSILSVKKIVEAIEEPVIVVVSALGGITDKLLATSTMASKGDLAYE CCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHH KELSEIIARHLDVIEGVIEDKEVRMDVQKKVMALLDELSNIFKGVYLINDLSAKTSDTIV HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHH SYGERLSSLIVSNVIKDAKLFDSRKYIKTVKQFNKHIVDFDLTNKLIKETFSPLPKVSLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCEEC PGFISSSTETGEVTNLGRGGSDYTASILATALDANTLEIWTDVDGFMTADPRVISSAYVI CCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHH DRLTFTEAMELCNFGAKVIYPPTIYPVYHKNIPIRILNTFNPTAPGTYISKERVKEEGKA HHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHH IIKGISSINDTCLITVQGLGMVGVIGVNYRIFKTLAKNGISVFMVSQASSENNTTFAVRN HHHHHHCCCCEEEEEEECCCEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEC ADADLAVQVLNDEFALERAQGDMNDTVAEKDLATVAIVGENMKRTPGIAGKLFGTLGRAG CCCCEEEEECCCHHHHHHHCCCCCHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHCC ISVIACAQGASETNISFVIKHKYLRKALNSIHDSFFLSEYKVLNLFIAGVGTVGGNLLEQ CEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IRIQQPKLMRQNGLKLNVVGISNSKKALLCREGINLDNYLEELKENGEESNPEHLCEEIV HHCCCCHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH KMNIFNSVFVDCTASPDVAALYETLMNNNVSVVAANKEAASSSYDNYTKLKETARHRDIK HHHHHHHEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHCCEE FLFETNVGAGLPIINTMNDLINSGDHILKLEAVLSGTLNYIFNTISADIPFSEAIHMAKE EEEECCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH AGYAEPDPRIDLSGKDVIRKLVILAREAGYPVEQADVKRNLFIPEKYFEGSLEDFWKNIK CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHCCCHHHHHHHCC DTDAGFEEKRQLLEAEGKRFRFVAKMENGACEVGLQAVDSHHPFYELEGSNNIIMISTER CCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCEEEEECCC YHEYPMIIKGYGAGADVTAAGVFADIISIANIR CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]