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The map label for this gene is trpC [H]

Identifier: 150006571

GI number: 150006571

Start: 5033839

End: 5034627

Strand: Direct

Name: trpC [H]

Synonym: BVU_4091

Alternate gene names: 150006571

Gene position: 5033839-5034627 (Clockwise)

Preceding gene: 150006570

Following gene: 150006572

Centisome position: 97.49

GC content: 48.92

Gene sequence:

>789_bases
ATGACAGATATATTAACAGAAATCATCGCCTGCAAGCAAATCGAGATCGAACTGCAAAAGGCTGCCATCAGCAAAGAAAT
GCTGATAAACAATTGTAACGAACCCATGCCACGTATCAGTATGCGTGCCAGTCTTGCCTCTTCTCCTTACGGCATCATCT
CCGAGTTCAAGCGTCGCTCTCCCTCCAAAGGATGGATAAAAGAAGACGCACAGGCAGATACCATTCCTCCCGCTTACGAA
GCGGCCGGAGCCTCCGCACTTTCCATCCTCACCGATGAAAAATACTTCGGCGGCAGCCTGAAAGATATCCGTTCGGCACG
CCCCCACGTGCAACTTCCCATTCTAAGGAAAGATTTCATTATAGATGAATACCAACTTTATCAGGCACGCATCGTAGGAG
CGGACGCTATCCTTCTTATAGCCGCCGCTTTGAAGAAAGAGCAATGCAAAGCCCTAGCCCTCAAAGCCCATGAACTGGAA
CTGGAAGTCCTGCTGGAAATCCACAACGAGCAAGAACTGGAATATATAGACGAGAACATTGACATGGTGGGAGTCAACAA
CCGTAATCTGGGAAGCTTCCACACAGAGGTGGAAAACTCTTTCCGTCTGGCGGAAAAACTACCCGAAGAAATGCTCCGGA
TCTCTGAAAGCGGCATCTCCAGCCCCGAAACAGTCAAACAACTCCGGGCTGCCGGCTTCCGAGGCTTCCTGATAGGGGAA
AACTTCATGAAAACACCCGCACCGGGAGAAGCCTTAAAAGAATTTATAACCCAACTAGAGAAATGTTAG

Upstream 100 bases:

>100_bases
AATCATTGGAAAGCGGAAAAGCATTGAATACATTGAAAAAATTTGTGGAACTGAACAGTTGACTACACACCCGGTATTCC
ACTACCAAACGCCTCATACA

Downstream 100 bases:

>100_bases
GATGAAGCAACAATGATTATCAAGGTATGCGGTATGCGCGAGCCCGAAAACATACGCGCCATAGAGCAAGCCGGAGCAGA
CTGGATGGGCTTCATCTTCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTDILTEIIACKQIEIELQKAAISKEMLINNCNEPMPRISMRASLASSPYGIISEFKRRSPSKGWIKEDAQADTIPPAYE
AAGASALSILTDEKYFGGSLKDIRSARPHVQLPILRKDFIIDEYQLYQARIVGADAILLIAAALKKEQCKALALKAHELE
LEVLLEIHNEQELEYIDENIDMVGVNNRNLGSFHTEVENSFRLAEKLPEEMLRISESGISSPETVKQLRAAGFRGFLIGE
NFMKTPAPGEALKEFITQLEKC

Sequences:

>Translated_262_residues
MTDILTEIIACKQIEIELQKAAISKEMLINNCNEPMPRISMRASLASSPYGIISEFKRRSPSKGWIKEDAQADTIPPAYE
AAGASALSILTDEKYFGGSLKDIRSARPHVQLPILRKDFIIDEYQLYQARIVGADAILLIAAALKKEQCKALALKAHELE
LEVLLEIHNEQELEYIDENIDMVGVNNRNLGSFHTEVENSFRLAEKLPEEMLRISESGISSPETVKQLRAAGFRGFLIGE
NFMKTPAPGEALKEFITQLEKC
>Mature_261_residues
TDILTEIIACKQIEIELQKAAISKEMLINNCNEPMPRISMRASLASSPYGIISEFKRRSPSKGWIKEDAQADTIPPAYEA
AGASALSILTDEKYFGGSLKDIRSARPHVQLPILRKDFIIDEYQLYQARIVGADAILLIAAALKKEQCKALALKAHELEL
EVLLEIHNEQELEYIDENIDMVGVNNRNLGSFHTEVENSFRLAEKLPEEMLRISESGISSPETVKQLRAAGFRGFLIGEN
FMKTPAPGEALKEFITQLEKC

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=39.5918367346939, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=217, Percent_Identity=37.3271889400922, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29292; Mature: 29161

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILTEIIACKQIEIELQKAAISKEMLINNCNEPMPRISMRASLASSPYGIISEFKRRS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHCC
PSKGWIKEDAQADTIPPAYEAAGASALSILTDEKYFGGSLKDIRSARPHVQLPILRKDFI
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHEECCCCCCCCHHHHHCCCCCEECCHHHHHHH
IDEYQLYQARIVGADAILLIAAALKKEQCKALALKAHELELEVLLEIHNEQELEYIDENI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
DMVGVNNRNLGSFHTEVENSFRLAEKLPEEMLRISESGISSPETVKQLRAAGFRGFLIGE
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECC
NFMKTPAPGEALKEFITQLEKC
CCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDILTEIIACKQIEIELQKAAISKEMLINNCNEPMPRISMRASLASSPYGIISEFKRRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHCC
PSKGWIKEDAQADTIPPAYEAAGASALSILTDEKYFGGSLKDIRSARPHVQLPILRKDFI
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHEECCCCCCCCHHHHHCCCCCEECCHHHHHHH
IDEYQLYQARIVGADAILLIAAALKKEQCKALALKAHELELEVLLEIHNEQELEYIDENI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
DMVGVNNRNLGSFHTEVENSFRLAEKLPEEMLRISESGISSPETVKQLRAAGFRGFLIGE
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECC
NFMKTPAPGEALKEFITQLEKC
CCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]