Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 150006477

GI number: 150006477

Start: 4916364

End: 4918709

Strand: Reverse

Name: luxQ [H]

Synonym: BVU_3996

Alternate gene names: 150006477

Gene position: 4918709-4916364 (Counterclockwise)

Preceding gene: 150006478

Following gene: 150006473

Centisome position: 95.26

GC content: 40.28

Gene sequence:

>2346_bases
ATGGATTGTGAACACAAGCTTAAAGTATTAGAGCAGGAAATTGAATCGTTGAAAGAGGAGAACAGGCTGCTGAAAGAAAA
ATTATCTTCTTCTGAAAAAAACTTTGATGGCGTTAGTTTCAAGGAGAAATATGCGGTAAGAATATTAGATTCCTTGCCGG
ATATGTTGACCGTTTTCAATCATGAGGAAATGGGGATAGAGGTGGTGTCTAATGAGGAAACAAATCATGTGGGTGTATCC
AACAACGATTTTAAGGGGATGCGTATGCAGGATATGGTTCCTAAAGAGGCTTATCACAATATACATAATAATCTTCAGAA
GGTTATTTCGACAGGTAGGGGTTCTACAGCCCATCATGAATTGGATGTGGACGGGACGCTTCATTATTATGAAAATCGTA
TTTTCCCCTTAGATGAAGAATATGTGTTGATAATGTGCCGTGATATTAGTGAAAGAGTTGCCACACAGCAGAATTTGGAA
ATATTTAAACGGATATTGGATAGGGTCAGTGATAGTATTCTGGCTGTATCGGCTGACGGAACCTTAGTCTATGCCAACCG
GCAGTTTATTGAGGAATATGGAGTGAAAGGGGAATTAGGAACACAGAAAATCTATGATTTGCCTGTTTCCTTGAATACTA
AAGAACAGTTTGATAAACGTGTTCAGGAGATTCGCGACAACGGAGGTAATTTTGCTTATCGTGCCAAATATACCCGTGTG
GGAGAAACAAAACTTCGTGTTCATCAGGTTTCGGCCTTTATGATTCAAAATCAGGGCGAGGAAATGATTTGGTTCTTTAC
ACAGGATATAACAGATGTTATCAAGAATCGTGATGAATTGCGTGAATTGAATTATCTGATGGATGCTATACTGAATAATA
TTCCTGTTTATTTGTTTGTGAAGGACCCTGAAGATGATTTCCGATATCTTTATTGGAATAAGGCGTTTGCCAGTCACTCT
AAAATTCCTGCTTCCAAAGCGTTGGGGCGTACTGATTTTGAAGTATTTCCCGAATATGAGAATGCGGAGAAGTTTCATCG
GGATGATTTGGAATTGATTCGTACCCGCGAACGTATGGAAATGCAGGAAACGTATGTGACGGCTACAGGAGAGCCCCGTA
TTGTGCAGACCTTGAAAACGTTGGTTCCTCTGGAAGGGAGGACACCGCTCATTATCGGTATTTCATGGGATATTACCAAT
ATACAGAATATAGAGCAGGAATTGATATTCGCCCGTATCAAAGCCGAACAGTCCGACAGGTTGAAAACCGCTTTCCTTGC
CAATATGAGCCATGAAATCCGTACTCCGCTGAATGCAATTGTGGGATTTTCGCATTTGATGACTATAGCGGATAACGCAG
AGGATGAAAAACTTTATTCGGACATCATCAACCAGAATTCGGAAATATTGTTGCAATTAATCAATGACATACTTGATTTG
GCAAAAATAGAGGCGGGTACATTGGAATACATCAGATATCCAATGGATTTGGGAGAATTGTGCCGTAATGTGTATGAGAT
GCATAAGGATCGGGTGCAGACTGGGGTTGTTTTGATATTAGACAATAAAGACACCAGCTTGATAATCAATGAAGATCAGA
ACCGAATTATGCAAGTTGTTACAAATTTGATAACCAATGCTATAAAATTTACTTTCAAAGGGGAAATCCGTTTTGGTTTT
GAAGTGAGGGAGGAGTATATTGATTTTTATGTAAAAGATACGGGAATGGGTATCTCCGAGGAGAAGATTAAAATGATTTT
TGAGCGTTTCGTGAAACTGAATACTTTTGTTCAGGGAACAGGTTTGGGGCTTGCGATTTGTAGGGTGATTGTAGAAAAAC
TAGGTGGAGAGATTACTGCGGAATCCAAACTGAATGAAGGTTCTACTTTTCGTTTTACGATTCCTTATAAGGCGGGTAAA
AAAATTCCGGAATCCGGAAAGGTTACGAAGTGTCCGGAATCAGGGAGTACGGGACCGAGAAAAGTGTTGCAAAGAAGAAC
AGTACTGGTGGCGGAAGATGTAGACAGCAACTTTTTGCTGTTAAAGACATTGTTAGGGAAAAGATGTAATCTGCTATGGG
CTAAGAATGGAGAGGATGCGGTGAATCAATTTAAAGAACATCAGCCCGACTTGATTTTGATGGATATCAAGATGCCCCAT
ATGGATGGGCTGGAGGCTACGCGCCTGATTCGTTCTTATTCAAAAGAAGTGCCTATTGTCGCTTTGACTGCCTTTGCTTT
TGAGTCCGACAAAGACAGGGCTATAGAAGCCGGATGCGATGATTTCCTGACTAAGCCGGTTTCACAAAATGCCTTGGAAA
AAGTGTTGGATAAATATGTTAAGTAG

Upstream 100 bases:

>100_bases
TGACTTCTCTTTTATCGGAAAATAAATCACTATTCTTTCTGTGTTTACAAAAAGTTTTCTACTTTTGTCCAATTAGGAAT
CCTAAAGATATTCAAAACAA

Downstream 100 bases:

>100_bases
ACATTGGCGAGGTATAGTGCGTAAAGACAACAGGCAATATGGAACAGAACAGGGAAGGGAGGATGCAATGCGAAGATTAT
AGATCTTACCCCCGGAAGAT

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 781; Mature: 781

Protein sequence:

>781_residues
MDCEHKLKVLEQEIESLKEENRLLKEKLSSSEKNFDGVSFKEKYAVRILDSLPDMLTVFNHEEMGIEVVSNEETNHVGVS
NNDFKGMRMQDMVPKEAYHNIHNNLQKVISTGRGSTAHHELDVDGTLHYYENRIFPLDEEYVLIMCRDISERVATQQNLE
IFKRILDRVSDSILAVSADGTLVYANRQFIEEYGVKGELGTQKIYDLPVSLNTKEQFDKRVQEIRDNGGNFAYRAKYTRV
GETKLRVHQVSAFMIQNQGEEMIWFFTQDITDVIKNRDELRELNYLMDAILNNIPVYLFVKDPEDDFRYLYWNKAFASHS
KIPASKALGRTDFEVFPEYENAEKFHRDDLELIRTRERMEMQETYVTATGEPRIVQTLKTLVPLEGRTPLIIGISWDITN
IQNIEQELIFARIKAEQSDRLKTAFLANMSHEIRTPLNAIVGFSHLMTIADNAEDEKLYSDIINQNSEILLQLINDILDL
AKIEAGTLEYIRYPMDLGELCRNVYEMHKDRVQTGVVLILDNKDTSLIINEDQNRIMQVVTNLITNAIKFTFKGEIRFGF
EVREEYIDFYVKDTGMGISEEKIKMIFERFVKLNTFVQGTGLGLAICRVIVEKLGGEITAESKLNEGSTFRFTIPYKAGK
KIPESGKVTKCPESGSTGPRKVLQRRTVLVAEDVDSNFLLLKTLLGKRCNLLWAKNGEDAVNQFKEHQPDLILMDIKMPH
MDGLEATRLIRSYSKEVPIVALTAFAFESDKDRAIEAGCDDFLTKPVSQNALEKVLDKYVK

Sequences:

>Translated_781_residues
MDCEHKLKVLEQEIESLKEENRLLKEKLSSSEKNFDGVSFKEKYAVRILDSLPDMLTVFNHEEMGIEVVSNEETNHVGVS
NNDFKGMRMQDMVPKEAYHNIHNNLQKVISTGRGSTAHHELDVDGTLHYYENRIFPLDEEYVLIMCRDISERVATQQNLE
IFKRILDRVSDSILAVSADGTLVYANRQFIEEYGVKGELGTQKIYDLPVSLNTKEQFDKRVQEIRDNGGNFAYRAKYTRV
GETKLRVHQVSAFMIQNQGEEMIWFFTQDITDVIKNRDELRELNYLMDAILNNIPVYLFVKDPEDDFRYLYWNKAFASHS
KIPASKALGRTDFEVFPEYENAEKFHRDDLELIRTRERMEMQETYVTATGEPRIVQTLKTLVPLEGRTPLIIGISWDITN
IQNIEQELIFARIKAEQSDRLKTAFLANMSHEIRTPLNAIVGFSHLMTIADNAEDEKLYSDIINQNSEILLQLINDILDL
AKIEAGTLEYIRYPMDLGELCRNVYEMHKDRVQTGVVLILDNKDTSLIINEDQNRIMQVVTNLITNAIKFTFKGEIRFGF
EVREEYIDFYVKDTGMGISEEKIKMIFERFVKLNTFVQGTGLGLAICRVIVEKLGGEITAESKLNEGSTFRFTIPYKAGK
KIPESGKVTKCPESGSTGPRKVLQRRTVLVAEDVDSNFLLLKTLLGKRCNLLWAKNGEDAVNQFKEHQPDLILMDIKMPH
MDGLEATRLIRSYSKEVPIVALTAFAFESDKDRAIEAGCDDFLTKPVSQNALEKVLDKYVK
>Mature_781_residues
MDCEHKLKVLEQEIESLKEENRLLKEKLSSSEKNFDGVSFKEKYAVRILDSLPDMLTVFNHEEMGIEVVSNEETNHVGVS
NNDFKGMRMQDMVPKEAYHNIHNNLQKVISTGRGSTAHHELDVDGTLHYYENRIFPLDEEYVLIMCRDISERVATQQNLE
IFKRILDRVSDSILAVSADGTLVYANRQFIEEYGVKGELGTQKIYDLPVSLNTKEQFDKRVQEIRDNGGNFAYRAKYTRV
GETKLRVHQVSAFMIQNQGEEMIWFFTQDITDVIKNRDELRELNYLMDAILNNIPVYLFVKDPEDDFRYLYWNKAFASHS
KIPASKALGRTDFEVFPEYENAEKFHRDDLELIRTRERMEMQETYVTATGEPRIVQTLKTLVPLEGRTPLIIGISWDITN
IQNIEQELIFARIKAEQSDRLKTAFLANMSHEIRTPLNAIVGFSHLMTIADNAEDEKLYSDIINQNSEILLQLINDILDL
AKIEAGTLEYIRYPMDLGELCRNVYEMHKDRVQTGVVLILDNKDTSLIINEDQNRIMQVVTNLITNAIKFTFKGEIRFGF
EVREEYIDFYVKDTGMGISEEKIKMIFERFVKLNTFVQGTGLGLAICRVIVEKLGGEITAESKLNEGSTFRFTIPYKAGK
KIPESGKVTKCPESGSTGPRKVLQRRTVLVAEDVDSNFLLLKTLLGKRCNLLWAKNGEDAVNQFKEHQPDLILMDIKMPH
MDGLEATRLIRSYSKEVPIVALTAFAFESDKDRAIEAGCDDFLTKPVSQNALEKVLDKYVK

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=409, Percent_Identity=30.0733496332518, Blast_Score=173, Evalue=4e-44,
Organism=Escherichia coli, GI1788713, Length=421, Percent_Identity=27.5534441805226, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1789149, Length=265, Percent_Identity=36.6037735849057, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI87081816, Length=395, Percent_Identity=28.6075949367089, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI145693157, Length=289, Percent_Identity=31.4878892733564, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=30.5439330543933, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=28.82096069869, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=26.5560165975104, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=28.3783783783784, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1790861, Length=225, Percent_Identity=27.5555555555556, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=28.936170212766, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=257, Percent_Identity=24.124513618677, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1786599, Length=81, Percent_Identity=39.5061728395062, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1790437, Length=112, Percent_Identity=31.25, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786911, Length=110, Percent_Identity=35.4545454545455, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=154, Percent_Identity=29.8701298701299, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323034, Length=153, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=123, Percent_Identity=34.9593495934959, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 89805; Mature: 89805

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCEHKLKVLEQEIESLKEENRLLKEKLSSSEKNFDGVSFKEKYAVRILDSLPDMLTVFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HEEMGIEVVSNEETNHVGVSNNDFKGMRMQDMVPKEAYHNIHNNLQKVISTGRGSTAHHE
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
LDVDGTLHYYENRIFPLDEEYVLIMCRDISERVATQQNLEIFKRILDRVSDSILAVSADG
ECCCCEEEHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
TLVYANRQFIEEYGVKGELGTQKIYDLPVSLNTKEQFDKRVQEIRDNGGNFAYRAKYTRV
EEEEECHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEC
GETKLRVHQVSAFMIQNQGEEMIWFFTQDITDVIKNRDELRELNYLMDAILNNIPVYLFV
CCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEE
KDPEDDFRYLYWNKAFASHSKIPASKALGRTDFEVFPEYENAEKFHRDDLELIRTRERME
ECCCCCCEEEEEEHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MQETYVTATGEPRIVQTLKTLVPLEGRTPLIIGISWDITNIQNIEQELIFARIKAEQSDR
HHHHEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHH
LKTAFLANMSHEIRTPLNAIVGFSHLMTIADNAEDEKLYSDIINQNSEILLQLINDILDL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
AKIEAGTLEYIRYPMDLGELCRNVYEMHKDRVQTGVVLILDNKDTSLIINEDQNRIMQVV
HHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHH
TNLITNAIKFTFKGEIRFGFEVREEYIDFYVKDTGMGISEEKIKMIFERFVKLNTFVQGT
HHHHHHHHEEEEECCEEECHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
GLGLAICRVIVEKLGGEITAESKLNEGSTFRFTIPYKAGKKIPESGKVTKCPESGSTGPR
CHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECHHCCCCCCCCCCEEECCCCCCCCHH
KVLQRRTVLVAEDVDSNFLLLKTLLGKRCNLLWAKNGEDAVNQFKEHQPDLILMDIKMPH
HHHHHHHEEEEECCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCC
MDGLEATRLIRSYSKEVPIVALTAFAFESDKDRAIEAGCDDFLTKPVSQNALEKVLDKYV
CCCHHHHHHHHHHCCCCCEEEEEEEHCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MDCEHKLKVLEQEIESLKEENRLLKEKLSSSEKNFDGVSFKEKYAVRILDSLPDMLTVFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HEEMGIEVVSNEETNHVGVSNNDFKGMRMQDMVPKEAYHNIHNNLQKVISTGRGSTAHHE
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
LDVDGTLHYYENRIFPLDEEYVLIMCRDISERVATQQNLEIFKRILDRVSDSILAVSADG
ECCCCEEEHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
TLVYANRQFIEEYGVKGELGTQKIYDLPVSLNTKEQFDKRVQEIRDNGGNFAYRAKYTRV
EEEEECHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEC
GETKLRVHQVSAFMIQNQGEEMIWFFTQDITDVIKNRDELRELNYLMDAILNNIPVYLFV
CCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEE
KDPEDDFRYLYWNKAFASHSKIPASKALGRTDFEVFPEYENAEKFHRDDLELIRTRERME
ECCCCCCEEEEEEHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MQETYVTATGEPRIVQTLKTLVPLEGRTPLIIGISWDITNIQNIEQELIFARIKAEQSDR
HHHHEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHH
LKTAFLANMSHEIRTPLNAIVGFSHLMTIADNAEDEKLYSDIINQNSEILLQLINDILDL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
AKIEAGTLEYIRYPMDLGELCRNVYEMHKDRVQTGVVLILDNKDTSLIINEDQNRIMQVV
HHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHH
TNLITNAIKFTFKGEIRFGFEVREEYIDFYVKDTGMGISEEKIKMIFERFVKLNTFVQGT
HHHHHHHHEEEEECCEEECHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
GLGLAICRVIVEKLGGEITAESKLNEGSTFRFTIPYKAGKKIPESGKVTKCPESGSTGPR
CHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECHHCCCCCCCCCCEEECCCCCCCCHH
KVLQRRTVLVAEDVDSNFLLLKTLLGKRCNLLWAKNGEDAVNQFKEHQPDLILMDIKMPH
HHHHHHHEEEEECCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCC
MDGLEATRLIRSYSKEVPIVALTAFAFESDKDRAIEAGCDDFLTKPVSQNALEKVLDKYV
CCCHHHHHHHHHHCCCCCEEEEEEEHCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]