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The map label for this gene is lysC [C]

Identifier: 150006337

GI number: 150006337

Start: 4756095

End: 4757414

Strand: Direct

Name: lysC [C]

Synonym: BVU_3856

Alternate gene names: 150006337

Gene position: 4756095-4757414 (Clockwise)

Preceding gene: 150006336

Following gene: 150006338

Centisome position: 92.12

GC content: 42.88

Gene sequence:

>1320_bases
ATGAAAGTTTTAAAGTTTGGAGGTACTTCGGTAGGTTCTGCACAAAGAATGAAAGAAGTAGCCAAATTAATTACCGACGG
TGAACAGAAGATTGTTGTACTTTCAGCCATGTCTGGAACAACAAACACGTTGGTTGAAATTTCGGATTATCTGTATAAGA
AAAATCCCGAAGGTGCGAATGAAATCATTAACAGACTGGAGGCTAAATATAAACAGCATGTTAATGAACTTTATTCTACT
GACGAGTATAAGCAGAAAACACAGGAATTTATAAAAGCACAGTTCGATTATATTCGTTCGTATACAAAAGATATTTTCAC
ACTGTTCGAAGAAAAAGTAATCCTGGCACAAGGCGAATTGATCTCCACCAACATGGTTACCAACTATTTGCAGGAACAAG
GGGTCAACGCCATCTTACTTCCGGCATTGGAATTCATGCGCACGGACAAGAACTCGGAGCCCGATCCTGTATATATCAAA
GAAAAACTGGCCGCACAGCTGGAAATACATCCGGATGCTGAAATTTATATCACACAAGGTTTTATCTGCCGTAACGCCTA
TGGCGAGATAGATAATCTGCAACGTGGCGGAAGCGACTATACCGCATCACTGATCGGTGCCGCTGTAAACGCCTCCGAAA
TCCAGATATGGACAGATATTGACGGTATGCACGATAATGACCCGCGCATCGTAGACAAGACTTCTCCTGTACGTCACCTG
CACTTCGAAGAAGCTGCCGAGTTGGCCTACTTTGGTGCGAAGATTCTGCATCCTACTTGCGTACAGCCTGCCAAATATGC
CAATATTCCCGTCCGTCTGCTTAATACAATGGAACCTACAGCCCCGGGGACTTTGATTTCCAATGATACGGAAAAAGGCA
AAATCAAGGCAGTTGCAGCCAAAGACAACATCACTGCCATCAAGATCAAATCAAGCCGTATGTTACTGGCCCACGGCTTC
TTGCGCAAAGTATTCGAAATCTTCGAAAGCTATCAGACCTCTATCGACATGATCTGTACTTCAGAGGTCGGTGTTTCCGT
ATCCATTGATAACACCAAACATCTGAATGAAATTCTGGACGACTTGAAGAAATATGGTACAGTAACCGTAGATCAGGATA
TGTGTATCATCTGTGTAGTCGGTGACCTGGAATGGGAAAACGTAGGCTTTGAAGCCAAAGCGTTGGACGCCATGCGCGAC
ATACCGGTACGTATGATTTCATTCGGCGGTAGCAACTACAATATTTCTTTCCTGATTCGTGAAGAAGACAAGAAGAAAGC
ATTGCAGTCATTAAGCGATCATTTATTCAACAATAAATAA

Upstream 100 bases:

>100_bases
AATGATAAATATCATCGCTAAAATGCTGATTTTTGCAGTCTTATTTGTATATTTGCACGCTAATTATCAATATAGGAACA
ATTAAAATACGAAACGAAAA

Downstream 100 bases:

>100_bases
TTTCTACTGTAGGGGCGGATTGAATCCGCCCGAATACATCCCACTCTACAAAGTTGGTGTTTTCGGGCGAATTTAATTCG
CCCTTGCTCATAAAAACAAA

Product: aspartokinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGANEIINRLEAKYKQHVNELYST
DEYKQKTQEFIKAQFDYIRSYTKDIFTLFEEKVILAQGELISTNMVTNYLQEQGVNAILLPALEFMRTDKNSEPDPVYIK
EKLAAQLEIHPDAEIYITQGFICRNAYGEIDNLQRGGSDYTASLIGAAVNASEIQIWTDIDGMHDNDPRIVDKTSPVRHL
HFEEAAELAYFGAKILHPTCVQPAKYANIPVRLLNTMEPTAPGTLISNDTEKGKIKAVAAKDNITAIKIKSSRMLLAHGF
LRKVFEIFESYQTSIDMICTSEVGVSVSIDNTKHLNEILDDLKKYGTVTVDQDMCIICVVGDLEWENVGFEAKALDAMRD
IPVRMISFGGSNYNISFLIREEDKKKALQSLSDHLFNNK

Sequences:

>Translated_439_residues
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGANEIINRLEAKYKQHVNELYST
DEYKQKTQEFIKAQFDYIRSYTKDIFTLFEEKVILAQGELISTNMVTNYLQEQGVNAILLPALEFMRTDKNSEPDPVYIK
EKLAAQLEIHPDAEIYITQGFICRNAYGEIDNLQRGGSDYTASLIGAAVNASEIQIWTDIDGMHDNDPRIVDKTSPVRHL
HFEEAAELAYFGAKILHPTCVQPAKYANIPVRLLNTMEPTAPGTLISNDTEKGKIKAVAAKDNITAIKIKSSRMLLAHGF
LRKVFEIFESYQTSIDMICTSEVGVSVSIDNTKHLNEILDDLKKYGTVTVDQDMCIICVVGDLEWENVGFEAKALDAMRD
IPVRMISFGGSNYNISFLIREEDKKKALQSLSDHLFNNK
>Mature_439_residues
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGANEIINRLEAKYKQHVNELYST
DEYKQKTQEFIKAQFDYIRSYTKDIFTLFEEKVILAQGELISTNMVTNYLQEQGVNAILLPALEFMRTDKNSEPDPVYIK
EKLAAQLEIHPDAEIYITQGFICRNAYGEIDNLQRGGSDYTASLIGAAVNASEIQIWTDIDGMHDNDPRIVDKTSPVRHL
HFEEAAELAYFGAKILHPTCVQPAKYANIPVRLLNTMEPTAPGTLISNDTEKGKIKAVAAKDNITAIKIKSSRMLLAHGF
LRKVFEIFESYQTSIDMICTSEVGVSVSIDNTKHLNEILDDLKKYGTVTVDQDMCIICVVGDLEWENVGFEAKALDAMRD
IPVRMISFGGSNYNISFLIREEDKKKALQSLSDHLFNNK

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=447, Percent_Identity=32.4384787472036, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1786183, Length=467, Percent_Identity=28.2655246252677, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790376, Length=404, Percent_Identity=26.2376237623762, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320893, Length=496, Percent_Identity=27.4193548387097, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49294; Mature: 49294

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGAN
CCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHH
EIINRLEAKYKQHVNELYSTDEYKQKTQEFIKAQFDYIRSYTKDIFTLFEEKVILAQGEL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCE
ISTNMVTNYLQEQGVNAILLPALEFMRTDKNSEPDPVYIKEKLAAQLEIHPDAEIYITQG
EEHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCEEEEHHHCEEEEECCCCEEEEECC
FICRNAYGEIDNLQRGGSDYTASLIGAAVNASEIQIWTDIDGMHDNDPRIVDKTSPVRHL
EEEECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCHHC
HFEEAAELAYFGAKILHPTCVQPAKYANIPVRLLNTMEPTAPGTLISNDTEKGKIKAVAA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEECCCCCCCEEEEEEE
KDNITAIKIKSSRMLLAHGFLRKVFEIFESYQTSIDMICTSEVGVSVSIDNTKHLNEILD
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHH
DLKKYGTVTVDQDMCIICVVGDLEWENVGFEAKALDAMRDIPVRMISFGGSNYNISFLIR
HHHHHCCEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEEEE
EEDKKKALQSLSDHLFNNK
CCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGAN
CCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHH
EIINRLEAKYKQHVNELYSTDEYKQKTQEFIKAQFDYIRSYTKDIFTLFEEKVILAQGEL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCE
ISTNMVTNYLQEQGVNAILLPALEFMRTDKNSEPDPVYIKEKLAAQLEIHPDAEIYITQG
EEHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCEEEEHHHCEEEEECCCCEEEEECC
FICRNAYGEIDNLQRGGSDYTASLIGAAVNASEIQIWTDIDGMHDNDPRIVDKTSPVRHL
EEEECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCHHC
HFEEAAELAYFGAKILHPTCVQPAKYANIPVRLLNTMEPTAPGTLISNDTEKGKIKAVAA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEECCCCCCCEEEEEEE
KDNITAIKIKSSRMLLAHGFLRKVFEIFESYQTSIDMICTSEVGVSVSIDNTKHLNEILD
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHH
DLKKYGTVTVDQDMCIICVVGDLEWENVGFEAKALDAMRDIPVRMISFGGSNYNISFLIR
HHHHHCCEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEEEE
EEDKKKALQSLSDHLFNNK
CCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]