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The map label for this gene is gcvT

Identifier: 150006317

GI number: 150006317

Start: 4726219

End: 4727304

Strand: Reverse

Name: gcvT

Synonym: BVU_3828

Alternate gene names: 150006317

Gene position: 4727304-4726219 (Counterclockwise)

Preceding gene: 150006318

Following gene: 150006316

Centisome position: 91.56

GC content: 43.0

Gene sequence:

>1086_bases
ATGAAAACAACTCCGTTTACCGAAACACACATTGCCTTGGGGGCGAAAATGCACGAATTTGCAGGTTATAATATGCCTAT
TGAATATTCGGGAATTATTGATGAACATCTTACTGTATGTAATGCCGTAGGTGTTTTTGATGTATCCCATATGGGTGAAT
TTTGGGTAAAAGGTCCTAATGCGTTGGAGTTTTTGCAGCAAGTGACTTCAAACAATGTGGCAACTTTGCCCGTCGGTAAA
GCGCAATATACTTGTTTCCCTAATGAGGAGGGAGGTATTGTTGATGACCTGTTGGTGTATCACTATGAATCCGAAAAATA
CTTGTTGGTGGTAAATGCGGCCAATATTGAGAAAGACTGGAACTGGTGTGTCAGCCATAACACAGTGGGTGCGGAATTGG
AAAATGCATCCGACCGTATGGCACAGCTTGCTATTCAGGGACCGAAGGCTATGGAAGTTTTGCAAAAACTGACTCCGGTC
AACTTGTCTGAAATTCCTTATTATGCTTTTACCACAGGTGAGTTCGCCGGTCAGAAAGATGTGATTATTTCGAATACCGG
TTATACCGGTGCAGGTGGTTTCGAGCTTTATTTTTATCCCGAAGCCGGTCAGGCTATCTGGAAAGCAATTTTTGAAGCAG
GTGCTCCTGAAGGGATTAAACCTATCGGGCTAGGGGCTCGTGATACATTACGTTTGGAAATGGGCTTTTGCCTGTATGGT
AATGATTTGAGTGATACCACTTCTCCGTTGGAAGCAGGATTGGGCTGGATTACCAAATTTGTTGAAGGAAAGAATTTCAC
TTCACGTGCTTTACTTGAAAAGCAGAAAGCCGAAGGATTGAAACGCAAGCTGATTGCTTTTGAAATGGTAGACCGTGGTA
TTCCCCGTCATGGTTATGAACTGGTAAATGCTGATGGAGAGAAAATAGGTGAAGTAACTAGTGGAACCATGTCTCCAATG
CGTAAGATTGGTATCGGTATGGGATATGTTCAGACCGCTTACACAGCATTAGGTACTGAAATATTTATTGATGTGCGCGG
ACGCAAGCTGAAAGCTGTAGTAGTAAAGGCCCCGTTCAGAAAATAA

Upstream 100 bases:

>100_bases
CAATCCAGTCTATTGAGAAAGCCATGAAAGTGGTGGTGAAAATCGCTGAATTGGTGGCAAGATAAGTAATTTATTAACCT
TAAAATAGTAAAGTAATAAC

Downstream 100 bases:

>100_bases
ATCGAAAGCCGGAAAAGAGAACGCTGATAACAAAGAAAACGCGGATATTCAAGAAATCTGAATATTCGCGTTTTCTTTAT
ATGGCTGATATACATTTACG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKTTPFTETHIALGAKMHEFAGYNMPIEYSGIIDEHLTVCNAVGVFDVSHMGEFWVKGPNALEFLQQVTSNNVATLPVGK
AQYTCFPNEEGGIVDDLLVYHYESEKYLLVVNAANIEKDWNWCVSHNTVGAELENASDRMAQLAIQGPKAMEVLQKLTPV
NLSEIPYYAFTTGEFAGQKDVIISNTGYTGAGGFELYFYPEAGQAIWKAIFEAGAPEGIKPIGLGARDTLRLEMGFCLYG
NDLSDTTSPLEAGLGWITKFVEGKNFTSRALLEKQKAEGLKRKLIAFEMVDRGIPRHGYELVNADGEKIGEVTSGTMSPM
RKIGIGMGYVQTAYTALGTEIFIDVRGRKLKAVVVKAPFRK

Sequences:

>Translated_361_residues
MKTTPFTETHIALGAKMHEFAGYNMPIEYSGIIDEHLTVCNAVGVFDVSHMGEFWVKGPNALEFLQQVTSNNVATLPVGK
AQYTCFPNEEGGIVDDLLVYHYESEKYLLVVNAANIEKDWNWCVSHNTVGAELENASDRMAQLAIQGPKAMEVLQKLTPV
NLSEIPYYAFTTGEFAGQKDVIISNTGYTGAGGFELYFYPEAGQAIWKAIFEAGAPEGIKPIGLGARDTLRLEMGFCLYG
NDLSDTTSPLEAGLGWITKFVEGKNFTSRALLEKQKAEGLKRKLIAFEMVDRGIPRHGYELVNADGEKIGEVTSGTMSPM
RKIGIGMGYVQTAYTALGTEIFIDVRGRKLKAVVVKAPFRK
>Mature_361_residues
MKTTPFTETHIALGAKMHEFAGYNMPIEYSGIIDEHLTVCNAVGVFDVSHMGEFWVKGPNALEFLQQVTSNNVATLPVGK
AQYTCFPNEEGGIVDDLLVYHYESEKYLLVVNAANIEKDWNWCVSHNTVGAELENASDRMAQLAIQGPKAMEVLQKLTPV
NLSEIPYYAFTTGEFAGQKDVIISNTGYTGAGGFELYFYPEAGQAIWKAIFEAGAPEGIKPIGLGARDTLRLEMGFCLYG
NDLSDTTSPLEAGLGWITKFVEGKNFTSRALLEKQKAEGLKRKLIAFEMVDRGIPRHGYELVNADGEKIGEVTSGTMSPM
RKIGIGMGYVQTAYTALGTEIFIDVRGRKLKAVVVKAPFRK

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=33.8753387533875, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI257796258, Length=355, Percent_Identity=32.9577464788732, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI257796254, Length=363, Percent_Identity=31.6804407713499, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=33.2268370607029, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24797151, Length=335, Percent_Identity=28.955223880597, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI197927446, Length=348, Percent_Identity=27.8735632183908, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21361378, Length=348, Percent_Identity=27.8735632183908, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI194306651, Length=372, Percent_Identity=24.4623655913978, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=35.8490566037736, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=32.972972972973, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71994045, Length=344, Percent_Identity=25.8720930232558, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71994052, Length=344, Percent_Identity=25.8720930232558, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32563613, Length=344, Percent_Identity=21.8023255813953, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=32.2250639386189, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=32.9787234042553, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI20130091, Length=380, Percent_Identity=25.7894736842105, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28571104, Length=277, Percent_Identity=25.2707581227437, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_BACV8 (A6L6X5)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001301061.1
- ProteinModelPortal:   A6L6X5
- SMR:   A6L6X5
- STRING:   A6L6X5
- GeneID:   5304787
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3828
- NMPDR:   fig|435590.6.peg.3552
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39664; Mature: 39664

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTPFTETHIALGAKMHEFAGYNMPIEYSGIIDEHLTVCNAVGVFDVSHMGEFWVKGPN
CCCCCCCHHHHHHCCHHHHHCCCCCCEEECCCHHHHHHHHHHHCCEEHHHCCHHEECCCH
ALEFLQQVTSNNVATLPVGKAQYTCFPNEEGGIVDDLLVYHYESEKYLLVVNAANIEKDW
HHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCHHEEEEEEECCCCEEEEEEECCCCCCC
NWCVSHNTVGAELENASDRMAQLAIQGPKAMEVLQKLTPVNLSEIPYYAFTTGEFAGQKD
CEEECCCCCCCCHHCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHCCEEEEECCCCCCCCC
VIISNTGYTGAGGFELYFYPEAGQAIWKAIFEAGAPEGIKPIGLGARDTLRLEMGFCLYG
EEEECCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEEC
NDLSDTTSPLEAGLGWITKFVEGKNFTSRALLEKQKAEGLKRKLIAFEMVDRGIPRHGYE
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LVNADGEKIGEVTSGTMSPMRKIGIGMGYVQTAYTALGTEIFIDVRGRKLKAVVVKAPFR
EECCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCEEEEEEECCCEEEEEEEECCCC
K
C
>Mature Secondary Structure
MKTTPFTETHIALGAKMHEFAGYNMPIEYSGIIDEHLTVCNAVGVFDVSHMGEFWVKGPN
CCCCCCCHHHHHHCCHHHHHCCCCCCEEECCCHHHHHHHHHHHCCEEHHHCCHHEECCCH
ALEFLQQVTSNNVATLPVGKAQYTCFPNEEGGIVDDLLVYHYESEKYLLVVNAANIEKDW
HHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCHHEEEEEEECCCCEEEEEEECCCCCCC
NWCVSHNTVGAELENASDRMAQLAIQGPKAMEVLQKLTPVNLSEIPYYAFTTGEFAGQKD
CEEECCCCCCCCHHCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHCCEEEEECCCCCCCCC
VIISNTGYTGAGGFELYFYPEAGQAIWKAIFEAGAPEGIKPIGLGARDTLRLEMGFCLYG
EEEECCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEEC
NDLSDTTSPLEAGLGWITKFVEGKNFTSRALLEKQKAEGLKRKLIAFEMVDRGIPRHGYE
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LVNADGEKIGEVTSGTMSPMRKIGIGMGYVQTAYTALGTEIFIDVRGRKLKAVVVKAPFR
EECCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCEEEEEEECCCEEEEEEEECCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA