Click here to switch to the map view.

The map label for this gene is pth

Identifier: 150006313

GI number: 150006313

Start: 4722214

End: 4722777

Strand: Direct

Name: pth

Synonym: BVU_3824

Alternate gene names: 150006313

Gene position: 4722214-4722777 (Clockwise)

Preceding gene: 150006312

Following gene: 150006314

Centisome position: 91.46

GC content: 45.57

Gene sequence:

>564_bases
ATGAAATATTTGATTACAGGACTGGGTAATATAGGTGAAGAATACCGAAATACCCGTCACAACATAGGATTCACAGTATT
GGACGCCCTTGCAAAGGCGTCCAATCTTGTTTTTACCGACGGACGTTATGGGGCTACTGCCACCCTCTCGCTCAAAGGAC
GCCAGCTTATCCTGCTGAAACCGTCTACTTACATGAACCTGAGTGGAAATGCAGTGCGCTACTGGATGCAGAAAGAAAAC
ATTCCGTTGGAAAATGTGTTGATAGTGGTGGACGACCTCGCCCTTCCTTTCGGTACACTACGCCTGAAAGGAAAAGGCAG
CGATGCCGGACACAATGGTTTGAAACATATAGCTGCTACGCTGGGTACACAGGATTATGCCCGTCTGCGCTTTGGTATCG
GCAACGATTTTCCCCGTGGCGGACAAATAGATTTTGTATTAGGTCACTTCACTGATGAAGATTTGAAGACCATGGACGAA
CGTGTAGCAACGGCTTGCGACATAATTAAGAGTTTTTGTCTGGCAGGCATCAGTATAACAATGAACCAATACAATAAAAA
GTAA

Upstream 100 bases:

>100_bases
CGCTAAAGAAGCCGTTGTTTGTGCAGTTAAATTGACTCGTGCCGCTCGTGGTGCTGCTGCAACTGCCGGCAAATAATCAG
TAACCTTTTAATCCTTATCA

Downstream 100 bases:

>100_bases
TGGCTGAAGCAAGAATTGATAAATGGCTGTGGGCCTCACGTATATTCAAGACCCGTACTATCGCTGCCGAAGCATGCAAG
AAAGGACGGGTTTCCATCAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKYLITGLGNIGEEYRNTRHNIGFTVLDALAKASNLVFTDGRYGATATLSLKGRQLILLKPSTYMNLSGNAVRYWMQKEN
IPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAATLGTQDYARLRFGIGNDFPRGGQIDFVLGHFTDEDLKTMDE
RVATACDIIKSFCLAGISITMNQYNKK

Sequences:

>Translated_187_residues
MKYLITGLGNIGEEYRNTRHNIGFTVLDALAKASNLVFTDGRYGATATLSLKGRQLILLKPSTYMNLSGNAVRYWMQKEN
IPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAATLGTQDYARLRFGIGNDFPRGGQIDFVLGHFTDEDLKTMDE
RVATACDIIKSFCLAGISITMNQYNKK
>Mature_187_residues
MKYLITGLGNIGEEYRNTRHNIGFTVLDALAKASNLVFTDGRYGATATLSLKGRQLILLKPSTYMNLSGNAVRYWMQKEN
IPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAATLGTQDYARLRFGIGNDFPRGGQIDFVLGHFTDEDLKTMDE
RVATACDIIKSFCLAGISITMNQYNKK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=172, Percent_Identity=33.1395348837209, Blast_Score=80, Evalue=9e-16,
Organism=Escherichia coli, GI1787455, Length=185, Percent_Identity=35.1351351351351, Blast_Score=85, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_BACV8 (A6L6X1)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001301057.1
- ProteinModelPortal:   A6L6X1
- SMR:   A6L6X1
- STRING:   A6L6X1
- GeneID:   5304783
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3824
- NMPDR:   fig|435590.6.peg.3548
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20617; Mature: 20617

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLITGLGNIGEEYRNTRHNIGFTVLDALAKASNLVFTDGRYGATATLSLKGRQLILLK
CCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEECCCEEEEEC
PSTYMNLSGNAVRYWMQKENIPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAAT
CCCEEECCCCEEEEEEECCCCCHHHEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHH
LGTQDYARLRFGIGNDFPRGGQIDFVLGHFTDEDLKTMDERVATACDIIKSFCLAGISIT
HCCCHHHEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
MNQYNKK
ECCCCCC
>Mature Secondary Structure
MKYLITGLGNIGEEYRNTRHNIGFTVLDALAKASNLVFTDGRYGATATLSLKGRQLILLK
CCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEECCCEEEEEC
PSTYMNLSGNAVRYWMQKENIPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAAT
CCCEEECCCCEEEEEEECCCCCHHHEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHH
LGTQDYARLRFGIGNDFPRGGQIDFVLGHFTDEDLKTMDERVATACDIIKSFCLAGISIT
HCCCHHHEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
MNQYNKK
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA