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The map label for this gene is pccB [H]

Identifier: 150005614

GI number: 150005614

Start: 3922555

End: 3924087

Strand: Reverse

Name: pccB [H]

Synonym: BVU_3102

Alternate gene names: 150005614

Gene position: 3924087-3922555 (Counterclockwise)

Preceding gene: 150005615

Following gene: 150005613

Centisome position: 76.0

GC content: 50.82

Gene sequence:

>1533_bases
ATGACAAGAGAAGAAATATACAGCCGGTTTGAAGAGCTGGACAAACGCGCGTCGCTGGGCGGCGGTGTGGACAAGATCGA
GAAACAACACGCCCAAGGGAAGATGACCGCTCGCGAGCGTATCGGAATGTTGCTGGACAAAGGTACGTTCAATGAACTGG
ACAAGCTGGTGAACCACCGTTGTACCAACTTCGGCATGGAGAAGAAGCAGATTGCCGGAGATGGTATGGTCACCGGTTAC
GGAAAGATAGACGGCCGTCCAGTGTTTGTCTATGCATATGATTTTACCGCACATGGCGGCTCGCTGAGCGAGACCAATGC
TGCCAAGATTGTAAAGGTTCAGCAACTGGCTTTGAAGACGGGAGCTCCCGTTATCGCCCTGAACGACTCGGGAGGCGCAC
GCATCCAAGAAGGGGTGAACAGCCTTGCCGGATATGCCTCTATTTTCTATCAGAACACTATCGCCTCAGGTGTTATCCCG
CAGATTTCCGCCATCTTGGGTCCTTGTGCCGGAGGAGCCTGCTACTCACCAGCACTAACCGATTTTATCTTTATGGTAAA
AGAGAAGAGCCACATGTTCATCACCGGCCCGGATGTGGTGAAGACTGTGACTAACGAGGAGGTGGGCAAGGAGGAACTGG
GCGGTGCCTATACCCACAGCAGCAAAAGCGGTGTGACCCATTTTATGTGCGACAATGAGGAGGAAACGCTGATGAGTATC
CGCGAATTGCTGAGTTTCCTGCCTTCCAACAATATGGAGGATGCGCCGTTGGTTCCCTGCAACGATGACATCCATCGTCA
GGTGGAGGCGTTGCAGACTGTCATTCCCGAAGATCCGAATATGCCTTATGATATAAAGGATATCATCGAACCGGTGCTGG
ATAACCAGTATTTCTTCGAGGTGATGCCTCACTTTGCTAAAAATGTGGTGGTGGGGTTCGGTCGCCTGGGAGGTCGTTCC
GTAGGTATTGTTGCCAATCAGCCCGCCTGGCTGGCCGGCGTCCTTGACATTGACGCCAGTGACAAGGCTGCCCGTTTTAT
CCGTTTCTGCGACTGCTTTAACATTCCTCTGATCACTTTCGAGGATGTTCCCGGCTTCCTGCCCGGAACAATACAGGAAC
ACAACGGCATCATCCGCCACGGTGCGAAGATAGTTTATGCATACGCCGAAGCTACAGTGCCCAAGGTAACTTTAATTACC
CGTAAAGCTTACGGAGGTGCCTACATTGTCATGTCCAGCAAACCGACGGGAGCCGATGTGAACCTGGCTTATCCACAGGC
GGAAATAGCCGTTATGGGAGCTGCGGGAGCTGTAAATATCCTCTATCGGAAATCCACTCCTGAAGAAAAACAAGAAATAA
TCAAAGATTACGAAGATAAATTCTCTAACCCTTATTGTGCGGCAGAACGCGGCTTGATTGATGAAGTGATTATGCCCCGT
GACACCCGCTATAAACTCATTCAGGCTTTGGAAATGTGTCACAACAAAAACCAAAGCAATCCGCCTAAAAAGCACGGCAA
TATGCCGTTGTAA

Upstream 100 bases:

>100_bases
CCTCGGACTGCACGGTAAGGGATATCCTGGTCAATGAAGGGGATTCCGTCAATGCTAACCAGGTATTAATAGTATTGGAT
ATAATAAAAGAAGATTGATC

Downstream 100 bases:

>100_bases
TTGTTCAATGTGTGTGTATCCCCGCAGAAGTGATTTTTCCGGGGATACTTTTACCAACCCACATGATGGGAAATTTTAAA
TATAAAATGATGACTTAGTT

Product: propionyl-CoA carboxylase beta chain

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHRCTNFGMEKKQIAGDGMVTGY
GKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKTGAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIP
QISAILGPCAGGACYSPALTDFIFMVKEKSHMFITGPDVVKTVTNEEVGKEELGGAYTHSSKSGVTHFMCDNEEETLMSI
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFEVMPHFAKNVVVGFGRLGGRS
VGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITFEDVPGFLPGTIQEHNGIIRHGAKIVYAYAEATVPKVTLIT
RKAYGGAYIVMSSKPTGADVNLAYPQAEIAVMGAAGAVNILYRKSTPEEKQEIIKDYEDKFSNPYCAAERGLIDEVIMPR
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL

Sequences:

>Translated_510_residues
MTREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHRCTNFGMEKKQIAGDGMVTGY
GKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKTGAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIP
QISAILGPCAGGACYSPALTDFIFMVKEKSHMFITGPDVVKTVTNEEVGKEELGGAYTHSSKSGVTHFMCDNEEETLMSI
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFEVMPHFAKNVVVGFGRLGGRS
VGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITFEDVPGFLPGTIQEHNGIIRHGAKIVYAYAEATVPKVTLIT
RKAYGGAYIVMSSKPTGADVNLAYPQAEIAVMGAAGAVNILYRKSTPEEKQEIIKDYEDKFSNPYCAAERGLIDEVIMPR
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL
>Mature_509_residues
TREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHRCTNFGMEKKQIAGDGMVTGYG
KIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKTGAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIPQ
ISAILGPCAGGACYSPALTDFIFMVKEKSHMFITGPDVVKTVTNEEVGKEELGGAYTHSSKSGVTHFMCDNEEETLMSIR
ELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFEVMPHFAKNVVVGFGRLGGRSV
GIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITFEDVPGFLPGTIQEHNGIIRHGAKIVYAYAEATVPKVTLITR
KAYGGAYIVMSSKPTGADVNLAYPQAEIAVMGAAGAVNILYRKSTPEEKQEIIKDYEDKFSNPYCAAERGLIDEVIMPRD
TRYKLIQALEMCHNKNQSNPPKKHGNMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=508, Percent_Identity=56.2992125984252, Blast_Score=587, Evalue=1e-168,
Organism=Homo sapiens, GI295821216, Length=528, Percent_Identity=54.3560606060606, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI11545863, Length=502, Percent_Identity=30.6772908366534, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI134142062, Length=342, Percent_Identity=26.3157894736842, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI38679971, Length=340, Percent_Identity=26.7647058823529, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679974, Length=340, Percent_Identity=26.7647058823529, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679977, Length=340, Percent_Identity=26.7647058823529, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679967, Length=340, Percent_Identity=26.7647058823529, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679960, Length=340, Percent_Identity=26.7647058823529, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788655, Length=207, Percent_Identity=29.951690821256, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=57.3122529644269, Blast_Score=612, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=57.3122529644269, Blast_Score=611, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17552936, Length=502, Percent_Identity=32.0717131474104, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71997163, Length=342, Percent_Identity=26.6081871345029, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI133931226, Length=307, Percent_Identity=23.7785016286645, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323863, Length=358, Percent_Identity=22.6256983240223, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24586065, Length=516, Percent_Identity=32.7519379844961, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI161076407, Length=390, Percent_Identity=26.4102564102564, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586460, Length=390, Percent_Identity=26.4102564102564, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586458, Length=390, Percent_Identity=26.4102564102564, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161076409, Length=390, Percent_Identity=26.4102564102564, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55920; Mature: 55788

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHH
CTNFGMEKKQIAGDGMVTGYGKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKT
HHCCCCCHHHHCCCCEEEEECCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIPQISAILGPCAGGACYSPALT
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHH
DFIFMVKEKSHMFITGPDVVKTVTNEEVGKEELGGAYTHSSKSGVTHFMCDNEEETLMSI
HHHHHEECCCEEEEECCHHHHHHCCHHCCHHHCCCCEECCCCCCCEEEEECCCHHHHHHH
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFE
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHH
VMPHFAKNVVVGFGRLGGRSVGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITF
HHHHHHHHHEEECCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
EDVPGFLPGTIQEHNGIIRHGAKIVYAYAEATVPKVTLITRKAYGGAYIVMSSKPTGADV
CCCCCCCCCCHHHCCCHHHCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCE
NLAYPQAEIAVMGAAGAVNILYRKSTPEEKQEIIKDYEDKFSNPYCAAERGLIDEVIMPR
EEECCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCC
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHR
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHH
CTNFGMEKKQIAGDGMVTGYGKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKT
HHCCCCCHHHHCCCCEEEEECCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIPQISAILGPCAGGACYSPALT
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHH
DFIFMVKEKSHMFITGPDVVKTVTNEEVGKEELGGAYTHSSKSGVTHFMCDNEEETLMSI
HHHHHEECCCEEEEECCHHHHHHCCHHCCHHHCCCCEECCCCCCCEEEEECCCHHHHHHH
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFE
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHH
VMPHFAKNVVVGFGRLGGRSVGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITF
HHHHHHHHHEEECCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
EDVPGFLPGTIQEHNGIIRHGAKIVYAYAEATVPKVTLITRKAYGGAYIVMSSKPTGADV
CCCCCCCCCCHHHCCCHHHCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCE
NLAYPQAEIAVMGAAGAVNILYRKSTPEEKQEIIKDYEDKFSNPYCAAERGLIDEVIMPR
EEECCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCC
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]