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The map label for this gene is nrdA [H]

Identifier: 150005610

GI number: 150005610

Start: 3917006

End: 3919525

Strand: Reverse

Name: nrdA [H]

Synonym: BVU_3098

Alternate gene names: 150005610

Gene position: 3919525-3917006 (Counterclockwise)

Preceding gene: 150005611

Following gene: 150005609

Centisome position: 75.91

GC content: 45.12

Gene sequence:

>2520_bases
ATGCAAATAATTAAAAGGAATGGGACAACAGAATCCTACGACAGGGAAAAAATAGCCGTTGCCATACGGAAAAGTTTTAT
CAGTACCCAAAAAGAAATAACAGATGAAGCTGTCTACACCATAGTAGATGAAGTGGAACAATTTCTGCATCAAAACGAAG
CAAATCGTAGTGTAGAACGCATTCAGGACGAAGTGGAACGTAGCTTGATGGAACATGGCTTTTACGCAGAAGCCAAAAAC
TATATACTTTACCGTTGGCAGCGCACAGAAAGAAGAAAAGTCCTCAGTCAAATCATTACCGGAACCGGTGATGATACTAT
AGCAAATATACTGAAAGAGATACAAAAAGACTTCTCCGGGAAGGAATATAGTCTAACCTTTCTCGCAGAGAAATTCACAA
GTTTCTGTAAACCGGATATGACATCCGGGGAACGGTTGGCGGCACTTGTCAAAGCGGCTGTAGAACTGACAACACAAGAA
ACTCCCGACTGGGAATTCATTGCAGCGCGTCTGCTGAATTTCCGATTGACAAAGAAACTGACCGAACAGGCGGAAGCTGC
CGGCATCTTTTCATTTTATGATAAATTACGCTACCTCACCGACGAGGGCTTGTATGGTAATTATATCTTGGCCTCCTATA
CTCCACAGGAGATAGAAACGGCAGCCGGCTTCATGTGTCCCGAACGTGACAAGCTTTTCAATTATTCAGGACTGGATCTG
CTTGCCAAACGTTATCTGATCCGTACCCGTTCACACGAACCTATAGAGTCTGTGCAGGAAATGTATTTAGGGATTGCCCT
TCATCTCGCTATGCCCGAAAAACAGAACAGACTGCAATGGGTAAAAAAGTTCTATGATATATTAAGTCGTCTGGAAGTCA
CAATGGCCACTCCTACCCTGGCAAATGCCCGAAAACCTTATCACCAGTTATCCAGTTGCTTCATCGATACAGTGCCCGAT
AGTCTGGAAGGCATTTACCGCAGCTTAGACAATTTTGCGATGGTAAGCAAATTTGGAGGAGGAATGGGAATGTACTTTGG
CAAAGTTCGTGCCGCAGGTGGAAACATACGCGGATTCAAAGGTGTGGCCGGAGGTGTAATCCGATGGATGAAACTGGTGA
ATGACACTGCTGTAGCCGTTGACCAGTTAGGTATGCGTCAGGGAGCCGTAGCCGTCTATCTGGATGTATGGCACAAAGAC
TTGCCTGAGTTTCTGCAACTCCGGACCAATAATGGAGATGACCGGATGAAAGCGCACGACATCTTCCCCGCCGTATGCTA
TCCGGACTTATTCTGGCGTATGGCGAAACGGGATTTAAACCAGCAATGGCATTTATTCTGCCCCAATGAAATAATGACCG
TCAAAGGATACTGTCTGGAAGACTACTACGGAGAGGAATGGGAACAAAGATACATGGATTGCGTAAATGACTCCCGACTC
TCCAAGCGCAGCATGAGCATCAAAGATATCGTCAGACTGATACTGCGTTCGGCTGTAGAAACAGGTACTCCCTTTACATT
CAATCGTGACACCGTGAACCGTGCCAATCCCAATGCGCACCGGGGAATCATTTATTGCTCCAATCTTTGCACGGAAATAG
CACAAAACATGTCCTCCATTGAAACAGTCTCTACAGAGATATGTACGGAAGATGGTGATACAGTGGTAGTCAAAACAATC
CGGCCCGGAGACTTTGTGGTATGTAATCTTGCCAGCCTTTCATTAGGACATTTGCCCTTGGAGGATGAAAAACAAATGAA
AGAAAAGGTGGCAACTGTAGTACGGGCATTGGATAATGTGATTGAACTGAACTTTTATCCGATTCCTTTCGCTCAGATTA
CCAATCATCGCTACCGCAGTATCGGCTTGGGAGTCAGCGGCTATCATCATGCTCTTGCTGTTCGCGGCATTCGTTGGGAA
AGCGAGGAACATCTCAGTTTTATGGATAAAGTTTTCGAACGTATCAACTATGCTGCCATAGCAGCAAGTAGCGAACTGGC
AAAAGAAAAAGGGGCCTATCATTATTTTGAAGGCAGCGACTGGCAGACCGGAGCTTATTTTATAAAACGGGGTTACAATT
CGCCAGAATGGAAAGCATTGGCTGTAAAGGTTTCCACACAAGGAATGAGAAATGCCTATCTTCTTGCCATTGCCCCCACC
AGCAGCACCAGTATCATTGCCGGAACCACTGCCGGAACAGATCCGGTAATGAAACGTTTCTTCTTGGAAGAAAAGAAAGG
AGCCATGCTGCCACGTGTTGCACCGGCATTGTCCGATAAGACCTATTGGATATATAAAAGTGCTTATCTGACAGATCAGA
CATGGAGTATCCGTGCCGCAGGGATCCGGCAGTTACATATAGACCAGGCACAAAGTCTGAATCTATACATTACCAATGAA
TTTACCCTGAGACAAGTATTAAACCTGTATTTGCTAGCATGGGAATGTGGCGTAAAAACAGTATATTATGTCCGCAGCAA
ATCATTGGAAGTAGAAGAATGTGAAAGCTGTGCTTCCTGA

Upstream 100 bases:

>100_bases
GAGCCAGTCAGAAGACCTGCCATTCATCAAAGGCCGTTTCTACTCGTGGGGTTAGGGAAGCGGTACGAAAATATACAATA
ATTCATACCAACAGCATCTC

Downstream 100 bases:

>100_bases
TCTTTTCGTAAACACTCCAGTACTGAATTGTCATGCTAAGACATTTCTTGTAGGGGCACCATGCTTGCGCCCCTACAAGA
AATGAATAACAAATTTATTT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 839; Mature: 839

Protein sequence:

>839_residues
MQIIKRNGTTESYDREKIAVAIRKSFISTQKEITDEAVYTIVDEVEQFLHQNEANRSVERIQDEVERSLMEHGFYAEAKN
YILYRWQRTERRKVLSQIITGTGDDTIANILKEIQKDFSGKEYSLTFLAEKFTSFCKPDMTSGERLAALVKAAVELTTQE
TPDWEFIAARLLNFRLTKKLTEQAEAAGIFSFYDKLRYLTDEGLYGNYILASYTPQEIETAAGFMCPERDKLFNYSGLDL
LAKRYLIRTRSHEPIESVQEMYLGIALHLAMPEKQNRLQWVKKFYDILSRLEVTMATPTLANARKPYHQLSSCFIDTVPD
SLEGIYRSLDNFAMVSKFGGGMGMYFGKVRAAGGNIRGFKGVAGGVIRWMKLVNDTAVAVDQLGMRQGAVAVYLDVWHKD
LPEFLQLRTNNGDDRMKAHDIFPAVCYPDLFWRMAKRDLNQQWHLFCPNEIMTVKGYCLEDYYGEEWEQRYMDCVNDSRL
SKRSMSIKDIVRLILRSAVETGTPFTFNRDTVNRANPNAHRGIIYCSNLCTEIAQNMSSIETVSTEICTEDGDTVVVKTI
RPGDFVVCNLASLSLGHLPLEDEKQMKEKVATVVRALDNVIELNFYPIPFAQITNHRYRSIGLGVSGYHHALAVRGIRWE
SEEHLSFMDKVFERINYAAIAASSELAKEKGAYHYFEGSDWQTGAYFIKRGYNSPEWKALAVKVSTQGMRNAYLLAIAPT
SSTSIIAGTTAGTDPVMKRFFLEEKKGAMLPRVAPALSDKTYWIYKSAYLTDQTWSIRAAGIRQLHIDQAQSLNLYITNE
FTLRQVLNLYLLAWECGVKTVYYVRSKSLEVEECESCAS

Sequences:

>Translated_839_residues
MQIIKRNGTTESYDREKIAVAIRKSFISTQKEITDEAVYTIVDEVEQFLHQNEANRSVERIQDEVERSLMEHGFYAEAKN
YILYRWQRTERRKVLSQIITGTGDDTIANILKEIQKDFSGKEYSLTFLAEKFTSFCKPDMTSGERLAALVKAAVELTTQE
TPDWEFIAARLLNFRLTKKLTEQAEAAGIFSFYDKLRYLTDEGLYGNYILASYTPQEIETAAGFMCPERDKLFNYSGLDL
LAKRYLIRTRSHEPIESVQEMYLGIALHLAMPEKQNRLQWVKKFYDILSRLEVTMATPTLANARKPYHQLSSCFIDTVPD
SLEGIYRSLDNFAMVSKFGGGMGMYFGKVRAAGGNIRGFKGVAGGVIRWMKLVNDTAVAVDQLGMRQGAVAVYLDVWHKD
LPEFLQLRTNNGDDRMKAHDIFPAVCYPDLFWRMAKRDLNQQWHLFCPNEIMTVKGYCLEDYYGEEWEQRYMDCVNDSRL
SKRSMSIKDIVRLILRSAVETGTPFTFNRDTVNRANPNAHRGIIYCSNLCTEIAQNMSSIETVSTEICTEDGDTVVVKTI
RPGDFVVCNLASLSLGHLPLEDEKQMKEKVATVVRALDNVIELNFYPIPFAQITNHRYRSIGLGVSGYHHALAVRGIRWE
SEEHLSFMDKVFERINYAAIAASSELAKEKGAYHYFEGSDWQTGAYFIKRGYNSPEWKALAVKVSTQGMRNAYLLAIAPT
SSTSIIAGTTAGTDPVMKRFFLEEKKGAMLPRVAPALSDKTYWIYKSAYLTDQTWSIRAAGIRQLHIDQAQSLNLYITNE
FTLRQVLNLYLLAWECGVKTVYYVRSKSLEVEECESCAS
>Mature_839_residues
MQIIKRNGTTESYDREKIAVAIRKSFISTQKEITDEAVYTIVDEVEQFLHQNEANRSVERIQDEVERSLMEHGFYAEAKN
YILYRWQRTERRKVLSQIITGTGDDTIANILKEIQKDFSGKEYSLTFLAEKFTSFCKPDMTSGERLAALVKAAVELTTQE
TPDWEFIAARLLNFRLTKKLTEQAEAAGIFSFYDKLRYLTDEGLYGNYILASYTPQEIETAAGFMCPERDKLFNYSGLDL
LAKRYLIRTRSHEPIESVQEMYLGIALHLAMPEKQNRLQWVKKFYDILSRLEVTMATPTLANARKPYHQLSSCFIDTVPD
SLEGIYRSLDNFAMVSKFGGGMGMYFGKVRAAGGNIRGFKGVAGGVIRWMKLVNDTAVAVDQLGMRQGAVAVYLDVWHKD
LPEFLQLRTNNGDDRMKAHDIFPAVCYPDLFWRMAKRDLNQQWHLFCPNEIMTVKGYCLEDYYGEEWEQRYMDCVNDSRL
SKRSMSIKDIVRLILRSAVETGTPFTFNRDTVNRANPNAHRGIIYCSNLCTEIAQNMSSIETVSTEICTEDGDTVVVKTI
RPGDFVVCNLASLSLGHLPLEDEKQMKEKVATVVRALDNVIELNFYPIPFAQITNHRYRSIGLGVSGYHHALAVRGIRWE
SEEHLSFMDKVFERINYAAIAASSELAKEKGAYHYFEGSDWQTGAYFIKRGYNSPEWKALAVKVSTQGMRNAYLLAIAPT
SSTSIIAGTTAGTDPVMKRFFLEEKKGAMLPRVAPALSDKTYWIYKSAYLTDQTWSIRAAGIRQLHIDQAQSLNLYITNE
FTLRQVLNLYLLAWECGVKTVYYVRSKSLEVEECESCAS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=722, Percent_Identity=31.3019390581717, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI2367133, Length=725, Percent_Identity=28.2758620689655, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI1789030, Length=679, Percent_Identity=29.7496318114875, Blast_Score=248, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17555242, Length=732, Percent_Identity=29.6448087431694, Blast_Score=297, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6322123, Length=721, Percent_Identity=29.4036061026352, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6320914, Length=729, Percent_Identity=29.9039780521262, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17352481, Length=743, Percent_Identity=29.6096904441454, Blast_Score=304, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 95731; Mature: 95731

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIKRNGTTESYDREKIAVAIRKSFISTQKEITDEAVYTIVDEVEQFLHQNEANRSVER
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
IQDEVERSLMEHGFYAEAKNYILYRWQRTERRKVLSQIITGTGDDTIANILKEIQKDFSG
HHHHHHHHHHHCCCHHCCCCEEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
KEYSLTFLAEKFTSFCKPDMTSGERLAALVKAAVELTTQETPDWEFIAARLLNFRLTKKL
CCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TEQAEAAGIFSFYDKLRYLTDEGLYGNYILASYTPQEIETAAGFMCPERDKLFNYSGLDL
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCCCHHCCCCCCCHHH
LAKRYLIRTRSHEPIESVQEMYLGIALHLAMPEKQNRLQWVKKFYDILSRLEVTMATPTL
HHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
ANARKPYHQLSSCFIDTVPDSLEGIYRSLDNFAMVSKFGGGMGMYFGKVRAAGGNIRGFK
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEECCCCCCCCC
GVAGGVIRWMKLVNDTAVAVDQLGMRQGAVAVYLDVWHKDLPEFLQLRTNNGDDRMKAHD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCHHHHHHHHCCCCCCCHHHHH
IFPAVCYPDLFWRMAKRDLNQQWHLFCPNEIMTVKGYCLEDYYGEEWEQRYMDCVNDSRL
CCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCEEHHHHCCCHHHHHHHHHHCHHHH
SKRSMSIKDIVRLILRSAVETGTPFTFNRDTVNRANPNAHRGIIYCSNLCTEIAQNMSSI
HHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHH
ETVSTEICTEDGDTVVVKTIRPGDFVVCNLASLSLGHLPLEDEKQMKEKVATVVRALDNV
HHHHHHHHCCCCCEEEEEEECCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IELNFYPIPFAQITNHRYRSIGLGVSGYHHALAVRGIRWESEEHLSFMDKVFERINYAAI
HCCCCCCCCHHHHCCCHHHEECCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHCHHHH
AASSELAKEKGAYHYFEGSDWQTGAYFIKRGYNSPEWKALAVKVSTQGMRNAYLLAIAPT
HHHHHHHHHCCCEEEECCCCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEEECC
SSTSIIAGTTAGTDPVMKRFFLEEKKGAMLPRVAPALSDKTYWIYKSAYLTDQTWSIRAA
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEEEECCCCCEEECC
GIRQLHIDQAQSLNLYITNEFTLRQVLNLYLLAWECGVKTVYYVRSKSLEVEECESCAS
CCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCC
>Mature Secondary Structure
MQIIKRNGTTESYDREKIAVAIRKSFISTQKEITDEAVYTIVDEVEQFLHQNEANRSVER
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
IQDEVERSLMEHGFYAEAKNYILYRWQRTERRKVLSQIITGTGDDTIANILKEIQKDFSG
HHHHHHHHHHHCCCHHCCCCEEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
KEYSLTFLAEKFTSFCKPDMTSGERLAALVKAAVELTTQETPDWEFIAARLLNFRLTKKL
CCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TEQAEAAGIFSFYDKLRYLTDEGLYGNYILASYTPQEIETAAGFMCPERDKLFNYSGLDL
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCCCHHCCCCCCCHHH
LAKRYLIRTRSHEPIESVQEMYLGIALHLAMPEKQNRLQWVKKFYDILSRLEVTMATPTL
HHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
ANARKPYHQLSSCFIDTVPDSLEGIYRSLDNFAMVSKFGGGMGMYFGKVRAAGGNIRGFK
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEECCCCCCCCC
GVAGGVIRWMKLVNDTAVAVDQLGMRQGAVAVYLDVWHKDLPEFLQLRTNNGDDRMKAHD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCHHHHHHHHCCCCCCCHHHHH
IFPAVCYPDLFWRMAKRDLNQQWHLFCPNEIMTVKGYCLEDYYGEEWEQRYMDCVNDSRL
CCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCEEHHHHCCCHHHHHHHHHHCHHHH
SKRSMSIKDIVRLILRSAVETGTPFTFNRDTVNRANPNAHRGIIYCSNLCTEIAQNMSSI
HHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHH
ETVSTEICTEDGDTVVVKTIRPGDFVVCNLASLSLGHLPLEDEKQMKEKVATVVRALDNV
HHHHHHHHCCCCCEEEEEEECCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IELNFYPIPFAQITNHRYRSIGLGVSGYHHALAVRGIRWESEEHLSFMDKVFERINYAAI
HCCCCCCCCHHHHCCCHHHEECCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHCHHHH
AASSELAKEKGAYHYFEGSDWQTGAYFIKRGYNSPEWKALAVKVSTQGMRNAYLLAIAPT
HHHHHHHHHCCCEEEECCCCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEEECC
SSTSIIAGTTAGTDPVMKRFFLEEKKGAMLPRVAPALSDKTYWIYKSAYLTDQTWSIRAA
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEEEECCCCCEEECC
GIRQLHIDQAQSLNLYITNEFTLRQVLNLYLLAWECGVKTVYYVRSKSLEVEECESCAS
CCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]