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The map label for this gene is dxs [H]

Identifier: 150005602

GI number: 150005602

Start: 3906005

End: 3907765

Strand: Direct

Name: dxs [H]

Synonym: BVU_3090

Alternate gene names: 150005602

Gene position: 3906005-3907765 (Clockwise)

Preceding gene: 150005601

Following gene: 150005605

Centisome position: 75.65

GC content: 48.5

Gene sequence:

>1761_bases
ATGTATATTGAACAAGTAAATTCTCCGCAAGACATAAAACAGTTTTCTGCGGAACAGTTAAGACAGTTGGCAGGTGAAGT
CCGCAATGCATTATTGACCAAGTTAAGTGCTCACGGAGGACATGTGGGACCTAATCTGGGAATGGTGGAGGCTACAATAG
CATTGCACTATGTATTCAATTCACCGACGGATAAGATGGTATATGATGTATCCCATCAAAGTTATACACATAAGATGCTG
ACCGGGCGTAAGGATGCTTTCCTGAATCCGGAGGATTATGATGTGGTGTCCGGATACACCAATCCCCGGGAAAGCGGGCA
CGATTTTTTCACTATCGGCCATACTTCCACCTCTGTCAGTCTGGCTTGCGGTCTTGCCAAAGCCAGAGATCTGAAAGGCG
GACACGAGAATATCATAGCCGTGATAGGGGATGGATCGCTCAGCGGCGGAGAAGCTTATGAAGGTCTGAGCAATGCGGGA
GAAATGGGAACCAACCTTATTATAGTGGTTAATGATAATGAAATGTCCATTGCCGAAAACCACGGCGGGCTCTATCAGAA
CCTGAAAGAACTGCGCGACACGGAGGGACGGTCGTCCTGTAATTTCTTCCGTTCTCTGGGGTTGGATTATCTTTATGTGG
GAGAGGGGAATGATATTCCGTCTTTGGTTGCGGCTTTTGCCAAGGTGAAAGATACATCACGTCCCACAGTGGTTCATATT
CACACACAGAAAGGAAAGGGATACGCTCCGGCAGAAGCCGACCGGGAGGAATTTCATTGGGAGATGCCTTTCGATCTGGA
AACGGGTAAGCCGAAGGTGGATTGCAGCGGTATGGAGGATTACCATAGCCTGACCGGGAAGTTTTTGTTGGAGAAGATGA
AGGAGGACCACACGGTTGTTGCCATCAGTTCGGGTACTCCTACTGTGATAGGTTTTACTCCTGAACGCCGGAAACAGGCA
GGGCGTCAGTTTGTGGATGTAGGTATTGCCGAGGAACATGCCGTGGCATTGGCATCGGGTATCGCTGCCGGTGGCGGACG
TCCGGTGTACGGGGTTTACAGTACTTTTATCCAGCGTTGCTATGACCAGTTGTCTCAGGATTTGTGTATCAATGGAAATC
CGGCGGTGATCACTGTGTTTATGGGGACAGTAGCCGGAATGAACGATGTGACTCATCTGGGTTTCTTCGATATTCCGCTT
ATCAGCAATATCCCGAATATGGTTTATCTGGCTCCTACGTGTTCCGAAGAGTATTTTGCTATGTTGGAATGGGCTGTCCG
CCAGACGGAATATCCCGTTGCCATCCGTGTGCCGGGAGTGGCAGTGGTGCATCGTAAGGAAGAGTTTGACACGGATTATA
GCGAGTTAAACCGCTACAAAATGACAGCCAGGGGAGAAACTGTCGCTATTCTTGCATTGGGTTCTTTCTATGATTTGGGA
CAGGCTTTGAAGAATAAGCTTCGGGAAGAGTCGGGTGTTGAGGCTACTTTGATTAATCCCCGTTACATAACAGGGCTTGA
CGAACCGATGCTGGAAGAGTTGAAAGTGGGGCATCGTATTGTCGTAACGTTGGAAGACGGGGTGCTGGATGGAGGATTCG
GCGAGAAGATAGCGCGTTATTATGGTAATTCTGAAATGCGGGTGCTGAATTACGGACTTCGTAAAGAATTTGCAGACCGC
TATAATCTGGATGAGCTGATGAAAGCCAACCGGTTGACTGACAAGCAGATGGCGGAGGATATTGCCGGTATATTGGAATA
A

Upstream 100 bases:

>100_bases
AATGGGGCCTGGCTTATCTTTGCATTGTGAAATGAAAGCGGCTTTGTCCGCATCGGAATGAAGCAAGACAACAGATGAAA
TCATTTAAACAGGTAGAACG

Downstream 100 bases:

>100_bases
CCTTTTACGGAATGGCTGAAGTCCGAGACTTCAGCCATTTTTGTAATAGTGAAATAGATAAGCCGGATTAAAACTGTTTG
TTACCATAAGCATGAGAACT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MYIEQVNSPQDIKQFSAEQLRQLAGEVRNALLTKLSAHGGHVGPNLGMVEATIALHYVFNSPTDKMVYDVSHQSYTHKML
TGRKDAFLNPEDYDVVSGYTNPRESGHDFFTIGHTSTSVSLACGLAKARDLKGGHENIIAVIGDGSLSGGEAYEGLSNAG
EMGTNLIIVVNDNEMSIAENHGGLYQNLKELRDTEGRSSCNFFRSLGLDYLYVGEGNDIPSLVAAFAKVKDTSRPTVVHI
HTQKGKGYAPAEADREEFHWEMPFDLETGKPKVDCSGMEDYHSLTGKFLLEKMKEDHTVVAISSGTPTVIGFTPERRKQA
GRQFVDVGIAEEHAVALASGIAAGGGRPVYGVYSTFIQRCYDQLSQDLCINGNPAVITVFMGTVAGMNDVTHLGFFDIPL
ISNIPNMVYLAPTCSEEYFAMLEWAVRQTEYPVAIRVPGVAVVHRKEEFDTDYSELNRYKMTARGETVAILALGSFYDLG
QALKNKLREESGVEATLINPRYITGLDEPMLEELKVGHRIVVTLEDGVLDGGFGEKIARYYGNSEMRVLNYGLRKEFADR
YNLDELMKANRLTDKQMAEDIAGILE

Sequences:

>Translated_586_residues
MYIEQVNSPQDIKQFSAEQLRQLAGEVRNALLTKLSAHGGHVGPNLGMVEATIALHYVFNSPTDKMVYDVSHQSYTHKML
TGRKDAFLNPEDYDVVSGYTNPRESGHDFFTIGHTSTSVSLACGLAKARDLKGGHENIIAVIGDGSLSGGEAYEGLSNAG
EMGTNLIIVVNDNEMSIAENHGGLYQNLKELRDTEGRSSCNFFRSLGLDYLYVGEGNDIPSLVAAFAKVKDTSRPTVVHI
HTQKGKGYAPAEADREEFHWEMPFDLETGKPKVDCSGMEDYHSLTGKFLLEKMKEDHTVVAISSGTPTVIGFTPERRKQA
GRQFVDVGIAEEHAVALASGIAAGGGRPVYGVYSTFIQRCYDQLSQDLCINGNPAVITVFMGTVAGMNDVTHLGFFDIPL
ISNIPNMVYLAPTCSEEYFAMLEWAVRQTEYPVAIRVPGVAVVHRKEEFDTDYSELNRYKMTARGETVAILALGSFYDLG
QALKNKLREESGVEATLINPRYITGLDEPMLEELKVGHRIVVTLEDGVLDGGFGEKIARYYGNSEMRVLNYGLRKEFADR
YNLDELMKANRLTDKQMAEDIAGILE
>Mature_586_residues
MYIEQVNSPQDIKQFSAEQLRQLAGEVRNALLTKLSAHGGHVGPNLGMVEATIALHYVFNSPTDKMVYDVSHQSYTHKML
TGRKDAFLNPEDYDVVSGYTNPRESGHDFFTIGHTSTSVSLACGLAKARDLKGGHENIIAVIGDGSLSGGEAYEGLSNAG
EMGTNLIIVVNDNEMSIAENHGGLYQNLKELRDTEGRSSCNFFRSLGLDYLYVGEGNDIPSLVAAFAKVKDTSRPTVVHI
HTQKGKGYAPAEADREEFHWEMPFDLETGKPKVDCSGMEDYHSLTGKFLLEKMKEDHTVVAISSGTPTVIGFTPERRKQA
GRQFVDVGIAEEHAVALASGIAAGGGRPVYGVYSTFIQRCYDQLSQDLCINGNPAVITVFMGTVAGMNDVTHLGFFDIPL
ISNIPNMVYLAPTCSEEYFAMLEWAVRQTEYPVAIRVPGVAVVHRKEEFDTDYSELNRYKMTARGETVAILALGSFYDLG
QALKNKLREESGVEATLINPRYITGLDEPMLEELKVGHRIVVTLEDGVLDGGFGEKIARYYGNSEMRVLNYGLRKEFADR
YNLDELMKANRLTDKQMAEDIAGILE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=491, Percent_Identity=22.8105906313646, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=600, Percent_Identity=31.5, Blast_Score=315, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17539652, Length=503, Percent_Identity=24.8508946322068, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 64594; Mature: 64594

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIEQVNSPQDIKQFSAEQLRQLAGEVRNALLTKLSAHGGHVGPNLGMVEATIALHYVFN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEC
SPTDKMVYDVSHQSYTHKMLTGRKDAFLNPEDYDVVSGYTNPRESGHDFFTIGHTSTSVS
CCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHH
LACGLAKARDLKGGHENIIAVIGDGSLSGGEAYEGLSNAGEMGTNLIIVVNDNEMSIAEN
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCHHCCCCEEEEEECCCCEEEECC
HGGLYQNLKELRDTEGRSSCNFFRSLGLDYLYVGEGNDIPSLVAAFAKVKDTSRPTVVHI
CCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEE
HTQKGKGYAPAEADREEFHWEMPFDLETGKPKVDCSGMEDYHSLTGKFLLEKMKEDHTVV
EECCCCCCCCCCCCHHHCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
AISSGTPTVIGFTPERRKQAGRQFVDVGIAEEHAVALASGIAAGGGRPVYGVYSTFIQRC
EECCCCCEEEECCHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YDQLSQDLCINGNPAVITVFMGTVAGMNDVTHLGFFDIPLISNIPNMVYLAPTCSEEYFA
HHHHHHCEEECCCCCEEEEEEHHHCCCCCCCCCCEECCHHHHCCCCEEEECCCCCHHHHH
MLEWAVRQTEYPVAIRVPGVAVVHRKEEFDTDYSELNRYKMTARGETVAILALGSFYDLG
HHHHHHHHCCCCEEEECCCEEEEEECHHCCCCHHHHHHEEEEECCCEEEEEEECCHHHHH
QALKNKLREESGVEATLINPRYITGLDEPMLEELKVGHRIVVTLEDGVLDGGFGEKIARY
HHHHHHHHHHCCCEEEEECCCEECCCCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHH
YGNSEMRVLNYGLRKEFADRYNLDELMKANRLTDKQMAEDIAGILE
HCCCCEEEEHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MYIEQVNSPQDIKQFSAEQLRQLAGEVRNALLTKLSAHGGHVGPNLGMVEATIALHYVFN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEC
SPTDKMVYDVSHQSYTHKMLTGRKDAFLNPEDYDVVSGYTNPRESGHDFFTIGHTSTSVS
CCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHH
LACGLAKARDLKGGHENIIAVIGDGSLSGGEAYEGLSNAGEMGTNLIIVVNDNEMSIAEN
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCHHCCCCEEEEEECCCCEEEECC
HGGLYQNLKELRDTEGRSSCNFFRSLGLDYLYVGEGNDIPSLVAAFAKVKDTSRPTVVHI
CCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEE
HTQKGKGYAPAEADREEFHWEMPFDLETGKPKVDCSGMEDYHSLTGKFLLEKMKEDHTVV
EECCCCCCCCCCCCHHHCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
AISSGTPTVIGFTPERRKQAGRQFVDVGIAEEHAVALASGIAAGGGRPVYGVYSTFIQRC
EECCCCCEEEECCHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YDQLSQDLCINGNPAVITVFMGTVAGMNDVTHLGFFDIPLISNIPNMVYLAPTCSEEYFA
HHHHHHCEEECCCCCEEEEEEHHHCCCCCCCCCCEECCHHHHCCCCEEEECCCCCHHHHH
MLEWAVRQTEYPVAIRVPGVAVVHRKEEFDTDYSELNRYKMTARGETVAILALGSFYDLG
HHHHHHHHCCCCEEEECCCEEEEEECHHCCCCHHHHHHEEEEECCCEEEEEEECCHHHHH
QALKNKLREESGVEATLINPRYITGLDEPMLEELKVGHRIVVTLEDGVLDGGFGEKIARY
HHHHHHHHHHCCCEEEEECCCEECCCCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHH
YGNSEMRVLNYGLRKEFADRYNLDELMKANRLTDKQMAEDIAGILE
HCCCCEEEEHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA