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The map label for this gene is gnd [H]

Identifier: 150005319

GI number: 150005319

Start: 3565795

End: 3567231

Strand: Direct

Name: gnd [H]

Synonym: BVU_2795

Alternate gene names: 150005319

Gene position: 3565795-3567231 (Clockwise)

Preceding gene: 150005317

Following gene: 150005320

Centisome position: 69.06

GC content: 48.23

Gene sequence:

>1437_bases
ATGGAAAAGGCAGATATAGGATTAATCGGATTAGGTGTGATGGGGCAGAACCTTGCTCTGAATCTTGCCAACAAGGGATG
GAAGGTTGTAGTATGGAACCGTACCGTTCCTGGAAAAGAAGAAAATGTAGTGGAACACTTTATAGCCAACCGCGCCAAAG
GAAAAGGCATCATAGGCAGTAATGAACTGACAGATTTTGTCGAAGCACTGAAAACTCCGCGTGTCATCCTTTTGATGGTA
CAGGCGGGTCCCGCTGTCGATGAACTGACGGGCAAGCTGTTTCCTTTGATGGAAAAGGGTGATATCCTCATTGACGGAGG
CAACTCTTATTATGAAGATACGGAACGTCGTGTAAAGGAACTTTATGATAAAGGAATGTACTTTGTAGGTTGCGGCATTT
CAGGAGGTGAGGAGGGTGCTTTGCATGGAGCGTCCATCATGCCCGGTGGTGCGCAAGAGGCATGGTCAGTCATTCAGCCG
ATGCTGAAAAGTATTGCGGCAAAAGCTGAGGATGGTACTCCGTGTTGTGAGTGGGTAGGTCCCGGTGGCGCAGGCCACTA
TGTAAAAATGGTGCATAATGGCATAGAATATGGGGATATGCAGCTGATTGCTGAAACTTATTTCGCCATGAAGCACCTGC
TGGCGTTGAAGAATGAACAGATGGCGGATATTTTTGAACAATGGGACAAAGGACGTCTGCATAGTTACCTGATAGAGATT
ACTTCGGCCATTCTGCGTCATAAAGAAGAAGGAGGCGATTATTTGCTCGATAACATTCTGGATGCTGCGGGACAAAAAGG
AACGGGTCGCTGGAGTGTCATTAACTCCCTACAACTAAATACACCACTGGGCGTGATTGCCGAGGCGGTTTTTGCCCGTA
ATCTGTCGGCAGAGAAGAACTTGCGCGTGCTGATGTCCAAACATTATATGCATGTGGAGAATCATCCGGTATATAATTAT
CAGGATACGGTGATCGGATTGGAAAGTACCTTATATGCGGCTCGTCTGACAGGCTATGCGCAAGGGTTTGCTCTGATGTG
CACTGCCAGTGAGCAATATGGCTGGAAGTTGAATCTTTCCACTATCGCGCTGTTGTGGCGCGCCGGATGCATTATTCGTT
CTGCTTTTCTGAACGACATTGCCGAGGCCTATCACCGTGCACCGGGATTGTCGCATCTGTTGCTGGACGAGCATTTCGGA
CGGGAAGTAATGGAAGCCCTGCCCGCGTGGAAGAAATACATCGGTGTCATGTTGAGAGAAGGGTTGCCCGTACCTGTACT
TTCCGCAGCGTTGAATTATTTTCTAGGTTTGACCACCAACCGTTCCCCAGCCAATATGATTCAAGCGATGCGTGATTATT
TCGGAGCTCATACCTTCGAGCGTGTGGACAGTCCACGGGGGGAATTTTTCCACGAACATTGGGAAGACAACTATTGA

Upstream 100 bases:

>100_bases
TTTTTAACCTCTTCATGATAATGTGTTATTATTCAAATTGCAAAGATAGAATTATTGAACAAATAACCTATCAAATTGTT
AAATATAAAAAGAATAATTT

Downstream 100 bases:

>100_bases
TATGTCGCAACACAAAGCATTATACATTCATTTTTAAAAGAAAGAATCATGAGTTTACCACATAGTTTATTTTTGGTCAT
CTTCGGTGCATCCGGTGATT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MEKADIGLIGLGVMGQNLALNLANKGWKVVVWNRTVPGKEENVVEHFIANRAKGKGIIGSNELTDFVEALKTPRVILLMV
QAGPAVDELTGKLFPLMEKGDILIDGGNSYYEDTERRVKELYDKGMYFVGCGISGGEEGALHGASIMPGGAQEAWSVIQP
MLKSIAAKAEDGTPCCEWVGPGGAGHYVKMVHNGIEYGDMQLIAETYFAMKHLLALKNEQMADIFEQWDKGRLHSYLIEI
TSAILRHKEEGGDYLLDNILDAAGQKGTGRWSVINSLQLNTPLGVIAEAVFARNLSAEKNLRVLMSKHYMHVENHPVYNY
QDTVIGLESTLYAARLTGYAQGFALMCTASEQYGWKLNLSTIALLWRAGCIIRSAFLNDIAEAYHRAPGLSHLLLDEHFG
REVMEALPAWKKYIGVMLREGLPVPVLSAALNYFLGLTTNRSPANMIQAMRDYFGAHTFERVDSPRGEFFHEHWEDNY

Sequences:

>Translated_478_residues
MEKADIGLIGLGVMGQNLALNLANKGWKVVVWNRTVPGKEENVVEHFIANRAKGKGIIGSNELTDFVEALKTPRVILLMV
QAGPAVDELTGKLFPLMEKGDILIDGGNSYYEDTERRVKELYDKGMYFVGCGISGGEEGALHGASIMPGGAQEAWSVIQP
MLKSIAAKAEDGTPCCEWVGPGGAGHYVKMVHNGIEYGDMQLIAETYFAMKHLLALKNEQMADIFEQWDKGRLHSYLIEI
TSAILRHKEEGGDYLLDNILDAAGQKGTGRWSVINSLQLNTPLGVIAEAVFARNLSAEKNLRVLMSKHYMHVENHPVYNY
QDTVIGLESTLYAARLTGYAQGFALMCTASEQYGWKLNLSTIALLWRAGCIIRSAFLNDIAEAYHRAPGLSHLLLDEHFG
REVMEALPAWKKYIGVMLREGLPVPVLSAALNYFLGLTTNRSPANMIQAMRDYFGAHTFERVDSPRGEFFHEHWEDNY
>Mature_478_residues
MEKADIGLIGLGVMGQNLALNLANKGWKVVVWNRTVPGKEENVVEHFIANRAKGKGIIGSNELTDFVEALKTPRVILLMV
QAGPAVDELTGKLFPLMEKGDILIDGGNSYYEDTERRVKELYDKGMYFVGCGISGGEEGALHGASIMPGGAQEAWSVIQP
MLKSIAAKAEDGTPCCEWVGPGGAGHYVKMVHNGIEYGDMQLIAETYFAMKHLLALKNEQMADIFEQWDKGRLHSYLIEI
TSAILRHKEEGGDYLLDNILDAAGQKGTGRWSVINSLQLNTPLGVIAEAVFARNLSAEKNLRVLMSKHYMHVENHPVYNY
QDTVIGLESTLYAARLTGYAQGFALMCTASEQYGWKLNLSTIALLWRAGCIIRSAFLNDIAEAYHRAPGLSHLLLDEHFG
REVMEALPAWKKYIGVMLREGLPVPVLSAALNYFLGLTTNRSPANMIQAMRDYFGAHTFERVDSPRGEFFHEHWEDNY

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=475, Percent_Identity=48.4210526315789, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI1788341, Length=476, Percent_Identity=46.6386554621849, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17542558, Length=477, Percent_Identity=47.5890985324948, Blast_Score=470, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321695, Length=464, Percent_Identity=50.6465517241379, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321977, Length=459, Percent_Identity=52.2875816993464, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24639279, Length=473, Percent_Identity=51.1627906976744, Blast_Score=453, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53030; Mature: 53030

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKADIGLIGLGVMGQNLALNLANKGWKVVVWNRTVPGKEENVVEHFIANRAKGKGIIGS
CCCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
NELTDFVEALKTPRVILLMVQAGPAVDELTGKLFPLMEKGDILIDGGNSYYEDTERRVKE
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHH
LYDKGMYFVGCGISGGEEGALHGASIMPGGAQEAWSVIQPMLKSIAAKAEDGTPCCEWVG
HHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
PGGAGHYVKMVHNGIEYGDMQLIAETYFAMKHLLALKNEQMADIFEQWDKGRLHSYLIEI
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHH
TSAILRHKEEGGDYLLDNILDAAGQKGTGRWSVINSLQLNTPLGVIAEAVFARNLSAEKN
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECEECCCCHHHHHHHHHHHCCCCCHH
LRVLMSKHYMHVENHPVYNYQDTVIGLESTLYAARLTGYAQGFALMCTASEQYGWKLNLS
HHHHHHHHHEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECHH
TIALLWRAGCIIRSAFLNDIAEAYHRAPGLSHLLLDEHFGREVMEALPAWKKYIGVMLRE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
GLPVPVLSAALNYFLGLTTNRSPANMIQAMRDYFGAHTFERVDSPRGEFFHEHWEDNY
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MEKADIGLIGLGVMGQNLALNLANKGWKVVVWNRTVPGKEENVVEHFIANRAKGKGIIGS
CCCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
NELTDFVEALKTPRVILLMVQAGPAVDELTGKLFPLMEKGDILIDGGNSYYEDTERRVKE
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHH
LYDKGMYFVGCGISGGEEGALHGASIMPGGAQEAWSVIQPMLKSIAAKAEDGTPCCEWVG
HHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
PGGAGHYVKMVHNGIEYGDMQLIAETYFAMKHLLALKNEQMADIFEQWDKGRLHSYLIEI
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHH
TSAILRHKEEGGDYLLDNILDAAGQKGTGRWSVINSLQLNTPLGVIAEAVFARNLSAEKN
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECEECCCCHHHHHHHHHHHCCCCCHH
LRVLMSKHYMHVENHPVYNYQDTVIGLESTLYAARLTGYAQGFALMCTASEQYGWKLNLS
HHHHHHHHHEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECHH
TIALLWRAGCIIRSAFLNDIAEAYHRAPGLSHLLLDEHFGREVMEALPAWKKYIGVMLRE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
GLPVPVLSAALNYFLGLTTNRSPANMIQAMRDYFGAHTFERVDSPRGEFFHEHWEDNY
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]