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The map label for this gene is cbh [H]

Identifier: 150005229

GI number: 150005229

Start: 3441027

End: 3442100

Strand: Direct

Name: cbh [H]

Synonym: BVU_2699

Alternate gene names: 150005229

Gene position: 3441027-3442100 (Clockwise)

Preceding gene: 150005228

Following gene: 150005230

Centisome position: 66.65

GC content: 41.06

Gene sequence:

>1074_bases
ATGAAAAAGATTTTGATAGCTTTGGCCTTATTGCTGACAGGCATTGCAAGCGGATCGGCATGTACCGGTATTTCATTCCT
CGCTGAAGATGGCGGATATGTGCAGGCACGTACTATAGAGTGGGGGAACAGTTATCTTCCGAGTGAATATGTTATTGTTC
CCAGAGGACAGGATTTGGTATCTTATACTCCAACGGGTGTAAATGGCTTGAGATTTCGGGCTAAATATGGTCTGGTAGGA
CTGGCTATCATTCAGAAAGAGTTTGTGGCTGAAGGACTGAATGAAGTAGGGCTTTCGGCTGGATTGTTTTATTTTCCCCA
TTATGGGAAGTATGAAGAATATGATGAGGCTCAAAATGCAATTACTTTGTCGGATTTGCAGGTGGTGAACTGGATGCTTT
CCCAATTTGCTACTATAGACGAAGTGAGAGAAGCTATAGAAGGGGTGAAGGTGGTGTCTCTTGATAAACCTGGTAAAAGT
TCTACGGTACATTGGCGCATTGGCGATGCTAAAGGAAATCAAATGGTGTTGGAATTTGTAGGTGGTGTTCCTTATTTTTA
TGAAAATAAAGTAGGAGTACTCACCAATTCTCCCGATTTTCCATGGCAGGTGATTAACTTGAATAATTATGTAAATCTAT
ATCCGGGAGCTGTCACTCCACAGCAATGGGGTGGGGTGACTATTTTCCCTTTTGGCGCAGGTGCCGGATTTCATGGTATT
CCGGGGGATGTAACTCCTCCATCCCGTTTTGTTCGTGTAGCGTTTTATAAGGCAACAGCTCCGGTGTGTCCTACAGCGTA
TGACGCTATATTACAAAGCTTTCATATCCTGAATAATTTTGATATTCCTATTGGTATAGAATATGCGTTAGGGAAAGCAC
CTGATATTCCTAGTGCCACACAATGGACTTCGGCTATTGATTTGACAAACAGGAAAGTGTATTATAAAACAGCATACAAT
AACAATATTCGTTGTATTAGTATGAAGAAGATTGATTTTGATAAAGTGAAGTATCAGTCGTATCCATTGGATAAGGAGTT
GAAACAGCCTGTAGAAGAGATTATTGTGAAATAG

Upstream 100 bases:

>100_bases
CGGAACATTGTTTGATGGCTTTGGTTATCTTTGTTGAGTAAACAAGAACTAAAATGTCCGATGCTTTGTTCTTACTATCA
TAAATAGATTTAAAATGGTT

Downstream 100 bases:

>100_bases
TGTAAGGGCTTGGAAACTGTTGGCGGAAGTACATGGAAGTTTTAATTGCAATGAATGAATAATGGATAAAATGCATTTTT
TTAGAAAAAAGTTCTAGAAA

Product: putative choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKKILIALALLLTGIASGSACTGISFLAEDGGYVQARTIEWGNSYLPSEYVIVPRGQDLVSYTPTGVNGLRFRAKYGLVG
LAIIQKEFVAEGLNEVGLSAGLFYFPHYGKYEEYDEAQNAITLSDLQVVNWMLSQFATIDEVREAIEGVKVVSLDKPGKS
STVHWRIGDAKGNQMVLEFVGGVPYFYENKVGVLTNSPDFPWQVINLNNYVNLYPGAVTPQQWGGVTIFPFGAGAGFHGI
PGDVTPPSRFVRVAFYKATAPVCPTAYDAILQSFHILNNFDIPIGIEYALGKAPDIPSATQWTSAIDLTNRKVYYKTAYN
NNIRCISMKKIDFDKVKYQSYPLDKELKQPVEEIIVK

Sequences:

>Translated_357_residues
MKKILIALALLLTGIASGSACTGISFLAEDGGYVQARTIEWGNSYLPSEYVIVPRGQDLVSYTPTGVNGLRFRAKYGLVG
LAIIQKEFVAEGLNEVGLSAGLFYFPHYGKYEEYDEAQNAITLSDLQVVNWMLSQFATIDEVREAIEGVKVVSLDKPGKS
STVHWRIGDAKGNQMVLEFVGGVPYFYENKVGVLTNSPDFPWQVINLNNYVNLYPGAVTPQQWGGVTIFPFGAGAGFHGI
PGDVTPPSRFVRVAFYKATAPVCPTAYDAILQSFHILNNFDIPIGIEYALGKAPDIPSATQWTSAIDLTNRKVYYKTAYN
NNIRCISMKKIDFDKVKYQSYPLDKELKQPVEEIIVK
>Mature_357_residues
MKKILIALALLLTGIASGSACTGISFLAEDGGYVQARTIEWGNSYLPSEYVIVPRGQDLVSYTPTGVNGLRFRAKYGLVG
LAIIQKEFVAEGLNEVGLSAGLFYFPHYGKYEEYDEAQNAITLSDLQVVNWMLSQFATIDEVREAIEGVKVVSLDKPGKS
STVHWRIGDAKGNQMVLEFVGGVPYFYENKVGVLTNSPDFPWQVINLNNYVNLYPGAVTPQQWGGVTIFPFGAGAGFHGI
PGDVTPPSRFVRVAFYKATAPVCPTAYDAILQSFHILNNFDIPIGIEYALGKAPDIPSATQWTSAIDLTNRKVYYKTAYN
NNIRCISMKKIDFDKVKYQSYPLDKELKQPVEEIIVK

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 39440; Mature: 39440

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILIALALLLTGIASGSACTGISFLAEDGGYVQARTIEWGNSYLPSEYVIVPRGQDLV
CHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCEEEEECCCCEE
SYTPTGVNGLRFRAKYGLVGLAIIQKEFVAEGLNEVGLSAGLFYFPHYGKYEEYDEAQNA
EECCCCCCCEEEEEECCEEEHHHHHHHHHHHCHHHHCCCCCEEECCCCCCCCHHHHHHCE
ITLSDLQVVNWMLSQFATIDEVREAIEGVKVVSLDKPGKSSTVHWRIGDAKGNQMVLEFV
EEEHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCEEEEEHH
GGVPYFYENKVGVLTNSPDFPWQVINLNNYVNLYPGAVTPQQWGGVTIFPFGAGAGFHGI
CCCCEEECCCEEEEECCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEEECCCCCCCCC
PGDVTPPSRFVRVAFYKATAPVCPTAYDAILQSFHILNNFDIPIGIEYALGKAPDIPSAT
CCCCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
QWTSAIDLTNRKVYYKTAYNNNIRCISMKKIDFDKVKYQSYPLDKELKQPVEEIIVK
CHHHEEEECCCEEEEEEECCCCEEEEEEECCCHHHHEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKILIALALLLTGIASGSACTGISFLAEDGGYVQARTIEWGNSYLPSEYVIVPRGQDLV
CHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCEEEEECCCCEE
SYTPTGVNGLRFRAKYGLVGLAIIQKEFVAEGLNEVGLSAGLFYFPHYGKYEEYDEAQNA
EECCCCCCCEEEEEECCEEEHHHHHHHHHHHCHHHHCCCCCEEECCCCCCCCHHHHHHCE
ITLSDLQVVNWMLSQFATIDEVREAIEGVKVVSLDKPGKSSTVHWRIGDAKGNQMVLEFV
EEEHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCEEEEEHH
GGVPYFYENKVGVLTNSPDFPWQVINLNNYVNLYPGAVTPQQWGGVTIFPFGAGAGFHGI
CCCCEEECCCEEEEECCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEEECCCCCCCCC
PGDVTPPSRFVRVAFYKATAPVCPTAYDAILQSFHILNNFDIPIGIEYALGKAPDIPSAT
CCCCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
QWTSAIDLTNRKVYYKTAYNNNIRCISMKKIDFDKVKYQSYPLDKELKQPVEEIIVK
CHHHEEEECCCEEEEEEECCCCEEEEEEECCCHHHHEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]