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The map label for this gene is hisG

Identifier: 150004898

GI number: 150004898

Start: 3040395

End: 3041246

Strand: Direct

Name: hisG

Synonym: BVU_2361

Alternate gene names: 150004898

Gene position: 3040395-3041246 (Clockwise)

Preceding gene: 150004897

Following gene: 150004899

Centisome position: 58.89

GC content: 42.37

Gene sequence:

>852_bases
ATGCTTAGAATTGCAGTACAGTCAAAAGGCCGTTTGTTTGAAGAGACAATGGCATTATTACAAGAGGCAGATATTAAAAT
CTCCACTTCTAAAAGAATTCTTTTAGTACAGTCGTCTAATTTTCCGATCGAAGTTCTTTTTCTTCGCGATGATGATATTC
CTCAGTCGGTGGCTGGTGGAGTGGCTGATTTAGGGATCGTAGGCGAGAATGAGTTTGTAGAGAGAAAAGAGGACGCTGAG
GTGATTAAACGTTTGGGGTTCAGCAAGTGCCGTTTGTCATTGGCTATACCTAAAGATGTGGACTATCCGGGTTTGTCTTG
GTTTGAAGGACGTAAGATTGCGACTTCTTATCCCGGCATTTTGAAAGATTTCATGGATCGGAATGGCATTCATTCTGATA
TTCATGTCATTACCGGTTCGGTAGAGATTGCTCCGGGAATCAGTTTGGCTGATGCTATTTTTGATATTGTCAGTTCGGGA
TCTACTTTGGTAAGCAATAGCTTGAAGGAAGTGGAAGTGGTTATGAAAAGTGAGGCGTTGCTGATAGGCAATAAGAATAT
GTCTGAGGAGAAGAAAGAGATTCTGAACGAACTCTTGTTCCGTATTGAAGCGGTGAAAGCTGCCGAAGACAAGAAATATG
TCTTGATGAATGCTCCGACAGAGCGTTTGAAAGAAATTATCGAAGTGCTGCCGGGTATGAAGAGTCCTACTGTGATGCCA
TTGGCACAAGAAGGATGGAGTTCGGTACATACAGTGCTTGACGAGAAGCGTTTTTGGGAGATCATCGGAAAACTGAAAGC
ATTGGGCGCGGAAGGTATTTTGGTATTGCCCATTGAGAAAATGATATTATAG

Upstream 100 bases:

>100_bases
TTCGGTGGGCTAAGGTGATATTGTAGTATAATGATATAGGGCTTGCCGAAAACGGTAAGCCCTTTTTATTGCCGGTTAAT
AATTAAAAACAGATAGAATC

Downstream 100 bases:

>100_bases
CCGGTCCATACGTCAGGCGAGATTTGTAAACTTATAAAAGAATACATGTATGAAGAAAATAATATATCCTGAAAAGAAAG
ACTGGATGGAAATTCTCCGT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLRIAVQSKGRLFEETMALLQEADIKISTSKRILLVQSSNFPIEVLFLRDDDIPQSVAGGVADLGIVGENEFVERKEDAE
VIKRLGFSKCRLSLAIPKDVDYPGLSWFEGRKIATSYPGILKDFMDRNGIHSDIHVITGSVEIAPGISLADAIFDIVSSG
STLVSNSLKEVEVVMKSEALLIGNKNMSEEKKEILNELLFRIEAVKAAEDKKYVLMNAPTERLKEIIEVLPGMKSPTVMP
LAQEGWSSVHTVLDEKRFWEIIGKLKALGAEGILVLPIEKMIL

Sequences:

>Translated_283_residues
MLRIAVQSKGRLFEETMALLQEADIKISTSKRILLVQSSNFPIEVLFLRDDDIPQSVAGGVADLGIVGENEFVERKEDAE
VIKRLGFSKCRLSLAIPKDVDYPGLSWFEGRKIATSYPGILKDFMDRNGIHSDIHVITGSVEIAPGISLADAIFDIVSSG
STLVSNSLKEVEVVMKSEALLIGNKNMSEEKKEILNELLFRIEAVKAAEDKKYVLMNAPTERLKEIIEVLPGMKSPTVMP
LAQEGWSSVHTVLDEKRFWEIIGKLKALGAEGILVLPIEKMIL
>Mature_283_residues
MLRIAVQSKGRLFEETMALLQEADIKISTSKRILLVQSSNFPIEVLFLRDDDIPQSVAGGVADLGIVGENEFVERKEDAE
VIKRLGFSKCRLSLAIPKDVDYPGLSWFEGRKIATSYPGILKDFMDRNGIHSDIHVITGSVEIAPGISLADAIFDIVSSG
STLVSNSLKEVEVVMKSEALLIGNKNMSEEKKEILNELLFRIEAVKAAEDKKYVLMNAPTERLKEIIEVLPGMKSPTVMP
LAQEGWSSVHTVLDEKRFWEIIGKLKALGAEGILVLPIEKMIL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=292, Percent_Identity=47.2602739726027, Blast_Score=257, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6320896, Length=283, Percent_Identity=32.1554770318021, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_BACV8 (A6L2V6)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001299642.1
- ProteinModelPortal:   A6L2V6
- SMR:   A6L2V6
- STRING:   A6L2V6
- GeneID:   5303325
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_2361
- NMPDR:   fig|435590.6.peg.2216
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31335; Mature: 31335

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAVQSKGRLFEETMALLQEADIKISTSKRILLVQSSNFPIEVLFLRDDDIPQSVAGG
CEEEEECCCCCHHHHHHHHHHHCCCEEECCCEEEEEECCCCCEEEEEEECCCCCHHHHCC
VADLGIVGENEFVERKEDAEVIKRLGFSKCRLSLAIPKDVDYPGLSWFEGRKIATSYPGI
HHHEEEECCCHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCCCCEECCCCCHH
LKDFMDRNGIHSDIHVITGSVEIAPGISLADAIFDIVSSGSTLVSNSLKEVEVVMKSEAL
HHHHHHCCCCCCCEEEEECCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEE
LIGNKNMSEEKKEILNELLFRIEAVKAAEDKKYVLMNAPTERLKEIIEVLPGMKSPTVMP
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCC
LAQEGWSSVHTVLDEKRFWEIIGKLKALGAEGILVLPIEKMIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCC
>Mature Secondary Structure
MLRIAVQSKGRLFEETMALLQEADIKISTSKRILLVQSSNFPIEVLFLRDDDIPQSVAGG
CEEEEECCCCCHHHHHHHHHHHCCCEEECCCEEEEEECCCCCEEEEEEECCCCCHHHHCC
VADLGIVGENEFVERKEDAEVIKRLGFSKCRLSLAIPKDVDYPGLSWFEGRKIATSYPGI
HHHEEEECCCHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCCCCEECCCCCHH
LKDFMDRNGIHSDIHVITGSVEIAPGISLADAIFDIVSSGSTLVSNSLKEVEVVMKSEAL
HHHHHHCCCCCCCEEEEECCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEE
LIGNKNMSEEKKEILNELLFRIEAVKAAEDKKYVLMNAPTERLKEIIEVLPGMKSPTVMP
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCC
LAQEGWSSVHTVLDEKRFWEIIGKLKALGAEGILVLPIEKMIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA