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The map label for this gene is pyrC [H]

Identifier: 150004795

GI number: 150004795

Start: 2919242

End: 2920582

Strand: Reverse

Name: pyrC [H]

Synonym: BVU_2258

Alternate gene names: 150004795

Gene position: 2920582-2919242 (Counterclockwise)

Preceding gene: 150004796

Following gene: 150004794

Centisome position: 56.57

GC content: 44.67

Gene sequence:

>1341_bases
ATGAAACGTACATGGATAAAGAATGCACGGATTGTGAATGAAGGCAAGATTTTTCACGGTTCGATAGTGATTGAGAATGA
AGTCATAGCTGAAGTGCTGGCAGAAGAAACAGTTCCCTCCCAGCCTTGTGGAGAAATAATAGATGCGAAAGGCTATTATC
TGATGCCGGGAGTAATAGACGATCATGTACACTTCCGTGACCCGGGACTGACTCATAAAGCCGACATACATACTGAAAGC
ACAGCGGCGGCGGCAGGTGGCGTCACCAGTTTTATGGACATGCCCAACACCACTCCGCAAACTACGACCCTGGAAGCTTT
GAATGCCAAGTTTGCGGATGCGGCAACCAAAAGCATCGTAAACTATTCATTCTATTTCGGAGCAACCAATACGAATGCGG
ATGTACTCCCCACACTAGATAAAAGCCGGGTATGCGGTGTTAAATTATTTATGGGAGCCAGCACGGGAAATATGTTGGTA
GACCGCATGGAAGTACTTAGAAAAGTATTTGCCAATGCAGGTATGCTGATTGCAGCACATTGTGAAGAACAATCTATAAT
CAGCGCCAATACAACAGCCTTCAAAGAAAAATATGGAGAAGATCCTGATATAAAATACCATCCGCAGATACGTAGTGCGG
AAGCATGTGCATATTCTTCCTCACTGGCCATCCGGCTGGCAAAAGAAAACAATGCCCGCCTGCACATCCTGCACATCAGC
ACCGCACAAGAACTGGATTTGCTTGAAGACAAACCCCTGAGTGAAAAAAAGATTACGGCGGAAGCTTGCGTGTCACATCT
ATACTTCTATGACAAAGATTATGAGACATTGAAAGGACGTATCAAGTGCAATCCGTCCATCAAAACTTCAGAAGACCGGA
ATGCTTTACGCAAAGCATTGTCTACCAATATGATAGATGTAATAGGTACCGACCATGCCCCTCACTTACTGAAAGAAAAG
GAAGGGGGAGCATTGAAAGCCGTATCGGGTATGCCGATGATACAGTTTTCATTAGTAGCTATCATGGAATTAGTACGCGA
AGGCATATTAAGCATAGAGCAACTGGTTCAGAAAATGTGCCATGCACCGGCCGAACTTTATCATATTGAAAGACGAGGCT
ACATCCGTCCTGGTTATCAAGCCGACCTCGTATTGGTAAATCCGGATCATGAATGGACTGTAACTGCCGACTGCGTTTTA
AGCAAATGCGGATGGACTCCGATGGAAGGACAGAAATTCCACACACGGGTAGAAAAAACATTCGTCAATGGTGATCTGGT
TTACAGTGACAACAAGGTAGACCAAAGTCATCGCGGACAAGAATTAAGGTTTAAAAGATGA

Upstream 100 bases:

>100_bases
CTTCAAAAATGAACGGAAGTATCTTCGGTGAAGCTGTATTAGGAGTCATTCAATTAAAACTGGGTAGCTGGTTCCGCAAA
TACCCGCAAAAGAAAACAGT

Downstream 100 bases:

>100_bases
TTGTAAATTACAAGATTCACGAAGTAAGCGAATACATTAACTGGATTTATTTTTTCCATGCATGGGGCTTTCAACCCAAG
TTTGCCGCCATTGCGGACAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKRTWIKNARIVNEGKIFHGSIVIENEVIAEVLAEETVPSQPCGEIIDAKGYYLMPGVIDDHVHFRDPGLTHKADIHTES
TAAAAGGVTSFMDMPNTTPQTTTLEALNAKFADAATKSIVNYSFYFGATNTNADVLPTLDKSRVCGVKLFMGASTGNMLV
DRMEVLRKVFANAGMLIAAHCEEQSIISANTTAFKEKYGEDPDIKYHPQIRSAEACAYSSSLAIRLAKENNARLHILHIS
TAQELDLLEDKPLSEKKITAEACVSHLYFYDKDYETLKGRIKCNPSIKTSEDRNALRKALSTNMIDVIGTDHAPHLLKEK
EGGALKAVSGMPMIQFSLVAIMELVREGILSIEQLVQKMCHAPAELYHIERRGYIRPGYQADLVLVNPDHEWTVTADCVL
SKCGWTPMEGQKFHTRVEKTFVNGDLVYSDNKVDQSHRGQELRFKR

Sequences:

>Translated_446_residues
MKRTWIKNARIVNEGKIFHGSIVIENEVIAEVLAEETVPSQPCGEIIDAKGYYLMPGVIDDHVHFRDPGLTHKADIHTES
TAAAAGGVTSFMDMPNTTPQTTTLEALNAKFADAATKSIVNYSFYFGATNTNADVLPTLDKSRVCGVKLFMGASTGNMLV
DRMEVLRKVFANAGMLIAAHCEEQSIISANTTAFKEKYGEDPDIKYHPQIRSAEACAYSSSLAIRLAKENNARLHILHIS
TAQELDLLEDKPLSEKKITAEACVSHLYFYDKDYETLKGRIKCNPSIKTSEDRNALRKALSTNMIDVIGTDHAPHLLKEK
EGGALKAVSGMPMIQFSLVAIMELVREGILSIEQLVQKMCHAPAELYHIERRGYIRPGYQADLVLVNPDHEWTVTADCVL
SKCGWTPMEGQKFHTRVEKTFVNGDLVYSDNKVDQSHRGQELRFKR
>Mature_446_residues
MKRTWIKNARIVNEGKIFHGSIVIENEVIAEVLAEETVPSQPCGEIIDAKGYYLMPGVIDDHVHFRDPGLTHKADIHTES
TAAAAGGVTSFMDMPNTTPQTTTLEALNAKFADAATKSIVNYSFYFGATNTNADVLPTLDKSRVCGVKLFMGASTGNMLV
DRMEVLRKVFANAGMLIAAHCEEQSIISANTTAFKEKYGEDPDIKYHPQIRSAEACAYSSSLAIRLAKENNARLHILHIS
TAQELDLLEDKPLSEKKITAEACVSHLYFYDKDYETLKGRIKCNPSIKTSEDRNALRKALSTNMIDVIGTDHAPHLLKEK
EGGALKAVSGMPMIQFSLVAIMELVREGILSIEQLVQKMCHAPAELYHIERRGYIRPGYQADLVLVNPDHEWTVTADCVL
SKCGWTPMEGQKFHTRVEKTFVNGDLVYSDNKVDQSHRGQELRFKR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=28.6458333333333, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=22.6666666666667, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4503379, Length=451, Percent_Identity=24.390243902439, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4503051, Length=452, Percent_Identity=22.1238938053097, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=22.5165562913907, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=22.4944320712695, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4503377, Length=449, Percent_Identity=22.71714922049, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI190194363, Length=415, Percent_Identity=22.6506024096386, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786722, Length=435, Percent_Identity=27.5862068965517, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87082175, Length=458, Percent_Identity=25.3275109170306, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193204318, Length=391, Percent_Identity=27.6214833759591, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71989490, Length=449, Percent_Identity=24.2761692650334, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17539558, Length=456, Percent_Identity=21.7105263157895, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=452, Percent_Identity=25, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24642586, Length=394, Percent_Identity=30.4568527918782, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI18859883, Length=450, Percent_Identity=28, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI221377917, Length=451, Percent_Identity=24.8337028824834, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137462, Length=446, Percent_Identity=24.4394618834081, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644287, Length=247, Percent_Identity=27.1255060728745, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49618; Mature: 49618

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTWIKNARIVNEGKIFHGSIVIENEVIAEVLAEETVPSQPCGEIIDAKGYYLMPGVID
CCCCCCCCCEEEECCCEEEEEEEECHHHHHHHHHHHCCCCCCCHHHHCCCCCEEECCEEC
DHVHFRDPGLTHKADIHTESTAAAAGGVTSFMDMPNTTPQTTTLEALNAKFADAATKSIV
CCCEECCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHCHHHHHHHHHHH
NYSFYFGATNTNADVLPTLDKSRVCGVKLFMGASTGNMLVDRMEVLRKVFANAGMLIAAH
EEEEEEECCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEE
CEEQSIISANTTAFKEKYGEDPDIKYHPQIRSAEACAYSSSLAIRLAKENNARLHILHIS
CCCCCEEECCHHHHHHHHCCCCCEEECCCCCCCHHHHCCCCEEEEEEECCCCEEEEEEEC
TAQELDLLEDKPLSEKKITAEACVSHLYFYDKDYETLKGRIKCNPSIKTSEDRNALRKAL
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHH
STNMIDVIGTDHAPHLLKEKEGGALKAVSGMPMIQFSLVAIMELVREGILSIEQLVQKMC
HCCCEEEECCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAPAELYHIERRGYIRPGYQADLVLVNPDHEWTVTADCVLSKCGWTPMEGQKFHTRVEKT
CCCHHHEEECCCCCCCCCCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCHHHHHHHHH
FVNGDLVYSDNKVDQSHRGQELRFKR
EECCEEEECCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MKRTWIKNARIVNEGKIFHGSIVIENEVIAEVLAEETVPSQPCGEIIDAKGYYLMPGVID
CCCCCCCCCEEEECCCEEEEEEEECHHHHHHHHHHHCCCCCCCHHHHCCCCCEEECCEEC
DHVHFRDPGLTHKADIHTESTAAAAGGVTSFMDMPNTTPQTTTLEALNAKFADAATKSIV
CCCEECCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHCHHHHHHHHHHH
NYSFYFGATNTNADVLPTLDKSRVCGVKLFMGASTGNMLVDRMEVLRKVFANAGMLIAAH
EEEEEEECCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEE
CEEQSIISANTTAFKEKYGEDPDIKYHPQIRSAEACAYSSSLAIRLAKENNARLHILHIS
CCCCCEEECCHHHHHHHHCCCCCEEECCCCCCCHHHHCCCCEEEEEEECCCCEEEEEEEC
TAQELDLLEDKPLSEKKITAEACVSHLYFYDKDYETLKGRIKCNPSIKTSEDRNALRKAL
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHH
STNMIDVIGTDHAPHLLKEKEGGALKAVSGMPMIQFSLVAIMELVREGILSIEQLVQKMC
HCCCEEEECCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAPAELYHIERRGYIRPGYQADLVLVNPDHEWTVTADCVLSKCGWTPMEGQKFHTRVEKT
CCCHHHEEECCCCCCCCCCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCHHHHHHHHH
FVNGDLVYSDNKVDQSHRGQELRFKR
EECCEEEECCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]