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The map label for this gene is ffh [H]

Identifier: 150004753

GI number: 150004753

Start: 2859946

End: 2861268

Strand: Direct

Name: ffh [H]

Synonym: BVU_2214

Alternate gene names: 150004753

Gene position: 2859946-2861268 (Clockwise)

Preceding gene: 150004752

Following gene: 150004754

Centisome position: 55.39

GC content: 46.18

Gene sequence:

>1323_bases
ATGTTCGATAATTTAAGTGAGAGACTGGAACGGTCTTTTAAGATTCTGAAAGGTGAGGGGAAAATCACCGAGATTAATGT
AGCGGAAACATTGAAGGATGTGCGTAAAGCTTTGTTGGATGCTGACGTGAACTATAAGGTCGCCAAAGGCTTTACTGATA
CTGTGAAAGAAAAAGCTTTGGGGCAGAATGTGCTTACGGCTGTGAAGCCCAGCCAGTTGATGGTAAAGATTGTACATGAT
GAACTGACTGCATTGATGGGCGGTGAGACTGCCGAATTGGTGTTGGAAGGTCGTCCGGCGGTTATCCTGATGTCAGGTCT
GCAAGGTTCCGGTAAGACTACTTTCTCCGGTAAACTGGCCCGTATGCTGAAAACCAAGAAGAACCGTAAGCCGCTGTTGG
TGGCTTGTGACGTTTATCGTCCCGCTGCTATCGAACAGTTAAGAGTATTGGGAGAACAAATCGAGGTTCCTGTATATAGT
GAATTGGACAGCAAGAATCCGGTGCAGATTGCATTGAACGCTATTCATGAAGCAAAAGCGAAAGGTTATGATTTGGTTAT
TGTCGATACAGCCGGTCGTCTGGCTATCGACGAACAGATGATGAATGAGATTGAGGCGATTAAGAAAGCGGTCAATCCGG
ATGAAACATTGTTCGTTGTCGATTCAATGACCGGTCAGGATGCGGTGAATACAGCCCGTGAATTTAATGAACGTCTGGAC
TTTAACGGTGTTGTGCTGACCAAGTTGGATGGTGATACCCGTGGCGGTGCCGCTCTTTCTATTCGTACCGTTGTGAATAA
GCCTATCAAGTTTGTGGGTACCGGCGAAAAGTTGGATGCTATCGACCAGTTCCATCCTGCACGTATGGCAGACCGTATTC
TCGGTATGGGTGATATCGTGTCTTTGGTAGAACGTGCGCAGGAGCAATATGACGAGGAAGAGGCAAAGCGCCTTCAGAAA
AAGATTGCCAAAAACCAGTTCGACTTCAATGACTTTTTGAGCCAGATTCATCAGATAAAGAAGATGGGTAACCTGAAAGA
GTTGGCTTCCATGATTCCGGGTGTGGGTAAAGCGATTAAAGACATTGATATCGATGATAATGCCTTCAAGAGCATTGAGG
CGATTATTTATTCCATGACTCCGCAGGAACGTACAAATCCCGAAATCCTGAACGGAACACGTCGTACGCGTATAGCCAAA
GGCAGTGGAACCAGCATTCAGGAGGTAAACCGTCTGCTGAAGCAGTTTGACCAGACCCGCAAGATGATGAAGATGGTGAC
CGGCAGCAAGATGGGTAAGATGATGCCGAAACTTAAAAAGTAA

Upstream 100 bases:

>100_bases
AAGGTTCATAAGTTTTTTGTATTTTTGCACCCTGTTGTTATTCTGAAGGTTAGTAAAGAAGGACAGGCAATCATAATTTG
TAATTTATAATTAAATATAT

Downstream 100 bases:

>100_bases
GGTTTAAATAAACAGGTAGGGAGAAAGTGCGGAACTTTCTCCTTTTTTTATTATGCAACGTGGCTGATTTATGCTACATT
TGTTGCTCAATGGATTATTT

Product: putative signal recognition protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MFDNLSERLERSFKILKGEGKITEINVAETLKDVRKALLDADVNYKVAKGFTDTVKEKALGQNVLTAVKPSQLMVKIVHD
ELTALMGGETAELVLEGRPAVILMSGLQGSGKTTFSGKLARMLKTKKNRKPLLVACDVYRPAAIEQLRVLGEQIEVPVYS
ELDSKNPVQIALNAIHEAKAKGYDLVIVDTAGRLAIDEQMMNEIEAIKKAVNPDETLFVVDSMTGQDAVNTAREFNERLD
FNGVVLTKLDGDTRGGAALSIRTVVNKPIKFVGTGEKLDAIDQFHPARMADRILGMGDIVSLVERAQEQYDEEEAKRLQK
KIAKNQFDFNDFLSQIHQIKKMGNLKELASMIPGVGKAIKDIDIDDNAFKSIEAIIYSMTPQERTNPEILNGTRRTRIAK
GSGTSIQEVNRLLKQFDQTRKMMKMVTGSKMGKMMPKLKK

Sequences:

>Translated_440_residues
MFDNLSERLERSFKILKGEGKITEINVAETLKDVRKALLDADVNYKVAKGFTDTVKEKALGQNVLTAVKPSQLMVKIVHD
ELTALMGGETAELVLEGRPAVILMSGLQGSGKTTFSGKLARMLKTKKNRKPLLVACDVYRPAAIEQLRVLGEQIEVPVYS
ELDSKNPVQIALNAIHEAKAKGYDLVIVDTAGRLAIDEQMMNEIEAIKKAVNPDETLFVVDSMTGQDAVNTAREFNERLD
FNGVVLTKLDGDTRGGAALSIRTVVNKPIKFVGTGEKLDAIDQFHPARMADRILGMGDIVSLVERAQEQYDEEEAKRLQK
KIAKNQFDFNDFLSQIHQIKKMGNLKELASMIPGVGKAIKDIDIDDNAFKSIEAIIYSMTPQERTNPEILNGTRRTRIAK
GSGTSIQEVNRLLKQFDQTRKMMKMVTGSKMGKMMPKLKK
>Mature_440_residues
MFDNLSERLERSFKILKGEGKITEINVAETLKDVRKALLDADVNYKVAKGFTDTVKEKALGQNVLTAVKPSQLMVKIVHD
ELTALMGGETAELVLEGRPAVILMSGLQGSGKTTFSGKLARMLKTKKNRKPLLVACDVYRPAAIEQLRVLGEQIEVPVYS
ELDSKNPVQIALNAIHEAKAKGYDLVIVDTAGRLAIDEQMMNEIEAIKKAVNPDETLFVVDSMTGQDAVNTAREFNERLD
FNGVVLTKLDGDTRGGAALSIRTVVNKPIKFVGTGEKLDAIDQFHPARMADRILGMGDIVSLVERAQEQYDEEEAKRLQK
KIAKNQFDFNDFLSQIHQIKKMGNLKELASMIPGVGKAIKDIDIDDNAFKSIEAIIYSMTPQERTNPEILNGTRRTRIAK
GSGTSIQEVNRLLKQFDQTRKMMKMVTGSKMGKMMPKLKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=440, Percent_Identity=31.8181818181818, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI226371618, Length=366, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI89061728, Length=158, Percent_Identity=35.4430379746835, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI23308697, Length=296, Percent_Identity=28.7162162162162, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI295424842, Length=296, Percent_Identity=28.7162162162162, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=52, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1789874, Length=221, Percent_Identity=34.3891402714932, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=419, Percent_Identity=32.2195704057279, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=289, Percent_Identity=30.4498269896194, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=415, Percent_Identity=34.2168674698795, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=216, Percent_Identity=31.4814814814815, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647949, Length=437, Percent_Identity=29.2906178489703, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24641198, Length=296, Percent_Identity=29.3918918918919, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48853; Mature: 48853

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLSERLERSFKILKGEGKITEINVAETLKDVRKALLDADVNYKVAKGFTDTVKEKAL
CCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHH
GQNVLTAVKPSQLMVKIVHDELTALMGGETAELVLEGRPAVILMSGLQGSGKTTFSGKLA
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHH
RMLKTKKNRKPLLVACDVYRPAAIEQLRVLGEQIEVPVYSELDSKNPVQIALNAIHEAKA
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHC
KGYDLVIVDTAGRLAIDEQMMNEIEAIKKAVNPDETLFVVDSMTGQDAVNTAREFNERLD
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCC
FNGVVLTKLDGDTRGGAALSIRTVVNKPIKFVGTGEKLDAIDQFHPARMADRILGMGDIV
CCCEEEEEECCCCCCCCEEEEHHHHCCCEEEEECCCHHHHHHHCCHHHHHHHHCCHHHHH
SLVERAQEQYDEEEAKRLQKKIAKNQFDFNDFLSQIHQIKKMGNLKELASMIPGVGKAIK
HHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
DIDIDDNAFKSIEAIIYSMTPQERTNPEILNGTRRTRIAKGSGTSIQEVNRLLKQFDQTR
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHEEECCCCCCHHHHHHHHHHHHHHH
KMMKMVTGSKMGKMMPKLKK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFDNLSERLERSFKILKGEGKITEINVAETLKDVRKALLDADVNYKVAKGFTDTVKEKAL
CCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHH
GQNVLTAVKPSQLMVKIVHDELTALMGGETAELVLEGRPAVILMSGLQGSGKTTFSGKLA
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHH
RMLKTKKNRKPLLVACDVYRPAAIEQLRVLGEQIEVPVYSELDSKNPVQIALNAIHEAKA
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHC
KGYDLVIVDTAGRLAIDEQMMNEIEAIKKAVNPDETLFVVDSMTGQDAVNTAREFNERLD
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCC
FNGVVLTKLDGDTRGGAALSIRTVVNKPIKFVGTGEKLDAIDQFHPARMADRILGMGDIV
CCCEEEEEECCCCCCCCEEEEHHHHCCCEEEEECCCHHHHHHHCCHHHHHHHHCCHHHHH
SLVERAQEQYDEEEAKRLQKKIAKNQFDFNDFLSQIHQIKKMGNLKELASMIPGVGKAIK
HHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
DIDIDDNAFKSIEAIIYSMTPQERTNPEILNGTRRTRIAKGSGTSIQEVNRLLKQFDQTR
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHEEECCCCCCHHHHHHHHHHHHHHH
KMMKMVTGSKMGKMMPKLKK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]