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The map label for this gene is resA [H]

Identifier: 150004738

GI number: 150004738

Start: 2837698

End: 2838693

Strand: Direct

Name: resA [H]

Synonym: BVU_2199

Alternate gene names: 150004738

Gene position: 2837698-2838693 (Clockwise)

Preceding gene: 150004736

Following gene: 150004745

Centisome position: 54.96

GC content: 41.16

Gene sequence:

>996_bases
ATGAAAAGAATGGTAAATGTGCTTTTTGCTGGTGTACTGGCTATGACTGTACTGTCCTGTGGCGAAGAGAAAAAAGGATA
TACTCTGAATGGAGAAATATCGGATGTTAAAGATGGAATGGTGTATCTGAAAAAATATCAGGATAAATCGTTCATAGCTG
TGGATTCGGCTGTGATTACTGACGGTACTTTCAAATTTGAAGGTGTTTGTACTGAGCCATTGGCTTATGGGCTGACTACG
TTCAGGGATAGCAAACGTCCGTTGGTATTCTTTTTAGATAACGAAAAGATGCAGTTGAAGATGAATGAATCAGAAAAGAT
ACTGACTGTGACAGGTTCTGCCATTAATGATCTGTATGCACAAAATGCTCCTTTGACTCGTCAGGATGGATATAGCATAG
ATAGTCTGGTTGCTGTTCACCCGGCATCTGCTGTTACCCCTTATTTCATAGTGAAGGATTTCGCTTATAAGTTGAATCTG
GAAGAAATGAAGGCATTGCGTGCCAAACTGGATGCTTCATTGGATGAAACCATGTATGTCAGTCAAATAGATGGCTTTAT
CAAGCGGATGAAAGATATTCAGGTCGGTGCTGTGGCTCCGGATTTTACATTGCCCGATGTAGACGGTAATCCTGTCACAT
TATCCGGTTTGAGAGGAAAATATGTACTGATTGATTTTTGGGCTTCCTGGTGTCCTGATTGTCGCAAGGAAAATCCGAAT
ATTGTTGCTGCCTGGAATAAATACAAGGATAAGAATTTTACTATTTTAGGAGTTTCTTTGGATCGTAAGAAAGAACCTTG
GTTGGCCGCTATTGAGAAAGATCAATTGGCATGGACTCATGTTTCAGACTTGAAGGACTGGAAATCGGATGCAGCCGTGC
AGTATGCTATTCGTTGGATTCCTATGAATTTCTTGTTGGACCCCAATGGGGTGATCTTGGCTGTAGGATTGGAAGGGGAG
GCTTTGCAACAAAAGCTGGATGAGGTTTTGAAATAA

Upstream 100 bases:

>100_bases
TAACTCAGGGAGAGTTAATTTCCAAATAGGAACGGTGGAGTTTGCATAATTGCATAGGAATATTTATTTTTGACGAGTTA
TAATAATAAGGAAGATAGAG

Downstream 100 bases:

>100_bases
CAAGTTTGCTGTAAGATTATGAAAATAAATGTACCAAAAGCCAGGGGTTACTGTTGGTTCTCCATTGGCTTTTGATACAT
TTTGTTGTCTTTGTTCACAT

Product: thiol-disulfide isomerase and thioredoxin

Products: Acceptor; H2O; oxidized thioredoxin [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKRMVNVLFAGVLAMTVLSCGEEKKGYTLNGEISDVKDGMVYLKKYQDKSFIAVDSAVITDGTFKFEGVCTEPLAYGLTT
FRDSKRPLVFFLDNEKMQLKMNESEKILTVTGSAINDLYAQNAPLTRQDGYSIDSLVAVHPASAVTPYFIVKDFAYKLNL
EEMKALRAKLDASLDETMYVSQIDGFIKRMKDIQVGAVAPDFTLPDVDGNPVTLSGLRGKYVLIDFWASWCPDCRKENPN
IVAAWNKYKDKNFTILGVSLDRKKEPWLAAIEKDQLAWTHVSDLKDWKSDAAVQYAIRWIPMNFLLDPNGVILAVGLEGE
ALQQKLDEVLK

Sequences:

>Translated_331_residues
MKRMVNVLFAGVLAMTVLSCGEEKKGYTLNGEISDVKDGMVYLKKYQDKSFIAVDSAVITDGTFKFEGVCTEPLAYGLTT
FRDSKRPLVFFLDNEKMQLKMNESEKILTVTGSAINDLYAQNAPLTRQDGYSIDSLVAVHPASAVTPYFIVKDFAYKLNL
EEMKALRAKLDASLDETMYVSQIDGFIKRMKDIQVGAVAPDFTLPDVDGNPVTLSGLRGKYVLIDFWASWCPDCRKENPN
IVAAWNKYKDKNFTILGVSLDRKKEPWLAAIEKDQLAWTHVSDLKDWKSDAAVQYAIRWIPMNFLLDPNGVILAVGLEGE
ALQQKLDEVLK
>Mature_331_residues
MKRMVNVLFAGVLAMTVLSCGEEKKGYTLNGEISDVKDGMVYLKKYQDKSFIAVDSAVITDGTFKFEGVCTEPLAYGLTT
FRDSKRPLVFFLDNEKMQLKMNESEKILTVTGSAINDLYAQNAPLTRQDGYSIDSLVAVHPASAVTPYFIVKDFAYKLNL
EEMKALRAKLDASLDETMYVSQIDGFIKRMKDIQVGAVAPDFTLPDVDGNPVTLSGLRGKYVLIDFWASWCPDCRKENPN
IVAAWNKYKDKNFTILGVSLDRKKEPWLAAIEKDQLAWTHVSDLKDWKSDAAVQYAIRWIPMNFLLDPNGVILAVGLEGE
ALQQKLDEVLK

Specific function: Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalent

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: 920 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: NA

Molecular weight: Translated: 37137; Mature: 37137

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRMVNVLFAGVLAMTVLSCGEEKKGYTLNGEISDVKDGMVYLKKYQDKSFIAVDSAVIT
CHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHEEEEHHCCCCEEEECCEEEE
DGTFKFEGVCTEPLAYGLTTFRDSKRPLVFFLDNEKMQLKMNESEKILTVTGSAINDLYA
CCCEEECCEECCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCEEEEEECCHHHHHHH
QNAPLTRQDGYSIDSLVAVHPASAVTPYFIVKDFAYKLNLEEMKALRAKLDASLDETMYV
CCCCCCCCCCCCHHHEEEECCCHHCCHHHEEEHHHHCCCHHHHHHHHHHHCCCCCHHHHH
SQIDGFIKRMKDIQVGAVAPDFTLPDVDGNPVTLSGLRGKYVLIDFWASWCPDCRKENPN
HHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEECCCCCEEEEEEHHHHCCCCCCCCCC
IVAAWNKYKDKNFTILGVSLDRKKEPWLAAIEKDQLAWTHVSDLKDWKSDAAVQYAIRWI
EEEEECCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEHHHHHHHHCCHHEEEEEEEE
PMNFLLDPNGVILAVGLEGEALQQKLDEVLK
EEEEEECCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MKRMVNVLFAGVLAMTVLSCGEEKKGYTLNGEISDVKDGMVYLKKYQDKSFIAVDSAVIT
CHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHEEEEHHCCCCEEEECCEEEE
DGTFKFEGVCTEPLAYGLTTFRDSKRPLVFFLDNEKMQLKMNESEKILTVTGSAINDLYA
CCCEEECCEECCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCEEEEEECCHHHHHHH
QNAPLTRQDGYSIDSLVAVHPASAVTPYFIVKDFAYKLNLEEMKALRAKLDASLDETMYV
CCCCCCCCCCCCHHHEEEECCCHHCCHHHEEEHHHHCCCHHHHHHHHHHHCCCCCHHHHH
SQIDGFIKRMKDIQVGAVAPDFTLPDVDGNPVTLSGLRGKYVLIDFWASWCPDCRKENPN
HHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEECCCCCEEEEEEHHHHCCCCCCCCCC
IVAAWNKYKDKNFTILGVSLDRKKEPWLAAIEKDQLAWTHVSDLKDWKSDAAVQYAIRWI
EEEEECCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEHHHHHHHHCCHHEEEEEEEE
PMNFLLDPNGVILAVGLEGEALQQKLDEVLK
EEEEEECCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced acceptor; H2O2; reduced thioredoxin [C]

Specific reaction: reduced acceptor + H2O2 = Acceptor + H2O reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: Oxidoreductases; Acting on a peroxide as acceptor; Peroxidase [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA