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The map label for this gene is ptpA [H]

Identifier: 150004372

GI number: 150004372

Start: 2359513

End: 2361954

Strand: Direct

Name: ptpA [H]

Synonym: BVU_1818

Alternate gene names: 150004372

Gene position: 2359513-2361954 (Clockwise)

Preceding gene: 150004371

Following gene: 150004375

Centisome position: 45.7

GC content: 41.65

Gene sequence:

>2442_bases
ATGAGGAAAATGCTATTCATTACCCTTTTAATGGGCGGTTTGTGTACGACAGTTTCTGTTGCAAAAGCGCAGGAACGCTT
GCCGGAATATCTGCAGGCAGAGAAATACACACAAGAAAAATTGAACACCATGTTGTTTTCTACTGTGGTGGATCCGCATT
GGTTCCAGAAAGGTAATAATTTCTGGTTCGAGTACAAAACAAGTGAAGGAACCTTTTGGTATGTGGTTGATCCGGCTGCC
CGGACAAAGAAGCTTTTGTTTGATAGGGATGAATTAGCTTCCCAGCTTACCGAAATTGTAAAAGATCCCTTTGAGGCACG
CCATTTGCCAATCACAAATCTGAAAGCGGAAGAAGATGGGCGTACCTTTACTTTTGAAGTAAAGTCAACAAAAGATGCGA
CACCAAAGAAAGATGGCAAGGATAAGAAGGACAAGAAGAATGAGAAGGAAATCTTTTATTTTTCTTATGACTATCCTACC
CGTAAATTGACCCATCTGAAAGATAAAGAAGACGACCTGAAGAAAATCTATTGGGGATCGGTCTCTCCTGATGGTAAAAC
GGTGATTTATGCCAAGGATTTGAATTTGTATCGCATGAGTCGTGAAGATTATGAAAAGGCGAAAAAAAATGAAAAGGATA
GTACGATCGTGGAAATCCAGCTTACTACAGATGGCATGAAGGATTTTGGCTATGGTATTCCCTATAGTATGTTGAATACA
GATACTTTATGTAATGGCAAGCGTCGTCGTGTAGGTGGAGTGTGGTCTCCGGATTCACGTTATTTTGCTATGACAGTTTC
TGACGATCGCGCTGTGAAAGAGTTATGGGTAATAAATTCGATGGCCCGTCCACGTCCCACATTGGAAACTTATAAATACC
AGATGCCGGGAGAAAAGGAAGCTCCCATAGAACACCTGTACTTGTTTGACTTGGTTGATAATAAACGTAAGGAAATTAAA
GTAGCAGCTTATAAAGATCAAAGCATTGGCCTGGAATACAAACCAATGATGCAAAAACAGCGTGATATGGAAGATCAGGC
TGCCGTTTGGCAGGGTGATAACAACCGTTTCTTCCTGACCCGCAGCAGCCGTGATTTACATCGGATTGATGTTTGTTCCT
ATACGATAGGACAGGATTCTGTTGTACCAGTAATAAAGGAACGGATGAATACCTATCAGGAAACTCGTCCTTTAAGAGTC
TTGAATGGTGGAAAGGAAATTATTCAATGGAGTGAGCGTGATGGTTGGGCACACCTTTATTTATATGATGATCAGGGTAA
TTTGAAAAATCGTATCACAAAAGGTCCCTGGCACGTGGAGGAAATCTTGAAAGTAGATGACAAGGCGCGTGTGATTTATT
TTACTGCCAATGGAATGAATGCGAAAGAACATCCTTATTATGAACATTTGTATCGTGTGAATCTGGATGGCAGCGGTTTG
AAATTACTGACCAAAGGGGATTATTTCCATCGTGTGGAAGTGGATGATGATGCTCGTTTTGTGGTGGATAACTATTCGCG
TGTAAATACGGTGCCCTGCGCCATCCTGCTGGATACTAATGGCAATAAGGTAATGGATATTCAGGAGAGTGATTTTTCAC
AGCTTTTTGCTGCCGGTTATAAATTTCCGGAAATATTTAAGGTAAAGGCGGCTGATGGCGTGACAGATCTGTATGGTGTG
ATGTATAAACCTTTTAATTTTGACTCAACTAAGGTTTATCCTATTGTGGATTATGTTTATCCTGGGCCACAGGTGGAAGG
TGTTTATTATCCGTTTACCCGTATGAGCCCCCGTACCGACCGTTTGGCACAGGCCGGATTTATTGTTATTTCTGTGGGAC
AACGCGGCGGGCATCCTAGCCGCTCTAAATGGTATCATAATTATGGATATGGAAATATGCGTGATTATCCGCTGGCCGAT
CATAAATATGCTATCGAGCAATTGGCGCAGCGTCATCATTTTATAGATATAGATAAGGTTGGTATTCATGGACATTCGGG
AGGTGGATTTATGAGTACGGCGGCTATGTGCCAATACCCGGATTTCTTCAAAGTGGCTGTTTCTTGTGCCGGAAATCATG
ATAACAATATCTATAACCGTTGGTGGAGTGAAACGCATCACGGCGTAAAAGAGGTGGTGAGTGAGAAAGGGGATACAACT
TTCGTTTATAAGATTGCTACTAATCCTGAAATAGCGAAGCAATTGAAAGGAAATTTGTTACTGATTCATGGTGATATTGA
TAATAATGTGCATCCGGGCAATACCTTACGGGTAGTTGACGCCTTGATTCGTGCCGGGAAGCGTTTTGATATGCTGATTC
TTCCTCAACAGCGTCATGGATTCGGTGATATGAATGAATATTTCTACTGGAAACTGGTTGATTACTTTTCCGAACATCTG
AAAGGGAAAAGTGAAAAATCGGTAGATATACCGAAACGGTAG

Upstream 100 bases:

>100_bases
GATAAATGAAACAAACATACACAAAATTCTTTGTTTAAGATTGTTAAATGAAGAATTTTGTGTATGTTTGTTTTTTATAA
ACACGATAAAAGTTCAATCT

Downstream 100 bases:

>100_bases
ATTTAGGATCATTGCCGGACGAATATGAAAGGAGCACAGAGGTTCGTGTCATTAAGATACCTTTGTGCTCCTTGTTGTTT
TTATATTATAGCAGACTGTT

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MRKMLFITLLMGGLCTTVSVAKAQERLPEYLQAEKYTQEKLNTMLFSTVVDPHWFQKGNNFWFEYKTSEGTFWYVVDPAA
RTKKLLFDRDELASQLTEIVKDPFEARHLPITNLKAEEDGRTFTFEVKSTKDATPKKDGKDKKDKKNEKEIFYFSYDYPT
RKLTHLKDKEDDLKKIYWGSVSPDGKTVIYAKDLNLYRMSREDYEKAKKNEKDSTIVEIQLTTDGMKDFGYGIPYSMLNT
DTLCNGKRRRVGGVWSPDSRYFAMTVSDDRAVKELWVINSMARPRPTLETYKYQMPGEKEAPIEHLYLFDLVDNKRKEIK
VAAYKDQSIGLEYKPMMQKQRDMEDQAAVWQGDNNRFFLTRSSRDLHRIDVCSYTIGQDSVVPVIKERMNTYQETRPLRV
LNGGKEIIQWSERDGWAHLYLYDDQGNLKNRITKGPWHVEEILKVDDKARVIYFTANGMNAKEHPYYEHLYRVNLDGSGL
KLLTKGDYFHRVEVDDDARFVVDNYSRVNTVPCAILLDTNGNKVMDIQESDFSQLFAAGYKFPEIFKVKAADGVTDLYGV
MYKPFNFDSTKVYPIVDYVYPGPQVEGVYYPFTRMSPRTDRLAQAGFIVISVGQRGGHPSRSKWYHNYGYGNMRDYPLAD
HKYAIEQLAQRHHFIDIDKVGIHGHSGGGFMSTAAMCQYPDFFKVAVSCAGNHDNNIYNRWWSETHHGVKEVVSEKGDTT
FVYKIATNPEIAKQLKGNLLLIHGDIDNNVHPGNTLRVVDALIRAGKRFDMLILPQQRHGFGDMNEYFYWKLVDYFSEHL
KGKSEKSVDIPKR

Sequences:

>Translated_813_residues
MRKMLFITLLMGGLCTTVSVAKAQERLPEYLQAEKYTQEKLNTMLFSTVVDPHWFQKGNNFWFEYKTSEGTFWYVVDPAA
RTKKLLFDRDELASQLTEIVKDPFEARHLPITNLKAEEDGRTFTFEVKSTKDATPKKDGKDKKDKKNEKEIFYFSYDYPT
RKLTHLKDKEDDLKKIYWGSVSPDGKTVIYAKDLNLYRMSREDYEKAKKNEKDSTIVEIQLTTDGMKDFGYGIPYSMLNT
DTLCNGKRRRVGGVWSPDSRYFAMTVSDDRAVKELWVINSMARPRPTLETYKYQMPGEKEAPIEHLYLFDLVDNKRKEIK
VAAYKDQSIGLEYKPMMQKQRDMEDQAAVWQGDNNRFFLTRSSRDLHRIDVCSYTIGQDSVVPVIKERMNTYQETRPLRV
LNGGKEIIQWSERDGWAHLYLYDDQGNLKNRITKGPWHVEEILKVDDKARVIYFTANGMNAKEHPYYEHLYRVNLDGSGL
KLLTKGDYFHRVEVDDDARFVVDNYSRVNTVPCAILLDTNGNKVMDIQESDFSQLFAAGYKFPEIFKVKAADGVTDLYGV
MYKPFNFDSTKVYPIVDYVYPGPQVEGVYYPFTRMSPRTDRLAQAGFIVISVGQRGGHPSRSKWYHNYGYGNMRDYPLAD
HKYAIEQLAQRHHFIDIDKVGIHGHSGGGFMSTAAMCQYPDFFKVAVSCAGNHDNNIYNRWWSETHHGVKEVVSEKGDTT
FVYKIATNPEIAKQLKGNLLLIHGDIDNNVHPGNTLRVVDALIRAGKRFDMLILPQQRHGFGDMNEYFYWKLVDYFSEHL
KGKSEKSVDIPKR
>Mature_813_residues
MRKMLFITLLMGGLCTTVSVAKAQERLPEYLQAEKYTQEKLNTMLFSTVVDPHWFQKGNNFWFEYKTSEGTFWYVVDPAA
RTKKLLFDRDELASQLTEIVKDPFEARHLPITNLKAEEDGRTFTFEVKSTKDATPKKDGKDKKDKKNEKEIFYFSYDYPT
RKLTHLKDKEDDLKKIYWGSVSPDGKTVIYAKDLNLYRMSREDYEKAKKNEKDSTIVEIQLTTDGMKDFGYGIPYSMLNT
DTLCNGKRRRVGGVWSPDSRYFAMTVSDDRAVKELWVINSMARPRPTLETYKYQMPGEKEAPIEHLYLFDLVDNKRKEIK
VAAYKDQSIGLEYKPMMQKQRDMEDQAAVWQGDNNRFFLTRSSRDLHRIDVCSYTIGQDSVVPVIKERMNTYQETRPLRV
LNGGKEIIQWSERDGWAHLYLYDDQGNLKNRITKGPWHVEEILKVDDKARVIYFTANGMNAKEHPYYEHLYRVNLDGSGL
KLLTKGDYFHRVEVDDDARFVVDNYSRVNTVPCAILLDTNGNKVMDIQESDFSQLFAAGYKFPEIFKVKAADGVTDLYGV
MYKPFNFDSTKVYPIVDYVYPGPQVEGVYYPFTRMSPRTDRLAQAGFIVISVGQRGGHPSRSKWYHNYGYGNMRDYPLAD
HKYAIEQLAQRHHFIDIDKVGIHGHSGGGFMSTAAMCQYPDFFKVAVSCAGNHDNNIYNRWWSETHHGVKEVVSEKGDTT
FVYKIATNPEIAKQLKGNLLLIHGDIDNNVHPGNTLRVVDALIRAGKRFDMLILPQQRHGFGDMNEYFYWKLVDYFSEHL
KGKSEKSVDIPKR

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=387, Percent_Identity=31.266149870801, Blast_Score=160, Evalue=6e-39,
Organism=Homo sapiens, GI18450280, Length=387, Percent_Identity=31.266149870801, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI194394146, Length=389, Percent_Identity=29.0488431876607, Blast_Score=138, Evalue=3e-32,
Organism=Homo sapiens, GI16933540, Length=389, Percent_Identity=24.1645244215938, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI37577091, Length=199, Percent_Identity=30.6532663316583, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI18450278, Length=174, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17508017, Length=266, Percent_Identity=25.9398496240602, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17508019, Length=266, Percent_Identity=25.9398496240602, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17564632, Length=249, Percent_Identity=25.3012048192771, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564634, Length=249, Percent_Identity=25.3012048192771, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324793, Length=687, Percent_Identity=23.4352256186317, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45550825, Length=394, Percent_Identity=29.6954314720812, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45553511, Length=394, Percent_Identity=29.6954314720812, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551969, Length=394, Percent_Identity=29.6954314720812, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 94288; Mature: 94288

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKMLFITLLMGGLCTTVSVAKAQERLPEYLQAEKYTQEKLNTMLFSTVVDPHWFQKGNN
CCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
FWFEYKTSEGTFWYVVDPAARTKKLLFDRDELASQLTEIVKDPFEARHLPITNLKAEEDG
EEEEEECCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCC
RTFTFEVKSTKDATPKKDGKDKKDKKNEKEIFYFSYDYPTRKLTHLKDKEDDLKKIYWGS
CEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCHHHHHEEECC
VSPDGKTVIYAKDLNLYRMSREDYEKAKKNEKDSTIVEIQLTTDGMKDFGYGIPYSMLNT
CCCCCCEEEEEECCCEEECCHHHHHHHHCCCCCCEEEEEEEECCCHHHCCCCCCHHHCCC
DTLCNGKRRRVGGVWSPDSRYFAMTVSDDRAVKELWVINSMARPRPTLETYKYQMPGEKE
CHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHEEEECCCCCC
APIEHLYLFDLVDNKRKEIKVAAYKDQSIGLEYKPMMQKQRDMEDQAAVWQGDNNRFFLT
CCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHHHEEECCCCEEEEE
RSSRDLHRIDVCSYTIGQDSVVPVIKERMNTYQETRPLRVLNGGKEIIQWSERDGWAHLY
ECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHEECCCCCEEEEE
LYDDQGNLKNRITKGPWHVEEILKVDDKARVIYFTANGMNAKEHPYYEHLYRVNLDGSGL
EECCCCCHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCE
KLLTKGDYFHRVEVDDDARFVVDNYSRVNTVPCAILLDTNGNKVMDIQESDFSQLFAAGY
EEEECCCEEEEEEECCCCEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHCC
KFPEIFKVKAADGVTDLYGVMYKPFNFDSTKVYPIVDYVYPGPQVEGVYYPFTRMSPRTD
CCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEECCCCCCCCHH
RLAQAGFIVISVGQRGGHPSRSKWYHNYGYGNMRDYPLADHKYAIEQLAQRHHFIDIDKV
HHHHCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEE
GIHGHSGGGFMSTAAMCQYPDFFKVAVSCAGNHDNNIYNRWWSETHHGVKEVVSEKGDTT
EEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
FVYKIATNPEIAKQLKGNLLLIHGDIDNNVHPGNTLRVVDALIRAGKRFDMLILPQQRHG
EEEEEECCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECHHHCC
FGDMNEYFYWKLVDYFSEHLKGKSEKSVDIPKR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRKMLFITLLMGGLCTTVSVAKAQERLPEYLQAEKYTQEKLNTMLFSTVVDPHWFQKGNN
CCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
FWFEYKTSEGTFWYVVDPAARTKKLLFDRDELASQLTEIVKDPFEARHLPITNLKAEEDG
EEEEEECCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCC
RTFTFEVKSTKDATPKKDGKDKKDKKNEKEIFYFSYDYPTRKLTHLKDKEDDLKKIYWGS
CEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCHHHHHEEECC
VSPDGKTVIYAKDLNLYRMSREDYEKAKKNEKDSTIVEIQLTTDGMKDFGYGIPYSMLNT
CCCCCCEEEEEECCCEEECCHHHHHHHHCCCCCCEEEEEEEECCCHHHCCCCCCHHHCCC
DTLCNGKRRRVGGVWSPDSRYFAMTVSDDRAVKELWVINSMARPRPTLETYKYQMPGEKE
CHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHEEEECCCCCC
APIEHLYLFDLVDNKRKEIKVAAYKDQSIGLEYKPMMQKQRDMEDQAAVWQGDNNRFFLT
CCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHHHEEECCCCEEEEE
RSSRDLHRIDVCSYTIGQDSVVPVIKERMNTYQETRPLRVLNGGKEIIQWSERDGWAHLY
ECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHEECCCCCEEEEE
LYDDQGNLKNRITKGPWHVEEILKVDDKARVIYFTANGMNAKEHPYYEHLYRVNLDGSGL
EECCCCCHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCE
KLLTKGDYFHRVEVDDDARFVVDNYSRVNTVPCAILLDTNGNKVMDIQESDFSQLFAAGY
EEEECCCEEEEEEECCCCEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHCC
KFPEIFKVKAADGVTDLYGVMYKPFNFDSTKVYPIVDYVYPGPQVEGVYYPFTRMSPRTD
CCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEECCCCCCCCHH
RLAQAGFIVISVGQRGGHPSRSKWYHNYGYGNMRDYPLADHKYAIEQLAQRHHFIDIDKV
HHHHCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEE
GIHGHSGGGFMSTAAMCQYPDFFKVAVSCAGNHDNNIYNRWWSETHHGVKEVVSEKGDTT
EEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
FVYKIATNPEIAKQLKGNLLLIHGDIDNNVHPGNTLRVVDALIRAGKRFDMLILPQQRHG
EEEEEECCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECHHHCC
FGDMNEYFYWKLVDYFSEHLKGKSEKSVDIPKR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA