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The map label for this gene is dxs

Identifier: 150004317

GI number: 150004317

Start: 2259920

End: 2261818

Strand: Reverse

Name: dxs

Synonym: BVU_1763

Alternate gene names: 150004317

Gene position: 2261818-2259920 (Counterclockwise)

Preceding gene: 150004321

Following gene: 150004316

Centisome position: 43.81

GC content: 43.81

Gene sequence:

>1899_bases
ATGGAACAGGATAATTTATATAACTTACTGCAAAGCATAGATACTCCGGATGATTTGCGCCATTTAAGCGCAGACAAACT
GCCCGAAGTGTGTAAAGAGCTAAGGCAAAAGATTATAGATGAGCTCTCATGTAATCCGGGGCATTTCGGTTCCAGTTTGG
GCGTAATAGAACTGACCGTCGCCTTACATTATGTATTCAACACACCCTATGACCGCATTGTATGGGATGTAGGGCATCAA
GCTTACGGGCATAAAATTTTAACCGGACGCCGGGATGCGTTCTGTACCAACCGTAAACTGAATGGCATACGTCCTTTTCC
TTCTCCATCCGAAAGTGAATATGACACATTTACTTGCGGGCATGCGTCAAATTCTATTTCCGCAGCTTTAGGTATGGCTG
TAGCAGCCAAAAAGCACGGAGAGAATAACCGGCATGTCGTTGCTGTAATTGGTGACGGTTCCATGAGTGGAGGGCTGGCT
TTCGAAGGGCTGAACAATGCCTCAGCAACTCCTAATAACCTTCTGATTATCCTGAATGACAACAACATGGCTATAGACCG
TAGTGTAGGAGGCATGAAACAATATCTGTTGAACCTGCAAATGTCTGAAGGATACAACCGGATACGCTATAAAATATCAC
AAATGTTCCATCGATGGGGTATCCTGAACGAAGAACGCCGGAAAAGCCTGATACGATTTAACAACAGCCTGAAATCCATG
CTGGTACAACAGCAAAACGTATTTGAAGGCATGAATATCCGTTATTTCGGACCTATTGATGGACACGATGTCAACAATTT
GGCACGTGTATTAAAAGAGATTAAAGATATGCAAGGACCTAAACTGCTCCATATACATACCACCAAAGGAAAAGGTTTCG
GTCCGGCAGAAAAAGCTGCCACCATCTGGCATGCTCCGGGCATATTCGACAAGGAAACCGGAGAGCGTATCGTTGTCGAT
ACCAAAGGAATGCCCCCTTTGTTTCAGGATGTTTTTGGAAATACCCTATTGGAACTGGCCCAAACAAATGATAAAATCGT
AGGAGTCACTCCCGCAATGCCCTCAGGGTGCTCTATGAACATATTAATGAAAGCCATGCCCGAAAGAGGTTTTGATGTGG
GAATTGCCGAAGGACATGCCGTTACCTTTTCAGGAGGAATGGCAAAAGATGGTCTATTGCCTTTCTGCAATATCTATTCG
TCTTTCATGCAACGTGCCTATGACAATGTGATTCACGATATAGCGATACAAAAACTCAATGTAGTATTGTGCCTGGACCG
CGCTGGATTGGTAGGAGAAGACGGTCCTACTCATCACGGAGCATTCGATCTGGCTTATATGAGACCGATACCCAATCTCA
TTGTGGCCTCCCCTTACAACGAACATGAACTGCGTTGTTTGATGTATACCGCCCAGTTACCTGACAAAGGTCCTTTTGTC
ATCCGTTATCCACGTGGAAGAGGTTCATTGGTAGACTGGAAATGTCCAATGCAAGAGATTGAGATAGGAAAAGGAAGAAA
ATTGAAAGAAGGAAAAGACATAGCGGTCATTACGCTGGGGCCCATTGGCGTTCAAGCAGAAAAGGCTATCACACATGCCG
AACAGGAAACAGGAAAAAGCATTGCTCACTATGATTTGCGTTTCTTAAAGCCGTTAGATGAAAGTATGTTACACGAAATA
GGCAAGAGATTCAAGCAAGTGGTCACTGTTGAAGACGGTGTGCTAAAAGGTGGAATGGGCAGTGCCATACTGGAATTTAT
GGCAGACAATGAGTATAATCCGCAAATAAAACGTATCGGACTACCGGATCAATTTGTCCAGCATGGTTCAGTAAAAGAAC
TATATCATATTTGCGGCATGGACGAAGAAGGTATTTACAAAGTTTTGATATCATTCTAA

Upstream 100 bases:

>100_bases
AAATTCATACGATAAGGAAAGCTTTTAAAATTTAAGGGCAAATGTAATCATAATACACATATTTATGCTATTTTTGCACG
ATATTTATCATATCATAGGA

Downstream 100 bases:

>100_bases
GAGAGACGAACAATGAAAATCATTATTGCAGGAGCAGGAGCAGTAGGCACCCATCTGGCGAAATTATTATCGGATGAAAA
GCAAGACATCATTTTGATGG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MEQDNLYNLLQSIDTPDDLRHLSADKLPEVCKELRQKIIDELSCNPGHFGSSLGVIELTVALHYVFNTPYDRIVWDVGHQ
AYGHKILTGRRDAFCTNRKLNGIRPFPSPSESEYDTFTCGHASNSISAALGMAVAAKKHGENNRHVVAVIGDGSMSGGLA
FEGLNNASATPNNLLIILNDNNMAIDRSVGGMKQYLLNLQMSEGYNRIRYKISQMFHRWGILNEERRKSLIRFNNSLKSM
LVQQQNVFEGMNIRYFGPIDGHDVNNLARVLKEIKDMQGPKLLHIHTTKGKGFGPAEKAATIWHAPGIFDKETGERIVVD
TKGMPPLFQDVFGNTLLELAQTNDKIVGVTPAMPSGCSMNILMKAMPERGFDVGIAEGHAVTFSGGMAKDGLLPFCNIYS
SFMQRAYDNVIHDIAIQKLNVVLCLDRAGLVGEDGPTHHGAFDLAYMRPIPNLIVASPYNEHELRCLMYTAQLPDKGPFV
IRYPRGRGSLVDWKCPMQEIEIGKGRKLKEGKDIAVITLGPIGVQAEKAITHAEQETGKSIAHYDLRFLKPLDESMLHEI
GKRFKQVVTVEDGVLKGGMGSAILEFMADNEYNPQIKRIGLPDQFVQHGSVKELYHICGMDEEGIYKVLISF

Sequences:

>Translated_632_residues
MEQDNLYNLLQSIDTPDDLRHLSADKLPEVCKELRQKIIDELSCNPGHFGSSLGVIELTVALHYVFNTPYDRIVWDVGHQ
AYGHKILTGRRDAFCTNRKLNGIRPFPSPSESEYDTFTCGHASNSISAALGMAVAAKKHGENNRHVVAVIGDGSMSGGLA
FEGLNNASATPNNLLIILNDNNMAIDRSVGGMKQYLLNLQMSEGYNRIRYKISQMFHRWGILNEERRKSLIRFNNSLKSM
LVQQQNVFEGMNIRYFGPIDGHDVNNLARVLKEIKDMQGPKLLHIHTTKGKGFGPAEKAATIWHAPGIFDKETGERIVVD
TKGMPPLFQDVFGNTLLELAQTNDKIVGVTPAMPSGCSMNILMKAMPERGFDVGIAEGHAVTFSGGMAKDGLLPFCNIYS
SFMQRAYDNVIHDIAIQKLNVVLCLDRAGLVGEDGPTHHGAFDLAYMRPIPNLIVASPYNEHELRCLMYTAQLPDKGPFV
IRYPRGRGSLVDWKCPMQEIEIGKGRKLKEGKDIAVITLGPIGVQAEKAITHAEQETGKSIAHYDLRFLKPLDESMLHEI
GKRFKQVVTVEDGVLKGGMGSAILEFMADNEYNPQIKRIGLPDQFVQHGSVKELYHICGMDEEGIYKVLISF
>Mature_632_residues
MEQDNLYNLLQSIDTPDDLRHLSADKLPEVCKELRQKIIDELSCNPGHFGSSLGVIELTVALHYVFNTPYDRIVWDVGHQ
AYGHKILTGRRDAFCTNRKLNGIRPFPSPSESEYDTFTCGHASNSISAALGMAVAAKKHGENNRHVVAVIGDGSMSGGLA
FEGLNNASATPNNLLIILNDNNMAIDRSVGGMKQYLLNLQMSEGYNRIRYKISQMFHRWGILNEERRKSLIRFNNSLKSM
LVQQQNVFEGMNIRYFGPIDGHDVNNLARVLKEIKDMQGPKLLHIHTTKGKGFGPAEKAATIWHAPGIFDKETGERIVVD
TKGMPPLFQDVFGNTLLELAQTNDKIVGVTPAMPSGCSMNILMKAMPERGFDVGIAEGHAVTFSGGMAKDGLLPFCNIYS
SFMQRAYDNVIHDIAIQKLNVVLCLDRAGLVGEDGPTHHGAFDLAYMRPIPNLIVASPYNEHELRCLMYTAQLPDKGPFV
IRYPRGRGSLVDWKCPMQEIEIGKGRKLKEGKDIAVITLGPIGVQAEKAITHAEQETGKSIAHYDLRFLKPLDESMLHEI
GKRFKQVVTVEDGVLKGGMGSAILEFMADNEYNPQIKRIGLPDQFVQHGSVKELYHICGMDEEGIYKVLISF

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=566, Percent_Identity=24.0282685512367, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4507521, Length=566, Percent_Identity=24.0282685512367, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI133778974, Length=410, Percent_Identity=24.6341463414634, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI225637461, Length=414, Percent_Identity=24.6376811594203, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI225637463, Length=414, Percent_Identity=24.6376811594203, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI225637459, Length=414, Percent_Identity=24.6376811594203, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=42.81098546042, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17539652, Length=635, Percent_Identity=22.992125984252, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645119, Length=569, Percent_Identity=22.1441124780316, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551847, Length=569, Percent_Identity=22.1441124780316, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550715, Length=569, Percent_Identity=22.1441124780316, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666278, Length=665, Percent_Identity=21.8045112781955, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BACV8 (A6L175)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001299061.1
- ProteinModelPortal:   A6L175
- SMR:   A6L175
- STRING:   A6L175
- GeneID:   5302729
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1763
- NMPDR:   fig|435590.6.peg.1659
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70236; Mature: 70236

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQDNLYNLLQSIDTPDDLRHLSADKLPEVCKELRQKIIDELSCNPGHFGSSLGVIELTV
CCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHEE
ALHYVFNTPYDRIVWDVGHQAYGHKILTGRRDAFCTNRKLNGIRPFPSPSESEYDTFTCG
HHHHHHCCCHHHHHHHCCCHHHCCEEECCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEC
HASNSISAALGMAVAAKKHGENNRHVVAVIGDGSMSGGLAFEGLNNASATPNNLLIILND
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECC
NNMAIDRSVGGMKQYLLNLQMSEGYNRIRYKISQMFHRWGILNEERRKSLIRFNNSLKSM
CCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LVQQQNVFEGMNIRYFGPIDGHDVNNLARVLKEIKDMQGPKLLHIHTTKGKGFGPAEKAA
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCC
TIWHAPGIFDKETGERIVVDTKGMPPLFQDVFGNTLLELAQTNDKIVGVTPAMPSGCSMN
EEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHH
ILMKAMPERGFDVGIAEGHAVTFSGGMAKDGLLPFCNIYSSFMQRAYDNVIHDIAIQKLN
HHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEE
VVLCLDRAGLVGEDGPTHHGAFDLAYMRPIPNLIVASPYNEHELRCLMYTAQLPDKGPFV
EEEEEECCCCCCCCCCCCCCCEEEHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCEE
IRYPRGRGSLVDWKCPMQEIEIGKGRKLKEGKDIAVITLGPIGVQAEKAITHAEQETGKS
EEECCCCCCEEECCCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
IAHYDLRFLKPLDESMLHEIGKRFKQVVTVEDGVLKGGMGSAILEFMADNEYNPQIKRIG
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECC
LPDQFVQHGSVKELYHICGMDEEGIYKVLISF
CCHHHHHCCCHHHHHHHHCCCCCCHHHHEEEC
>Mature Secondary Structure
MEQDNLYNLLQSIDTPDDLRHLSADKLPEVCKELRQKIIDELSCNPGHFGSSLGVIELTV
CCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHEE
ALHYVFNTPYDRIVWDVGHQAYGHKILTGRRDAFCTNRKLNGIRPFPSPSESEYDTFTCG
HHHHHHCCCHHHHHHHCCCHHHCCEEECCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEC
HASNSISAALGMAVAAKKHGENNRHVVAVIGDGSMSGGLAFEGLNNASATPNNLLIILND
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECC
NNMAIDRSVGGMKQYLLNLQMSEGYNRIRYKISQMFHRWGILNEERRKSLIRFNNSLKSM
CCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LVQQQNVFEGMNIRYFGPIDGHDVNNLARVLKEIKDMQGPKLLHIHTTKGKGFGPAEKAA
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCC
TIWHAPGIFDKETGERIVVDTKGMPPLFQDVFGNTLLELAQTNDKIVGVTPAMPSGCSMN
EEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHH
ILMKAMPERGFDVGIAEGHAVTFSGGMAKDGLLPFCNIYSSFMQRAYDNVIHDIAIQKLN
HHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEE
VVLCLDRAGLVGEDGPTHHGAFDLAYMRPIPNLIVASPYNEHELRCLMYTAQLPDKGPFV
EEEEEECCCCCCCCCCCCCCCEEEHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCEE
IRYPRGRGSLVDWKCPMQEIEIGKGRKLKEGKDIAVITLGPIGVQAEKAITHAEQETGKS
EEECCCCCCEEECCCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
IAHYDLRFLKPLDESMLHEIGKRFKQVVTVEDGVLKGGMGSAILEFMADNEYNPQIKRIG
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECC
LPDQFVQHGSVKELYHICGMDEEGIYKVLISF
CCHHHHHCCCHHHHHHHHCCCCCCHHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA