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The map label for this gene is nuoI2 [H]

Identifier: 150004309

GI number: 150004309

Start: 2252384

End: 2252836

Strand: Reverse

Name: nuoI2 [H]

Synonym: BVU_1755

Alternate gene names: 150004309

Gene position: 2252836-2252384 (Counterclockwise)

Preceding gene: 150004310

Following gene: 150004308

Centisome position: 43.63

GC content: 42.6

Gene sequence:

>453_bases
ATGAAAGAAGAAAAACATTCCTATATAAAAGGGCTGCTTCATGGCATCGGTACATTACTTACCGGCATGAAAGTGACAGG
ACGAGAGTTCTTCACTCCTAAAGTCACTGAACAATATCCCGAAAACCGTGCCACATTAAAAATATCGCCCCGTTTCCGAG
GACGGCTTATCATGCCGGTTGATGAGAATGGTAATAACAAATGTATTGCTTGCGGACTTTGCCAGATGGCTTGCCCCAAT
GATACAATCACCATTACCAGCGAATCTGTGACCAACGAAGAAACAGGCAAGAAAAAGAAAATATTGGTAAAGTATGAGTA
CGACCTGGGAGCCTGTATGTTCTGTCAACTTTGTGTGAACGCTTGTCCACACGATGCCATTCGGTTCGATACAGAATTCG
AAAATGCTGTATTCGACCGCAGCAAACTAGTTCTCACTCTGAACAAAAAATAA

Upstream 100 bases:

>100_bases
TTGACCAAATTCTAACGCTGGAATGGAAGTACTTGGTTCCAATAGGTTTGTGCAACCTGTTGTTGATGGTAATTATTGTT
GTATTTAAATTACATTTCTG

Downstream 100 bases:

>100_bases
AAAACAAACGATATTATGACACTACAACTAATTGTATTCATTGTACTGGCGTTGTTTATCGCTGTCTGTTCGGTATTGGC
AGTCACGACCTCACGTATCT

Product: NADH dehydrogenase I chain I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 2; NDH-1 subunit I 2 [H]

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MKEEKHSYIKGLLHGIGTLLTGMKVTGREFFTPKVTEQYPENRATLKISPRFRGRLIMPVDENGNNKCIACGLCQMACPN
DTITITSESVTNEETGKKKKILVKYEYDLGACMFCQLCVNACPHDAIRFDTEFENAVFDRSKLVLTLNKK

Sequences:

>Translated_150_residues
MKEEKHSYIKGLLHGIGTLLTGMKVTGREFFTPKVTEQYPENRATLKISPRFRGRLIMPVDENGNNKCIACGLCQMACPN
DTITITSESVTNEETGKKKKILVKYEYDLGACMFCQLCVNACPHDAIRFDTEFENAVFDRSKLVLTLNKK
>Mature_150_residues
MKEEKHSYIKGLLHGIGTLLTGMKVTGREFFTPKVTEQYPENRATLKISPRFRGRLIMPVDENGNNKCIACGLCQMACPN
DTITITSESVTNEETGKKKKILVKYEYDLGACMFCQLCVNACPHDAIRFDTEFENAVFDRSKLVLTLNKK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=133, Percent_Identity=33.8345864661654, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788617, Length=136, Percent_Identity=34.5588235294118, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1789075, Length=113, Percent_Identity=29.2035398230088, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17555194, Length=145, Percent_Identity=33.1034482758621, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17864306, Length=141, Percent_Identity=34.7517730496454, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 16944; Mature: 16944

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEEKHSYIKGLLHGIGTLLTGMKVTGREFFTPKVTEQYPENRATLKISPRFRGRLIMPV
CCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHCCCCCCEEEECCCCCCEEEEEE
DENGNNKCIACGLCQMACPNDTITITSESVTNEETGKKKKILVKYEYDLGACMFCQLCVN
CCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHH
ACPHDAIRFDTEFENAVFDRSKLVLTLNKK
CCCCCCEEECCCHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MKEEKHSYIKGLLHGIGTLLTGMKVTGREFFTPKVTEQYPENRATLKISPRFRGRLIMPV
CCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHCCCCCCEEEECCCCCCEEEEEE
DENGNNKCIACGLCQMACPNDTITITSESVTNEETGKKKKILVKYEYDLGACMFCQLCVN
CCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHH
ACPHDAIRFDTEFENAVFDRSKLVLTLNKK
CCCCCCEEECCCHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA