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The map label for this gene is dxr

Identifier: 150004210

GI number: 150004210

Start: 2132851

End: 2133999

Strand: Direct

Name: dxr

Synonym: BVU_1651

Alternate gene names: 150004210

Gene position: 2132851-2133999 (Clockwise)

Preceding gene: 150004209

Following gene: 150004211

Centisome position: 41.31

GC content: 44.39

Gene sequence:

>1149_bases
ATGAAAAAACAAATAGCGATATTAGGTTCTACCGGCTCTATCGGTACACAAGCTTTACAGGTAATAGAGGAACATCCAGA
TTTATATGAGGTCTATGCGTTGACAGCCAATAACAGGGTCGATTTATTGGTAGAACAAGCCCGTAAGTTCATGCCCGAGG
CGGTAGTGATAGCCAATGAGGAAAAATACCTTCAATTGAAAGAGGCGCTGAGTGATCTGCCTGTCAAAGTATATGCAGGA
GCGGATGCGCTCTCTCAAATTGTGGAATCACAACCTATTGACATTGTACTGGCTTCTATGGTAGGTTATGCCGGATTGCG
TCCTACTATAAATGCGATAAAGGCAGGTAAAGCTATTGCTTTGGCTAATAAAGAAACACTGGTTGTAGCCGGGGAGTTGA
TTAATGCACTGGCAAATCAGTACCATACACCTGTACTTCCCGTGGATTCGGAGCATTCGGCTATCTTCCAGTGTCTGGAA
ATAAATAACCGGTTGGAGAAAGTGATCTTGACAGCTTCAGGAGGGCCGTTCCGTACTTATACCATGGAGCAGTTGCAAAC
AGTGACCAAAGCACAAGCTTTGAAGCATCCCAATTGGGAGATGGGAGCGAAGATAACCATTGATTCGGCTTCCATGATGA
ACAAAGGGTTTGAAGTGATTGAGGCTAAATGGTTATTCGGAATGCGTCCGGAGCAAATTGAAGTGGTAGTTCATCCACAA
TCTGTCATTCATTCTATGGTGCAGTTTGAGGATGGGGCTGTGAAAGCACAGTTGGGCATGCCCGATATGCGTTTACCTAT
TCAATATGCTTTTTCGTATCCGGAGCGCGTGAAATCTTCTTTCGAGCGGTTGGATTTTGCCCGTATAACAGACCTGACTT
TTGAACAGCCTGATACCAAACGTTTTCGTAATTTGGCATTGGCATACGAGGCTTTGTATCGGGCCGGAAATATGCCCTGT
ATAGTGAATGCAGCTAATGAAGTGGTGGTGGATGCTTTCCTGAAAGACAAAATATCTTTCCTGGGTATGAGTGATGTCAT
AGAACAGACTATGGGTAAAGTTGCTTATATCAAGGAACCGACTTATGAAGACTATGTGGATACTGATGCTGAGGCGCGTC
GGGTAGCGTTGTCCCTTTTGTCATCTTAA

Upstream 100 bases:

>100_bases
AATACCGGTGAAAAAACTACCGGACCGCATCTGCATTTCGAATTATGGCATAAGGGACGTGCGATTGATCCCTCAAAATA
CATTGTATTTTAACAACATT

Downstream 100 bases:

>100_bases
ATGGTAGTTGGCAGAGAATTATGTTAATTATAAATTATAAAATAGTAAATAGTTAGATGGAAACATTTTTGATTCGTGCT
CTTCAATTGATAATGAGCCT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKKQIAILGSTGSIGTQALQVIEEHPDLYEVYALTANNRVDLLVEQARKFMPEAVVIANEEKYLQLKEALSDLPVKVYAG
ADALSQIVESQPIDIVLASMVGYAGLRPTINAIKAGKAIALANKETLVVAGELINALANQYHTPVLPVDSEHSAIFQCLE
INNRLEKVILTASGGPFRTYTMEQLQTVTKAQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGMRPEQIEVVVHPQ
SVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPERVKSSFERLDFARITDLTFEQPDTKRFRNLALAYEALYRAGNMPC
IVNAANEVVVDAFLKDKISFLGMSDVIEQTMGKVAYIKEPTYEDYVDTDAEARRVALSLLSS

Sequences:

>Translated_382_residues
MKKQIAILGSTGSIGTQALQVIEEHPDLYEVYALTANNRVDLLVEQARKFMPEAVVIANEEKYLQLKEALSDLPVKVYAG
ADALSQIVESQPIDIVLASMVGYAGLRPTINAIKAGKAIALANKETLVVAGELINALANQYHTPVLPVDSEHSAIFQCLE
INNRLEKVILTASGGPFRTYTMEQLQTVTKAQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGMRPEQIEVVVHPQ
SVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPERVKSSFERLDFARITDLTFEQPDTKRFRNLALAYEALYRAGNMPC
IVNAANEVVVDAFLKDKISFLGMSDVIEQTMGKVAYIKEPTYEDYVDTDAEARRVALSLLSS
>Mature_382_residues
MKKQIAILGSTGSIGTQALQVIEEHPDLYEVYALTANNRVDLLVEQARKFMPEAVVIANEEKYLQLKEALSDLPVKVYAG
ADALSQIVESQPIDIVLASMVGYAGLRPTINAIKAGKAIALANKETLVVAGELINALANQYHTPVLPVDSEHSAIFQCLE
INNRLEKVILTASGGPFRTYTMEQLQTVTKAQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGMRPEQIEVVVHPQ
SVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPERVKSSFERLDFARITDLTFEQPDTKRFRNLALAYEALYRAGNMPC
IVNAANEVVVDAFLKDKISFLGMSDVIEQTMGKVAYIKEPTYEDYVDTDAEARRVALSLLSS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=43.8144329896907, Blast_Score=307, Evalue=7e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_BACV8 (A6L0W8)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298954.1
- ProteinModelPortal:   A6L0W8
- SMR:   A6L0W8
- STRING:   A6L0W8
- GeneID:   5302617
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1651
- NMPDR:   fig|435590.6.peg.1556
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42378; Mature: 42378

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: BINDING 124-124 BINDING 151-151 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQIAILGSTGSIGTQALQVIEEHPDLYEVYALTANNRVDLLVEQARKFMPEAVVIANE
CCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECC
EKYLQLKEALSDLPVKVYAGADALSQIVESQPIDIVLASMVGYAGLRPTINAIKAGKAIA
HHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEE
LANKETLVVAGELINALANQYHTPVLPVDSEHSAIFQCLEINNRLEKVILTASGGPFRTY
EECCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEH
TMEQLQTVTKAQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGMRPEQIEVVVHPQ
HHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHCCHHHHHHHHHCCCCCCEEEEEECCH
SVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPERVKSSFERLDFARITDLTFEQPDTK
HHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHCCHHHHCCCCCCCCCHH
RFRNLALAYEALYRAGNMPCIVNAANEVVVDAFLKDKISFLGMSDVIEQTMGKVAYIKEP
HHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECC
TYEDYVDTDAEARRVALSLLSS
CCHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKQIAILGSTGSIGTQALQVIEEHPDLYEVYALTANNRVDLLVEQARKFMPEAVVIANE
CCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECC
EKYLQLKEALSDLPVKVYAGADALSQIVESQPIDIVLASMVGYAGLRPTINAIKAGKAIA
HHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEE
LANKETLVVAGELINALANQYHTPVLPVDSEHSAIFQCLEINNRLEKVILTASGGPFRTY
EECCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEH
TMEQLQTVTKAQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGMRPEQIEVVVHPQ
HHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHCCHHHHHHHHHCCCCCCEEEEEECCH
SVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPERVKSSFERLDFARITDLTFEQPDTK
HHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHCCHHHHCCCCCCCCCHH
RFRNLALAYEALYRAGNMPCIVNAANEVVVDAFLKDKISFLGMSDVIEQTMGKVAYIKEP
HHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECC
TYEDYVDTDAEARRVALSLLSS
CCHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA