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The map label for this gene is gmk [H]

Identifier: 150004203

GI number: 150004203

Start: 2127165

End: 2127734

Strand: Reverse

Name: gmk [H]

Synonym: BVU_1644

Alternate gene names: 150004203

Gene position: 2127734-2127165 (Counterclockwise)

Preceding gene: 150004204

Following gene: 150004202

Centisome position: 41.21

GC content: 43.33

Gene sequence:

>570_bases
ATGGCAACAGGAAAACTTATCATTTTTTCAGCCCCCTCGGGTTCGGGCAAATCAACCATTATCAACTATCTGTTGACACA
AAACCTGAACCTGTCTTTCTCTATTTCTGCCACCAGCCGCCCTCCTCGCGGAAAAGAACGGCATGGTGTGGAATATTTCT
TCCTATCTCCTGAGGAATTCAGACAACGCATTGCCAATAATGAGTTTCTGGAATACGAAGAAGTATACGAAAACCGTTTC
TACGGAACCTTGAAAGCACAAGTGGAAAAACAATTGGAAGCCGGACAAAATGTGATTTTTGACGTAGATGTGGTAGGCGG
ATGTAATATCAAAAAATATTATGGCAGCCGCGCATTGTCTGTTTTCATTCAACCACCCAGTGTAGAAGAACTCCGTAAAC
GCCTGCAAGGCCGTGGTACTGATGCCCCCGAAGTGATTGAAAGCCGAATCGCAAAAGCAGAATTCGAATTGGGGTTCGCC
GATAAATTCGATACCGTGATAGTAAATGACGATTTGGAGAAGGCAAAGGCGGAAGCACTGAAAGTTATTAGAAACTTTAT
TGAACAATAA

Upstream 100 bases:

>100_bases
CAGATGAAGGACGAACTGGAACAAATCAAAGAACAGGTGTTAAATGTAATGTAACCGGTTCACATACCGGACACCATTCT
CATAAGCAAAGAATCAAGAT

Downstream 100 bases:

>100_bases
GACGATGATCAAAGATCCGAAAAAACTGGCCCAAAGAATGTCGATACTTTGTATCCTCATTGGTTTTATAGCTTTGGCTG
TAGGCATCATTGCAATGGCA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MATGKLIIFSAPSGSGKSTIINYLLTQNLNLSFSISATSRPPRGKERHGVEYFFLSPEEFRQRIANNEFLEYEEVYENRF
YGTLKAQVEKQLEAGQNVIFDVDVVGGCNIKKYYGSRALSVFIQPPSVEELRKRLQGRGTDAPEVIESRIAKAEFELGFA
DKFDTVIVNDDLEKAKAEALKVIRNFIEQ

Sequences:

>Translated_189_residues
MATGKLIIFSAPSGSGKSTIINYLLTQNLNLSFSISATSRPPRGKERHGVEYFFLSPEEFRQRIANNEFLEYEEVYENRF
YGTLKAQVEKQLEAGQNVIFDVDVVGGCNIKKYYGSRALSVFIQPPSVEELRKRLQGRGTDAPEVIESRIAKAEFELGFA
DKFDTVIVNDDLEKAKAEALKVIRNFIEQ
>Mature_188_residues
ATGKLIIFSAPSGSGKSTIINYLLTQNLNLSFSISATSRPPRGKERHGVEYFFLSPEEFRQRIANNEFLEYEEVYENRFY
GTLKAQVEKQLEAGQNVIFDVDVVGGCNIKKYYGSRALSVFIQPPSVEELRKRLQGRGTDAPEVIESRIAKAEFELGFAD
KFDTVIVNDDLEKAKAEALKVIRNFIEQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=35.1648351648352, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=35.1648351648352, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=35.1648351648352, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI38570142, Length=188, Percent_Identity=29.7872340425532, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI186700627, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI186700629, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI186972120, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI111154074, Length=165, Percent_Identity=29.6969696969697, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI262118263, Length=186, Percent_Identity=30.1075268817204, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI262118259, Length=189, Percent_Identity=30.6878306878307, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI4505237, Length=186, Percent_Identity=30.1075268817204, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118255, Length=186, Percent_Identity=30.1075268817204, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=186, Percent_Identity=44.0860215053763, Blast_Score=146, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=37.7659574468085, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=37.7659574468085, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=41.304347826087, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21356141, Length=187, Percent_Identity=36.8983957219251, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI161077626, Length=187, Percent_Identity=26.2032085561497, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554489, Length=187, Percent_Identity=26.2032085561497, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640542, Length=187, Percent_Identity=26.2032085561497, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007136, Length=187, Percent_Identity=26.2032085561497, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45554481, Length=187, Percent_Identity=26.2032085561497, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI85724806, Length=187, Percent_Identity=26.2032085561497, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21366; Mature: 21235

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGKLIIFSAPSGSGKSTIINYLLTQNLNLSFSISATSRPPRGKERHGVEYFFLSPEEF
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECHHHH
RQRIANNEFLEYEEVYENRFYGTLKAQVEKQLEAGQNVIFDVDVVGGCNIKKYYGSRALS
HHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHCCEEEE
VFIQPPSVEELRKRLQGRGTDAPEVIESRIAKAEFELGFADKFDTVIVNDDLEKAKAEAL
EEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHH
KVIRNFIEQ
HHHHHHHCC
>Mature Secondary Structure 
ATGKLIIFSAPSGSGKSTIINYLLTQNLNLSFSISATSRPPRGKERHGVEYFFLSPEEF
CCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECHHHH
RQRIANNEFLEYEEVYENRFYGTLKAQVEKQLEAGQNVIFDVDVVGGCNIKKYYGSRALS
HHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHCCEEEE
VFIQPPSVEELRKRLQGRGTDAPEVIESRIAKAEFELGFADKFDTVIVNDDLEKAKAEAL
EEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHH
KVIRNFIEQ
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]