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The map label for this gene is menE [C]

Identifier: 150004049

GI number: 150004049

Start: 1966209

End: 1968014

Strand: Direct

Name: menE [C]

Synonym: BVU_1484

Alternate gene names: 150004049

Gene position: 1966209-1968014 (Clockwise)

Preceding gene: 150004047

Following gene: 150004050

Centisome position: 38.08

GC content: 42.86

Gene sequence:

>1806_bases
ATGAGTAGTTCTTTCTTATCTGTCCTGATACAACGTCAGGCAGGGAAATATGGTGATCGTGTAGCGTTGCGTTACCGCGA
TTATAAAACAGAAACATGGATTCCGGTTTCTTGGAACCAGTTTGCCGCAACTGTAAAAACAGTTTCGAATGCATTGATAG
AATTAGGTATAGGCATACAGGAAAATATAGCAGTTTTTTCTCAAAATAAACCGGAATGTCTGTATGTGGACTTTGGAGCT
TTTGGGGTACGGGCTGTTACTGTACCATTTTATGCTACCAGTTCCGAGGCGCAGGTACATTATATGGTAGGTGATGCCGA
AATACGTTATATCTTTGTAGGTGAACAGTTGCAATATGATGTGGCGTTCCGGGTTATGCAACTGGGAAGCCAACTGAAAC
AGATTATAATTTTCGACAAGGAGGTAAAACGTGATGAGCGGGACCAGACTTCCATTTATTTTGATGACTTTCTGAAATTG
GGCGAGGCGCATCCGCATCAAGCTGAGGTAGACAAGCGTACTTCAGAGTCGGGTAATGGTGATCTTGCCAATATTCTTTA
TACCAGTGGAACAACCGGAGACAGCAAGGGGGTGATGTTGCATCATTCTTGCTATGAGGCGGCCATTCCGGCACACGATG
AACGTTTCCCTCAATTGGGTGATCAGGATGTGATTATGAATTTCCTTCCTTTTACTCATGTGTTTGAGCGTGCATGGACT
TGCTGGTGTCTTTCGATGGGGTGTACTTTGTCTATCAACTTGCGTCCTGCTGATATCCAGAAGACAATAAAGGAGATCCG
TCCTACGGCTATGTGCAGTGTTCCCCGTTTCTGGGAGAAAGTGTATGCCGGCGTGCAAGAAAAAATCAATGAGACAACCG
GATTGAAAAAGAAGTTGATGCTGGATGCTATTAAAGTGGGACGTGAACATAATTTGGAATATGTGTACAAAGGGCTGACT
CCTCCGCCTGTATTGCACATGAAATATAAATTTTATGAGAAAACGATCTATAGCTTGTTGAAAAAGACTATTGGCATTGA
AAACGGGCGTTTCTTCCCTACTGCCGGTGCGGCTATTCCGCCGGCTGTACAGGAGTTTGTTTTGTCGGTGGGAATTAATA
TGGTAGCGGGTTATGGATTGACGGAATCTACTGCAACGGTTGCTTGTGAGAATGATAATGACCATGTGGTTGGTTCGGTG
GGGCGTATCATGCCTCATGTGCAGGTCAGAATAGGGGAGAATAACGAAATAATGCTACGTGGTGAGGGAATCACTCATGG
CTATTATAAAAAGGAAGCTGCTACGAAAGCAGCGTTTACTGAAGACGGATGGTTCCATACCGGTGATGCGGGTTATATAA
AAGATGGGCATTTGTTCCTTACAGAGCGTATCAAGGACTTGTTTAAAACTTCAAACGGGAAGTATATCGCTCCTCAAGCC
ATTGAAGCCAAATTGGTGGTAGACCGTTATATCGATCAGATTTCTATTATTGCCGATGAACGTAAATTTGTTTCTGCTTT
GATAATTCCTGAATATAAACTGGTGAAAGAGTATGCCGCAAAAAAAGGTATTCGCTATGAAAGTATGGAGGAACTGTTGC
AGAAACCGGAAATTATCGATTTGTTTAAAGAGCGGATTGATACACTGCAGCAGCAGTTTGCACATTATGAACAGATCAAG
AGGTTTACCTTGTTGCCCCATCCTTTCAGTATGGAACGTGGTGAGCTGACCAATACGTTGAAAATAAAACGTAATGTGCT
GAACAAGAACTATGCTGCCGAAATAGAAAAGATGTACGAAGAATAA

Upstream 100 bases:

>100_bases
TCTAACTCTTTGACTGGTTGGGAAAATTAATGCCTGTTTATAGAGGATAATTCCAAATTAAACGATAACTTTGCCGATGA
ATTAAAAATAAATCTTTGGA

Downstream 100 bases:

>100_bases
TGGGAAAATGAATAGATTTCCACTATCTTTGCACCTTGAAATGCAAAAATTCTCAAGATGATAACAATAGAGCAACTGAA
AGACGTAAAAGAACGTACTG

Product: putative long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MSSSFLSVLIQRQAGKYGDRVALRYRDYKTETWIPVSWNQFAATVKTVSNALIELGIGIQENIAVFSQNKPECLYVDFGA
FGVRAVTVPFYATSSEAQVHYMVGDAEIRYIFVGEQLQYDVAFRVMQLGSQLKQIIIFDKEVKRDERDQTSIYFDDFLKL
GEAHPHQAEVDKRTSESGNGDLANILYTSGTTGDSKGVMLHHSCYEAAIPAHDERFPQLGDQDVIMNFLPFTHVFERAWT
CWCLSMGCTLSINLRPADIQKTIKEIRPTAMCSVPRFWEKVYAGVQEKINETTGLKKKLMLDAIKVGREHNLEYVYKGLT
PPPVLHMKYKFYEKTIYSLLKKTIGIENGRFFPTAGAAIPPAVQEFVLSVGINMVAGYGLTESTATVACENDNDHVVGSV
GRIMPHVQVRIGENNEIMLRGEGITHGYYKKEAATKAAFTEDGWFHTGDAGYIKDGHLFLTERIKDLFKTSNGKYIAPQA
IEAKLVVDRYIDQISIIADERKFVSALIIPEYKLVKEYAAKKGIRYESMEELLQKPEIIDLFKERIDTLQQQFAHYEQIK
RFTLLPHPFSMERGELTNTLKIKRNVLNKNYAAEIEKMYEE

Sequences:

>Translated_601_residues
MSSSFLSVLIQRQAGKYGDRVALRYRDYKTETWIPVSWNQFAATVKTVSNALIELGIGIQENIAVFSQNKPECLYVDFGA
FGVRAVTVPFYATSSEAQVHYMVGDAEIRYIFVGEQLQYDVAFRVMQLGSQLKQIIIFDKEVKRDERDQTSIYFDDFLKL
GEAHPHQAEVDKRTSESGNGDLANILYTSGTTGDSKGVMLHHSCYEAAIPAHDERFPQLGDQDVIMNFLPFTHVFERAWT
CWCLSMGCTLSINLRPADIQKTIKEIRPTAMCSVPRFWEKVYAGVQEKINETTGLKKKLMLDAIKVGREHNLEYVYKGLT
PPPVLHMKYKFYEKTIYSLLKKTIGIENGRFFPTAGAAIPPAVQEFVLSVGINMVAGYGLTESTATVACENDNDHVVGSV
GRIMPHVQVRIGENNEIMLRGEGITHGYYKKEAATKAAFTEDGWFHTGDAGYIKDGHLFLTERIKDLFKTSNGKYIAPQA
IEAKLVVDRYIDQISIIADERKFVSALIIPEYKLVKEYAAKKGIRYESMEELLQKPEIIDLFKERIDTLQQQFAHYEQIK
RFTLLPHPFSMERGELTNTLKIKRNVLNKNYAAEIEKMYEE
>Mature_600_residues
SSSFLSVLIQRQAGKYGDRVALRYRDYKTETWIPVSWNQFAATVKTVSNALIELGIGIQENIAVFSQNKPECLYVDFGAF
GVRAVTVPFYATSSEAQVHYMVGDAEIRYIFVGEQLQYDVAFRVMQLGSQLKQIIIFDKEVKRDERDQTSIYFDDFLKLG
EAHPHQAEVDKRTSESGNGDLANILYTSGTTGDSKGVMLHHSCYEAAIPAHDERFPQLGDQDVIMNFLPFTHVFERAWTC
WCLSMGCTLSINLRPADIQKTIKEIRPTAMCSVPRFWEKVYAGVQEKINETTGLKKKLMLDAIKVGREHNLEYVYKGLTP
PPVLHMKYKFYEKTIYSLLKKTIGIENGRFFPTAGAAIPPAVQEFVLSVGINMVAGYGLTESTATVACENDNDHVVGSVG
RIMPHVQVRIGENNEIMLRGEGITHGYYKKEAATKAAFTEDGWFHTGDAGYIKDGHLFLTERIKDLFKTSNGKYIAPQAI
EAKLVVDRYIDQISIIADERKFVSALIIPEYKLVKEYAAKKGIRYESMEELLQKPEIIDLFKERIDTLQQQFAHYEQIKR
FTLLPHPFSMERGELTNTLKIKRNVLNKNYAAEIEKMYEE

Specific function: Converts O-Succinylbenzoate (Osb) To O-Succinylbenzoyl- CoA (Osb-CoA). [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=619, Percent_Identity=26.1712439418417, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI42794754, Length=586, Percent_Identity=28.6689419795222, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI42794752, Length=586, Percent_Identity=28.6689419795222, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI83745141, Length=621, Percent_Identity=25.4428341384863, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI40807491, Length=620, Percent_Identity=27.741935483871, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4758332, Length=601, Percent_Identity=26.4559068219634, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI12669909, Length=601, Percent_Identity=26.4559068219634, Blast_Score=198, Evalue=2e-50,
Organism=Homo sapiens, GI42794760, Length=595, Percent_Identity=27.8991596638655, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI42794758, Length=595, Percent_Identity=27.8991596638655, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI42794756, Length=595, Percent_Identity=27.8991596638655, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI57165412, Length=566, Percent_Identity=27.3851590106007, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI57165410, Length=566, Percent_Identity=26.8551236749117, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI187761345, Length=474, Percent_Identity=23.4177215189873, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI187761343, Length=474, Percent_Identity=23.4177215189873, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1788595, Length=143, Percent_Identity=32.8671328671329, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17541856, Length=609, Percent_Identity=27.9146141215107, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17510401, Length=625, Percent_Identity=28.16, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI193204819, Length=625, Percent_Identity=26.72, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147511, Length=608, Percent_Identity=25.1644736842105, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17556552, Length=585, Percent_Identity=26.8376068376068, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17553312, Length=602, Percent_Identity=24.4186046511628, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17564090, Length=556, Percent_Identity=25.8992805755396, Blast_Score=159, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI133901848, Length=215, Percent_Identity=33.0232558139535, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=267, Percent_Identity=28.4644194756554, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=325, Percent_Identity=25.5384615384615, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17559526, Length=135, Percent_Identity=35.5555555555556, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324893, Length=610, Percent_Identity=26.2295081967213, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323903, Length=623, Percent_Identity=25.2006420545746, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322182, Length=485, Percent_Identity=27.6288659793814, Blast_Score=156, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6320852, Length=454, Percent_Identity=26.8722466960352, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666501, Length=610, Percent_Identity=27.0491803278689, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24666497, Length=610, Percent_Identity=27.0491803278689, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI281366413, Length=610, Percent_Identity=27.0491803278689, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17933690, Length=639, Percent_Identity=24.5696400625978, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI62471679, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI62471683, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI62471685, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24586636, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI62471681, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI62471687, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24586634, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI22026970, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI62471689, Length=630, Percent_Identity=27.6190476190476, Blast_Score=182, Evalue=9e-46,
Organism=Drosophila melanogaster, GI19921316, Length=651, Percent_Identity=25.0384024577573, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI21355181, Length=515, Percent_Identity=23.1067961165049, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648260, Length=148, Percent_Identity=34.4594594594595, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 68365; Mature: 68234

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSFLSVLIQRQAGKYGDRVALRYRDYKTETWIPVSWNQFAATVKTVSNALIELGIGIQ
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCC
ENIAVFSQNKPECLYVDFGAFGVRAVTVPFYATSSEAQVHYMVGDAEIRYIFVGEQLQYD
CCEEEEECCCCCEEEEECCCCCEEEEEEEEEECCCCCEEEEEECCCEEEEEEECCCHHHH
VAFRVMQLGSQLKQIIIFDKEVKRDERDQTSIYFDDFLKLGEAHPHQAEVDKRTSESGNG
HHHHHHHHHHHHHHHEEECHHHCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHCCCCCCC
DLANILYTSGTTGDSKGVMLHHSCYEAAIPAHDERFPQLGDQDVIMNFLPFTHVFERAWT
CEEEEEEECCCCCCCCCEEEEECHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
CWCLSMGCTLSINLRPADIQKTIKEIRPTAMCSVPRFWEKVYAGVQEKINETTGLKKKLM
HHEEECCCEEEEECCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHH
LDAIKVGREHNLEYVYKGLTPPPVLHMKYKFYEKTIYSLLKKTIGIENGRFFPTAGAAIP
HHHHHCCCCCCCHHEECCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC
PAVQEFVLSVGINMVAGYGLTESTATVACENDNDHVVGSVGRIMPHVQVRIGENNEIMLR
HHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCCCEEECHHHHCCEEEEEECCCCEEEEE
GEGITHGYYKKEAATKAAFTEDGWFHTGDAGYIKDGHLFLTERIKDLFKTSNGKYIAPQA
ECCCCCCHHHHHHHHHHCCCCCCCEECCCCCEEECCCEEHHHHHHHHHHCCCCCEECCCH
IEAKLVVDRYIDQISIIADERKFVSALIIPEYKLVKEYAAKKGIRYESMEELLQKPEIID
HHHHHHHHHHHHHHHEEECHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHH
LFKERIDTLQQQFAHYEQIKRFTLLPHPFSMERGELTNTLKIKRNVLNKNYAAEIEKMYE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
E
C
>Mature Secondary Structure 
SSSFLSVLIQRQAGKYGDRVALRYRDYKTETWIPVSWNQFAATVKTVSNALIELGIGIQ
CHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCC
ENIAVFSQNKPECLYVDFGAFGVRAVTVPFYATSSEAQVHYMVGDAEIRYIFVGEQLQYD
CCEEEEECCCCCEEEEECCCCCEEEEEEEEEECCCCCEEEEEECCCEEEEEEECCCHHHH
VAFRVMQLGSQLKQIIIFDKEVKRDERDQTSIYFDDFLKLGEAHPHQAEVDKRTSESGNG
HHHHHHHHHHHHHHHEEECHHHCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHCCCCCCC
DLANILYTSGTTGDSKGVMLHHSCYEAAIPAHDERFPQLGDQDVIMNFLPFTHVFERAWT
CEEEEEEECCCCCCCCCEEEEECHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
CWCLSMGCTLSINLRPADIQKTIKEIRPTAMCSVPRFWEKVYAGVQEKINETTGLKKKLM
HHEEECCCEEEEECCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHH
LDAIKVGREHNLEYVYKGLTPPPVLHMKYKFYEKTIYSLLKKTIGIENGRFFPTAGAAIP
HHHHHCCCCCCCHHEECCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC
PAVQEFVLSVGINMVAGYGLTESTATVACENDNDHVVGSVGRIMPHVQVRIGENNEIMLR
HHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCCCEEECHHHHCCEEEEEECCCCEEEEE
GEGITHGYYKKEAATKAAFTEDGWFHTGDAGYIKDGHLFLTERIKDLFKTSNGKYIAPQA
ECCCCCCHHHHHHHHHHCCCCCCCEECCCCCEEECCCEEHHHHHHHHHHCCCCCEECCCH
IEAKLVVDRYIDQISIIADERKFVSALIIPEYKLVKEYAAKKGIRYESMEELLQKPEIID
HHHHHHHHHHHHHHHEEECHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHH
LFKERIDTLQQQFAHYEQIKRFTLLPHPFSMERGELTNTLKIKRNVLNKNYAAEIEKMYE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]