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The map label for this gene is folK [H]

Identifier: 150003743

GI number: 150003743

Start: 1588255

End: 1588701

Strand: Direct

Name: folK [H]

Synonym: BVU_1174

Alternate gene names: 150003743

Gene position: 1588255-1588701 (Clockwise)

Preceding gene: 150003742

Following gene: 150003753

Centisome position: 30.76

GC content: 47.65

Gene sequence:

>447_bases
ATGAGGGTTTATTTGGGACTTGGAACCAATCTGGGTGATAAAGAATCAAATCTGCATGTTGCTGTCCGGAAGATAAATGA
GCGGATAGGGGAGGTTACTGCCCTTTCCGCTTTTTATGTTACCGCCCCTTGGGGGTTTTCTTCTGAAAATTCTTTTCTGA
ATGCCGCCTGTTGCGTGGAGAGTGTGCTTCCTCCCTTGGATATATTGCGGGAAACACAGGAGATAGAGCGTGAATTAGGT
CGGATGAAGAAGTCGGCGGGAGGTAATTATAGTGACCGCCTGATTGATATAGATATTTTGTTGTACGGCGATTTAATACT
GCATACGCCGGAATTGGAAATCCCTCATCCCCTGATGACTGAACGGAGGTTTGTCATGGACCCGCTGGCGGAGATTGCAT
CGGATGTGGTGCATCCGGTATTGGGAAAAAGGCTGGGGGAGCTTTAA

Upstream 100 bases:

>100_bases
GATGGAGGCTTATCACACAGCGTTGAAGGAAGATTACCGTTTCGGTACTTATGGCGACGCTATGTTGATTTTGGATAAGT
AATACCGGTTGGAGCAGCGT

Downstream 100 bases:

>100_bases
ACCTGTAAGAGTATATTAATTAAAAGAGGACGGAAAATTCTTCAAATCCGTCATTGTGGTGTAGATAGCTGATTGATAGT
GTATTGTTATGAAGAATTCG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MRVYLGLGTNLGDKESNLHVAVRKINERIGEVTALSAFYVTAPWGFSSENSFLNAACCVESVLPPLDILRETQEIERELG
RMKKSAGGNYSDRLIDIDILLYGDLILHTPELEIPHPLMTERRFVMDPLAEIASDVVHPVLGKRLGEL

Sequences:

>Translated_148_residues
MRVYLGLGTNLGDKESNLHVAVRKINERIGEVTALSAFYVTAPWGFSSENSFLNAACCVESVLPPLDILRETQEIERELG
RMKKSAGGNYSDRLIDIDILLYGDLILHTPELEIPHPLMTERRFVMDPLAEIASDVVHPVLGKRLGEL
>Mature_148_residues
MRVYLGLGTNLGDKESNLHVAVRKINERIGEVTALSAFYVTAPWGFSSENSFLNAACCVESVLPPLDILRETQEIERELG
RMKKSAGGNYSDRLIDIDILLYGDLILHTPELEIPHPLMTERRFVMDPLAEIASDVVHPVLGKRLGEL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=34.5323741007194, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324073, Length=150, Percent_Identity=34, Blast_Score=90, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 16502; Mature: 16502

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYLGLGTNLGDKESNLHVAVRKINERIGEVTALSAFYVTAPWGFSSENSFLNAACCVE
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHH
SVLPPLDILRETQEIERELGRMKKSAGGNYSDRLIDIDILLYGDLILHTPELEIPHPLMT
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHEEECHHHEECCCCCCCCCHHH
ERRFVMDPLAEIASDVVHPVLGKRLGEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVYLGLGTNLGDKESNLHVAVRKINERIGEVTALSAFYVTAPWGFSSENSFLNAACCVE
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHH
SVLPPLDILRETQEIERELGRMKKSAGGNYSDRLIDIDILLYGDLILHTPELEIPHPLMT
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHEEECHHHEECCCCCCCCCHHH
ERRFVMDPLAEIASDVVHPVLGKRLGEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA