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The map label for this gene is hutH [H]

Identifier: 150003581

GI number: 150003581

Start: 1345560

End: 1347131

Strand: Direct

Name: hutH [H]

Synonym: BVU_1010

Alternate gene names: 150003581

Gene position: 1345560-1347131 (Clockwise)

Preceding gene: 150003580

Following gene: 150003582

Centisome position: 26.06

GC content: 45.42

Gene sequence:

>1572_bases
TTGCGGAAATTATACAAAACTGCTTATCACACCAATCCAATGCTAGCTGAGAATAAGATAACTTTAGCGTCCCTGTATAA
GATTTTGTTTGAAGAAGAGCCACTGACACTCTCCGACCAATGTATGCAAAAATTGGAAGAGAGTTTCCATTTTCTGAAAA
CATTCTCCAACGACAAGATCATCTATGGCATCAATACCGGCTTTGGACCGATGGCCCAATACCGTATTGAAGATGAATCC
TTGTCACAATTACAGTATAATATCATCCGCAGCCATGCCACCGGAGCAGGGCAACCCCTTCCGGAACTCTATGTCAAAGC
TGCCATGATAGCGCGTCTCTATACTTTTCTGCAAGGAAAATCCGGCGTACATAAAGAACTGGCATTGCTCATTACCGAGT
TTATCAACCGGGGGATTACTCCATACGTACCCGAACACGGCAGTGTAGGGGCCAGTGGCGATTTGGTACAGCTTGCCCAT
ATCGCCCTCACCCTGATTGGAGAAGGAGAGGTCTTTTACCAAGGCAAGAAAAGAGATACGGCATCCGTTTTGGCGGAAAA
CGGATTGCAACCCTTCAAAATGCATATCCGCGAAGGGCTTTCAGTGACCAACGGCACTTCGGTAATGACAGGTATAGGCA
TTGTCAACCTGATTTATGCCCGCCAACTGATGCATTGGGCAGTAGGCGCATCGGTCATGATGAATGAAATTGCCGCCTCG
TACGATGATTTCATGTCTGAACCGCTGAACGAAGCCAAACGGCATGAAGGACAGCAAGAGATAGCCCGCATGATGCGCCA
ATGGGTGGAAGGCAGCCAATGTGTACGCAAAAGAGAGAATGAACTTTACAACGGAAAACACGAAGAGAAAATCTTCACCC
ATAAGGTTCAACCCTATTATTCGTTGCGTTGCATTCCGCAGATTCTAGGACCGGTTTATGATGAATTGCTCAATGCCGAA
AAAGTATTGATAAACGAAATAAATTCAGCCTGTGACAACCCGATAGTGGACCCCGACACGCAAAACGTGTATCATGGCGG
TAACTTTCACGGAGATTACGTTTCTTTTGAAATGGATAAACTGAAAATAGCGGTCACCAAACTGGCCATGCTTGCCGAAC
GGCAGATCAATTACTTGTTTCACGACCGCATCAACGGCATTCTGCCCCCCTTTGTCAATATGGGAGTGCTGGGATTGAAC
TATGGTTTGCAGGCGTCACAATTTACCGCGACTTCTACCACAGCGGAGTGCCAGACTTTGTCCAATCCGATGTATGTGCA
TAGCATCCCCAACAACAATGACAATCAGGATATTGTAAGCATGGGAACCAATTCCGCACTGCTGGCAAAAACAGTCATAG
AAAATGCTTATCAGGTGATGGCTATCCTGATGATGGGTATTGTACAAGCTGTAGACTGTTTGGAAATAGCCGGTCGGCTA
AGCCCCCGGTCACAACAAGTATATAAAGAGATACGAGCATTTTTTCCTGTGTTCCGGGAAGATACGCCTAAATATAAAGA
GATAGAAAGAATGATGGTATATCTTAAAAAAGGGAGGTTGCAAGAAAAATGA

Upstream 100 bases:

>100_bases
TCTGCGTTTATTTGTATAATCTGTGGTGAACCTTTCAGATAACCATCAAAACTGAAAAATCTCCCTTCGGATGGTAATAC
TTATTTTTAAATAACTATTT

Downstream 100 bases:

>100_bases
AATACGCACTAGTAACAGGAGGAAGCCGGGGCATCGGACGGGCTGTATGTCTGAAACTGGCCGAAATGGGATATCATATA
CTGATAAACTACCAAAACAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MRKLYKTAYHTNPMLAENKITLASLYKILFEEEPLTLSDQCMQKLEESFHFLKTFSNDKIIYGINTGFGPMAQYRIEDES
LSQLQYNIIRSHATGAGQPLPELYVKAAMIARLYTFLQGKSGVHKELALLITEFINRGITPYVPEHGSVGASGDLVQLAH
IALTLIGEGEVFYQGKKRDTASVLAENGLQPFKMHIREGLSVTNGTSVMTGIGIVNLIYARQLMHWAVGASVMMNEIAAS
YDDFMSEPLNEAKRHEGQQEIARMMRQWVEGSQCVRKRENELYNGKHEEKIFTHKVQPYYSLRCIPQILGPVYDELLNAE
KVLINEINSACDNPIVDPDTQNVYHGGNFHGDYVSFEMDKLKIAVTKLAMLAERQINYLFHDRINGILPPFVNMGVLGLN
YGLQASQFTATSTTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENAYQVMAILMMGIVQAVDCLEIAGRL
SPRSQQVYKEIRAFFPVFREDTPKYKEIERMMVYLKKGRLQEK

Sequences:

>Translated_523_residues
MRKLYKTAYHTNPMLAENKITLASLYKILFEEEPLTLSDQCMQKLEESFHFLKTFSNDKIIYGINTGFGPMAQYRIEDES
LSQLQYNIIRSHATGAGQPLPELYVKAAMIARLYTFLQGKSGVHKELALLITEFINRGITPYVPEHGSVGASGDLVQLAH
IALTLIGEGEVFYQGKKRDTASVLAENGLQPFKMHIREGLSVTNGTSVMTGIGIVNLIYARQLMHWAVGASVMMNEIAAS
YDDFMSEPLNEAKRHEGQQEIARMMRQWVEGSQCVRKRENELYNGKHEEKIFTHKVQPYYSLRCIPQILGPVYDELLNAE
KVLINEINSACDNPIVDPDTQNVYHGGNFHGDYVSFEMDKLKIAVTKLAMLAERQINYLFHDRINGILPPFVNMGVLGLN
YGLQASQFTATSTTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENAYQVMAILMMGIVQAVDCLEIAGRL
SPRSQQVYKEIRAFFPVFREDTPKYKEIERMMVYLKKGRLQEK
>Mature_523_residues
MRKLYKTAYHTNPMLAENKITLASLYKILFEEEPLTLSDQCMQKLEESFHFLKTFSNDKIIYGINTGFGPMAQYRIEDES
LSQLQYNIIRSHATGAGQPLPELYVKAAMIARLYTFLQGKSGVHKELALLITEFINRGITPYVPEHGSVGASGDLVQLAH
IALTLIGEGEVFYQGKKRDTASVLAENGLQPFKMHIREGLSVTNGTSVMTGIGIVNLIYARQLMHWAVGASVMMNEIAAS
YDDFMSEPLNEAKRHEGQQEIARMMRQWVEGSQCVRKRENELYNGKHEEKIFTHKVQPYYSLRCIPQILGPVYDELLNAE
KVLINEINSACDNPIVDPDTQNVYHGGNFHGDYVSFEMDKLKIAVTKLAMLAERQINYLFHDRINGILPPFVNMGVLGLN
YGLQASQFTATSTTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENAYQVMAILMMGIVQAVDCLEIAGRL
SPRSQQVYKEIRAFFPVFREDTPKYKEIERMMVYLKKGRLQEK

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=487, Percent_Identity=30.8008213552361, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17567831, Length=496, Percent_Identity=32.6612903225806, Blast_Score=228, Evalue=8e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 59095; Mature: 59095

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLYKTAYHTNPMLAENKITLASLYKILFEEEPLTLSDQCMQKLEESFHFLKTFSNDKI
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
IYGINTGFGPMAQYRIEDESLSQLQYNIIRSHATGAGQPLPELYVKAAMIARLYTFLQGK
EEEECCCCCCCHHEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SGVHKELALLITEFINRGITPYVPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGKKRDT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCEEECCCCCHH
ASVLAENGLQPFKMHIREGLSVTNGTSVMTGIGIVNLIYARQLMHWAVGASVMMNEIAAS
HHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDDFMSEPLNEAKRHEGQQEIARMMRQWVEGSQCVRKRENELYNGKHEEKIFTHKVQPYY
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHH
SLRCIPQILGPVYDELLNAEKVLINEINSACDNPIVDPDTQNVYHGGNFHGDYVSFEMDK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHH
LKIAVTKLAMLAERQINYLFHDRINGILPPFVNMGVLGLNYGLQASQFTATSTTAECQTL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHEECCCCCCCCEECCCCHHHHHHC
SNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENAYQVMAILMMGIVQAVDCLEIAGRL
CCCEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPRSQQVYKEIRAFFPVFREDTPKYKEIERMMVYLKKGRLQEK
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRKLYKTAYHTNPMLAENKITLASLYKILFEEEPLTLSDQCMQKLEESFHFLKTFSNDKI
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
IYGINTGFGPMAQYRIEDESLSQLQYNIIRSHATGAGQPLPELYVKAAMIARLYTFLQGK
EEEECCCCCCCHHEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SGVHKELALLITEFINRGITPYVPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGKKRDT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCEEECCCCCHH
ASVLAENGLQPFKMHIREGLSVTNGTSVMTGIGIVNLIYARQLMHWAVGASVMMNEIAAS
HHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDDFMSEPLNEAKRHEGQQEIARMMRQWVEGSQCVRKRENELYNGKHEEKIFTHKVQPYY
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHH
SLRCIPQILGPVYDELLNAEKVLINEINSACDNPIVDPDTQNVYHGGNFHGDYVSFEMDK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHH
LKIAVTKLAMLAERQINYLFHDRINGILPPFVNMGVLGLNYGLQASQFTATSTTAECQTL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHEECCCCCCCCEECCCCHHHHHHC
SNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENAYQVMAILMMGIVQAVDCLEIAGRL
CCCEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPRSQQVYKEIRAFFPVFREDTPKYKEIERMMVYLKKGRLQEK
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454913; 7704263; 9384377 [H]