Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 150003448

GI number: 150003448

Start: 1177355

End: 1177993

Strand: Reverse

Name: mdmC [H]

Synonym: BVU_0875

Alternate gene names: 150003448

Gene position: 1177993-1177355 (Counterclockwise)

Preceding gene: 150003449

Following gene: 150003447

Centisome position: 22.82

GC content: 46.17

Gene sequence:

>639_bases
ATGAAAGAAACGGACGCTATTGACGAATATATCCTTCAGCACATTGATGAAGAAAGTGATTATCTGAAGGCACTTTATCG
CGATACGCACGTCAAGCTTTTACGTCCCCGTATGGCTTCCGGCCACTTGCAGGGACGTATGCTGAAAATGTTTGTGCAAA
TGATACGCCCCCGTCAGGTGCTGGAAATCGGGACTTACAGTGGCTACTCCGCACTTTGCCTGGCCGAAGGGTTGGAAGAG
GGGGCCACGTTGCACACATTTGAGATAAACGATGAGCAGGAGGACTTTACACGTCCCTGGCTGGAAGGTTCGCCTTACGC
CGGCAAGATTAAATTTTATATAGGTGATGCGCTGAAGTTGCTGCCTGGCATGAACATTACCTTTGATTTGGCGTTTGTAG
ACGGTGATAAGCGGAAGTATATTGAATATTACGAAATGGTACTGGAGAAATTATCACCCGGCGGATACATCATTGCCGAT
AACACATTGTGGGACGGACATGTATTGGAGGAACCGCATCATACAGATCTTCAGACTATTGGAATAAAGAAATTTAATGA
TTTGGTAGCTGCCGACAAACGGGTTGAAAAGGTGATTCTTCCCTTGCGCGACGGGCTGACAATCATAAGAAAATGTTGA

Upstream 100 bases:

>100_bases
TTCTTTCCTTGAAATCAATGTAGTGGGAGATGTGTTGAAGTATGCTATGGACTATGTGCTGCCCAACCGCAACCGTTACC
TATAATAATAGAAGATAGGA

Downstream 100 bases:

>100_bases
ATAATGTGCCAATAGGTTATGCTATGAACCGTATGGCATATTAACAAATTAGCAAACTGAATAATTATTAATTATGGAAA
CGACCAGACAAAATAAGATT

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKETDAIDEYILQHIDEESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVQMIRPRQVLEIGTYSGYSALCLAEGLEE
GATLHTFEINDEQEDFTRPWLEGSPYAGKIKFYIGDALKLLPGMNITFDLAFVDGDKRKYIEYYEMVLEKLSPGGYIIAD
NTLWDGHVLEEPHHTDLQTIGIKKFNDLVAADKRVEKVILPLRDGLTIIRKC

Sequences:

>Translated_212_residues
MKETDAIDEYILQHIDEESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVQMIRPRQVLEIGTYSGYSALCLAEGLEE
GATLHTFEINDEQEDFTRPWLEGSPYAGKIKFYIGDALKLLPGMNITFDLAFVDGDKRKYIEYYEMVLEKLSPGGYIIAD
NTLWDGHVLEEPHHTDLQTIGIKKFNDLVAADKRVEKVILPLRDGLTIIRKC
>Mature_212_residues
MKETDAIDEYILQHIDEESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVQMIRPRQVLEIGTYSGYSALCLAEGLEE
GATLHTFEINDEQEDFTRPWLEGSPYAGKIKFYIGDALKLLPGMNITFDLAFVDGDKRKYIEYYEMVLEKLSPGGYIIAD
NTLWDGHVLEEPHHTDLQTIGIKKFNDLVAADKRVEKVILPLRDGLTIIRKC

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=173, Percent_Identity=34.1040462427746, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17565612, Length=217, Percent_Identity=29.4930875576037, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI72001127, Length=217, Percent_Identity=29.9539170506912, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72001028, Length=213, Percent_Identity=30.5164319248826, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25148771, Length=217, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24382; Mature: 24382

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETDAIDEYILQHIDEESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVQMIRPRQV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCHHH
LEIGTYSGYSALCLAEGLEEGATLHTFEINDEQEDFTRPWLEGSPYAGKIKFYIGDALKL
EEECCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCEEEEEECHHHHH
LPGMNITFDLAFVDGDKRKYIEYYEMVLEKLSPGGYIIADNTLWDGHVLEEPHHTDLQTI
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCEECCCCCCCCCCCCHHHH
GIKKFNDLVAADKRVEKVILPLRDGLTIIRKC
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MKETDAIDEYILQHIDEESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVQMIRPRQV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCHHH
LEIGTYSGYSALCLAEGLEEGATLHTFEINDEQEDFTRPWLEGSPYAGKIKFYIGDALKL
EEECCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCEEEEEECHHHHH
LPGMNITFDLAFVDGDKRKYIEYYEMVLEKLSPGGYIIADNTLWDGHVLEEPHHTDLQTI
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCEECCCCCCCCCCCCHHHH
GIKKFNDLVAADKRVEKVILPLRDGLTIIRKC
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]