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The map label for this gene is argH

Identifier: 150003431

GI number: 150003431

Start: 1161703

End: 1163043

Strand: Reverse

Name: argH

Synonym: BVU_0858

Alternate gene names: 150003431

Gene position: 1163043-1161703 (Counterclockwise)

Preceding gene: 150003432

Following gene: 150003430

Centisome position: 22.53

GC content: 43.33

Gene sequence:

>1341_bases
ATGGCACAGAAACTTTGGGAAAAAAATGTCCGGGTAAATGAGGAGATAGATCGTTTTACTGTAGGACGTGACCGTGAAAT
GGATCTTTATCTGGCTAAACACGATGTATTGGGCTCAATGGCACATATCACCATGTTGGAAAGTATCGGTTTGCTTACAG
CCGGAGAATTGGAAATGCTATTAGCGGAATTAAAGAATATCTATGCTTCTGCCGAAAAGGGAGAGTTTGTAATAGAGGAT
GGTATAGAGGATGTACACTCGCAAGTAGAATTGATGTTGACGCGTAAGTTGGGAGATGTCGGAAAGAAAATTCATAGTGG
ACGTTCACGCAATGACCAGGTGTTGGTGGATTTGAAGCTGTTTACTCGTGCGGAATTAAAAGAAGTGGCCGAAGAGGTGG
AGCAACTTTTTCATGTGCTGATTTCTCAAAGCAATACATATAAGGATGTGTTAATGCCGGGTTACACTCATTTGCAGATA
GCGATGCCTTCTTCATTTGGCTTGTGGTTTGGCGCGTATGCTGAGAGTCTGGTGGACGATATGATGTTTCTGCAGGCTGC
ATTCAAAATGTGCAACCGCAATCCGTTGGGCTCTGCTGCCGGGTATGGTTCTTCTTTTCCGCTCGATCGTGAGATGACCA
CCCGCTTGTTGGGATTTGATTCGATGGATTATAATGTGGTGTATGCGCAGATGGGGCGTGGTAAGATGGAACGTAATGTG
GCTTTTGCTTTGGCTTCTATTGCCGGGACAGTTTCTAAAATGGCTTTTGACGCTTGTATGTTCAGTAGCCAAAACTTTGG
CTTTGTAAAACTTCCGGATGAATGTACTACCGGCTCCAGTATAATGCCTCATAAAAAGAACCCTGATGTCTTTGAATTGA
CACGGGCAAAATGCAACAAGCTGCAGGCTCTTCCTCAGCAGATTATGATGATAATGAATAATTTGCCTTCGGGGTATTTT
CGTGATTTGCAGATTATAAAAGAAGTTTTCTTGCCTGCGTTCCGGGAGTTGAAGGAATGTCTGCAAATGGCTGCCTATAT
TATGGACAAAATTAAAATCAACGAACATATTCTGGATGATAACCGTTACCTTTATATCTTTAGTGTGGAAGAGGTCAACC
GTTTGGCGTCTGAAGGTATGCCGTTCCGTGATGCTTATAAAAAGGTTGGCTTGGACATAGAAGCCGGCAAGTTCACCCAT
GACAAGAAGGTGCATCATACTCATGAGGGTAGTATCGGTAATTTGTGTAATGACAGGATCGAAAGCTTGATGCGGCAAGT
AGTGGACGGATTTAATTTCTCAGTCATGGAACAGGCTGAACGAAGCCTTTTAGGTAGATAG

Upstream 100 bases:

>100_bases
ATATGTTTATGAAGGCGATGGTTGCTAAACCTTTACAGGATGGTGTGGATAAACTGGCTGAGATGTTATCGATGATTCCT
TATTAAAAATAAAGACAAAT

Downstream 100 bases:

>100_bases
AAATAATTGTAAAACGTAATAGCATGAAATATCAACCTTCGGCAGACCGTTATAGCAAAATGCAGTACAAATACTGCGGA
AATAGCGGCTTGCTTTTACC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAQKLWEKNVRVNEEIDRFTVGRDREMDLYLAKHDVLGSMAHITMLESIGLLTAGELEMLLAELKNIYASAEKGEFVIED
GIEDVHSQVELMLTRKLGDVGKKIHSGRSRNDQVLVDLKLFTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQI
AMPSSFGLWFGAYAESLVDDMMFLQAAFKMCNRNPLGSAAGYGSSFPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNV
AFALASIAGTVSKMAFDACMFSSQNFGFVKLPDECTTGSSIMPHKKNPDVFELTRAKCNKLQALPQQIMMIMNNLPSGYF
RDLQIIKEVFLPAFRELKECLQMAAYIMDKIKINEHILDDNRYLYIFSVEEVNRLASEGMPFRDAYKKVGLDIEAGKFTH
DKKVHHTHEGSIGNLCNDRIESLMRQVVDGFNFSVMEQAERSLLGR

Sequences:

>Translated_446_residues
MAQKLWEKNVRVNEEIDRFTVGRDREMDLYLAKHDVLGSMAHITMLESIGLLTAGELEMLLAELKNIYASAEKGEFVIED
GIEDVHSQVELMLTRKLGDVGKKIHSGRSRNDQVLVDLKLFTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQI
AMPSSFGLWFGAYAESLVDDMMFLQAAFKMCNRNPLGSAAGYGSSFPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNV
AFALASIAGTVSKMAFDACMFSSQNFGFVKLPDECTTGSSIMPHKKNPDVFELTRAKCNKLQALPQQIMMIMNNLPSGYF
RDLQIIKEVFLPAFRELKECLQMAAYIMDKIKINEHILDDNRYLYIFSVEEVNRLASEGMPFRDAYKKVGLDIEAGKFTH
DKKVHHTHEGSIGNLCNDRIESLMRQVVDGFNFSVMEQAERSLLGR
>Mature_445_residues
AQKLWEKNVRVNEEIDRFTVGRDREMDLYLAKHDVLGSMAHITMLESIGLLTAGELEMLLAELKNIYASAEKGEFVIEDG
IEDVHSQVELMLTRKLGDVGKKIHSGRSRNDQVLVDLKLFTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQIA
MPSSFGLWFGAYAESLVDDMMFLQAAFKMCNRNPLGSAAGYGSSFPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNVA
FALASIAGTVSKMAFDACMFSSQNFGFVKLPDECTTGSSIMPHKKNPDVFELTRAKCNKLQALPQQIMMIMNNLPSGYFR
DLQIIKEVFLPAFRELKECLQMAAYIMDKIKINEHILDDNRYLYIFSVEEVNRLASEGMPFRDAYKKVGLDIEAGKFTHD
KKVHHTHEGSIGNLCNDRIESLMRQVVDGFNFSVMEQAERSLLGR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=364, Percent_Identity=33.2417582417582, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI68303542, Length=364, Percent_Identity=33.2417582417582, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI68303549, Length=366, Percent_Identity=31.6939890710383, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI68303547, Length=364, Percent_Identity=31.3186813186813, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1790398, Length=388, Percent_Identity=36.8556701030928, Blast_Score=235, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6321806, Length=400, Percent_Identity=30.75, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI221473854, Length=363, Percent_Identity=30.8539944903581, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI78706858, Length=363, Percent_Identity=30.8539944903581, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_BACV8 (A6KYN9)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298175.1
- ProteinModelPortal:   A6KYN9
- SMR:   A6KYN9
- STRING:   A6KYN9
- GeneID:   5301825
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_0858
- NMPDR:   fig|435590.6.peg.815
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   IMEEVKL
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50608; Mature: 50477

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKLWEKNVRVNEEIDRFTVGRDREMDLYLAKHDVLGSMAHITMLESIGLLTAGELEML
CCCHHHHCCCCCCCHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAELKNIYASAEKGEFVIEDGIEDVHSQVELMLTRKLGDVGKKIHSGRSRNDQVLVDLKL
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHH
FTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQIAMPSSFGLWFGAYAESLVDD
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
MMFLQAAFKMCNRNPLGSAAGYGSSFPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHH
AFALASIAGTVSKMAFDACMFSSQNFGFVKLPDECTTGSSIMPHKKNPDVFELTRAKCNK
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LQALPQQIMMIMNNLPSGYFRDLQIIKEVFLPAFRELKECLQMAAYIMDKIKINEHILDD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
NRYLYIFSVEEVNRLASEGMPFRDAYKKVGLDIEAGKFTHDKKVHHTHEGSIGNLCNDRI
CCEEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ESLMRQVVDGFNFSVMEQAERSLLGR
HHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQKLWEKNVRVNEEIDRFTVGRDREMDLYLAKHDVLGSMAHITMLESIGLLTAGELEML
CCHHHHCCCCCCCHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAELKNIYASAEKGEFVIEDGIEDVHSQVELMLTRKLGDVGKKIHSGRSRNDQVLVDLKL
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHH
FTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQIAMPSSFGLWFGAYAESLVDD
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
MMFLQAAFKMCNRNPLGSAAGYGSSFPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHH
AFALASIAGTVSKMAFDACMFSSQNFGFVKLPDECTTGSSIMPHKKNPDVFELTRAKCNK
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LQALPQQIMMIMNNLPSGYFRDLQIIKEVFLPAFRELKECLQMAAYIMDKIKINEHILDD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
NRYLYIFSVEEVNRLASEGMPFRDAYKKVGLDIEAGKFTHDKKVHHTHEGSIGNLCNDRI
CCEEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ESLMRQVVDGFNFSVMEQAERSLLGR
HHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA