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The map label for this gene is lpxB [H]

Identifier: 148828224

GI number: 148828224

Start: 1654122

End: 1655294

Strand: Reverse

Name: lpxB [H]

Synonym: CGSHiGG_08930

Alternate gene names: 148828224

Gene position: 1655294-1654122 (Counterclockwise)

Preceding gene: 148828225

Following gene: 148828223

Centisome position: 87.71

GC content: 40.66

Gene sequence:

>1173_bases
ATGAACAAAACAAATCCAACCATTGCTCTTGTTGCAGGAGAAGTATCTGGTGATATTCTCGGTGCTGGTTTAATTCGCCA
GCTCAAAGCACATTATCCTAATGCGCGCTTTATTGGTATTGCAGGCACAAGAATGTTGGCTGAAGGCTGTAAAACGCTCG
TCGATATGGAAGAGCTTTCAGTCATGGGTTTGGCTGAAATCTTGAAACATCTTCCTCGTCTGTTAAAAATTCGCAAAAAT
GTCATTCAAACTATGTTGCAAGAAAAACCTGATGTTTACATCGGCATTGATGCGCCTGATTTTAATTTGGATGTAGAACT
CAAGCTCAAAGCTAACGGAATTAAAACCATTCATTACGTGAGCCCCTCTGTATGGGCATGGCGTCAAAATCGTATCCATA
AAATTGCCAAAGCGACCCATCAAGTTCTTGCCTTTTTGCCTTTTGAGAAAGCCTTTTACGATAAATTTAATGTCCCTTGC
CGTTTTATTGGACACACAATGGCAGATGCTATTCCGCTCAAACCAAACCGTGCCGAAGCCTGCCAAATGCTACAGATTGA
TCCCGCACAACGCTATTTAGCTATCCTAGTTGGAAGTCGTGGTTCAGAAGTGGAATTTCTGGCTGAGCCTTTCTTGAAAA
CCGCTTTATTATTAAAAGAACAATTCCCAGATTTGCAATTGCTCGTTCCTTTGGTAAACGAAAAACGACGAATTCAATTT
GAATCCATTAAAGCTAAAATTGCGCCAAATCTAGACCTGCATTTAATTGACGGCAATGCACGACAAGCAATGATCGCCGC
TGATGCAACACTGCTTGCTTCAGGAACAGCAGCGCTTGAAGCAATGCTTTGTAAATCCCCAATGGTGGTAGGCTATCGAA
TGAAACCACTGACCTATTTCTTAGCAAAACGTTTAGTGAAAACTGATTATATTTCTTTACCAAACTTGCTTGCGAATGAA
ATGCTCGTGCCTGAAATGATTCAAGAAGAATGCACGCCAGAATTGCTCGCTGAAAAACTATCTGCTTATCTTTCTGATGA
TGAAAGTGCGGTAAAAAATCGCCTTGTTTTAATTCAGCACTTCACGGATTTACACCAAAAAATTCAATGCAATGCCGATA
AGCAAGCGGCTCAAGCGGTCATTGATTTATTAGAAGGAAAAGAAAATGTTTGA

Upstream 100 bases:

>100_bases
TTTCAAACGTTCAACTCGCGGAATTATTCGTTAATAAAACTTCTTCATTTTCAACCGCACTTTGCACACCAAAGTGCGGT
TATTTTTTAGGATAAATTTG

Downstream 100 bases:

>100_bases
ATATCCACAAGGCTATGAATTGATCGCTGGCGTTGATGAAGTTGGGCGAGGCCCTTTAGTTGGGGCGGTTGTCACGGCTG
CCGTTATTTTGGATCCGAAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGTRMLAEGCKTLVDMEELSVMGLAEILKHLPRLLKIRKN
VIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQMLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQLLVPLVNEKRRIQF
ESIKAKIAPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSAYLSDDESAVKNRLVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV

Sequences:

>Translated_390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGTRMLAEGCKTLVDMEELSVMGLAEILKHLPRLLKIRKN
VIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQMLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQLLVPLVNEKRRIQF
ESIKAKIAPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSAYLSDDESAVKNRLVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV
>Mature_390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGTRMLAEGCKTLVDMEELSVMGLAEILKHLPRLLKIRKN
VIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQMLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQLLVPLVNEKRRIQF
ESIKAKIAPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSAYLSDDESAVKNRLVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=384, Percent_Identity=63.0208333333333, Blast_Score=485, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43541; Mature: 43541

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGTRMLAEGCKTLVDMEELS
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
VMGLAEILKHLPRLLKIRKNVIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEE
SPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
CQMLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQLLVPLVNEKRRIQF
HHHHCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCHHEEH
ESIKAKIAPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYF
HHHHHEECCCCEEEEECCCCCEEEEEECHHHHHCCHHHHHHHHHCCCCEEEEEHHHHHHH
LAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSAYLSDDESAVKNRLVLIQH
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FTDLHQKIQCNADKQAAQAVIDLLEGKENV
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGTRMLAEGCKTLVDMEELS
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
VMGLAEILKHLPRLLKIRKNVIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEE
SPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
CQMLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQLLVPLVNEKRRIQF
HHHHCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCHHEEH
ESIKAKIAPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYF
HHHHHEECCCCEEEEECCCCCEEEEEECHHHHHCCHHHHHHHHHCCCCEEEEEHHHHHHH
LAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSAYLSDDESAVKNRLVLIQH
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FTDLHQKIQCNADKQAAQAVIDLLEGKENV
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA