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The map label for this gene is dmsA [H]

Identifier: 148828213

GI number: 148828213

Start: 1640630

End: 1642909

Strand: Reverse

Name: dmsA [H]

Synonym: CGSHiGG_08875

Alternate gene names: 148828213

Gene position: 1642909-1640630 (Counterclockwise)

Preceding gene: 148828217

Following gene: 148828212

Centisome position: 87.06

GC content: 38.51

Gene sequence:

>2280_bases
ATGAGTAACTTTAATCAAATAAGTCGCCGAGATTTTGTCAAGGCGTCATCTGCGGGAGCTGCACTGGCAGTTTCAAATCT
TACTTTACCTTTCAATGTAATGGCTAAAGAGACACAATACCTCAATGAAAATAGCCAGGAACGTATTGTTTGGAGTGCTT
GTACAGTAAACTGTGGTAGCCGTTGTCCATTACGAATGCACGTAAAAGATAACCGAATCACTTATGTGGAAACCGATAAT
ACGGGGACAGAAACATATAATCTTGATCATCAGGTTCGTGCTTGTCTACGTGGACGTTCTATGCGTCGTCGGGTGTATAA
CCCAGACCGTTTAAAATATCCAATGAAACGTATAGGTAAACGCGGAGAAGGTAAATTCAAACGAATCAGTTGGGATGAGG
CTTTAACTGAAATTGCAGACGCATTGAAACGCAATATCAAAAAATATGGCAATGAATCAATTTATTTAAACTATGGTACG
GGAACACTCGGTGGCACAATGGCTAAATCTTGGCCACCTGCATCCACTATGATCGCTCGTTTTATGAATTGTATTGGTGG
ATATTTAAACCATTATGGTGATTACAGCACCGCACAAATTGCAGTCGGTTTAGATTATACCTATGGTGGTGGTTGGGCAT
TGGGAAATGGAATGGCTGACATTGAAAACACCAAATTAATAGTGTTATTCGGTAATAATCCTGCAGAAACTCGTATGAGT
GGAGGTGGTTTAACTTATTGTATTGAACAAGCCAAAGCTCGTTCCAATGCCAAAATGATTATTATCGATCCTCGTTATAA
TGATACTGGTGCAGGGCGTGAAGATGAGTGGATCCCAATTCGTCCAGGCACTGATGCAGCCCTCGTTTCTGCCCTTGCTT
ATGTAATGATTCAAGAAAATCTCGTGGATCAACCTTTCTTAGATAAATATTGTGTTGGTTATGATGAAAAAACATTACCT
GCGGATGCCCCTAAAAATGGTCATTATAAAGCCTATATTTTAGGTTATGGTAATGATGGTATCGCTAAAACCCCAGAATG
GGCGGCTAAAATCACGGGTATTCCGGCGGAGAGAATTATTAAACTCGCACGTGAAATTGGTAGTACAAAACCTGCCTTTA
TTTCCCAAGGTTGGGGGCCTCAACGTCGTAGTAATGGAGAATTAATCTCTCGTGCCATTGCGATGTTGCCAATCTTAACA
GGTAATGTTGGAATTCACGGCGGTAACACTGGTGCACGTGAAAGTGCGTATAGCATTCCATTTGTGCGGATGCCAACGCT
AAAAAATCCTGTGAAAGCAAGCATTCCAATGTTTTTATGGACAGATGCAATTATTCGTGGCACAGAAATGACCGCACTTA
CAGATGGTATTCGTGGTGTTGATAAATTATCGTCCCCAATTAAAGTAATTTGGAATTACGCAAGTAACTGTTTGATTAAT
CAACACGCACAAATCAATCGTACTCACGATATTTTACAAGATGATACCCAATGTGAAATGATCATTACTATTGATAATCA
TATGACATCTACTGCCAAATACAGTGATATTTTATTACCAGATTGTACAACTTCAGAACAAATGGATTTCGCTTTAGATG
CCTTTGTATCCAATATGGCATATGTCATTTTTGCAGATCAAGTGATCAAACCATCTTTTGAATGTAGACCTATTTACGAT
ATGTTAAGTGATTTAGCTGAGAAAATGGGCGTAAAGGAAAAATTTACTGAAGGACGAACACAAGAAGAGTGGTTACGCCA
TATTTATGAGCAATCTCGAGAAAAATTACCTGAATTACCTACTTTTGAAGAATTTAGACAACAAGGTATTTTTAAAAAAG
TTGATCCTAATGGCTTTAAAGTTGCATACAAAGATTTCCGCGATAATCCAGAAGCCCATCCACTTAAAACGCCATCTGGC
AAAATTGAAATTTATTCTTCTCGTCTAGCTGAAATAGCAAAAACTTGGAAATTAGCAGAAGATGACGTAATTCATCCCTT
ACCTATTCACGCCCAAAGTTTTGAGCATTACGGTGATCCATTAATGGAAAAATATCCGTTACAACTAAGTGGTTTTCACT
ATAAAGCGAGAACCCATTCAACTTATGGCAATGTGGATGTATTAAAAGCAGCTAATCCACAAGAAGTTTGGATGAATCCT
ATTGATGCAGAACCTCGTAATATTAAAAATGGCGATATGATTCGTATCTTTAATGATCGAGGCGAAGTACGTATTAATGT
AAAAATTACCCCCGTATTATTCCAGGGGTTGTGGCATTAA

Upstream 100 bases:

>100_bases
TATTAATAATTAGTTGATTTGGCTCAAGTAAAACTTCTATACAAAGATTATAATTAACTCGTTTTAGTTATTACTCAATC
TTACTGTGGGGGACGATATT

Downstream 100 bases:

>100_bases
GCGAGGGGGCTTGGTATGCACCAGATAAAGATCGTATCGATCATTCAGGTTGCATTAATGTACTTACGACACAACGCCCA
TCACCGCTTGCGAAAGGTAA

Product: anaerobic dimethyl sulfoxide reductase chain A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MSNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQYLNENSQERIVWSACTVNCGSRCPLRMHVKDNRITYVETDN
TGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGKRGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGT
GTLGGTMAKSWPPASTMIARFMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMS
GGGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVSALAYVMIQENLVDQPFLDKYCVGYDEKTLP
ADAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERIIKLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILT
GNVGIHGGNTGARESAYSIPFVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLIN
QHAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMAYVIFADQVIKPSFECRPIYD
MLSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELPTFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSG
KIEIYSSRLAEIAKTWKLAEDDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNP
IDAEPRNIKNGDMIRIFNDRGEVRINVKITPVLFQGLWH

Sequences:

>Translated_759_residues
MSNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQYLNENSQERIVWSACTVNCGSRCPLRMHVKDNRITYVETDN
TGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGKRGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGT
GTLGGTMAKSWPPASTMIARFMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMS
GGGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVSALAYVMIQENLVDQPFLDKYCVGYDEKTLP
ADAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERIIKLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILT
GNVGIHGGNTGARESAYSIPFVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLIN
QHAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMAYVIFADQVIKPSFECRPIYD
MLSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELPTFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSG
KIEIYSSRLAEIAKTWKLAEDDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNP
IDAEPRNIKNGDMIRIFNDRGEVRINVKITPVLFQGLWH
>Mature_758_residues
SNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQYLNENSQERIVWSACTVNCGSRCPLRMHVKDNRITYVETDNT
GTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGKRGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGTG
TLGGTMAKSWPPASTMIARFMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMSG
GGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVSALAYVMIQENLVDQPFLDKYCVGYDEKTLPA
DAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERIIKLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILTG
NVGIHGGNTGARESAYSIPFVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLINQ
HAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMAYVIFADQVIKPSFECRPIYDM
LSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELPTFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSGK
IEIYSSRLAEIAKTWKLAEDDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNPI
DAEPRNIKNGDMIRIFNDRGEVRINVKITPVLFQGLWH

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=754, Percent_Identity=72.8116710875332, Blast_Score=1157, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=763, Percent_Identity=63.4338138925295, Blast_Score=1035, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=755, Percent_Identity=60.794701986755, Blast_Score=966, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=740, Percent_Identity=30.5405405405405, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI145693196, Length=699, Percent_Identity=30.6151645207439, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI87081994, Length=811, Percent_Identity=27.8668310727497, Blast_Score=249, Evalue=5e-67,
Organism=Escherichia coli, GI3868721, Length=744, Percent_Identity=25.1344086021505, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI3868720, Length=469, Percent_Identity=26.4392324093817, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI3868719, Length=461, Percent_Identity=25.3796095444685, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788534, Length=820, Percent_Identity=23.780487804878, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 85393; Mature: 85262

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQYLNENSQERIVWSACTVNCGS
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
RCPLRMHVKDNRITYVETDNTGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGK
CCCEEEEEECCEEEEEEECCCCCEEECCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHCCC
RGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGTGTLGGTMAKSWPPASTMIAR
CCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
FMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMS
HHHHHHHHHHHCCCCCCEEEEEEEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHCEEC
GGGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVSALAYVMIQEN
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LVDQPFLDKYCVGYDEKTLPADAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERII
CCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCHHHHH
KLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILTGNVGIHGGNTGARESAYSIP
HHHHHHCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHEECCEEEECCCCCCCCCCCCCC
FVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLIN
EEECCCCCCCCHHCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEC
QHAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMA
CCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCE
YVIFADQVIKPSFECRPIYDMLSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELP
EEEEEHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
TFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSGKIEIYSSRLAEIAKTWKLAE
CHHHHHHCCCCEECCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCC
DDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNP
CCCCCCCCCCHHHHHHHCCHHHHHCCCEECCEEEEEECCCCCCCEEEEECCCCHHHCCCC
IDAEPRNIKNGDMIRIFNDRGEVRINVKITPVLFQGLWH
CCCCCCCCCCCCEEEEECCCCEEEEEEEECHHHHCCCCC
>Mature Secondary Structure 
SNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQYLNENSQERIVWSACTVNCGS
CCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
RCPLRMHVKDNRITYVETDNTGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGK
CCCEEEEEECCEEEEEEECCCCCEEECCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHCCC
RGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGTGTLGGTMAKSWPPASTMIAR
CCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
FMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMS
HHHHHHHHHHHCCCCCCEEEEEEEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHCEEC
GGGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVSALAYVMIQEN
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LVDQPFLDKYCVGYDEKTLPADAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERII
CCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCHHHHH
KLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILTGNVGIHGGNTGARESAYSIP
HHHHHHCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHEECCEEEECCCCCCCCCCCCCC
FVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLIN
EEECCCCCCCCHHCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEC
QHAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMA
CCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCE
YVIFADQVIKPSFECRPIYDMLSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELP
EEEEEHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
TFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSGKIEIYSSRLAEIAKTWKLAE
CHHHHHHCCCCEECCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCC
DDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNP
CCCCCCCCCCHHHHHHHCCHHHHHCCCEECCEEEEEECCCCCCCEEEEECCCCHHHCCCC
IDAEPRNIKNGDMIRIFNDRGEVRINVKITPVLFQGLWH
CCCCCCCCCCCCEEEEECCCCEEEEEEEECHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 8635740 [H]