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The map label for this gene is tktA [H]

Identifier: 148828190

GI number: 148828190

Start: 1616348

End: 1618345

Strand: Reverse

Name: tktA [H]

Synonym: CGSHiGG_08730

Alternate gene names: 148828190

Gene position: 1618345-1616348 (Counterclockwise)

Preceding gene: 148828191

Following gene: 148828186

Centisome position: 85.75

GC content: 42.64

Gene sequence:

>1998_bases
ATGGCAACTCGTAGACAATTAGCCAATGCAATTCGTGTCTTAGCAATGGATTCTGTACAAAAAGCAAAATCTGGTCACCC
TGGTGCACCAATGGGGATGGCGGATATTGCTGAAGTATTATGGCGCGACTTTTTAAAACACAATCCAACCAATCCTAAAT
GGGCTGATCGAGATCGTTTTGTACTTTCTAACGGCCATGGTTCTATGTTGATTTATAGTCTTTTACATTTAACTGGCTAT
GATCTTTCTATCGAAGATTTAAAACAATTCCGTCAATTACATTCTAAAACCCCTGGCCACCCAGAATATGGTTATGCCCC
CGGTGTTGAAACCACCACTGGCCCGTTAGGTCAAGGTATCACTAATGCGGTGGGTATGGCAATTGCTGAGAAAACCTTAG
CTGGACAATTTAACCGTGAAGGTCATGAAATTGTCGATCACCACACTTATGTGTTCTTAGGCGATGGCTGTTTAATGGAA
GGGATCTCTCACGAGGCTTGCTCTTTAGCAGGAACCTTAGGTCTGGGTAAATTAATCGCATTCTACGATGACAACAATAT
TTCCATTGATGGTCATGTTGATGGCTGGTTCAGTGATGACACTGCCGAGCGTTTTGAAGCTTATGGCTGGCAAGTAATCC
GTAATGTAGATGGTCACGATGCAGAGCAAATTCGTGCTGCTACCATTCTTGCTCAAGCAGAAAAAGAAAAACCAACGTTA
ATTATTTGTAAAACCATCATCGGCTTTGGTTCACCAAATAAATCAGGTTCTCATGATTCCCATGGCGCACCATTAGGCGA
TGAAGAAATCGATTTAACCCGTAAAGCTCTTGGTTGGGAATATGCGCCATTTGAAATTCCAGCTGAATACTATGCTGAAT
GGTCGGCAAAAGAGAAAGGTGCTGCAGCAGAAAAATCTTGGGAAGAAAAATTTGCCGCTTATGCAAAAGCCTATCCTGAA
TTGGCAGCAGAATTTAAACGTCGTGTTTCTGGCGAATTACCAACAAACTGGGCGGCAGAATCTAAAGCGTTCATCGAAAA
ATTACAAGCAAATCCAGCGAGTATTGCAAGCCGTAAAGCATCACAAAATGCCATTGAAGCCTATGCACACGTATTGCCAG
AATTTTTAGGTGGTTCTGCAGACTTAGCAAGCTCCAACTTAACCTTATGGAGTGGGTCTAAACCAATTCGTGCACACGAA
AACGTAGGCGGTAACTACATTAACTACGGTGTTCGTGAATTTGGTATGTCTGCCATTATGAACGGTATTGCTTTACACGG
CGGTTTCATTCCTTACGGCGCAACCTTCTTAATGTTCTATGAATATGCTCACAATGCGGTGCGTATGGCAGCATTAATGA
AACAACGCACATTATTCGTTTATACCCACGATTCCATCGGTTTAGGCGAAGATGGGCCTACACACCAACCAGTAGAACAA
ACGGCTTCACTACGCTTAATTCCAAACCTTGAAACATGGCGTCCATGTGACCAAGTGGAATCTGCTATTGCATGGCAACA
AGCTGTCGAGCGTCAAGATGGCCCAAGTGCGTTAATCTTTACCCGTCAAAATCTTGCTCAAATGAACCGAACTTCTGCAC
AATTAGATGCGGTTAAACGTGGTGCTTATGTGTTAAAAGATTGTGATGGCACACCTGAATTAATCTTCATTGCGACAGGT
TCTGAAGTAGAATTAGCGGTAAAAGCAGCCGAAGCATTAAGTGCTGAAGGTAAAAAAGTACGTGTAGTCTCTATGCCAAG
CACTAATCGTTTTGATAAACAAGATGCAGCATACCGCGAAAGCGTATTACCTGCAGCTGTAACCAAACGTGTTGCAATTG
AAGCGGGTATTGCTGACTTCTGGTATAAATACGTTGGATTCAACGGTCGTGTTGTCGGTATGAATAGCTTTGGCGAATCC
GCACCAGCAGATCAATTATTTAAACTCTTTGGTTTCACTGTTGAAAACGTGGTAGCGAAAGTGAAAGAAATTCTTTAA

Upstream 100 bases:

>100_bases
CTAATTTTCACATAGTAACCTTGCAAGATATTGTTACAAGTATTTGCACTCACTTTCGGTCAAGATTAGGAAAATAACAA
AATATTCACAGGAGAACAAA

Downstream 100 bases:

>100_bases
GATTGATATAAATAGCTCCTTGATATTCAAGGAGCTATTTTATTGGCTATTAAAAATTATTGTGAGATATGAAATAAAGA
AAGGAATAGATTTATACTTA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPE
LAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHE
NVGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKRGAYVLKDCDGTPELIFIATG
SEVELAVKAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGES
APADQLFKLFGFTVENVVAKVKEIL

Sequences:

>Translated_665_residues
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPE
LAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHE
NVGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKRGAYVLKDCDGTPELIFIATG
SEVELAVKAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGES
APADQLFKLFGFTVENVVAKVKEIL
>Mature_664_residues
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGYD
LSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTLI
ICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPEL
AAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHEN
VGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQT
ASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKRGAYVLKDCDGTPELIFIATGS
EVELAVKAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGESA
PADQLFKLFGFTVENVVAKVKEIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=684, Percent_Identity=26.1695906432749, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI4507521, Length=684, Percent_Identity=26.1695906432749, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI133778974, Length=692, Percent_Identity=25, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=673, Percent_Identity=21.5453194650817, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637463, Length=594, Percent_Identity=21.8855218855219, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI225637461, Length=594, Percent_Identity=21.8855218855219, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI48994911, Length=665, Percent_Identity=77.4436090225564, Blast_Score=1095, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=69.079939668175, Blast_Score=995, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=672, Percent_Identity=24.8511904761905, Blast_Score=165, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=49.0990990990991, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=44.9925261584454, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI45551847, Length=694, Percent_Identity=25.5043227665706, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45550715, Length=694, Percent_Identity=25.5043227665706, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24645119, Length=660, Percent_Identity=25.1515151515152, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24666278, Length=269, Percent_Identity=31.9702602230483, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72804; Mature: 72673

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
EEECCCEEECCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCE
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKG
EEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
AAAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHENVGGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHH
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GAYVLKDCDGTPELIFIATGSEVELAVKAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRE
CCEEEECCCCCCCEEEEEECCCEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
SVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGESAPADQLFKLFGFTVENVVAK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
VKEIL
HHHHC
>Mature Secondary Structure 
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
EEECCCEEECCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCE
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKG
EEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
AAAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHENVGGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHH
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GAYVLKDCDGTPELIFIATGSEVELAVKAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRE
CCEEEECCCCCCCEEEEEECCCEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
SVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGESAPADQLFKLFGFTVENVVAK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
VKEIL
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]