Click here to switch to the map view.

The map label for this gene is pepB [H]

Identifier: 148828057

GI number: 148828057

Start: 1459156

End: 1460460

Strand: Direct

Name: pepB [H]

Synonym: CGSHiGG_07915

Alternate gene names: 148828057

Gene position: 1459156-1460460 (Clockwise)

Preceding gene: 148828056

Following gene: 148828058

Centisome position: 77.32

GC content: 38.7

Gene sequence:

>1305_bases
ATGCAAATTACACTTTCAAATAACTTAGCGAATGATGCTTGGGGAAAAAATGCTATTTTGAGCTTTGACTCTAATAAAGC
AACAATTCATTTAAAAAATAATGAAAAAACTGACCGCACTTTAGTTCAACAAGCTGCTCGTAAATTGCGTGGGCAGGGAA
TTAAAGATGTGGAATTAGTCGGTGAAGAATGGGATTTGGAATTTTGCTGGGCGTTTTATCAAGGTTTTTATACCGCAAAA
CAAGATTACGGGATTGAGTTTCCGCATTTAGATGATGAACCGCAAGATGAATTATTAGCGCGTATTGAATGTGGCGATTT
TGTGCGTGGGATTATTAATGAGCCAGCACAAAGCCTAACACCAGTAAAATTAGCAGAACGTGCGGCTGAATTTATCTTAA
ACCAAGCTGATATTTATAATGAAAAAAGTGCGGTCAGTTTTAAGATTATTTCTGGTGAGGAACTTGAGCAACAAGGTTAT
CACGGAATTTGGACTGTGGGTAAAGGCTCTGCTAACTTGCCCGCCATGTTGCAACTTGATTTCAATCCAACACAAGATCC
GAATGCGCCAGTGTTAGCTTGTTTAGTTGGTAAGGGGATTACTTTTGACAGTGGCGGCTACAGTATCAAACCAAGTGATG
GAATGAGTACAATGCGAACCGATATGGGTGGGGCAGCATTATTAACAGGGGCTTTAGGTTTCGCTATTGCTCGCGGATTA
AATCAACGCGTTAAACTGTATTTATGTTGTGCAGAAAATTTGGTAAGCAATAATGCTTTTAAACTAGGCGATATTATTAC
TTATAAAAATGGCGTGACAGCAGAAGTGCTGAATACTGACGCTGAAGGGCGTTTGGTGTTAGCTGATGGATTGATTGAAG
CGGACAGCCAAAATCCGGGTTTTATTATTGATTGTGCGACTTTAACTGGGGCTGCAAAAGTGGCTGTAGGAAATGACTAT
CATTCGGTATTATCTATGGATGATGATCTCGTGAAGAATCTTTTCCAATCAGCAAAAGAAGAAAATGAACCTTTTTGGCG
TTTACCATTTGAAGATTTTCATCGCTCACAAATTAATTCATCTTTTGCCGATATTGCTAATATTGGTTCTGTTCCAGTTG
GGGCGGGGGCAAGTACAGCAACGGCATTTTTATCGTATTTTATAAAAAATTATCAGCAAAATTGGTTGCATATTGATTGT
TCCGCAACTTATCGTAAATCTAGTAGTGATTTATGGGCTGTTGGGGCGACAGGGATTGGTGTGCAAACTTTAGCAAATTT
AATGTTATCAAAATCATTGAAGTAA

Upstream 100 bases:

>100_bases
ATTTGTAAAATGCTTGTTATTCATGATTGAATGATGTGAAATTAGGTATAAAGCTGGTATAGCTTCTAAATTTATTTTGT
TTATACATGGGGGAATAAAT

Downstream 100 bases:

>100_bases
GGAGATATGATGACAGAAAGAACGTTTTCGATTATTAAACCTGATGCGGTAAAGCGTAATCTAATTGGAGCAATCTTAAC
TCGTTTTGAGCAAAATGGCT

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MQITLSNNLANDAWGKNAILSFDSNKATIHLKNNEKTDRTLVQQAARKLRGQGIKDVELVGEEWDLEFCWAFYQGFYTAK
QDYGIEFPHLDDEPQDELLARIECGDFVRGIINEPAQSLTPVKLAERAAEFILNQADIYNEKSAVSFKIISGEELEQQGY
HGIWTVGKGSANLPAMLQLDFNPTQDPNAPVLACLVGKGITFDSGGYSIKPSDGMSTMRTDMGGAALLTGALGFAIARGL
NQRVKLYLCCAENLVSNNAFKLGDIITYKNGVTAEVLNTDAEGRLVLADGLIEADSQNPGFIIDCATLTGAAKVAVGNDY
HSVLSMDDDLVKNLFQSAKEENEPFWRLPFEDFHRSQINSSFADIANIGSVPVGAGASTATAFLSYFIKNYQQNWLHIDC
SATYRKSSSDLWAVGATGIGVQTLANLMLSKSLK

Sequences:

>Translated_434_residues
MQITLSNNLANDAWGKNAILSFDSNKATIHLKNNEKTDRTLVQQAARKLRGQGIKDVELVGEEWDLEFCWAFYQGFYTAK
QDYGIEFPHLDDEPQDELLARIECGDFVRGIINEPAQSLTPVKLAERAAEFILNQADIYNEKSAVSFKIISGEELEQQGY
HGIWTVGKGSANLPAMLQLDFNPTQDPNAPVLACLVGKGITFDSGGYSIKPSDGMSTMRTDMGGAALLTGALGFAIARGL
NQRVKLYLCCAENLVSNNAFKLGDIITYKNGVTAEVLNTDAEGRLVLADGLIEADSQNPGFIIDCATLTGAAKVAVGNDY
HSVLSMDDDLVKNLFQSAKEENEPFWRLPFEDFHRSQINSSFADIANIGSVPVGAGASTATAFLSYFIKNYQQNWLHIDC
SATYRKSSSDLWAVGATGIGVQTLANLMLSKSLK
>Mature_434_residues
MQITLSNNLANDAWGKNAILSFDSNKATIHLKNNEKTDRTLVQQAARKLRGQGIKDVELVGEEWDLEFCWAFYQGFYTAK
QDYGIEFPHLDDEPQDELLARIECGDFVRGIINEPAQSLTPVKLAERAAEFILNQADIYNEKSAVSFKIISGEELEQQGY
HGIWTVGKGSANLPAMLQLDFNPTQDPNAPVLACLVGKGITFDSGGYSIKPSDGMSTMRTDMGGAALLTGALGFAIARGL
NQRVKLYLCCAENLVSNNAFKLGDIITYKNGVTAEVLNTDAEGRLVLADGLIEADSQNPGFIIDCATLTGAAKVAVGNDY
HSVLSMDDDLVKNLFQSAKEENEPFWRLPFEDFHRSQINSSFADIANIGSVPVGAGASTATAFLSYFIKNYQQNWLHIDC
SATYRKSSSDLWAVGATGIGVQTLANLMLSKSLK

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=326, Percent_Identity=36.5030674846626, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI47155554, Length=283, Percent_Identity=34.982332155477, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI87082123, Length=428, Percent_Identity=57.9439252336449, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1790710, Length=322, Percent_Identity=38.5093167701863, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=297, Percent_Identity=33.6700336700337, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=207, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357381, Length=303, Percent_Identity=35.973597359736, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221379063, Length=303, Percent_Identity=35.973597359736, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221379062, Length=303, Percent_Identity=35.973597359736, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355725, Length=295, Percent_Identity=29.8305084745763, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=28.8135593220339, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077148, Length=377, Percent_Identity=25.9946949602122, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI20130057, Length=377, Percent_Identity=25.9946949602122, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24662227, Length=305, Percent_Identity=27.5409836065574, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20129969, Length=371, Percent_Identity=25.8760107816712, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355645, Length=315, Percent_Identity=25.7142857142857, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24662223, Length=315, Percent_Identity=25.7142857142857, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20129963, Length=328, Percent_Identity=27.4390243902439, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI19922386, Length=377, Percent_Identity=24.9336870026525, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24646701, Length=276, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24646703, Length=276, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21358201, Length=276, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 47339; Mature: 47339

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00631 CYTOSOL_AP ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITLSNNLANDAWGKNAILSFDSNKATIHLKNNEKTDRTLVQQAARKLRGQGIKDVELV
CEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEC
GEEWDLEFCWAFYQGFYTAKQDYGIEFPHLDDEPQDELLARIECGDFVRGIINEPAQSLT
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCC
PVKLAERAAEFILNQADIYNEKSAVSFKIISGEELEQQGYHGIWTVGKGSANLPAMLQLD
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCEEEEECCCCCCCCEEEEEC
FNPTQDPNAPVLACLVGKGITFDSGGYSIKPSDGMSTMRTDMGGAALLTGALGFAIARGL
CCCCCCCCCCEEEEEECCCEEECCCCCEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHCC
NQRVKLYLCCAENLVSNNAFKLGDIITYKNGVTAEVLNTDAEGRLVLADGLIEADSQNPG
CCCEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEECCCCCCEEEEECCEEECCCCCCC
FIIDCATLTGAAKVAVGNDYHSVLSMDDDLVKNLFQSAKEENEPFWRLPFEDFHRSQINS
EEEECCCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
SFADIANIGSVPVGAGASTATAFLSYFIKNYQQNWLHIDCSATYRKSSSDLWAVGATGIG
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCC
VQTLANLMLSKSLK
HHHHHHHHHHHCCC
>Mature Secondary Structure
MQITLSNNLANDAWGKNAILSFDSNKATIHLKNNEKTDRTLVQQAARKLRGQGIKDVELV
CEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEC
GEEWDLEFCWAFYQGFYTAKQDYGIEFPHLDDEPQDELLARIECGDFVRGIINEPAQSLT
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCC
PVKLAERAAEFILNQADIYNEKSAVSFKIISGEELEQQGYHGIWTVGKGSANLPAMLQLD
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCEEEEECCCCCCCCEEEEEC
FNPTQDPNAPVLACLVGKGITFDSGGYSIKPSDGMSTMRTDMGGAALLTGALGFAIARGL
CCCCCCCCCCEEEEEECCCEEECCCCCEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHCC
NQRVKLYLCCAENLVSNNAFKLGDIITYKNGVTAEVLNTDAEGRLVLADGLIEADSQNPG
CCCEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEECCCCCCEEEEECCEEECCCCCCC
FIIDCATLTGAAKVAVGNDYHSVLSMDDDLVKNLFQSAKEENEPFWRLPFEDFHRSQINS
EEEECCCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
SFADIANIGSVPVGAGASTATAFLSYFIKNYQQNWLHIDCSATYRKSSSDLWAVGATGIG
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCC
VQTLANLMLSKSLK
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA