Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 148827715

GI number: 148827715

Start: 1070940

End: 1072019

Strand: Reverse

Name: fba [H]

Synonym: CGSHiGG_05870

Alternate gene names: 148827715

Gene position: 1072019-1070940 (Counterclockwise)

Preceding gene: 148827716

Following gene: 148827714

Centisome position: 56.8

GC content: 40.74

Gene sequence:

>1080_bases
ATGGCTAAATTATTAGATATCGTGAAACCCGGTGTTATAACAGGCGAAGATGTGCAAAAAGTTTTTGCTTATGCTAAAGA
GCATAACTTTGCTATTCCTGCCGTAAACTGTGTGGGTTCTGACTCCGTTAATGCCGTGTTAGAAACTGCTGCACGCGTAA
AAGCACCAGTGATTATCCAATTTTCAAATGGTGGCGCAGCGTTCTATGCAGGTAAAGGTATCAAACCAACGAGTGGTACT
CGTCCAGATGTTTTAGGGGCGATTGCTGGAGCGAAACAGGTTCATACTTTAGCGAAAGAATACGGTGTGCCTGTTATTCT
TCATACTGATCACGCAGCGAAAAAATTATTACCTTGGATCGACGGTTTATTAGATGCAGGCGAAAAACATTTTGCCGAAA
CGGGTCGTCCACTTTTCTCTTCACATATGATCGATTTATCTGAAGAGTCAATGGAAGAAAATATGGCAATCTGCCGTGAA
TATCTTGCTCGTATGGATAAAATGGGGATGACCCTTGAAATCGAAATTGGCATTACTGGTGGCGAAGAAGACGGCGTTGA
TAACTCTGATGTAGATGAATCTCGTTTATATACACAACCTTCTGATGTGCTTTATGTTTACGATCAATTGCATCCAGTAA
GCCCTAACTTTACCGTTGCTGCTGCATTCGGTAACGTACATGGTGTTTACAAACCAGGTAATGTAAAATTAAAACCATCT
ATTTTAGGTGCATCACAAGAGTTCGTTGCGAAAGAACGCAATCTTCCTGCAAAACCAATTAATTTCGTATTCCACGGTGG
TTCAGGTTCTAGCCGCGAAGAAATCCGCGAAGCAATTGGCTACGGTGCAATCAAAATGAACATTGATACTGATACGCAAT
GGGCGTCTTGGAATGGTATTTTGAACTTCTACAAAGCAAATGAAGCATATCTTCAAGGTCAATTAGGTAACCCTGAAGGC
CCAGACGCGCCAAATAAAAAATACTACGATCCACGTGTTTGGTTACGTAAAATGGAAGAATCTATGTCTAAACGCTTAGA
GCAATCTTTCGAAGACTTAAATTGTGTTGATGTTTTATAA

Upstream 100 bases:

>100_bases
CCTCTATAACATATTGATGATGGCATCAAAAATGCCATCATCAATACAAATTCTTCAAATTGTGGGCTTATCCCACTAAA
CATAAAAAGGAAACACAAGT

Downstream 100 bases:

>100_bases
TCCACAAAAATAACATAAAATACGACCGCACTTTCAAGTGCGGTTTTTTTATTTTAGCGGAGAAATTATGGAAAAGATTT
TAGTTATTCGTAACGATAAA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGT
RPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
ILGASQEFVAKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL

Sequences:

>Translated_359_residues
MAKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGT
RPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
ILGASQEFVAKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
>Mature_358_residues
AKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGTR
PDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICREY
LARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPSI
LGASQEFVAKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEGP
DAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=71.3091922005571, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI87082041, Length=331, Percent_Identity=26.5861027190332, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788072, Length=274, Percent_Identity=26.2773722627737, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322790, Length=352, Percent_Identity=50.8522727272727, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 39280; Mature: 39149

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00152 ATPASE_ALPHA_BETA ; PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFYAGKGIKPTSGTRPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWI
ECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHCCHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGASQEFVAKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGI
HHCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCE
LNFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFYAGKGIKPTSGTRPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWI
ECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHCCHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGASQEFVAKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGI
HHCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCE
LNFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]