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The map label for this gene is menA [H]

Identifier: 148827702

GI number: 148827702

Start: 1051466

End: 1052356

Strand: Reverse

Name: menA [H]

Synonym: CGSHiGG_05805

Alternate gene names: 148827702

Gene position: 1052356-1051466 (Counterclockwise)

Preceding gene: 148827704

Following gene: 148827701

Centisome position: 55.76

GC content: 39.51

Gene sequence:

>891_bases
ATGTGGTGGGAAACGGCTCGACCAAAAACTTTGCCCTTAGCGTTGGCATCGATTTTCACGGGTTCGGCATTAGGTTATTG
GGCGAATCCACAAGGTTTTAATGGGCTTGTAATGGTGCTTTGTTTACTCACGACAATTTTATTGCAGGTGCTTTCTAATT
TTGCCAATGATTATGGGGATCATCAAAAAGGTTCAGATACTGAAGAACGTATTGGGCCATTACGTGGCATTCAAAAAGGC
GCAATTTCAGCAAAAGAACTGAAATGGGGATTAATTCTAATGGTGATGGCAAGTTTTCTTTCAGGAAGTTTCTTGATTGG
AATCGCTTATGAAAGCCTCTCAGATTTATTCGCTTTCGCTGGGCTTGGAATTTTAGCTATTGTTGCTGCCATTACTTACA
CAGTTGGGGTAAAACCTTATGGCTATATGGGCTTGGGCGATATTTCTGTGTTGGTATTTTTTGGTTTGCTTGGTGTTGGC
GGTACTTATTATTTGCAAACTCACAGTATTGATAGCCACATTATTTTGCCTGCTATTGGTTCTGGCTTATTGGCAAGTGC
GGTATTAAATATCAATAATTTACGCGATATTGAACAGGATGCGAAAGCTAGCAAAAATACCCTAGCCGTTCGTTTAGGTG
CATATAAAGGGCGTGTTTATCATTGTATTTTATTAAGTGTGGCGGCTCTATGTTATTTAGCATTTGCGGTGGCAACGGCT
ATTTCTTGGACAAATTATTTATTTGTATTAGCAATGCCGTTGTTAGCTAAACATGCGATCTTTGTTTATCGCAGTCAGCA
GCCAAGTGAATTGCGTCCAATGTTGGCTCAAATGTCTATGATTTCGTTATTAATCAATATCTTGTTTAGTTTAGGCTTGC
TTATCGGCTAA

Upstream 100 bases:

>100_bases
TAAGGTTAAATCATTCATAAATTGGGTGTCTTAGTGTAGAATACGCGGCTTATTGTAATCAAAAGTGCGGTCAAAAAAAA
TGATAAATGAAAAATTGAAA

Downstream 100 bases:

>100_bases
ATCGGCATATACTAAAGCAAACAAAATTTCAACAATCGATAGGGGAAAGTTATGTTTATTGATACTTCAGAACTTTGCGA
TCTTTATGCAGAACAAGTGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGPLRGIQKG
AISAKELKWGLILMVMASFLSGSFLIGIAYESLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVG
GTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKASKNTLAVRLGAYKGRVYHCILLSVAALCYLAFAVATA
ISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG

Sequences:

>Translated_296_residues
MWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGPLRGIQKG
AISAKELKWGLILMVMASFLSGSFLIGIAYESLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVG
GTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKASKNTLAVRLGAYKGRVYHCILLSVAALCYLAFAVATA
ISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG
>Mature_296_residues
MWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGPLRGIQKG
AISAKELKWGLILMVMASFLSGSFLIGIAYESLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVG
GTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKASKNTLAVRLGAYKGRVYHCILLSVAALCYLAFAVATA
ISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=294, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790365, Length=295, Percent_Identity=53.5593220338983, Blast_Score=291, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31932; Mature: 31932

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGD
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
HQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYESLSDLFAFA
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
GLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIDSHIILPAIG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHC
SGLLASAVLNINNLRDIEQDAKASKNTLAVRLGAYKGRVYHCILLSVAALCYLAFAVATA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
ISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG
HHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGD
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
HQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYESLSDLFAFA
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
GLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIDSHIILPAIG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHC
SGLLASAVLNINNLRDIEQDAKASKNTLAVRLGAYKGRVYHCILLSVAALCYLAFAVATA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
ISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG
HHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]