Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 148827666

GI number: 148827666

Start: 1016881

End: 1017792

Strand: Direct

Name: hisG [H]

Synonym: CGSHiGG_05585

Alternate gene names: 148827666

Gene position: 1016881-1017792 (Clockwise)

Preceding gene: 148827662

Following gene: 148827667

Centisome position: 53.88

GC content: 39.58

Gene sequence:

>912_bases
ATGACAAACACAACAATGCAACCAAACCGCCTTCGTATAGCTTTGCAAAGAAAAGGGCGTTTAAGCCAAGATTGTGCCAT
ATTACTTAAACAATGTGGCGTGAAAATTAATTGGAATGAACAACGTTTAATCGCTTATGCGGAAAATTTGCCGATTGAAA
TTCTTCGCGTACGTGATGATGATATTCCTGGATTGATTTTTGATGGCGTAGTGGATCTTGGGATTATTGGCGAAAATGTG
TTAGAAGAGGAAGAGCTTGGTCGCCGTGCAGCAAATGAAACAGTTACATACAAAAAACTTTGCCAACTTGATTTTGGTGA
TTGTCGTCTATCACTTGCGGTTGATCGCGATTGTCATTATGAGAATGTGAAAGATCTTGCTAATAGGCGTATTGCAACTT
CTTACCCGCATTTACTCAAACGTTATATGAATGAGAATGGGGTGTCGTTTAAAAGTTGTTTATTAAATGGTTCAGTAGAA
GTCGCACCTAGTGCGGGTATTGCTTATGCGATTTGCGATTTAGTATCATCAGGGGCAACGCTTGAAGCAAATGGCTTAAA
AGAAGTGGACGTGATTTATCGTTCTAAAGCTTGTTTAATTCAGCGTGCTGAACCGCTTGAATCAACTAAACAAGCTCTTG
TGGATAAACTACTCACTCGTATTCAAGGTGTGCAGCAGGCAGCAGAAAGTAAATATATTATGCTCCACGCTCCGAAAGAA
AAACTTGAAAAAATCACTGCGCTTTTACCTGGCGTTGAAAATCCGACCATTTTACCATTAGCCACTGATACAACTCGGGT
AGCAATGCACGTAGTGAGCCAAGAAAATTTATTTTGGGAAACAATGGAACAGTTAAAAGAGGCAGGAGCTAGTTCAATTT
TAGTGTTACCAATTGAGAAGATGATGGAGTAA

Upstream 100 bases:

>100_bases
CCGAGTGTAATAAAAATCAGTGTAAAAGCAATAAATACCCCTCGGAAGGCAATTTTCGAGGGGTTTTCTTTTATCTCAAC
TTTAAAATAGGAAAAACATT

Downstream 100 bases:

>100_bases
ATATAGTGCGAGCTTTGACTCGCCATTTAAATAATCAATATCTCAAAATGGTGGGTTATCATCCATTTTACGGATACAAA
GGAAAATAAAACAATGCAAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTNTTMQPNRLRIALQRKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDDDIPGLIFDGVVDLGIIGENV
LEEEELGRRAANETVTYKKLCQLDFGDCRLSLAVDRDCHYENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVE
VAPSAGIAYAICDLVSSGATLEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
KLEKITALLPGVENPTILPLATDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEKMME

Sequences:

>Translated_303_residues
MTNTTMQPNRLRIALQRKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDDDIPGLIFDGVVDLGIIGENV
LEEEELGRRAANETVTYKKLCQLDFGDCRLSLAVDRDCHYENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVE
VAPSAGIAYAICDLVSSGATLEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
KLEKITALLPGVENPTILPLATDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEKMME
>Mature_302_residues
TNTTMQPNRLRIALQRKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDDDIPGLIFDGVVDLGIIGENVL
EEEELGRRAANETVTYKKLCQLDFGDCRLSLAVDRDCHYENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVEV
APSAGIAYAICDLVSSGATLEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKEK
LEKITALLPGVENPTILPLATDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=303, Percent_Identity=70.6270627062706, Blast_Score=426, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320896, Length=296, Percent_Identity=28.3783783783784, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33811; Mature: 33679

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTMQPNRLRIALQRKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDD
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEEECCC
DIPGLIFDGVVDLGIIGENVLEEEELGRRAANETVTYKKLCQLDFGDCRLSLAVDRDCHY
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEECCCCCH
ENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVEVAPSAGIAYAICDLVSSGAT
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHCCCE
LEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
KLEKITALLPGVENPTILPLATDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEK
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHH
MME
HCC
>Mature Secondary Structure 
TNTTMQPNRLRIALQRKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDD
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEEECCC
DIPGLIFDGVVDLGIIGENVLEEEELGRRAANETVTYKKLCQLDFGDCRLSLAVDRDCHY
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEECCCCCH
ENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVEVAPSAGIAYAICDLVSSGAT
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHCCCE
LEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
KLEKITALLPGVENPTILPLATDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEK
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHH
MME
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA