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The map label for this gene is serA [H]

Identifier: 148827662

GI number: 148827662

Start: 1013443

End: 1014675

Strand: Direct

Name: serA [H]

Synonym: CGSHiGG_05565

Alternate gene names: 148827662

Gene position: 1013443-1014675 (Clockwise)

Preceding gene: 148827661

Following gene: 148827666

Centisome position: 53.7

GC content: 41.12

Gene sequence:

>1233_bases
ATGACAAACAAAGTCTCTCTAGACAAATCAAAAATCAAATTTGTATTGTTTGAAGGTGTGCACCAAAGCGCACTTGATAC
GCTCCATGCGGCAGGCTATACCAATATTGATTACTATAAAAAAGCACTAGATGGCGATGAATTAAAAGAAGCCATTAAAG
ATGCACATTTTATCGGCTTGCGTTCTCGCACCCATTTAACGGCAGAAATGATTGAGGCCGCACCCAAATTAATCGCTGTG
GGATGTTTCTGTATTGGTACCAACCAAGTGGATTTAAATGCAGCAAAAGCGCGTGGAATTCCTGTATTTAATGCCCCATT
CTCAAACACTCGTTCCGTCGCAGAACTAGTATTAGGCGAGATTTTATTACTTATGCGCAATGTGCCACAGGCTAATGCCG
AAGTACATCGTGGCGTCTGGAATAAATCCGCGACGGGATCTTATGAAGTGCGGGGTAAAAAATTAGGCATTATTGGTTAC
GGCCACATTGGTTCACAATTAAGTATTATTGCTGAATCATTAGGCATGGATGTGTATTTCTACGATATTGAAAACAAACT
TCCACTCGGTAATGCCAAACAGCTTCGTAGCCTTGAAGAATTACTCAGTTCTTGCGATGTGGTTTCATTACATGTGCCAG
AACTGCCATCTACCAAAAACTTAATGAACGCAGCACGTATCGCACAATTAAAACAAGGGGCAATTTTGATCAATGCTGCG
CGTGGCACAGTGGTAGATATTGACGCTCTCGCTCAAGCCTTAAAAGACGGGAAACTTCAAGGTGCAGCAATTGATGTATT
CCCAATTGAACCTGCTTCAATTAATGAAGAATTTATCTCGCCGTTACGTGAATTTGATAATGTGATTTTAACGCCACATA
TCGGCGGCTCAACAGCGGAAGCACAAGAAAATATCGGTTTTGAAGTGGCAGGCAAATTTGTCAAATATTCAGACAACGGA
TCAACCCTTTCTTCAGTAAACTTCCCAGAGGTCTCTTTACCAGAACACGAGGGAACAAAACGCTTATTGCATATTCACGA
AAATCGTCCTGGTATATTGAACAAACTGAACCAAATTTTCGTCGAAGCTAACCTCAATATTGCAGCGCAATATTTACAAA
CTGACCCGAAAATTGGTTATGTTGTCGTAGATGTAGAAACGAATGATGCATCGCCATTACTGACGAAATTGAAGGAAATA
GATGGCACAATTCGTGCGCGTGTACTGTACTAA

Upstream 100 bases:

>100_bases
GGATATTCGCGTTACGTGGCGCAGACGTTGTGATCGTCGGGACGCCTGAAGGCGCCAAAATTATTGACTAATTCATAATA
AAAATCATAAGGAAGCAAAC

Downstream 100 bases:

>100_bases
ATAGAAAAAAGATCAGGTTAATGCCTGATCTTTTTTGCTTTCTTATTCAGTAATCGAATAAGGTAACTGCACTCGCTCTA
ACAATATTTCACTATTCAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDAHFIGLRSRTHLTAEMIEAAPKLIAV
GCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSYEVRGKKLGIIGY
GHIGSQLSIIAESLGMDVYFYDIENKLPLGNAKQLRSLEELLSSCDVVSLHVPELPSTKNLMNAARIAQLKQGAILINAA
RGTVVDIDALAQALKDGKLQGAAIDVFPIEPASINEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVKYSDNG
STLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEI
DGTIRARVLY

Sequences:

>Translated_410_residues
MTNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDAHFIGLRSRTHLTAEMIEAAPKLIAV
GCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSYEVRGKKLGIIGY
GHIGSQLSIIAESLGMDVYFYDIENKLPLGNAKQLRSLEELLSSCDVVSLHVPELPSTKNLMNAARIAQLKQGAILINAA
RGTVVDIDALAQALKDGKLQGAAIDVFPIEPASINEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVKYSDNG
STLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEI
DGTIRARVLY
>Mature_409_residues
TNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDAHFIGLRSRTHLTAEMIEAAPKLIAVG
CFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSYEVRGKKLGIIGYG
HIGSQLSIIAESLGMDVYFYDIENKLPLGNAKQLRSLEELLSSCDVVSLHVPELPSTKNLMNAARIAQLKQGAILINAAR
GTVVDIDALAQALKDGKLQGAAIDVFPIEPASINEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVKYSDNGS
TLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEID
GTIRARVLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=40, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=34.453781512605, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=34.453781512605, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=35.3413654618474, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=35.3413654618474, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=35.3413654618474, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI6912396, Length=275, Percent_Identity=28.3636363636364, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=71.1491442542787, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=33.596837944664, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787645, Length=237, Percent_Identity=31.2236286919831, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1788660, Length=337, Percent_Identity=28.7833827893175, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=161, Percent_Identity=34.1614906832298, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=36.0248447204969, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=28.9795918367347, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.3091787439614, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.5845410628019, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324055, Length=245, Percent_Identity=31.0204081632653, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=263, Percent_Identity=30.0380228136882, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=32.258064516129, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=116, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=27.1604938271605, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=316, Percent_Identity=32.9113924050633, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=30.3370786516854, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646446, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24646448, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24646452, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24646450, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI62472511, Length=220, Percent_Identity=36.3636363636364, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571528, Length=302, Percent_Identity=28.8079470198675, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585514, Length=271, Percent_Identity=27.3062730627306, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574282, Length=271, Percent_Identity=27.3062730627306, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574284, Length=271, Percent_Identity=27.3062730627306, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45552429, Length=271, Percent_Identity=27.3062730627306, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=27.3062730627306, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=24.9158249158249, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44664; Mature: 44533

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDAHFIGL
CCCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHEEEC
RSRTHLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGE
CCCHHHHHHHHHHCCCEEEEEEEEEECCEEECCHHHHCCCEEECCCCCCHHHHHHHHHHH
ILLLMRNVPQANAEVHRGVWNKSATGSYEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYF
HHHHHHCCCCCCHHHHHCCCCCCCCCCEEECCEEEEEEEECCCCCHHHHHHHHHCCEEEE
YDIENKLPLGNAKQLRSLEELLSSCDVVSLHVPELPSTKNLMNAARIAQLKQGAILINAA
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEC
RGTVVDIDALAQALKDGKLQGAAIDVFPIEPASINEEFISPLREFDNVILTPHIGGSTAE
CCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCH
AQENIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIF
HHHCCCCEEECEEEEECCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHEE
VEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEIDGTIRARVLY
EECCCCCEEHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure 
TNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDAHFIGL
CCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHEEEC
RSRTHLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGE
CCCHHHHHHHHHHCCCEEEEEEEEEECCEEECCHHHHCCCEEECCCCCCHHHHHHHHHHH
ILLLMRNVPQANAEVHRGVWNKSATGSYEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYF
HHHHHHCCCCCCHHHHHCCCCCCCCCCEEECCEEEEEEEECCCCCHHHHHHHHHCCEEEE
YDIENKLPLGNAKQLRSLEELLSSCDVVSLHVPELPSTKNLMNAARIAQLKQGAILINAA
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEC
RGTVVDIDALAQALKDGKLQGAAIDVFPIEPASINEEFISPLREFDNVILTPHIGGSTAE
CCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCH
AQENIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIF
HHHCCCCEEECEEEEECCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHEE
VEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEIDGTIRARVLY
EECCCCCEEHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]