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The map label for this gene is tmk [H]

Identifier: 148827653

GI number: 148827653

Start: 1003587

End: 1004219

Strand: Reverse

Name: tmk [H]

Synonym: CGSHiGG_05520

Alternate gene names: 148827653

Gene position: 1004219-1003587 (Counterclockwise)

Preceding gene: 148827654

Following gene: 148827650

Centisome position: 53.21

GC content: 42.81

Gene sequence:

>633_bases
ATGAAAGGAAAGTTTATTGTCATTGAGGGCTTAGAAGGTGCGGGGAAAAGTTCCGCTCATCAGTCTGTTGTGCGAGTCTT
GCATGAACTTGGGATTAAAGATGTCGTGTTTACACGCGAACCTGGTGGAACGCCACTGGCTGAGAAATTACGTCATCTCA
TCAAACATGAAACCGAAGAACCCGTGACAGATAAAGCAGAGTTATTAATGCTTTATGCCGCACGTATTCAGTTGGTGGAA
AATGTGATTAAACCAGCTTTAATGCAAGGAAAATGGGTGGTAGGTGATCGCCACGATATGTCATCTCAGGCGTATCAAGG
CGGCGGGCGTCAATTAGACCCGCATTTTATGCTCACCTTGAAAGAAACCGTATTAGGTGATTTTGAGCCAGATCTCACCA
TTTATTTGGATATAGATCCGATAGTCGGTTTAGCGCGAGCTCGTGGACGTGGTGAATTAGATCGTATTGAGCAAATGGAT
TTGGATTTTTTCCGCCGCACTCGAGCACGTTATTTAGCGTTAGTAAAAGATAATCCAAAAGCAGTCATGATTAATGCAGA
GCAGAGTATTGAACTTGTTCAAGCTGATATCGAAAGAGCGGTAAAAAATTGGTGGAAATCAAACGAAAAATGA

Upstream 100 bases:

>100_bases
AAATTTACCCGAAATTTGAATGAACATAATAAAGCGGTGCAAGAATATTTACGTTGGTATCGCAGTCAGAAAAATGCCAA
ATAAAAGTGCGGAAGAAAAT

Downstream 100 bases:

>100_bases
CCGCACTTTTAAAATAAAAAATCGGCAGAAAATTTTCCTGCCGATTTTTTTGTTACTACTAAGCTTAAAACGTCCACTGT
AAATTCAACGCACCTTGTTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIKDVVFTREPGGTPLAEKLRHLIKHETEEPVTDKAELLMLYAARIQLVE
NVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFMLTLKETVLGDFEPDLTIYLDIDPIVGLARARGRGELDRIEQMD
LDFFRRTRARYLALVKDNPKAVMINAEQSIELVQADIERAVKNWWKSNEK

Sequences:

>Translated_210_residues
MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIKDVVFTREPGGTPLAEKLRHLIKHETEEPVTDKAELLMLYAARIQLVE
NVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFMLTLKETVLGDFEPDLTIYLDIDPIVGLARARGRGELDRIEQMD
LDFFRRTRARYLALVKDNPKAVMINAEQSIELVQADIERAVKNWWKSNEK
>Mature_210_residues
MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIKDVVFTREPGGTPLAEKLRHLIKHETEEPVTDKAELLMLYAARIQLVE
NVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFMLTLKETVLGDFEPDLTIYLDIDPIVGLARARGRGELDRIEQMD
LDFFRRTRARYLALVKDNPKAVMINAEQSIELVQADIERAVKNWWKSNEK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=62.200956937799, Blast_Score=263, Evalue=8e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23783; Mature: 23783

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIKDVVFTREPGGTPLAEKLRHLIKHETEE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
PVTDKAELLMLYAARIQLVENVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFMLTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCCCCHHEEEE
KETVLGDFEPDLTIYLDIDPIVGLARARGRGELDRIEQMDLDFFRRTRARYLALVKDNPK
HHHHCCCCCCCEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCC
AVMINAEQSIELVQADIERAVKNWWKSNEK
EEEEECHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIKDVVFTREPGGTPLAEKLRHLIKHETEE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
PVTDKAELLMLYAARIQLVENVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFMLTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCCCCHHEEEE
KETVLGDFEPDLTIYLDIDPIVGLARARGRGELDRIEQMDLDFFRRTRARYLALVKDNPK
HHHHCCCCCCCEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCC
AVMINAEQSIELVQADIERAVKNWWKSNEK
EEEEECHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA