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The map label for this gene is rnd [H]

Identifier: 148827593

GI number: 148827593

Start: 935686

End: 936891

Strand: Direct

Name: rnd [H]

Synonym: CGSHiGG_05130

Alternate gene names: 148827593

Gene position: 935686-936891 (Clockwise)

Preceding gene: 148827592

Following gene: 148827597

Centisome position: 49.58

GC content: 36.24

Gene sequence:

>1206_bases
ATGTCAAAATGGGATAGCAATATCCCATTTTTGTTCTTTTCAAATAAAAAAATCACTATGATAAAAGAATGTCAAAATCC
ACCGCACTTTAGGGTCGTTACGGATAATACTGCGCTATTAGAAGTTTGTAATTTAGCCCAACAGAAAAGTGCGGTCGCCT
TAGATACAGAATTTATGCGTGTTTCCACTTATTTTCCTAAGCTGGGATTAATCCAACTTTATGATGGTGAGCGCGTCTCT
TTAATTGATCCTTTAGCGATTACGGATTTTTCGCCTTTTGTTGCACTATTAGCCAATCCTAAGGTATTAAAAATCTTACA
TTCTTGTAGTGAGGATTTATTGGTTTTCTTACAAGAATTTGATCAGCTTCCACGCCCAATGATTGATACGCAAATTATGG
CGCGCTTTCTTGGGCTTGGCACATCAGCAGGCTTGGCAAAATTAGCACAACAATACTTAAATATAGAAATCGATAAAGGC
GCAACTCTCACCAATTGGATCAAACGCCCCCTTTCTGATATTCAACTTCAATATGCCGCAGGTGATGTTTGGTATTTGTT
GCCGCTTTATCATATTCTTGAAAAAGAGTTAGCTAAAACACCTTGGGAACAAGCAGTAAGAGATGATTGCGAACTTATTC
TTGCTAAAACGCATAAATTACAAGAGCGAGATTCAGAAAAAGCGTATTTAGATATTCCAAATGCTTGGAAATTAAATCCA
TTAGAATTGTCTCGTTTAAGAGTTTTGGCGCAGTGGCGACAAAACGTGGCAATAGAACGTGATTTAGCACTTTCTTATAT
TGTGAAATCAGAACATCTTTGGAAAGTGGCAAAGAATAATCCACGTAATACATCTGAAATGTTAGAAATGGGATTAACTG
AAAATGAAGTGCGTGTACGTGGTAAAAAGATTTTACAATTGCTTGCTCAAGCAAGACGTGTTTCTTCTAATGACTATCCA
AAACCTATTGAACGTATTTCTGAAGATCCTCGTTATAAAAAAACAATTCGATTATTACAAGAAAAAGTGAATAGCCTAAC
ACCAGAAGGTTTAACCCCTGAAATCGTTGCAAGTAAACGCACTTTGGAAGAATTGATTAAATGGGTTTGGAAATATGATT
GTTCTCAAGATAAACTACCAGAGTTGCTGATTGGATGGCGAAAACCTATTGGTGAAAAGTTAGTGGATGTACTTAAGCAG
ATATAA

Upstream 100 bases:

>100_bases
AAGAAATTGAGTTCCGAGACGAACTGCCAAAAACCAATGTAGGTAAGATTTTACGTCGGGTTTTACGCGATGAAGAGATC
GCAAAACGTCCAAAACATTA

Downstream 100 bases:

>100_bases
AAAAGCGTTGGGCAAATAGCTCAACGCTTTTCGTTTTTACTCGTAGAGTTTTTTCACTTGTTCAGGTGTCATCACTCGTT
GGTATTTACTAAATTCTTTT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGERVS
LIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNIEIDKG
ATLTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELILAKTHKLQERDSEKAYLDIPNAWKLNP
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKKILQLLAQARRVSSNDYP
KPIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKLPELLIGWRKPIGEKLVDVLKQ
I

Sequences:

>Translated_401_residues
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGERVS
LIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNIEIDKG
ATLTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELILAKTHKLQERDSEKAYLDIPNAWKLNP
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKKILQLLAQARRVSSNDYP
KPIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKLPELLIGWRKPIGEKLVDVLKQ
I
>Mature_400_residues
SKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGERVSL
IDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNIEIDKGA
TLTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELILAKTHKLQERDSEKAYLDIPNAWKLNPL
ELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKKILQLLAQARRVSSNDYPK
PIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKLPELLIGWRKPIGEKLVDVLKQI

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=244, Percent_Identity=25.4098360655738, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI50301240, Length=244, Percent_Identity=25.4098360655738, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788105, Length=374, Percent_Identity=40.1069518716578, Blast_Score=301, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI17531757, Length=270, Percent_Identity=24.8148148148148, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161078302, Length=253, Percent_Identity=25.6916996047431, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 46275; Mature: 46144

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMR
CCCCCCCCCEEEECCCCEEEHHHCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHH
VSTYFPKLGLIQLYDGERVSLIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEF
HHHHCCCCCEEEEECCCEEEEECCHHHCCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
DQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNIEIDKGATLTNWIKRPLSDIQLQYAA
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEECCCCHHHHHHHCCHHHHEEEECC
GDVWYLLPLYHILEKELAKTPWEQAVRDDCELILAKTHKLQERDSEKAYLDIPNAWKLNP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCH
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHH
GKKILQLLAQARRVSSNDYPKPIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKR
HHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TLEELIKWVWKYDCSQDKLPELLIGWRKPIGEKLVDVLKQI
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMR
CCCCCCCCEEEECCCCEEEHHHCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHH
VSTYFPKLGLIQLYDGERVSLIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEF
HHHHCCCCCEEEEECCCEEEEECCHHHCCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
DQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNIEIDKGATLTNWIKRPLSDIQLQYAA
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEECCCCHHHHHHHCCHHHHEEEECC
GDVWYLLPLYHILEKELAKTPWEQAVRDDCELILAKTHKLQERDSEKAYLDIPNAWKLNP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCH
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHH
GKKILQLLAQARRVSSNDYPKPIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKR
HHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TLEELIKWVWKYDCSQDKLPELLIGWRKPIGEKLVDVLKQI
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]