Click here to switch to the map view.

The map label for this gene is ntpA [H]

Identifier: 148827468

GI number: 148827468

Start: 826051

End: 826515

Strand: Reverse

Name: ntpA [H]

Synonym: CGSHiGG_04395

Alternate gene names: 148827468

Gene position: 826515-826051 (Counterclockwise)

Preceding gene: 148827469

Following gene: 148827467

Centisome position: 43.8

GC content: 36.13

Gene sequence:

>465_bases
TTGACCGCATTTTTAATGATGCAATACAAAAATAATCAGTCTGTTCTCGTTGTAATTTACACTAAAGATACAAACAGAGT
TTTAATGCTCCAACGCCAAGATGATCCTGATTTTTGGCAGTCTGTTACTGGCACCATTGAAAGTGGTGAAACACCAAAAA
ACACAGCAATTCGTGAGCTATGGGAAGAAGTGCGGTTAGAAATTTCGGAAAATTCCACCGCACTTTTTGATTGCAATGAG
AGCATAGAATTTGAAATTTTTCCACATTTCCGCTATAAATACGCACCGAATATTACTCACTGCAAAGAACATTGGTTTTT
GTGTGAGGTGGAAAAAGAATTTATGCCAGTATTGAGTGAGCATTTAGATTTTTGCTGGATATCGGCGAAAAAAGCAGTAG
AAATGACGAAATCCCAGAATAATGCGGAAGCTATTAAAAAATATCTTTTTAATCTCCGTAGGTAA

Upstream 100 bases:

>100_bases
AGCACCGAGTTTTGCGAATCCGCAAGCATTGGAAGAGTTGGCAATTTCTGTCGTTAAAGCAGAATAAGTTTGAAATATTA
GGAATGAAGTGCGGTCAGAT

Downstream 100 bases:

>100_bases
GTATACTTACAGCTAATTATGGTAATAGCGGTTCTCTTTTGGGAAAAGTTACATCCACCCCCAACGGGGTAACACTTTTA
CTAACCTAGGCTATACCTAG

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESGETPKNTAIRELWEEVRLEISENSTALFDCNE
SIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFMPVLSEHLDFCWISAKKAVEMTKSQNNAEAIKKYLFNLRR

Sequences:

>Translated_154_residues
MTAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESGETPKNTAIRELWEEVRLEISENSTALFDCNE
SIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFMPVLSEHLDFCWISAKKAVEMTKSQNNAEAIKKYLFNLRR
>Mature_153_residues
TAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESGETPKNTAIRELWEEVRLEISENSTALFDCNES
IEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFMPVLSEHLDFCWISAKKAVEMTKSQNNAEAIKKYLFNLRR

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=143, Percent_Identity=48.951048951049, Blast_Score=155, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18329; Mature: 18198

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESGETPKNTAIREL
CCEEEEEEEECCCEEEEEEEECCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHH
WEEVRLEISENSTALFDCNESIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFMPVLSE
HHHHCEEECCCCEEEEECCCCCEEEEECCEEEEECCCCCCHHHCEEEEEECHHHHHHHHH
HLDFCWISAKKAVEMTKSQNNAEAIKKYLFNLRR
HCCEEEECHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESGETPKNTAIREL
CEEEEEEEECCCEEEEEEEECCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHH
WEEVRLEISENSTALFDCNESIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFMPVLSE
HHHHCEEECCCCEEEEECCCCCEEEEECCEEEEECCCCCCHHHCEEEEEECHHHHHHHHH
HLDFCWISAKKAVEMTKSQNNAEAIKKYLFNLRR
HCCEEEECHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]