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The map label for this gene is guaA [H]

Identifier: 148827363

GI number: 148827363

Start: 707649

End: 709220

Strand: Direct

Name: guaA [H]

Synonym: CGSHiGG_03740

Alternate gene names: 148827363

Gene position: 707649-709220 (Clockwise)

Preceding gene: 148827362

Following gene: 148827365

Centisome position: 37.5

GC content: 44.02

Gene sequence:

>1572_bases
ATGACAAACATCCACAATCACAAAATCCTAATCCTCGACTTCGGTTCACAATATACTCAACTGATTGCACGTCGTGTGCG
TGAAATCGGTGTGTACTGTGAACTTTGGGCTTGGGATGTAACCGAACAACAAATTCGTGAATTTGCCCCAACGGGTATCA
TTCTTTCAGGTGGCCCTGAAAGCACAACTGAAGAAAACAGCCCTCGTGCGCCTGAATATGTATTTAATGCTGGTGTACCA
GTATTAGGCGTTTGCTATGGAATGCAAACGATGGCGATGCAACTTGGCGGTTTAACCGAAACTTCTGACCACCGAGAGTT
CGGCTATGCTTCCGTTTCTCTTGAAAATTCAACCGCACTTTTTGCAAATTTAAACGATAATTCGACCGCTTCTGAGCCGA
AGTTAGACGTTTGGATGAGCCACGGCGATAAAGTAACGCGCTTACCAGAAAACTTCAAAGTAACTGGCACAACGCTAACC
TGCCCAATTGCTGCAATGTCGGATGAAAATCGTCGTTTCTACGGCGTACAATTCCACCCTGAAGTAACGCATACTAAAAA
AGGCTTGGAATTATTAACCAACTTCGTAGTAAACATCTGTGGTTGCGAAACTAAATGGACAGCTGAAAACATTATCGAAG
ATGCCGTTGCTCGCATCAAAGAACAAGTGGGCAATGATGAAGTGATTTTAGGCTTATCTGGTGGTGTGGACTCTTCAGTG
GTTGCATTACTTTTACACCGTGCTATCGGCAAAAACTTACACTGCGTATTCGTGGATAACGGTTTACTCCGCTTACACGA
AGGCGATCAAGTCATGGAAATGTTTGGCGATAAATTCGGTTTAAACATCACTCGTGTTGATGCTGAAAGTCGTTTCCTAG
GCGAACTTGCAGGCGTATCTGATCCTGAAGCGAAACGTAAAATTATCGGTAAAGTATTCGTCGATGTGTTCGATGATGAA
TCGAAAAAACTCACTAATGTGAAATGGTTAGCACAAGGTACGATTTACCCTGATGTCATCGAATCTGCAGCCAGCAAAAC
AGGGAAAGCCCACGTCATTAAATCACACCATAACGTAGGTGGCTTACCAGACTATATGAAACTTGGCTTAGTTGAACCGT
TACGTGAGTTATTTAAAGATGAAGTGCGTAAAATCGGTTTGGCATTAGGCTTACCAGCTGAAATGATCAACCGCCACCCA
TTCCCTGGCCCAGGCTTAGGCGTGCGAGTATTAGGTGAAGTGAAAAAAGAATACTGCGATTTATTACGCCGTGCGGATGC
GATCTTTATCGAAGAATTACGCAACAGCGGTTGGTATGAAAAAACCAGCCAAGCGTTCAGCGTATTCTTACCAGTGAAAT
CTGTAGGTGTGATGGGCGATGGCCGTAAATACGATTGGGTTATTTCCCTACGCGCGGTAGAAACAATCGATTTTATGACC
GCACATTGGGCACATTTGCCTTATGATTTATTAGGCAAAGTGTCTAACCGTATCATCAACGAAGTGAATGGAATTTCCCG
CGTCGTATACGACATCAGCGGAAAACCACCCGCAACAATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TGGGCTTTAGCCTGCCTTTTGCTGTTTAAAGTGCGGTTAGTTTTTGCAAAGTTTTAAATAATATGAACCGCTTACACTAT
CAATAATAAGAGCATTATAA

Downstream 100 bases:

>100_bases
AAAATCACTTTTTCAGATACTTTCTAATTATTTCAGTAACTTTAATAAGTGCGGTTAATTTTCACCGCACTTTATTTTTG
TTTAAAAGCCCTTCTATGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MTNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGGPESTTEENSPRAPEYVFNAGVP
VLGVCYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNSTASEPKLDVWMSHGDKVTRLPENFKVTGTTLT
CPIAAMSDENRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGNDEVILGLSGGVDSSV
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDE
SKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHP
FPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

Sequences:

>Translated_523_residues
MTNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGGPESTTEENSPRAPEYVFNAGVP
VLGVCYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNSTASEPKLDVWMSHGDKVTRLPENFKVTGTTLT
CPIAAMSDENRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGNDEVILGLSGGVDSSV
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDE
SKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHP
FPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
>Mature_522_residues
TNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGGPESTTEENSPRAPEYVFNAGVPV
LGVCYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNSTASEPKLDVWMSHGDKVTRLPENFKVTGTTLTC
PIAAMSDENRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGNDEVILGLSGGVDSSVV
ALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDES
KKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHPF
PGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMTA
HWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=569, Percent_Identity=35.1493848857645, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=78.1609195402299, Blast_Score=861, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=35.8260869565217, Blast_Score=302, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=35.8260869565217, Blast_Score=302, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=35.8260869565217, Blast_Score=302, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323873, Length=524, Percent_Identity=49.8091603053435, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI281365319, Length=561, Percent_Identity=36.541889483066, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58093; Mature: 57962

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCCEEEECCCC
STTEENSPRAPEYVFNAGVPVLGVCYGMQTMAMQLGGLTETSDHREFGYASVSLENSTAL
CCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEE
FANLNDNSTASEPKLDVWMSHGDKVTRLPENFKVTGTTLTCPIAAMSDENRRFYGVQFHP
EEECCCCCCCCCCCEEEEECCCCEEEECCCCCEEECEEEEEEEEECCCCCCEEEEEEECC
EVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGNDEVILGLSGGVDSSV
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVS
HHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHCCHHHCCEEEEECCHHHHHHHHCCCC
DPEAKRKIIGKVFVDVFDDESKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVG
CCHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHPFPGPGLGVRVLGEVKKEYCD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHHHH
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCCEEEECCCC
STTEENSPRAPEYVFNAGVPVLGVCYGMQTMAMQLGGLTETSDHREFGYASVSLENSTAL
CCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEE
FANLNDNSTASEPKLDVWMSHGDKVTRLPENFKVTGTTLTCPIAAMSDENRRFYGVQFHP
EEECCCCCCCCCCCEEEEECCCCEEEECCCCCEEECEEEEEEEEECCCCCCEEEEEEECC
EVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGNDEVILGLSGGVDSSV
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVS
HHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHCCHHHCCEEEEECCHHHHHHHHCCCC
DPEAKRKIIGKVFVDVFDDESKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVG
CCHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHPFPGPGLGVRVLGEVKKEYCD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHHHH
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA